The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Attenuating Staphylococcus aureus Virulence Gene Regulation: A Medicinal Chemistry Perspective
Open accessAbstract
Virulence gene expression in Staphylococcus aureus is tightly regulated by intricate networks of transcriptional regulators and two-component signal transduction systems. There is now an emerging body of evidence to suggest that the blockade of S. aureus virulence gene expression significantly attenuates infection in experimental models. In this Perspective, we will provide insights into medicinal chemistry strategies for the development of chemical reagents that have the capacity to inhibit staphylococcal virulence expression. These reagents can be broadly grouped into four categories: (1) competitive inhibitors of the accessory gene regulator (agr) quorum sensing system, (2) inhibitors of AgrA-DNA interactions, (3) RNAIII transcription inhibitors, and (4) inhibitors of the SarA family of transcriptional regulators. We discuss the potential of specific examples of antivirulence agents for the management and treatment of staphylococcal infections.
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Cites
Klevens, R. M. (2007) · JAMA · doi:10.1001/jama.298.15.1763 · Cited by 3,726
Waves of resistance: Staphylococcus aureus in the antibiotic era
Chambers, H. F., & DeLeo, F. R. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2200 · Cited by 2,718
The biology and future prospects of antivirulence therapies
Cegelski, L., Marshall, G. R., Eldridge, G. R., & Hultgren, S. J. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1818 · Cited by 788
Probiotic Lactobacillus dose required to restore and maintain a normal vaginal flora
Reid, G., Beuerman, D., Heinemann, C., & Bruce, A. W. (2001) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2001.tb00531.x · Cited by 328
Cited by
Regulation of Staphylococcus aureus Virulence
Jenul, C., & Horswill, A. R. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0031-2018 · Cited by 549
Sully, E. K., Malachowa, N., Elmore, B. O., Alexander, S. M., Femling, J. K., Gray, B. M., DeLeo, F. R., Otto, M., Cheung, A. L., Edwards, B. S., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004174 · Cited by 386
Prevention and treatment of Staphylococcus aureus biofilms
Bhattacharya, M., Wozniak, D. J., Stoodley, P., & Hall-Stoodley, L. (2015) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2015.1100533 · Cited by 265
Mull, R. W., Harrington, A., Sanchez, L. A., & Tal-Gan, Y. (2018) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026618666180518090705 · Cited by 41
A Small Molecule That Inhibits the Quorum Sensing Receptor AgrC in Staphylococcus aureus
Polaske, T. J., Vulpis, T. D., Nelson, A. E., Zhao, K., & Blackwell, H. E. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.5c21051 · Cited by 3
Metadata
- Authors
- Gordon, C. P., Williams, P., & Chan, W. C.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-01-22
- Volume
- 56
- Issue
- 4
- Pages
- 1389-1404
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2035274199
- Cited by
- 161
- References
- 4
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
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