Multi-target-Directed Ligands To Combat Neurodegenerative Diseases
Cavalli, Andrea, Bolognesi, Maria Laura, Minarini, Anna, Rosini, Michela, Tumiatti, Vincenzo, Recanatini, Maurizio, Melchiorre, Carlo·2008·Journal of Medicinal Chemistry
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- Case studies on computer-based identification of natural products as lead moleculesConrad Veranso Simoben, Fidele Ntie‐Kang, Dina Robaa, Wolfgang Sippl · 2020 · Physical Sciences Reviews
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- [Design of acetylcholinesterase inhibitor for Alzheimer's disease therapy: from multi-binding site inhibitors to multi-target directed ligands].Wen‐Chao Yang, Qi Sun, Ningxi Yu, Xiao‐Lei Zhu, Guang‐Fu Yang · 2012 · PubMed