Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

Cavalli, Andrea, Bolognesi, Maria Laura, Minarini, Anna, Rosini, Michela, Tumiatti, Vincenzo, Recanatini, Maurizio, Melchiorre, Carlo·2008·Journal of Medicinal Chemistry

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  75. Computational design of new tacrine analogs: an in silico prediction of their cholinesterase inhibitory, antioxidant, and hepatotoxic activities
    Selsabil Djafarou, Imene Amine Khodja, H. Boulebd · 2021 · Journal of Biomolecular Structure and Dynamics
  76. Design, synthesis and anticholinergic properties of novel α-benzyl dopamine, tyramine, and phenethylamine derivatives
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  78. Synthesis, In vitro biological evaluation and molecular modeling study of thiadiazole-sulphonamide hybrid derivatives as potential anti-Alzheimer agents
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  79. Computational evidence to design an appropriate candidate for the treatment of Alzheimer's disease through replacement of the heptamethylene linker of bis(7)tacrine with S-allylcysteine
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  80. Bioinorganic Neurochemistry
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  81. Knowledgebase for addiction-related genes: Is it possible an extrapolation to rational multi-target drug design?
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  87. Synthesis and Activity of Miconazole Derivatives as Dual BChE/IDO1 Inhibitors for the Treatment of Alzheimer's Disease
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  88. Discovery of potent dual ligands for dopamine D4 and σ1 receptors
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  91. Polypharmacology in Drug Discovery
    Oscar Méndez‐Lucio, J. Jesús Naveja, Hugo Vite‐Caritino, Fernando Daniel Prieto-Martínez, José L. Medina‐Franco · 2017 · Methods and principles in medicinal chemistry
  92. Multitarget Drug Discovery
    María Laura Bolognesi, Michele Rossi · 2020 · Encyclopedia of Life Sciences
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    Grace Hohman, Mohamed A. Eldeeb · 2025 · Anti-Cancer Agents in Medicinal Chemistry
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  100. [Design of acetylcholinesterase inhibitor for Alzheimer's disease therapy: from multi-binding site inhibitors to multi-target directed ligands].
    Wen‐Chao Yang, Qi Sun, Ningxi Yu, Xiao‐Lei Zhu, Guang‐Fu Yang · 2012 · PubMed