Multi-target-Directed Ligands To Combat Neurodegenerative Diseases
Cavalli, Andrea, Bolognesi, Maria Laura, Minarini, Anna, Rosini, Michela, Tumiatti, Vincenzo, Recanatini, Maurizio, Melchiorre, Carlo·2008·Journal of Medicinal Chemistry
Cited by (1,000)
Items 701–800 of 1,000
- Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule interactionLuca Pinzi, Christian Conze, Nicolò Bisi, Gabriele Dalla Torre, Ahmed Soliman, Nanci Monteiro-Abreu, Nataliya I. Trushina, Andrea Krusenbaum, Maryam Khodaei Dolouei, Andrea Hellwig et al. · 2024 · Nature Communications
- Synthetic polyamines as potential amine oxidase inhibitors: a preliminary studyEmanuela Bonaiuto, Anna Minarini, Vincenzo Tumiatti, Andrea Milelli, Michele Lunelli, Maurizio Pegoraro, Valeria Rizzoli, Maria Luisa Di Paolo · 2011 · Amino Acids
- Multitarget-directed oxoisoaporphine derivatives: Anti-acetylcholinesterase, anti-β-amyloid aggregation and enhanced autophagy activity against Alzheimer’s diseaseShenqi Wei, Wei Chen, Jingfang Qin, Yingzi Huangli, Li Wang, Yue Shen, Huang Tang · 2016 · Bioorganic & Medicinal Chemistry
- Chemoenzymatic synthesis of optically active phenolic 3,4-dihydropyridin-2-ones: a way to access enantioenriched 1,4-dihydropyridine and benzodiazepine derivativesSusana Y. Torres, Rosario Brieva, Francisca Rebolledo · 2017 · Organic & Biomolecular Chemistry
- Virtual Screening in the Search of New and Potent Anti-Alzheimer AgentsLivia Basile · 2017 · Neuromethods
- Novel, Dual Target‐Directed Annelated Xanthine Derivatives Acting on Adenosine Receptors and Monoamine Oxidase BKamil Kuder, Michał Załuski, Jakub Schabikowski, Gniewomir Latacz, Agnieszka Olejarz‐Maciej, Piotr Jaśko, Agata Doroż-Płonka, Andreas Brockmann, Christa Elisabeth Müller, Katarzyna Kieć‐Kononowicz · 2020 · ChemMedChem
- Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer’s Disease TherapyLazhar Zribi, Irène Pachón-Angona, Óscar M. Bautista‐Aguilera, Daniel Diez‐Iriepa, Jose Luis Marco, Lhassane Ismaïli, Isabel Iriepa, Fakher Chabchoub · 2020 · Molecules
- Pursuing the Complexity of Alzheimer’s Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor AntagonistsJan Konecny, Anna Misiachna, Martina Hrabinová, Lenka Pulkrabkova, Markéta Benková, Lukáš Prchal, Tomas Kucera, Tereza Kobrlová, Vladimír Finger, Marharyta Kolcheva et al. · 2020 · Biomolecules
- A Boron-Containing Compound Acting on Multiple Targets Against Alzheimer’s Disease. Insights from Ab Initio and Molecular Dynamics SimulationsAlessandra Gilda Ritacca, Ida Ritacco, Eslam Dabbish, Nino Russo, Gloria Mazzone, Emilia Sicilia · 2021 · Journal of Chemical Information and Modeling
- Miniaturized electrochemical system for cholinesterase inhibitor detectionAnthony J. Veloso, Paul Michael Nagy, Biao Zhang, Devjani Dhar, Anqi Liang, Tarek Ibrahim, Svetlana N. Mikhaylichenko, Isabelle Aubert, Kağan Kerman · 2013 · Analytica Chimica Acta
- Metabolism‐Activated Multitargeting (MAMUT): An Innovative Multitargeting Approach to Drug Design and DevelopmentPéter Mátyus, Christina L. L. Chai · 2015 · ChemMedChem
- Pharmacophore-based design and discovery of (−)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesisQiong Xie, Zhaoxi Zheng, Biyun Shao, Wei Fu, Zheng Xia, Wei Li, Jian Qi Sun, Wei Zheng, Weiwei Zhang, Wei Sheng et al. · 2017 · Journal of Enzyme Inhibition and Medicinal Chemistry
- Aminoadamantane conjugates with carbazole derivatives as potential multitarget agents for the treatment of Alzheimer’s disease. Effect of the spacer structureГалина Ф. Махаева, E. F. Shevtsova, Надежда Владимировна Ковалева, Елена Владимировна Рудакова, Неганова Маргарита Евгеньевна, L. G. Dubova, Pavel N. Shevtsov, Aleksey Yu. Aksinenko, Vladimir B. Sokolov, Сергей Олегович Бачурин · 2018 · Russian Chemical Bulletin
- Investigating the effects of different natural molecules on the structure and oligomerization propensity of hen egg-white lysozymeAli Châari, Christine Fahy, Alexandre Chevillot‐Biraud, Mohamed Rholam · 2019 · International Journal of Biological Macromolecules
- Potent Acetylcholinesterase Selective and Reversible Homodimeric Agent Based on Tacrine for TheranosticsVirendra Kumar Meena, Shubhra Chaturvedi, Rakesh Kumar Sharma, Anil Kumar Mishra, Puja Panwar Hazari · 2019 · Molecular Pharmaceutics
- Design, synthesis and in-vitro evaluation of fluorinated triazoles as multi-target directed ligands for Alzheimer diseaseTanay Dalvi, Bhaskar Dewangan, Gopal Agarwal, Dattatray Shinde Suchita, Alok K. Jain, Akshay Srivastava, Bichismita Sahu · 2021 · Bioorganic & Medicinal Chemistry Letters
- Mutual Prodrugs - CodrugsAbraham Nudelman · 2022 · Current Medicinal Chemistry
- Synthesis, acetylcholinesterase and butyrylcholinesterase inhibitory potential and molecular docking study of thiazole bearing thiourea analoguesHayat Ullah, Mehvish Jabeen, Fazal Rahim, Amjad Hussain, Fahad Khan, Muhammad Perviaz, Muhammad Sajid, Imad Uddin, Muhammad Usman Khan, Muhammad Nabi · 2023 · Chemical Data Collections
- Recent Advancements in the Treatment of Alzheimer’s Disease: A Multitarget-directed Ligand ApproachSumit Kumar, Amol Tarachand Mahajan, Ramesh Ambatwar, Gopal Lal Khatik · 2023 · Current Medicinal Chemistry
- Current Small Molecule–Based Medicinal Chemistry Approaches for Neurodegeneration TherapeuticsNitesh Sanghai, Billy Vuong, Ahmet Burak Berk, Muhammad Shaharyar Khan Afridi, Geoffrey K. Tranmer · 2024 · ChemMedChem
- Insights on synthetic strategies and structure-activity relationship of donepezil and its derivativesSaraswati Patel, Sonika Jain, Ritika Gururani, Swapnil K. Sharma, Jaya Dwivedi · 2024 · Medicinal Chemistry Research
- Design, Synthesis, and Biological Evaluation of Ferulic Acid-Piperazine Derivatives Targeting Pathological Hallmarks of Alzheimer’s DiseaseGourav Singh, Sunil Kumar, Samir Ranjan Panda, Prabhat Kumar, Sanskriti Rai, Himanshu Verma, Yash Pal Singh, Saroj Kumar, Saripella Srikrishna, V.G.M. Naidu et al. · 2024 · ACS Chemical Neuroscience
- Incorporating the HPLC‐ESI‐Q‐TOF‐MS profiles with the biochemical properties of eight Salvia speciesEulogio Jose Llorent-Martínez, Nilofar Nilofar, Kouadio Ibrahime Sinan, Ekrem Darendelioğlu, Muammer Bahşi, Rıdvan Polat, Uğur Çakılcıoğlu, Giustino Orlando, Claudio Ferrante, Gökhan Zengin · 2025 · eFood
- Protective effect of the multitarget compound DPH‐4 on human SSAO/VAP‐1‐expressing hCMEC/D3 cells under oxygen–glucose deprivation conditions: anin vitroexperimental model of cerebral ischaemiaPing Sun, Gerard Esteban, Tsutomu Inokuchi, J Marco‐Contelles, Babette Barbash Weksler, Ignacio Andres Romero, Pierre‐Olivier Couraud, Mercedes Unzeta, Montse Solé · 2015 · British Journal of Pharmacology
- Purine Homo- N -Nucleoside+Coumarin Hybrids as Pleiotropic Agents for the Potential Treatment of Alzheimer's DiseaseMichael G. Kallitsakis, Matilde Yáñez, Elena Soriano, Jose Luis Marco, Dimitra Hadjipavlou‐Litina, Κonstantinos E. Litinas · 2015 · Future Medicinal Chemistry
- Targeting Oxidative Stress in StrokeAnders Bach · 2017 · Springer series in translational stroke research
- Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain BarrierSlávka Hamuľaková, Ladislav Janovec, Ondřej Soukup, Daniel Jun, Jana Janočková, Martina Hrabinová, Vendula Šepsová, Kamil Kuča · 2018 · Current Alzheimer Research
- Structure–Functional–Selectivity Relationship Studies of Novel Apomorphine Analogs to Develop D1R/D2R Biased LigandsHyejin Park, Aarti N. Urs, Joseph Zimmerman, Chuan Liu, Qiu Wang, Nikhil M. Urs · 2020 · ACS Medicinal Chemistry Letters
- Development of genistein-O-alkylamines derivatives as multifunctional agents for the treatment of Alzheimer’s diseaseZhipei Sang, Jian Shi, Yi Ming Zhou, Keren Wang, Yiyang Zhao, Qingfeng Li, Zhanpin Qiao, Anguo Wu, Zhenghuai Tan, Wenmin Liu · 2021 · Bioorganic Chemistry
- Discovery of effective phosphodiesterase 2 inhibitors with antioxidant activities for the treatment of Alzheimer’s diseaseMei-Yan Jiang, Chuan Han, Chen Zhang, Qian Zhou, Bei Zhang, Mei-Ling Le, Mengxing Huang, Yinuo Wu, Hai‐Bin Luo · 2021 · Bioorganic & Medicinal Chemistry Letters
- Design, synthesis and biological evaluation of new naphtalene diimides bearing isothiocyanate functionalityAnna Minarini, Andrea Milelli, Vincenzo Tumiatti, Lorenzo Ferruzzi, Melinda-Rita Márton, Eleonora Turrini, Patrizia Hrelia, Carmela Fimognari · 2011 · European Journal of Medicinal Chemistry
- ITH12410/SC058: A New Neuroprotective Compound with Potential in the Treatment of Alzheimer’s DiseaseAlejandro Romero, Javier Egea, Gema C. González-Muñoz, María Dolores Martin‐de‐Saavedra, Laura del Barrio, Marı́a Isabel Rodrı́guez-Franco, Santiago Conde, Manuela G. López, Mércedes Villarroya, Cristóbal de los Rı́os · 2014 · ACS Chemical Neuroscience
- Identification of 2-subsituted benzothiazole derivatives as triple-functional agents with potential for AD therapyLiu Jiang, Minkui Zhang, Li Tang, Qinjie Weng, Yanhong Shen, Yongzhou Hu, Rong Sheng · 2016 · RSC Advances
- Multitarget Anti-Alzheimer Hybrid CompoundsDiego Muñoz‐Torrero · 2017 · Elsevier eBooks
- Discovery of New Cyclopentaquinoline Analogues as Multifunctional Agents for the Treatment of Alzheimer’s DiseaseKamila Czarnecka, Małgorzata K. Girek, Paweł Kręcisz, Robert Skibiński, Kamil Łątka, Jakub Jończyk, Marek Bajda, Jacek Kabziński, Ireneusz Majsterek, Piotr Szymczyk et al. · 2019 · International Journal of Molecular Sciences
- On the Development of New Antiepileptic Drugs for the Treatment of Pharmacoresistant Epilepsy: Different Approaches to Different HypothesisAlan Talevi, Luis E. Bruno‐Blanch · 2013 · Springer eBooks
- Synthesis of a second generation chroman/catechol hybrids and evaluation of their activity in protecting neuronal cells from oxidative stress-induced cell deathMaria Koufaki, Elissavet Theodorou, Xanthippi Alexi, Μichael N. Alexis · 2010 · Bioorganic & Medicinal Chemistry
- Design of a structural framework with potential use to develop balanced multifunctional agents against Alzheimer's diseaseNeng Jiang, Xiaobing Wang, Zhongrui Li, Suyi Li, Sai‐Sai Xie, Ming Y. Huang, Ling‐Yi Kong · 2015 · RSC Advances
- Targeting misfolding and aggregation of the amyloid-β peptide and mutant p53 protein using multifunctional moleculesLauryn Grcic, Grace Leech, Kalvin Kwan, Tim Storr · 2024 · Chemical Communications
- Design of Multi-Target drugs of HDACs and other Anti-Alzheimer related Targets: Current strategies and future prospects in Alzheimer’s diseases therapyOsama M. Soltan, Kamal S. Abdelrahman, Amr K. A. Bass, Kazuki Takizawa, Atsushi Narumi, Hiroyuki Konno · 2024 · Bioorganic Chemistry
- Exploring effective diagnosis of Alzheimer disease: Experimental and computational analysis of hybrid benzimidazole based thiazolidinone derivativesShoaib Khan, Yousaf Khan, Ayman M. Al‐Qaaneh, Rafaqat Hussain, Tayyiaba Iqbal, Hayat Ullah, Khurram Shoaib, Aneela Maalik, Muhammad Bilal Khan, Muhammad Akif et al. · 2024 · Results in Chemistry
- New 4-methanesulfonyloxy benzohydrazide derivatives as potential antioxidant and carbonic anhydrase I and II inhibitors: synthesis, characterization, molecular docking, dynamics & ADME studiesAytekin Köse, Leyla Polat Köse, Halil Şenol, Nuray Ulusoy-Güzeldemirci · 2024 · Journal of Molecular Structure
- Attenuating Aβ1–42-induced toxicity by a novel acetylcholinesterase inhibitorN. Mishra, D. Sasmal, K.K. Singh · 2013 · Neuroscience
- Biological Networks and Drug Discovery—Where Do We Stand?Tim Geppert, Herbert Koeppen · 2014 · Drug Development Research
- Tacrine-Natural-Product Hybrids for Alzheimer’s Disease TherapyMaría Jesús Oset‐Gasque, Jose Luis Marco · 2018 · Current Medicinal Chemistry
- WBQ5187, a Multitarget Directed Agent, Ameliorates Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease and Modulates Cerebral β-Amyloid, Gliosis, cAMP Levels, and NeurodegenerationZhiren Wang, Mengru Cao, Hongling Xiang, Wei Wang, Xing Feng, Xiaoping Yang · 2019 · ACS Chemical Neuroscience
- human monoamine oxidase (hMAO) A and hMAO B inhibitors from Artemisia dracunculus L. herniarin and skimmin: human mononamine oxidase A and B inhibitors from A. dracunculus L.Tuba Aydın, Hülya Akıncıoğlu, Mehmet Gümüştaş, İlhami Gülçın, Cavit Kazaz, Ahmet Çakır · 2020 · Zeitschrift für Naturforschung C
- Design, Synthesis and Evaluation of O ‐Pentyne Substituted Diphenylpyrimidines as Monoamine Oxidase and Acetylcholinesterase InhibitorsVijay Kumar, Bhupinder Kumar, Ashish Ranjan Dwivedi, Devashish Mehta, Naveen Kumar, Beenu Bajaj, Tania Arora, Vikash Prashar, Jyoti Parkash, Vinod Kumar · 2020 · ChemistrySelect
- α-Linolenic Acid–Valproic Acid Conjugates: Toward Single-Molecule Polypharmacology for Multiple SclerosisMichele Rossi, Sabrina Petralla, Michele Protti, Monica Baiula, Tereza Kobrlová, Ondřej Soukup, Santi Mario Spampinato, Laura Mercolini, Barbara Monti, María Laura Bolognesi · 2020 · ACS Medicinal Chemistry Letters
- In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative DiseasesAnna Więckowska, Natalia Szałaj, Izabella Góral, Adam Bucki, Gniewomir Latacz, Katarzyna Kieć‐Kononowicz, Óscar M. Bautista‐Aguilera, Alejandro Romero, Eva Ramos, Javier Egea et al. · 2020 · ACS Chemical Neuroscience
- Conjugation of tacrine with genipin derivative not only enhances effects on AChE but also leads to autophagy against Alzheimer’s diseaseRongtian Lin, Shuwen Rao, Yanbing Li, Lei Zhang, Liyu Xu, Yepu He, Zhijun Liu, Heru Chen · 2020 · European Journal of Medicinal Chemistry
- Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinasesVolkmar Tell, Max Holzer, Lydia Herrmann, Kazem Mahmoud, Christoph Schächtele, Frank Totzke, Andreas Hilgeroth · 2012 · Bioorganic & Medicinal Chemistry Letters
- An Expedient Synthesis, Acetylcholinesterase Inhibitory Activity, and Molecular Modeling Study of Highly Functionalized Hexahydro-1,6-naphthyridinesAbdulrahman Ibrahim Almansour, Raju Suresh Kumar, Natarajan Arumugam, Alireza Basiri, Yalda Kia, Mohamed Ashraf Ali · 2015 · BioMed Research International
- Development of glycine-α-methyl-proline-containing tripeptides with neuroprotective propertiesIvana Cacciatore, Erika Fornasari, Antonio Di Stefano, Lisa Marinelli, Laura Serafina Cerasa, Hasan Türkez, Elanur Aydın, Alessandro Moretto, Alessio Ferrone, Mirko Pesce et al. · 2015 · European Journal of Medicinal Chemistry
- Development of multifunctional heterocyclic Schiff base as a potential metal chelator: a comprehensive spectroscopic approach towards drug discoveryManojkumar Jadhao, Chayan Das, Anoop Rawat, Himank Kumar, Ritika Joshi, Sudipta Maiti, Sujit Kumar Ghosh · 2016 · JBIC Journal of Biological Inorganic Chemistry
- Synthesis, molecular docking and biochemical analysis of aminoalkylated naphthalene-based chalcones as acetylcholinesterase inhibitorsGhadah Faraj Aljohani, Adeeb Al-Sheikh Ali, Shaya Y. Al‐Raqa, Syazwani Itri Amran, Norazah Basar · 2021 · Journal of Taibah University for Science
- Unveiling promising inhibitors of superoxide dismutase 1 (SOD1) for therapeutic interventionsAkhtar Atiya, Abdullatif Bin Muhsinah, Mohammed Alrouji, Fahad Abdulrahman Alhumaydhi, Waleed Al Abdulmonem, Mohammad Abdullah Aljasir, Sharaf E. Sharaf, Mohammad Furkan, Rizwan Hasan Khan, Moyad Jamal Shahwan et al. · 2023 · International Journal of Biological Macromolecules
- Unleashing new MTDL AChE and BuChE inhibitors as potential anti-AD therapeutic agents: In vitro, in vivo and in silico studiesDalia K. Zaafar, Nehal H. Elghazawy, Afnan Hassan, Mohamed Y. Mahmoud, Alaa F. Bakr, Reem K. Arafa · 2024 · International Journal of Biological Macromolecules
- Recent development and strategies towards target interactions: Synthesis, characterization and in silico analysis of benzimidazole based thiadiazole as potential anti-Alzheimer agentsShoaib Ahmed Khan, Rafaqat Hussain, Tayyiaba Iqbal, Fazal Rahim, Yousaf Khan · 2024 · Biochemical and Biophysical Research Communications
- Enhanced Recognition Memory through Dual Modulation of Brain Carbonic Anhydrases and CholinesterasesAlessio Nocentini, Alessia Costa, Alessandro Bonardi, Andrea Ammara, Simone Giovannuzzi, Andrea Petreni, Gianluca Bartolucci, Barbara Rani, Manuela Leri, Monica Bucciantini et al. · 2024 · Journal of Medicinal Chemistry
- An insight into allele-selective approaches to lowering mutant huntingtin protein for Huntington’s disease treatmentJia-yuan Yao, Ting Liu, Xin-Ru Hu, Hui Sheng, Zi-hao Chen, Haiyang Zhao, Xiaojia Li, Yang Wang, Liang Hao · 2024 · Biomedicine & Pharmacotherapy
- Coumarin Derivative Hybrids: Novel Dual Inhibitors Targeting Acetylcholinesterase and Monoamine Oxidases for Alzheimer’s TherapyTeresa Żołek, Rosa Purgatorio, Łukasz Kłopotowski, Marco Catto, Kinga Ostrowska · 2024 · International Journal of Molecular Sciences
- Anti-inflammatory drugs as potential antimicrobial agents: a reviewOnyedika Emmanuel Okpala, Johana Rondevaldová, Ladislav Kokoška · 2025 · Frontiers in Pharmacology
- Synthesis and biological evaluation of ranitidine analogs as multiple-target-directed cognitive enhancers for the treatment of Alzheimer’s diseaseJie Gao, Narasimha M. Midde, Jun Zhu, Alvin V. Terry, Campbell McInnes, James M. Chapman · 2016 · Bioorganic & Medicinal Chemistry Letters
- Highlights of ASS234: a novel and promising therapeutic agent for Alzheimer’s disease therapyAlejandro Romero, Eva Ramos, Jose Luis Marco · 2019 · Neural Regeneration Research
- Evaluation of the Therapeutic Effect of Lycoramine on Alzheimer’s Disease in Mouse Modelİrem Kiris, Merve Karayel‐Basar, Betül Şahin, Büşra Gürel, Julide Coşkun, Tomasz Mroczek, Ahmet Tarık Baykal · 2020 · Current Medicinal Chemistry
- Molecular hybridization based design and synthesis of new benzo[5,6]chromeno[2,3-b]-quinolin-13(14H)-one analogs as cholinesterase inhibitorsBaswaraju Macha, Ravindra Kulkarni, Chandrakant Bagul, Anil Kumar Garige, Raghuram Rao Akkinepally, Achaiah Garlapati · 2021 · Medicinal Chemistry Research
- An overview on the synthesis of carbohydrate-based molecules with biological activity related to neurodegenerative diseasesJoão Paulo Bizarro Lopes, Luana Aparecida Alves da Silva, Diogo Seibert Lüdtke · 2021 · RSC Medicinal Chemistry
- Progress and Development of Carbazole Scaffold Based as Potential Anti- Alzheimer Agents Using MTDL ApproachNitin Kumar, Pankaj Gupta, Sahil Bansal · 2022 · Letters in Drug Design & Discovery
- Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer’s diseaseSarah Macedo Vaz, Matheus de Freitas Silva, Graziella dos Reis Rosa Franco, Marcos Jorge R. Guimarães, Fernanda Motta R. da Silva, Newton Gonçalves Castro, Isabella Alvim Guedes, Laurent E. Dardenne, Marina Amaral Alves, Rafael Garrett da Costa et al. · 2022 · Bioorganic & Medicinal Chemistry
- Optical, electrochemical and DFT studies of donor-acceptor typed indole derivativesBuket Bezgin Çarbaş, Hussein Ali NOORI, Emrah Kavak, Yasemin Kaya, Arif Kıvrak · 2022 · Journal of Molecular Structure
- From tryptamine to the discovery of efficient multi-target directed ligands against cholinesterase-associated neurodegenerative disordersJunbo Wu, Honghua Zhang, Yuying Wang, Gaofeng Yin, Qien Li, Linsheng Zhuo, Hongjin Chen, Zhen Wang · 2022 · Frontiers in Pharmacology
- Molecular docking/dynamics simulations, MEP analysis, bioisosteric replacement and ADME/T prediction for identification of dual targets inhibitors of Parkinson’s disease with novel scaffoldMerzaka Mettai, Ismail Daoud, Fouzia Mesli, Samir Kenouche, Nadjib Melkemi, Rania Kherachi, Ahlem Belkadi · 2023 · In Silico Pharmacology
- Rational Design of N-Methylcarbamoylguanidinyl Derivatives as Highly Potent Dual-Target Chitin Hydrolase Inhibitors for Retarding Growth of Pest InsectsZhixiang Zhao, Wei Chen, Simin Wang, Yanhong Dong, Qing Kun Yang, Jianjun Zhang · 2023 · Journal of Agricultural and Food Chemistry
- Neuritogenic activity of bi-functional bis-tryptoline triazoleJutamas Jiaranaikulwanitch, Sarin Tadtong, Piyarat Govitrapong, Valery V. Fokin, Opa Vajragupta · 2016 · Bioorganic & Medicinal Chemistry
- Multi-targeting effects of a new synthetic molecule (JM-20) in experimental models of cerebral ischemiaYanier Núñez-Figueredo, Jeney Ramírez-Sánchez, Gilberto L. Pardo‐Andreu, Estael Ochoa, Yamila Verdecia-Reyes, Diogo Onofre Souza · 2018 · Pharmacological Reports
- Proteochemometric Modeling for Drug RepositioningNalini Schaduangrat, Nuttapat Anuwongcharoen, Chuleeporn Phanus‐umporn, Nagaya Sriwanichpoom, Jarl E. S. Wikberg, Chanin Nantasenamat · 2019 · Elsevier eBooks
- Novel antileukemic agents derived from tamibarotene and nitric oxide donorsHaiyong Bian, Jinhong Feng, Minyong Li, Wenfang Xu · 2011 · Bioorganic & Medicinal Chemistry Letters
- Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 ActivationR.S. Malek, Alexey Simakov, Audrey Davis, Maciej Maj, Paul J. Bernard, Artur Wnorowski, Hélène Martin, Jose Luis Marco, Fakher Chabchoub, Patrick Dallemagne et al. · 2022 · Molecules
- QSAR studies of novel 1-(4-methoxyphenethyl)-1H-benzimidazole-5-carboxylic acid derivatives and their precursors as antileukaemic agentsMukesh Chandra Sharma · 2015 · Journal of Taibah University for Science
- Applications of Click Chemistry in Drug Discovery and DevelopmentBalasubramanian Gopalan, Kalpattu Kuppusamy Balasubramanian · 2016
- Multifunctional agents against Alzheimer’s disease based on oxidative stress: Polysubstituted pyrazine derivatives synthesized by multicomponent reactionsWenxiu Wei, Lanlan Jing, Ye Tian, Anna Więckowska, Dongwei Kang, Bairu Meng, Dawid Panek, Justyna Godyń, Izabella Góral, Yuning Song et al. · 2023 · Bioorganic & Medicinal Chemistry
- Advances in drug design and therapeutic potential of selective or multitarget 5‐HT1A receptor ligandsG. Giorgioni, A. Bonifazi, L. Botticelli, C. Cifani, Federica Matteucci, Emanuela Micioni Di Bonaventura, M. V. Micioni Di Bonaventura, M. Giannella, A. Piergentili, Alessia Piergentili et al. · 2024 · Medicinal research reviews (Print)
- Alzheimer's disease approaches - Focusing on pathology, biomarkers and clinical trial candidatesJana Hroudová, Zdeněk Fišar · 2024 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Hybrid Lipoic Acid Derivatives to Attack Prion Disease on Multiple FrontsSalvatore Bongarzone, Hoang Ngoc Ai Tran, Andrea Cavalli, Marinella Roberti, Michela Rosini, Paolo Carloni, Giuseppe Legname, María Laura Bolognesi · 2011 · ChemMedChem
- Neuroprotective effects of Shende’an tablet in the Parkinson’s disease modelXiaoyan Sheng, Shuiyuan Yang, Xiaomin Wen, Xin Zhang, Yongfeng Ye, Peng Zhao, Limin Zang, Kang Peng, Enming Du, Sai Li · 2021 · Chinese Medicine
- Huprine Y – Tryptophan heterodimers with potential implication to Alzheimer’s disease treatmentEva Mezeiová, Martina Hrabinová, Vendula Hepnarová, Daniel Jun, Jana Janočková, Ľubica Múčková, Lukáš Prchal, Zdena Krištofíková, Tomas Kucera, Lukáš Górecki et al. · 2021 · Bioorganic & Medicinal Chemistry Letters
- Investigation of glutathione as a natural antioxidant and multitarget inhibitor for Alzheimer’s disease: Insights from molecular simulationsSara Roosta, Seyed Majid Hashemianzadeh, Mokhtar Ganjali Koli · 2021 · Journal of Molecular Liquids
- Design, synthesis and structure-activity relationship studies of 3-phenylpyrazino[1,2-a]indol-1(2H)-ones as amyloid aggregation and cholinesterase inhibitors with antioxidant activityS. Gujral, A. Shakeri, L. Hejazi, Praveen P. N. Rao · 2022 · European Journal of Medicinal Chemistry Reports
- Synthesis of indole derivatives as Alzheimer inhibitors and their molecular docking studyZahra Abdulkarim Homoud, Muhammad Taha, Fazal Rahim, Naveed Iqbal, Muhammad Nawaz, Rai Khalid Farooq, Abdul Wadood, Munther Alomari, Imadul Islam, Shatha Algheribe et al. · 2022 · Journal of Biomolecular Structure and Dynamics
- Multiple Ligands Targeting Cholinesterases and β‐Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine PharmacophoreNatalia Szałaj, Marek Bajda, Katarzyna Dudek, Boris Brus, Stanislav Gobec, Barbara Malawska · 2015 · Archiv der Pharmazie
- Synthesis and biological evaluation of genistein‐O‐alkylamine derivatives as potential multifunctional anti‐Alzheimer agentsHong Chen, Hui‐yan Guo, Daiwen Chen, Jianwu Lv, Xin Zhang, Ya‐cheng Yang, Kang Huang, Yijuan Zhang, Zhiyong Tian, Wen Luo et al. · 2018 · Chemical Biology & Drug Design
- 3‐Aryl Coumarin Derivatives Bearing Aminoalkoxy Moiety as Multi‐Target‐Directed Ligands against Alzheimer's DiseaseHelia Abdshahzadeh, Mostafa Golshani, Hamid Nadri, Iraj Saberi Kia, Zahra Abdolahi, Hamid Forootanfar, Alieh Ameri, Tuba Tüylü Küçükkılınç, Beyza Ayazgök, Leili Jalili‐Baleh et al. · 2019 · Chemistry & Biodiversity
- Herbal Medicines as a Rational Alternative for Treatment of Human DiseasesAnand Kumar Chaudhari, Somenath Das, Bijendra Kumar Singh, Jitendra Prasad, Nawal Kishore Dubey, Abhishek Kumar Dwivedy · 2020 · Springer eBooks
- Multiple target-based pharmacophore design from active site structuresPawan Kumar, Rama Kaalia, Ashwin Srinivasan, Indira Ghosh · 2017 · SAR and QSAR in environmental research
- Advances in prodrug design for Alzheimer’s disease: the state of the artValentin Travers--Lesage, Serge M. Mignani, Patrick Dallemagne, Christophe Rochais · 2022 · Expert Opinion on Drug Discovery
- Impact of GSK-3β and CK-1δ on Wnt signaling pathway in alzheimer disease: A dual target approachVinita Sharma, Prabodh Chander Sharma, Jurnal Reang, Vivek Yadav, Rajiv Kumar Tonk, Jaseela Majeed, Kalicharan Sharma · 2024 · Bioorganic Chemistry
- Structure based design, synthesis of novel fused triazole-thiazole derivatives and their comparative study on Alzheimer disease along with in silico modelingShoaib Ahmed Khan, Tayyiaba Iqbal, Rafaqat Hussain, Yousaf Khan, Hayat Ullah, Urooj Jamal, Muqadas, Rashid Iqbal, Saleh A. Alfarraj, Sulaiman Ali Alharbi · 2024 · Results in Chemistry
- Hydroxyl chalcone derivative DK02 as a multi‐target‐directed ligand for Alzheimer's disease: A preclinical study in zebrafishBalasubramanian Haridevamuthu, Ankit Kumar Bharti, S.P. Ramya Ranjan Nayak, Dhaareeshwar Narayanan, Loganathan Sumathi Dhivya, Bharath Kumar Chagaleti, Venkatesan Saravanan, Rajakrishnan Rajagopal, Ahmed Alfarhan, M. K. Kathiravan et al. · 2024 · British Journal of Pharmacology
- Rational Approach to an Antiprion Compound with a Multiple Mechanism of ActionMaría Laura Bolognesi, Salvatore Bongarzone, Suzana Aulić, Hoang Ngoc Ai Tran, Federica Prati, Paolo Carloni, Giuseppe Legname · 2015 · Future Medicinal Chemistry