Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

Cavalli, Andrea, Bolognesi, Maria Laura, Minarini, Anna, Rosini, Michela, Tumiatti, Vincenzo, Recanatini, Maurizio, Melchiorre, Carlo·2008·Journal of Medicinal Chemistry

Cited by (1,000)

Items 701–800 of 1,000

  1. Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule interaction
    Luca Pinzi, Christian Conze, Nicolò Bisi, Gabriele Dalla Torre, Ahmed Soliman, Nanci Monteiro-Abreu, Nataliya I. Trushina, Andrea Krusenbaum, Maryam Khodaei Dolouei, Andrea Hellwig et al. · 2024 · Nature Communications
  2. Synthetic polyamines as potential amine oxidase inhibitors: a preliminary study
    Emanuela Bonaiuto, Anna Minarini, Vincenzo Tumiatti, Andrea Milelli, Michele Lunelli, Maurizio Pegoraro, Valeria Rizzoli, Maria Luisa Di Paolo · 2011 · Amino Acids
  3. Multitarget-directed oxoisoaporphine derivatives: Anti-acetylcholinesterase, anti-β-amyloid aggregation and enhanced autophagy activity against Alzheimer’s disease
    Shenqi Wei, Wei Chen, Jingfang Qin, Yingzi Huangli, Li Wang, Yue Shen, Huang Tang · 2016 · Bioorganic & Medicinal Chemistry
  4. Chemoenzymatic synthesis of optically active phenolic 3,4-dihydropyridin-2-ones: a way to access enantioenriched 1,4-dihydropyridine and benzodiazepine derivatives
    Susana Y. Torres, Rosario Brieva, Francisca Rebolledo · 2017 · Organic & Biomolecular Chemistry
  5. Virtual Screening in the Search of New and Potent Anti-Alzheimer Agents
    Livia Basile · 2017 · Neuromethods
  6. Novel, Dual Target‐Directed Annelated Xanthine Derivatives Acting on Adenosine Receptors and Monoamine Oxidase B
    Kamil Kuder, Michał Załuski, Jakub Schabikowski, Gniewomir Latacz, Agnieszka Olejarz‐Maciej, Piotr Jaśko, Agata Doroż-Płonka, Andreas Brockmann, Christa Elisabeth Müller, Katarzyna Kieć‐Kononowicz · 2020 · ChemMedChem
  7. Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer’s Disease Therapy
    Lazhar Zribi, Irène Pachón-Angona, Óscar M. Bautista‐Aguilera, Daniel Diez‐Iriepa, Jose Luis Marco, Lhassane Ismaïli, Isabel Iriepa, Fakher Chabchoub · 2020 · Molecules
  8. Pursuing the Complexity of Alzheimer’s Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists
    Jan Konecny, Anna Misiachna, Martina Hrabinová, Lenka Pulkrabkova, Markéta Benková, Lukáš Prchal, Tomas Kucera, Tereza Kobrlová, Vladimír Finger, Marharyta Kolcheva et al. · 2020 · Biomolecules
  9. A Boron-Containing Compound Acting on Multiple Targets Against Alzheimer’s Disease. Insights from Ab Initio and Molecular Dynamics Simulations
    Alessandra Gilda Ritacca, Ida Ritacco, Eslam Dabbish, Nino Russo, Gloria Mazzone, Emilia Sicilia · 2021 · Journal of Chemical Information and Modeling
  10. Miniaturized electrochemical system for cholinesterase inhibitor detection
    Anthony J. Veloso, Paul Michael Nagy, Biao Zhang, Devjani Dhar, Anqi Liang, Tarek Ibrahim, Svetlana N. Mikhaylichenko, Isabelle Aubert, Kağan Kerman · 2013 · Analytica Chimica Acta
  11. Metabolism‐Activated Multitargeting (MAMUT): An Innovative Multitargeting Approach to Drug Design and Development
    Péter Mátyus, Christina L. L. Chai · 2015 · ChemMedChem
  12. Pharmacophore-based design and discovery of (−)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesis
    Qiong Xie, Zhaoxi Zheng, Biyun Shao, Wei Fu, Zheng Xia, Wei Li, Jian Qi Sun, Wei Zheng, Weiwei Zhang, Wei Sheng et al. · 2017 · Journal of Enzyme Inhibition and Medicinal Chemistry
  13. Aminoadamantane conjugates with carbazole derivatives as potential multitarget agents for the treatment of Alzheimer’s disease. Effect of the spacer structure
    Галина Ф. Махаева, E. F. Shevtsova, Надежда Владимировна Ковалева, Елена Владимировна Рудакова, Неганова Маргарита Евгеньевна, L. G. Dubova, Pavel N. Shevtsov, Aleksey Yu. Aksinenko, Vladimir B. Sokolov, Сергей Олегович Бачурин · 2018 · Russian Chemical Bulletin
  14. Investigating the effects of different natural molecules on the structure and oligomerization propensity of hen egg-white lysozyme
    Ali Châari, Christine Fahy, Alexandre Chevillot‐Biraud, Mohamed Rholam · 2019 · International Journal of Biological Macromolecules
  15. Potent Acetylcholinesterase Selective and Reversible Homodimeric Agent Based on Tacrine for Theranostics
    Virendra Kumar Meena, Shubhra Chaturvedi, Rakesh Kumar Sharma, Anil Kumar Mishra, Puja Panwar Hazari · 2019 · Molecular Pharmaceutics
  16. Design, synthesis and in-vitro evaluation of fluorinated triazoles as multi-target directed ligands for Alzheimer disease
    Tanay Dalvi, Bhaskar Dewangan, Gopal Agarwal, Dattatray Shinde Suchita, Alok K. Jain, Akshay Srivastava, Bichismita Sahu · 2021 · Bioorganic & Medicinal Chemistry Letters
  17. Mutual Prodrugs - Codrugs
    Abraham Nudelman · 2022 · Current Medicinal Chemistry
  18. Synthesis, acetylcholinesterase and butyrylcholinesterase inhibitory potential and molecular docking study of thiazole bearing thiourea analogues
    Hayat Ullah, Mehvish Jabeen, Fazal Rahim, Amjad Hussain, Fahad Khan, Muhammad Perviaz, Muhammad Sajid, Imad Uddin, Muhammad Usman Khan, Muhammad Nabi · 2023 · Chemical Data Collections
  19. Recent Advancements in the Treatment of Alzheimer’s Disease: A Multitarget-directed Ligand Approach
    Sumit Kumar, Amol Tarachand Mahajan, Ramesh Ambatwar, Gopal Lal Khatik · 2023 · Current Medicinal Chemistry
  20. Current Small Molecule–Based Medicinal Chemistry Approaches for Neurodegeneration Therapeutics
    Nitesh Sanghai, Billy Vuong, Ahmet Burak Berk, Muhammad Shaharyar Khan Afridi, Geoffrey K. Tranmer · 2024 · ChemMedChem
  21. Insights on synthetic strategies and structure-activity relationship of donepezil and its derivatives
    Saraswati Patel, Sonika Jain, Ritika Gururani, Swapnil K. Sharma, Jaya Dwivedi · 2024 · Medicinal Chemistry Research
  22. Design, Synthesis, and Biological Evaluation of Ferulic Acid-Piperazine Derivatives Targeting Pathological Hallmarks of Alzheimer’s Disease
    Gourav Singh, Sunil Kumar, Samir Ranjan Panda, Prabhat Kumar, Sanskriti Rai, Himanshu Verma, Yash Pal Singh, Saroj Kumar, Saripella Srikrishna, V.G.M. Naidu et al. · 2024 · ACS Chemical Neuroscience
  23. Incorporating the HPLC‐ESI‐Q‐TOF‐MS profiles with the biochemical properties of eight Salvia species
    Eulogio Jose Llorent-Martínez, Nilofar Nilofar, Kouadio Ibrahime Sinan, Ekrem Darendelioğlu, Muammer Bahşi, Rıdvan Polat, Uğur Çakılcıoğlu, Giustino Orlando, Claudio Ferrante, Gökhan Zengin · 2025 · eFood
  24. Protective effect of the multitarget compound DPH‐4 on human SSAO/VAP‐1‐expressing hCMEC/D3 cells under oxygen–glucose deprivation conditions: anin vitroexperimental model of cerebral ischaemia
    Ping Sun, Gerard Esteban, Tsutomu Inokuchi, J Marco‐Contelles, Babette Barbash Weksler, Ignacio Andres Romero, Pierre‐Olivier Couraud, Mercedes Unzeta, Montse Solé · 2015 · British Journal of Pharmacology
  25. Purine Homo- N -Nucleoside+Coumarin Hybrids as Pleiotropic Agents for the Potential Treatment of Alzheimer's Disease
    Michael G. Kallitsakis, Matilde Yáñez, Elena Soriano, Jose Luis Marco, Dimitra Hadjipavlou‐Litina, Κonstantinos E. Litinas · 2015 · Future Medicinal Chemistry
  26. Targeting Oxidative Stress in Stroke
    Anders Bach · 2017 · Springer series in translational stroke research
  27. Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier
    Slávka Hamuľaková, Ladislav Janovec, Ondřej Soukup, Daniel Jun, Jana Janočková, Martina Hrabinová, Vendula Šepsová, Kamil Kuča · 2018 · Current Alzheimer Research
  28. Structure–Functional–Selectivity Relationship Studies of Novel Apomorphine Analogs to Develop D1R/D2R Biased Ligands
    Hyejin Park, Aarti N. Urs, Joseph Zimmerman, Chuan Liu, Qiu Wang, Nikhil M. Urs · 2020 · ACS Medicinal Chemistry Letters
  29. Development of genistein-O-alkylamines derivatives as multifunctional agents for the treatment of Alzheimer’s disease
    Zhipei Sang, Jian Shi, Yi Ming Zhou, Keren Wang, Yiyang Zhao, Qingfeng Li, Zhanpin Qiao, Anguo Wu, Zhenghuai Tan, Wenmin Liu · 2021 · Bioorganic Chemistry
  30. Discovery of effective phosphodiesterase 2 inhibitors with antioxidant activities for the treatment of Alzheimer’s disease
    Mei-Yan Jiang, Chuan Han, Chen Zhang, Qian Zhou, Bei Zhang, Mei-Ling Le, Mengxing Huang, Yinuo Wu, Hai‐Bin Luo · 2021 · Bioorganic & Medicinal Chemistry Letters
  31. Design, synthesis and biological evaluation of new naphtalene diimides bearing isothiocyanate functionality
    Anna Minarini, Andrea Milelli, Vincenzo Tumiatti, Lorenzo Ferruzzi, Melinda-Rita Márton, Eleonora Turrini, Patrizia Hrelia, Carmela Fimognari · 2011 · European Journal of Medicinal Chemistry
  32. ITH12410/SC058: A New Neuroprotective Compound with Potential in the Treatment of Alzheimer’s Disease
    Alejandro Romero, Javier Egea, Gema C. González-Muñoz, María Dolores Martin‐de‐Saavedra, Laura del Barrio, Marı́a Isabel Rodrı́guez-Franco, Santiago Conde, Manuela G. López, Mércedes Villarroya, Cristóbal de los Rı́os · 2014 · ACS Chemical Neuroscience
  33. Identification of 2-subsituted benzothiazole derivatives as triple-functional agents with potential for AD therapy
    Liu Jiang, Minkui Zhang, Li Tang, Qinjie Weng, Yanhong Shen, Yongzhou Hu, Rong Sheng · 2016 · RSC Advances
  34. Multitarget Anti-Alzheimer Hybrid Compounds
    Diego Muñoz‐Torrero · 2017 · Elsevier eBooks
  35. Discovery of New Cyclopentaquinoline Analogues as Multifunctional Agents for the Treatment of Alzheimer’s Disease
    Kamila Czarnecka, Małgorzata K. Girek, Paweł Kręcisz, Robert Skibiński, Kamil Łątka, Jakub Jończyk, Marek Bajda, Jacek Kabziński, Ireneusz Majsterek, Piotr Szymczyk et al. · 2019 · International Journal of Molecular Sciences
  36. On the Development of New Antiepileptic Drugs for the Treatment of Pharmacoresistant Epilepsy: Different Approaches to Different Hypothesis
    Alan Talevi, Luis E. Bruno‐Blanch · 2013 · Springer eBooks
  37. Synthesis of a second generation chroman/catechol hybrids and evaluation of their activity in protecting neuronal cells from oxidative stress-induced cell death
    Maria Koufaki, Elissavet Theodorou, Xanthippi Alexi, Μichael N. Alexis · 2010 · Bioorganic & Medicinal Chemistry
  38. Design of a structural framework with potential use to develop balanced multifunctional agents against Alzheimer's disease
    Neng Jiang, Xiaobing Wang, Zhongrui Li, Suyi Li, Sai‐Sai Xie, Ming Y. Huang, Ling‐Yi Kong · 2015 · RSC Advances
  39. Targeting misfolding and aggregation of the amyloid-β peptide and mutant p53 protein using multifunctional molecules
    Lauryn Grcic, Grace Leech, Kalvin Kwan, Tim Storr · 2024 · Chemical Communications
  40. Design of Multi-Target drugs of HDACs and other Anti-Alzheimer related Targets: Current strategies and future prospects in Alzheimer’s diseases therapy
    Osama M. Soltan, Kamal S. Abdelrahman, Amr K. A. Bass, Kazuki Takizawa, Atsushi Narumi, Hiroyuki Konno · 2024 · Bioorganic Chemistry
  41. Exploring effective diagnosis of Alzheimer disease: Experimental and computational analysis of hybrid benzimidazole based thiazolidinone derivatives
    Shoaib Khan, Yousaf Khan, Ayman M. Al‐Qaaneh, Rafaqat Hussain, Tayyiaba Iqbal, Hayat Ullah, Khurram Shoaib, Aneela Maalik, Muhammad Bilal Khan, Muhammad Akif et al. · 2024 · Results in Chemistry
  42. New 4-methanesulfonyloxy benzohydrazide derivatives as potential antioxidant and carbonic anhydrase I and II inhibitors: synthesis, characterization, molecular docking, dynamics & ADME studies
    Aytekin Köse, Leyla Polat Köse, Halil Şenol, Nuray Ulusoy-Güzeldemirci · 2024 · Journal of Molecular Structure
  43. Attenuating Aβ1–42-induced toxicity by a novel acetylcholinesterase inhibitor
    N. Mishra, D. Sasmal, K.K. Singh · 2013 · Neuroscience
  44. Biological Networks and Drug Discovery—Where Do We Stand?
    Tim Geppert, Herbert Koeppen · 2014 · Drug Development Research
  45. Tacrine-Natural-Product Hybrids for Alzheimer’s Disease Therapy
    María Jesús Oset‐Gasque, Jose Luis Marco · 2018 · Current Medicinal Chemistry
  46. WBQ5187, a Multitarget Directed Agent, Ameliorates Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease and Modulates Cerebral β-Amyloid, Gliosis, cAMP Levels, and Neurodegeneration
    Zhiren Wang, Mengru Cao, Hongling Xiang, Wei Wang, Xing Feng, Xiaoping Yang · 2019 · ACS Chemical Neuroscience
  47. human monoamine oxidase (hMAO) A and hMAO B inhibitors from Artemisia dracunculus L. herniarin and skimmin: human mononamine oxidase A and B inhibitors from A. dracunculus L.
    Tuba Aydın, Hülya Akıncıoğlu, Mehmet Gümüştaş, İlhami Gülçın, Cavit Kazaz, Ahmet Çakır · 2020 · Zeitschrift für Naturforschung C
  48. Design, Synthesis and Evaluation of O ‐Pentyne Substituted Diphenylpyrimidines as Monoamine Oxidase and Acetylcholinesterase Inhibitors
    Vijay Kumar, Bhupinder Kumar, Ashish Ranjan Dwivedi, Devashish Mehta, Naveen Kumar, Beenu Bajaj, Tania Arora, Vikash Prashar, Jyoti Parkash, Vinod Kumar · 2020 · ChemistrySelect
  49. α-Linolenic Acid–Valproic Acid Conjugates: Toward Single-Molecule Polypharmacology for Multiple Sclerosis
    Michele Rossi, Sabrina Petralla, Michele Protti, Monica Baiula, Tereza Kobrlová, Ondřej Soukup, Santi Mario Spampinato, Laura Mercolini, Barbara Monti, María Laura Bolognesi · 2020 · ACS Medicinal Chemistry Letters
  50. In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases
    Anna Więckowska, Natalia Szałaj, Izabella Góral, Adam Bucki, Gniewomir Latacz, Katarzyna Kieć‐Kononowicz, Óscar M. Bautista‐Aguilera, Alejandro Romero, Eva Ramos, Javier Egea et al. · 2020 · ACS Chemical Neuroscience
  51. Conjugation of tacrine with genipin derivative not only enhances effects on AChE but also leads to autophagy against Alzheimer’s disease
    Rongtian Lin, Shuwen Rao, Yanbing Li, Lei Zhang, Liyu Xu, Yepu He, Zhijun Liu, Heru Chen · 2020 · European Journal of Medicinal Chemistry
  52. Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases
    Volkmar Tell, Max Holzer, Lydia Herrmann, Kazem Mahmoud, Christoph Schächtele, Frank Totzke, Andreas Hilgeroth · 2012 · Bioorganic & Medicinal Chemistry Letters
  53. An Expedient Synthesis, Acetylcholinesterase Inhibitory Activity, and Molecular Modeling Study of Highly Functionalized Hexahydro-1,6-naphthyridines
    Abdulrahman Ibrahim Almansour, Raju Suresh Kumar, Natarajan Arumugam, Alireza Basiri, Yalda Kia, Mohamed Ashraf Ali · 2015 · BioMed Research International
  54. Development of glycine-α-methyl-proline-containing tripeptides with neuroprotective properties
    Ivana Cacciatore, Erika Fornasari, Antonio Di Stefano, Lisa Marinelli, Laura Serafina Cerasa, Hasan Türkez, Elanur Aydın, Alessandro Moretto, Alessio Ferrone, Mirko Pesce et al. · 2015 · European Journal of Medicinal Chemistry
  55. Development of multifunctional heterocyclic Schiff base as a potential metal chelator: a comprehensive spectroscopic approach towards drug discovery
    Manojkumar Jadhao, Chayan Das, Anoop Rawat, Himank Kumar, Ritika Joshi, Sudipta Maiti, Sujit Kumar Ghosh · 2016 · JBIC Journal of Biological Inorganic Chemistry
  56. Synthesis, molecular docking and biochemical analysis of aminoalkylated naphthalene-based chalcones as acetylcholinesterase inhibitors
    Ghadah Faraj Aljohani, Adeeb Al-Sheikh Ali, Shaya Y. Al‐Raqa, Syazwani Itri Amran, Norazah Basar · 2021 · Journal of Taibah University for Science
  57. Unveiling promising inhibitors of superoxide dismutase 1 (SOD1) for therapeutic interventions
    Akhtar Atiya, Abdullatif Bin Muhsinah, Mohammed Alrouji, Fahad Abdulrahman Alhumaydhi, Waleed Al Abdulmonem, Mohammad Abdullah Aljasir, Sharaf E. Sharaf, Mohammad Furkan, Rizwan Hasan Khan, Moyad Jamal Shahwan et al. · 2023 · International Journal of Biological Macromolecules
  58. Unleashing new MTDL AChE and BuChE inhibitors as potential anti-AD therapeutic agents: In vitro, in vivo and in silico studies
    Dalia K. Zaafar, Nehal H. Elghazawy, Afnan Hassan, Mohamed Y. Mahmoud, Alaa F. Bakr, Reem K. Arafa · 2024 · International Journal of Biological Macromolecules
  59. Recent development and strategies towards target interactions: Synthesis, characterization and in silico analysis of benzimidazole based thiadiazole as potential anti-Alzheimer agents
    Shoaib Ahmed Khan, Rafaqat Hussain, Tayyiaba Iqbal, Fazal Rahim, Yousaf Khan · 2024 · Biochemical and Biophysical Research Communications
  60. Enhanced Recognition Memory through Dual Modulation of Brain Carbonic Anhydrases and Cholinesterases
    Alessio Nocentini, Alessia Costa, Alessandro Bonardi, Andrea Ammara, Simone Giovannuzzi, Andrea Petreni, Gianluca Bartolucci, Barbara Rani, Manuela Leri, Monica Bucciantini et al. · 2024 · Journal of Medicinal Chemistry
  61. An insight into allele-selective approaches to lowering mutant huntingtin protein for Huntington’s disease treatment
    Jia-yuan Yao, Ting Liu, Xin-Ru Hu, Hui Sheng, Zi-hao Chen, Haiyang Zhao, Xiaojia Li, Yang Wang, Liang Hao · 2024 · Biomedicine & Pharmacotherapy
  62. Coumarin Derivative Hybrids: Novel Dual Inhibitors Targeting Acetylcholinesterase and Monoamine Oxidases for Alzheimer’s Therapy
    Teresa Żołek, Rosa Purgatorio, Łukasz Kłopotowski, Marco Catto, Kinga Ostrowska · 2024 · International Journal of Molecular Sciences
  63. Anti-inflammatory drugs as potential antimicrobial agents: a review
    Onyedika Emmanuel Okpala, Johana Rondevaldová, Ladislav Kokoška · 2025 · Frontiers in Pharmacology
  64. Synthesis and biological evaluation of ranitidine analogs as multiple-target-directed cognitive enhancers for the treatment of Alzheimer’s disease
    Jie Gao, Narasimha M. Midde, Jun Zhu, Alvin V. Terry, Campbell McInnes, James M. Chapman · 2016 · Bioorganic & Medicinal Chemistry Letters
  65. Highlights of ASS234: a novel and promising therapeutic agent for Alzheimer’s disease therapy
    Alejandro Romero, Eva Ramos, Jose Luis Marco · 2019 · Neural Regeneration Research
  66. Evaluation of the Therapeutic Effect of Lycoramine on Alzheimer’s Disease in Mouse Model
    İrem Kiris, Merve Karayel‐Basar, Betül Şahin, Büşra Gürel, Julide Coşkun, Tomasz Mroczek, Ahmet Tarık Baykal · 2020 · Current Medicinal Chemistry
  67. Molecular hybridization based design and synthesis of new benzo[5,6]chromeno[2,3-b]-quinolin-13(14H)-one analogs as cholinesterase inhibitors
    Baswaraju Macha, Ravindra Kulkarni, Chandrakant Bagul, Anil Kumar Garige, Raghuram Rao Akkinepally, Achaiah Garlapati · 2021 · Medicinal Chemistry Research
  68. An overview on the synthesis of carbohydrate-based molecules with biological activity related to neurodegenerative diseases
    João Paulo Bizarro Lopes, Luana Aparecida Alves da Silva, Diogo Seibert Lüdtke · 2021 · RSC Medicinal Chemistry
  69. Progress and Development of Carbazole Scaffold Based as Potential Anti- Alzheimer Agents Using MTDL Approach
    Nitin Kumar, Pankaj Gupta, Sahil Bansal · 2022 · Letters in Drug Design & Discovery
  70. Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer’s disease
    Sarah Macedo Vaz, Matheus de Freitas Silva, Graziella dos Reis Rosa Franco, Marcos Jorge R. Guimarães, Fernanda Motta R. da Silva, Newton Gonçalves Castro, Isabella Alvim Guedes, Laurent E. Dardenne, Marina Amaral Alves, Rafael Garrett da Costa et al. · 2022 · Bioorganic & Medicinal Chemistry
  71. Optical, electrochemical and DFT studies of donor-acceptor typed indole derivatives
    Buket Bezgin Çarbaş, Hussein Ali NOORI, Emrah Kavak, Yasemin Kaya, Arif Kıvrak · 2022 · Journal of Molecular Structure
  72. From tryptamine to the discovery of efficient multi-target directed ligands against cholinesterase-associated neurodegenerative disorders
    Junbo Wu, Honghua Zhang, Yuying Wang, Gaofeng Yin, Qien Li, Linsheng Zhuo, Hongjin Chen, Zhen Wang · 2022 · Frontiers in Pharmacology
  73. Molecular docking/dynamics simulations, MEP analysis, bioisosteric replacement and ADME/T prediction for identification of dual targets inhibitors of Parkinson’s disease with novel scaffold
    Merzaka Mettai, Ismail Daoud, Fouzia Mesli, Samir Kenouche, Nadjib Melkemi, Rania Kherachi, Ahlem Belkadi · 2023 · In Silico Pharmacology
  74. Rational Design of N-Methylcarbamoylguanidinyl Derivatives as Highly Potent Dual-Target Chitin Hydrolase Inhibitors for Retarding Growth of Pest Insects
    Zhixiang Zhao, Wei Chen, Simin Wang, Yanhong Dong, Qing Kun Yang, Jianjun Zhang · 2023 · Journal of Agricultural and Food Chemistry
  75. Neuritogenic activity of bi-functional bis-tryptoline triazole
    Jutamas Jiaranaikulwanitch, Sarin Tadtong, Piyarat Govitrapong, Valery V. Fokin, Opa Vajragupta · 2016 · Bioorganic & Medicinal Chemistry
  76. Multi-targeting effects of a new synthetic molecule (JM-20) in experimental models of cerebral ischemia
    Yanier Núñez-Figueredo, Jeney Ramírez-Sánchez, Gilberto L. Pardo‐Andreu, Estael Ochoa, Yamila Verdecia-Reyes, Diogo Onofre Souza · 2018 · Pharmacological Reports
  77. Proteochemometric Modeling for Drug Repositioning
    Nalini Schaduangrat, Nuttapat Anuwongcharoen, Chuleeporn Phanus‐umporn, Nagaya Sriwanichpoom, Jarl E. S. Wikberg, Chanin Nantasenamat · 2019 · Elsevier eBooks
  78. Novel antileukemic agents derived from tamibarotene and nitric oxide donors
    Haiyong Bian, Jinhong Feng, Minyong Li, Wenfang Xu · 2011 · Bioorganic & Medicinal Chemistry Letters
  79. Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation
    R.S. Malek, Alexey Simakov, Audrey Davis, Maciej Maj, Paul J. Bernard, Artur Wnorowski, Hélène Martin, Jose Luis Marco, Fakher Chabchoub, Patrick Dallemagne et al. · 2022 · Molecules
  80. QSAR studies of novel 1-(4-methoxyphenethyl)-1H-benzimidazole-5-carboxylic acid derivatives and their precursors as antileukaemic agents
    Mukesh Chandra Sharma · 2015 · Journal of Taibah University for Science
  81. Applications of Click Chemistry in Drug Discovery and Development
    Balasubramanian Gopalan, Kalpattu Kuppusamy Balasubramanian · 2016
  82. Multifunctional agents against Alzheimer’s disease based on oxidative stress: Polysubstituted pyrazine derivatives synthesized by multicomponent reactions
    Wenxiu Wei, Lanlan Jing, Ye Tian, Anna Więckowska, Dongwei Kang, Bairu Meng, Dawid Panek, Justyna Godyń, Izabella Góral, Yuning Song et al. · 2023 · Bioorganic & Medicinal Chemistry
  83. Advances in drug design and therapeutic potential of selective or multitarget 5‐HT1A receptor ligands
    G. Giorgioni, A. Bonifazi, L. Botticelli, C. Cifani, Federica Matteucci, Emanuela Micioni Di Bonaventura, M. V. Micioni Di Bonaventura, M. Giannella, A. Piergentili, Alessia Piergentili et al. · 2024 · Medicinal research reviews (Print)
  84. Alzheimer's disease approaches - Focusing on pathology, biomarkers and clinical trial candidates
    Jana Hroudová, Zdeněk Fišar · 2024 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
  85. Hybrid Lipoic Acid Derivatives to Attack Prion Disease on Multiple Fronts
    Salvatore Bongarzone, Hoang Ngoc Ai Tran, Andrea Cavalli, Marinella Roberti, Michela Rosini, Paolo Carloni, Giuseppe Legname, María Laura Bolognesi · 2011 · ChemMedChem
  86. Neuroprotective effects of Shende’an tablet in the Parkinson’s disease model
    Xiaoyan Sheng, Shuiyuan Yang, Xiaomin Wen, Xin Zhang, Yongfeng Ye, Peng Zhao, Limin Zang, Kang Peng, Enming Du, Sai Li · 2021 · Chinese Medicine
  87. Huprine Y – Tryptophan heterodimers with potential implication to Alzheimer’s disease treatment
    Eva Mezeiová, Martina Hrabinová, Vendula Hepnarová, Daniel Jun, Jana Janočková, Ľubica Múčková, Lukáš Prchal, Zdena Krištofíková, Tomas Kucera, Lukáš Górecki et al. · 2021 · Bioorganic & Medicinal Chemistry Letters
  88. Investigation of glutathione as a natural antioxidant and multitarget inhibitor for Alzheimer’s disease: Insights from molecular simulations
    Sara Roosta, Seyed Majid Hashemianzadeh, Mokhtar Ganjali Koli · 2021 · Journal of Molecular Liquids
  89. Design, synthesis and structure-activity relationship studies of 3-phenylpyrazino[1,2-a]indol-1(2H)-ones as amyloid aggregation and cholinesterase inhibitors with antioxidant activity
    S. Gujral, A. Shakeri, L. Hejazi, Praveen P. N. Rao · 2022 · European Journal of Medicinal Chemistry Reports
  90. Synthesis of indole derivatives as Alzheimer inhibitors and their molecular docking study
    Zahra Abdulkarim Homoud, Muhammad Taha, Fazal Rahim, Naveed Iqbal, Muhammad Nawaz, Rai Khalid Farooq, Abdul Wadood, Munther Alomari, Imadul Islam, Shatha Algheribe et al. · 2022 · Journal of Biomolecular Structure and Dynamics
  91. Multiple Ligands Targeting Cholinesterases and β‐Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine Pharmacophore
    Natalia Szałaj, Marek Bajda, Katarzyna Dudek, Boris Brus, Stanislav Gobec, Barbara Malawska · 2015 · Archiv der Pharmazie
  92. Synthesis and biological evaluation of genistein‐O‐alkylamine derivatives as potential multifunctional anti‐Alzheimer agents
    Hong Chen, Hui‐yan Guo, Daiwen Chen, Jianwu Lv, Xin Zhang, Ya‐cheng Yang, Kang Huang, Yijuan Zhang, Zhiyong Tian, Wen Luo et al. · 2018 · Chemical Biology & Drug Design
  93. 3‐Aryl Coumarin Derivatives Bearing Aminoalkoxy Moiety as Multi‐Target‐Directed Ligands against Alzheimer's Disease
    Helia Abdshahzadeh, Mostafa Golshani, Hamid Nadri, Iraj Saberi Kia, Zahra Abdolahi, Hamid Forootanfar, Alieh Ameri, Tuba Tüylü Küçükkılınç, Beyza Ayazgök, Leili Jalili‐Baleh et al. · 2019 · Chemistry & Biodiversity
  94. Herbal Medicines as a Rational Alternative for Treatment of Human Diseases
    Anand Kumar Chaudhari, Somenath Das, Bijendra Kumar Singh, Jitendra Prasad, Nawal Kishore Dubey, Abhishek Kumar Dwivedy · 2020 · Springer eBooks
  95. Multiple target-based pharmacophore design from active site structures
    Pawan Kumar, Rama Kaalia, Ashwin Srinivasan, Indira Ghosh · 2017 · SAR and QSAR in environmental research
  96. Advances in prodrug design for Alzheimer’s disease: the state of the art
    Valentin Travers--Lesage, Serge M. Mignani, Patrick Dallemagne, Christophe Rochais · 2022 · Expert Opinion on Drug Discovery
  97. Impact of GSK-3β and CK-1δ on Wnt signaling pathway in alzheimer disease: A dual target approach
    Vinita Sharma, Prabodh Chander Sharma, Jurnal Reang, Vivek Yadav, Rajiv Kumar Tonk, Jaseela Majeed, Kalicharan Sharma · 2024 · Bioorganic Chemistry
  98. Structure based design, synthesis of novel fused triazole-thiazole derivatives and their comparative study on Alzheimer disease along with in silico modeling
    Shoaib Ahmed Khan, Tayyiaba Iqbal, Rafaqat Hussain, Yousaf Khan, Hayat Ullah, Urooj Jamal, Muqadas, Rashid Iqbal, Saleh A. Alfarraj, Sulaiman Ali Alharbi · 2024 · Results in Chemistry
  99. Hydroxyl chalcone derivative DK02 as a multi‐target‐directed ligand for Alzheimer's disease: A preclinical study in zebrafish
    Balasubramanian Haridevamuthu, Ankit Kumar Bharti, S.P. Ramya Ranjan Nayak, Dhaareeshwar Narayanan, Loganathan Sumathi Dhivya, Bharath Kumar Chagaleti, Venkatesan Saravanan, Rajakrishnan Rajagopal, Ahmed Alfarhan, M. K. Kathiravan et al. · 2024 · British Journal of Pharmacology
  100. Rational Approach to an Antiprion Compound with a Multiple Mechanism of Action
    María Laura Bolognesi, Salvatore Bongarzone, Suzana Aulić, Hoang Ngoc Ai Tran, Federica Prati, Paolo Carloni, Giuseppe Legname · 2015 · Future Medicinal Chemistry