Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

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2. Thiosemicarbazone derivatives as potential inhibitors of acetylcholinesterase, butyrylcholinesterase and their molecular docking studies
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3. Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer’s Disease Treatment
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4. Protective effect of a standardized Allium jesdianum extract in an Alzheimer's disease induced rat model
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5. Calcium channel blockers’ contribution to overcoming Current drug discovery challenges in Alzheimer’s disease
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6. Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinetriones as Promising Agents for Alzheimer'S Disease Therapy
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7. Biological Evaluation of 8-Hydroxyquinolines as Multi-Target Directed Ligands for Treating Alzheimer’s Disease
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8. Alzheimer's Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development and Promising Results Obtained from Multi-target Approaches
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9. Novel conjugates of 4-amino-2,3-polymethylenequinolines and vanillin as potential multitarget agents for AD treatment
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11. Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE‐1 and GSK‐3β Inhibitors
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12. Combining Data-Driven and Structure-Based Approaches in Designing Dual PARP1-BRD4 Inhibitors for Breast Cancer Treatment
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13. De novo generation of dual-target compounds using artificial intelligence
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14. In silico design of novel pyridazine derivatives as balanced multifunctional agents against Alzheimer’s disease
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15. Novel aromatic–polyamine conjugates as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase
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17. Site-activated multi target iron chelators with acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitory activities for Alzheimer’s disease therapy
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18. N‐Substituted piperidine‐3‐carbohydrazide‐hydrazones against Alzheimer's disease: Synthesis and evaluation of cholinesterase, beta‐amyloid inhibitory activity, and antioxidant capacity
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19. Chapter 3 Small-Molecule Protein–Protein Interaction Inhibitors as Therapeutic Agents for Neurodegenerative Diseases: Recent Progress and Future Directions
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20. Multitarget Ligands and Theranostics: Sharpening the Medicinal Chemistry Sword Against Prion Diseases
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21. Manipulating a Multicomponent Reaction: A Straightforward Approach to Chromenopyrazole Hybrid Scaffolds
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23. Novel 3-aminobenzofuran derivatives as multifunctional agents for the treatment of Alzheimer’s disease
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24. Chemical synthesis and antifouling activity of monoterpene–furan hybrid molecules
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25. Buchwald–Hartwig Amination Approach for the Synthesis of Functionalized 1,2,3,4‐Tetrahydroacridine Derivatives
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26. Computational Modeling of Multi-target-Directed Inhibitors Against Alzheimer’s Disease
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27. In vitro Antioxidant and Anticholinesterase Activities of Colombian Plants as Potential Neuroprotective Agents
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29. The Literature of Heterocyclic Chemistry, Part XI, 2008–2009
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32. Novel multifunctional tacrine–donepezil hybrids against Alzheimer's disease: Design synthesis and bioactivity studies
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33. Indole-based heterocyclic conjugates: Design, synthesis, in silico studies and cholinesterase inhibition
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34. Identification of Novel Pyrazole-Diphenyl Ether Hybrids as Potential HPPD/PPO Dual-Target Inhibitors
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35. Targeting mitochondrial dysfunction in Alzheimer's disease: New findings and perspectives
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36. Unlocking Novel Therapeutic Potential of Angiotensin II Receptor Blockers
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37. 1,1′-Butylenebis(3-methyl-3H-imidazol-1-ium) hydrogen sulfate as an efficient binuclear Brønsted ionic liquid for the synthesis of tacrine analogues
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39. An Overview on Potential Neuroprotective Compounds for Management of Alzheimer’s Disease
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40. Recent Applications of the MultiTarget Directed Ligands Approach for the Treatment of Alzheimer's Disease
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41. Structure–activity relationship studies of benzyl‐, phenethyl‐, and pyridyl‐substituted tetrahydroacridin‐9‐amines as multitargeting agents to treat Alzheimer's disease
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42. Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation
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43. Medicinal Chemistry of Hybrids for Neurodegenerative Diseases
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45. From Combinations to Single-Molecule Polypharmacology—Cromolyn-Ibuprofen Conjugates for Alzheimer’s Disease
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46. Phenylalanine-Based AMPA Receptor Antagonist as the Anticonvulsant Agent with Neuroprotective Activity—In Vitro and In Vivo Studies
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48. A Drug Mystery of Heterocycles: Various Molecules for One Target or One Compound for Multiple Targets?
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49. Therapeutic Approaches to Prion Diseases
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50. Design of Multi-target Directed Ligands as a Modern Approach for the Development of Innovative Drug Candidates for Alzheimer’s Disease
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51. Synthesis and Biological Evaluation of Novel Chromone+Donepezil Hybrids for Alzheimer’s Disease Therapy
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52. Synthesis, Molecular Simulation, DFT, and Kinetic Study of Imidazotriazole-Based Thiazolidinone as Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase Enzymes
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53. Novel tacrine-based multi-target directed Ligands: Enhancing cholinesterase inhibition, NMDA receptor antagonism, and CNS bioavailability for Alzheimer's disease treatment.
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54. Advances in the Synthetic Approaches to β-Secretase (BACE-1) Inhibitors in Countering Alzheimer’s: A Comprehensive Review
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56. Design, synthesis, and biological evaluation of novel 2-acetylphenol-rivastigmine hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease
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