Multi-target-Directed Ligands To Combat Neurodegenerative Diseases
Cavalli, Andrea, Bolognesi, Maria Laura, Minarini, Anna, Rosini, Michela, Tumiatti, Vincenzo, Recanatini, Maurizio, Melchiorre, Carlo·2008·Journal of Medicinal Chemistry
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- Synthesis and structure–activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activityGiovanni Morini, Mara Comini, Mirko Rivara, Silvia Rivara, Fabrizio Bordi, Pier Vincenzo Plazzi, Lisa Flammini, Francesca Saccani, Simona Bertoni, Vigilio Ballabeni et al. · 2008 · Bioorganic & Medicinal Chemistry