Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

Cavalli, Andrea, Bolognesi, Maria Laura, Minarini, Anna, Rosini, Michela, Tumiatti, Vincenzo, Recanatini, Maurizio, Melchiorre, Carlo·2008·Journal of Medicinal Chemistry

Cited by (1,000)

Items 401–500 of 1,000

  1. A Triazolotriazine‐Based Dual GSK‐3β/CK‐1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition
    Sara Redenti, Irene Marcovich, Teresa De Vita, Concepción Pérez, Rita De Zorzi, Nicola Demitri, Daniel I. Pérez, Giovanni Bottegoni, Paola Bisignano, Maicol Bissaro et al. · 2018 · ChemMedChem
  2. Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets
    Francisco Javier Luque, Diego Muñoz‐Torrero · 2024 · Accounts of Chemical Research
  3. Novel frontiers in epilepsy treatments: preventing epileptogenesis by targeting inflammation
    Raimondo D’Ambrosio, Clifford L. Eastman, Cinzia Fattore, Emilio Perucca · 2013 · Expert Review of Neurotherapeutics
  4. Design of potent inhibitors of acetylcholinesterase using morin as the starting compound
    Chandran Remya, Kalarickal Vijayan Dileep, Ignatius Tintu, E. Jayadevi Variyar, Chittalakkottu Sadasivan · 2012 · Frontiers in Life Science
  5. 1,4-Substituted 4-(1H)-pyridylene-hydrazone-type inhibitors of AChE, BuChE, and amyloid-β aggregation crossing the blood–brain barrier
    Michaela Prinz, Sülünay Parlar, Gülşah Bayraktar, Vildan Alptüzün, Erçin Erciyas, Adyary Fallarero, Daniela Karlsson, Pia Maarit Vuorela, Małgorzata Burek, Carola Yvette Förster et al. · 2013 · European Journal of Pharmaceutical Sciences
  6. Design, synthesis and bioevaluation of tacrine hybrids with cinnamate and cinnamylidene acetate derivatives as potential anti-Alzheimer drugs
    Catarina Quintanova, Rangappa Sangappa Keri, Sérgio M. Marques, Maria G-Fernandes, Sandra M. Cardoso, Maria Luísa Serralheiro, Maria Amélia Santos · 2015 · MedChemComm
  7. The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats
    Nadia Khan, Ali K. Saad, Syed M. Nurulain, Fouad H. Darras, Michael W. Decker, Bassem Shaban Sadek · 2015 · Behavioural Brain Research
  8. Effects of N -Substitutions on the Tetrahydroquinoline (THQ) Core of Mixed-Efficacy μ-Opioid Receptor (MOR)/δ-Opioid Receptor (DOR) Ligands
    Aubrie A. Harland, Aaron M. Bender, Nicholas W. Griggs, Chao Gao, Jessica P. Anand, Irina D. Pogozheva, John R. Traynor, Emily M. Jutkiewicz, Henry I. Mosberg · 2016 · Journal of Medicinal Chemistry
  9. Design, synthesis and evaluation of indole derivatives as multifunctional agents against Alzheimer's disease
    Ireen Denya, Sarel F. Malan, Adaze Bijou Enogieru, Sylvester Ifeanyi Omoruyi, Okobi Eko Ekpo, Erika Kapp, Frank T. Zindo, Jacques Joubert · 2018 · MedChemComm
  10. L-Dopa Prodrugs: An Overview of Trends for Improving Parkinsons Disease Treatment
    Antonio Di Stefano, Piera Sozio, Laura Serafina Cerasa, Antonio Iannitelli · 2011 · Current Pharmaceutical Design
  11. Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer’s Disease
    Галина Ф. Махаева, Надежда Владимировна Ковалева, Елена Владимировна Рудакова, Natalia P. Boltneva, Maria V. Grishchenko, Sofya V. Lushchekina, T. Yu. Astakhova, Olga G. Serebryakova, Elena N. Timokhina, Ekaterina F. Zhilina et al. · 2023 · International Journal of Molecular Sciences
  12. Recent Developments in Coumarin Derivatives as Neuroprotective Agents
    Prakash Shyambabu Mishra, Amit Kumar, Kamalpreet Kaur, Vikas Jaitak · 2023 · Current Medicinal Chemistry
  13. Possibility of a New Anti-Alzheimerʼs Disease Pharmaceutical Composition Combining Memantine and Vitamin D
    Cédric Annweiler, Olivier Beauchet · 2012 · Drugs & Aging
  14. Multifunctional Mercapto-tacrine Derivatives for Treatment of Age-Related Neurodegenerative Diseases
    Yue Wang, Xin‐Lei Guan, Pengfei Wu, Canming Wang, Hui Cao, Lei Li, Xiaojuan Guo, Fang Wang, Na Xie, Fengchao Jiang et al. · 2012 · Journal of Medicinal Chemistry
  15. Dopamine D2/D3 Agonists with Potent Iron Chelation, Antioxidant and Neuroprotective Properties: Potential Implication in Symptomatic and Neuroprotective Treatment of Parkinson’s Disease
    Sanjib Gogoi, Tamara Antonio, Subramanian Rajagopalan, Maarten E. A. Reith, Julie Kay Andersen, Aloke K. Dutta · 2011 · ChemMedChem
  16. Design, synthesis and evaluation of genistein-polyamine conjugates as multi-functional anti-Alzheimer agents
    Xin Zhang, Jiang Wang, Chen Hong, Wen Luo, Chaojie Wang · 2015 · Acta Pharmaceutica Sinica B
  17. In Vivo Characterization of ARN14140, a Memantine/Galantamine-Based Multi-Target Compound for Alzheimer’s Disease
    Angelo M. Reggiani, Elena Simoni, Roberta Caporaso, Johann Meunier, Emeline Keller, Tangui Maurice, Anna Minarini, Michela Rosini, Andrea Cavalli · 2016 · Scientific Reports
  18. Rivastigmine and metabolite analogues with putative Alzheimer’s disease-modifying properties in a Caenorhabditis elegans model
    Satish N. Dighe, E. De la Mora, Stephen Chan, Srinivas Kantham, Gawain McColl, Jared A. Miles, Suresh Kumar Veliyath, B. Yogi Sreenivas, Zeyad D. Nassar, Israel Silman et al. · 2019 · Communications Chemistry
  19. Dual-target anti-Alzheimer’s disease agents with both iron ion chelating and monoamine oxidase-B inhibitory activity
    Zhisheng Mi, Bing Gan, Sihang Yu, Jianan Guo, Changjun Zhang, Xiaoying Jiang, Tao Zhou, Jing Su, Renren Bai, Yuanyuan Xie · 2019 · Journal of Enzyme Inhibition and Medicinal Chemistry
  20. Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer’s disease
    Julien Lalut, Hugo Payan, Audrey Davis, Cédric Lecoutey, Rémi Legay, Jana Sopková‐de Oliveira Santos, Sylvie Claeysen, Patrick Dallemagne, Christophe Rochais · 2020 · Scientific Reports
  21. Design, synthesis, and biological evaluation of diosgenin-indole derivatives as dual-functional agents for the treatment of Alzheimer’s disease
    Licheng Zhou, Ying-Fan Liang, Yi Huang, Guixiang Yang, Lulu Zheng, Jiamin Sun, Yang Li, Fuli Zhu, Hewen Qian, Rui Wang et al. · 2021 · European Journal of Medicinal Chemistry
  22. Huprine Derivatives as Sub‐Nanomolar Human Acetylcholinesterase Inhibitors: From Rational Design to Validation by X‐ray Crystallography
    Cyril Ronco, E. Carletti, Jacques‐Philippe Colletier, Martin Weik, Florian Nachon, Ludovic Jean, Pierre‐Yves Renard · 2011 · ChemMedChem
  23. Development of the “hidden” multi-target-directed ligands by AChE/BuChE for the treatment of Alzheimer's disease
    Rui Chen, Xinjuan Li, Hongsong Chen, Keren Wang, Teng Xue, Jing Mi, Yujuan Ban, Gaofeng Zhu, Yi Ming Zhou, Wu Dong et al. · 2023 · European Journal of Medicinal Chemistry
  24. Insight into role of triazole derived Schiff base bearing sulfonamide derivatives in targeting Alzheimer's disease: Synthesis, characterization, in vitro and in silico assessment
    Shoaib Ahmed Khan, Rafaqat Hussain, Yousaf Khan, Tayyiaba Iqbal, Muhammad Bilal Khan, Khairia Mohammed Al‐Ahmary, Saedah Rwede AL-Mhyawi · 2024 · Journal of Molecular Structure
  25. Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease
    Wanli Pan, Ke Hu, Ping Bai, Lintao Yu, Qinge Ma, Tao Li, Xu Zhang, Changzhong Chen, Kelin Peng, Wenmin Liu et al. · 2016 · Bioorganic & Medicinal Chemistry Letters
  26. Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer’s disease
    Zhipei Sang, Keren Wang, Huifang Wang, Lintao Yu, Huijuan Wang, Qianwen Ma, Mengyao Ye, Xue Han, Wenmin Liu · 2017 · Bioorganic & Medicinal Chemistry Letters
  27. Multi-target 1,4-dihydropyridines showing calcium channel blockade and antioxidant capacity for Alzheimer’s disease therapy
    R.S. Malek, Maciej Maj, Artur Wnorowski, Krzysztof Jóźwiak, Hélène Martin, Isabel Iriepa, Ignacio Moraleda, Fakher Chabchoub, Jose Luis Marco, Lhassane Ismaïli · 2019 · Bioorganic Chemistry
  28. Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile
    Kateřina Sobolová, Martina Hrabinová, Vendula Hepnarová, Tomas Kucera, Tereza Kobrlová, Markéta Benková, Jana Janočková, Rafael Doležal, Lukáš Prchal, Ondřej Benek et al. · 2020 · European Journal of Medicinal Chemistry
  29. Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer's disease.
    François-Xavier Toublet, Julien Lalut, Bérénice Hatat, Cédric Lecoutey, Audrey Davis, Marc Since, S. Corvaisier, T. Freret, J. Sopková-de Oliveira Santos, S. Claeysen et al. · 2020 · European journal of medicinal chemistry
  30. Does the application of acetylcholinesterase inhibitors in the treatment of Alzheimer’s disease lead to depression?
    Miloš Mitić, Tamara D. Lazarević Pašti · 2021 · Expert Opinion on Drug Metabolism & Toxicology
  31. Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget‐Directed Ligands for the Treatment of Alzheimer's Disease
    Ondřej Benek, Ondřej Soukup, Markéta Benková, Lukáš Hroch, Vendula Šepsová, Petr Jošt, Martina Hrabinová, Daniel Jun, Kamil Kuča, Dominykas Zala et al. · 2015 · ChemMedChem
  32. Design, synthesis and anticholinesterase activity of novel benzylidenechroman-4-ones bearing cyclic amine side chain
    Yaghoub Pourshojaei, Ali Gouranourimi, Shohre Hekmat, Ali Asadipour, Samira Rahmani‐Nezhad, Alireza Moradi, Hamid Nadri, Farshad Homayouni Moghadam, Saeed Emami, Alireza Foroumadi et al. · 2015 · European Journal of Medicinal Chemistry
  33. Highly enantioselective Rh-catalyzed transfer hydrogenation of N-sulfonyl ketimines
    Se Hun Kwak, Sun Ah Lee, Kee‐In Lee · 2010 · Tetrahedron Asymmetry
  34. Pro-neurogenic, Memory-Enhancing and Anti-stress Effects of DF302, a Novel Fluorine Gamma-Carboline Derivative with Multi-target Mechanism of Action
    Tatyana V. Strekalova, Nataliia Bahzenova, А. Н. Трофимов, Angelika G. Schmitt-Böhrer, Nataliia Markova, Vladimir V. Grigoriev, Vladimir L. Zamoyski, Tatiana P. Serkova, Olga M. Redkozubova, Daria V. Vinogradova et al. · 2017 · Molecular Neurobiology
  35. Design, synthesis, biological evaluation and molecular docking study of novel pyridoxine–triazoles as anti-Alzheimer's agents
    Tiyas Pal, Saipriyanka Bhimaneni, Abha Sharma, Swaran J.S. Flora · 2020 · RSC Advances
  36. Modulating Nitric Oxide Signaling in the Cns for Alzheimer’s Disease Therapy
    Qin Zhihui · 2013 · Future Medicinal Chemistry
  37. Plant-derived acetylcholinesterase inhibitory alkaloids for the treatment of Alzheimer's disease
    Stefano Dall’Acqua · 2013 · Botanics Targets and Therapy
  38. Multifunctional novel Diallyl disulfide (DADS) derivatives with β-amyloid-reducing, cholinergic, antioxidant and metal chelating properties for the treatment of Alzheimer’s disease
    Apra Manral, Vikas Saini, Poonam Meena, Manisha Tiwari · 2015 · Bioorganic & Medicinal Chemistry
  39. Diaryl Hydrazones as Multifunctional Inhibitors of Amyloid Self-Assembly
    Béla Török, Abha Sood, Seema Bag, Rekha Tulsan, Sanjukta Ghosh, Dmitry Borkin, Arleen R. Kennedy, Michelle Melanson, Richard Madden, Weihong Zhou et al. · 2013 · Biochemistry
  40. Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines
    Emna Maalej, Fakher Chabchoub, Abdelouahid Samadi, Cristóbal de los Rı́os, Almudena Perona, Antonio Morreale, Jose Luis Marco · 2011 · Bioorganic & Medicinal Chemistry Letters
  41. Rapid Label-Free Identification of Estrogen-Induced Differential Protein ExpressionIn Vivofrom Mouse Brain and Uterine Tissue
    László Prókai, Stanley M. Stevens, Navin Rauniyar, Vien Nguyen · 2009 · Journal of Proteome Research
  42. Characterization of the anxiolytic and sedative profile of JM-20: a novel benzodiazepine–dihydropyridine hybrid molecule
    Y. N. Figueredo, E. O. Rodríguez, Y. Reyes, C. Domínguez, A. L. Parra, Jeney Ramírez Sánchez, R. D. Hernández, Marlene Porto Verdecia, Gilberto L. Pardo Andreu · 2013 · Neurological Research
  43. Design and synthesis of tacrine-phenothiazine hybrids as multitarget drugs for Alzheimer’s disease
    Ailing Hui, Yan Chen, Shi-jing Zhu, Changsheng Gan, Jian Pan, An Zhou · 2014 · Medicinal Chemistry Research
  44. Tacrine-allyl/propargylcysteine–benzothiazole trihybrids as potential anti-Alzheimer's drug candidates
    Asha Hiremathad, Karam Chand, A. Raquel Esteves, Sandra M. Cardoso, Rona Ruth Ramsay, Sı́lvia Chaves, Rangappa Sangappa Keri, Maria Amélia Santos · 2016 · RSC Advances
  45. Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease
    Yao Chen, Jie Zhu, Jun Mo, Hongyu Yang, Xueyang Jiang, Hongzhi Lin, Kai Xuan Gu, Yuqiong Pei, Liang Wu, Ren Xiang Tan et al. · 2017 · Journal of Enzyme Inhibition and Medicinal Chemistry
  46. Simultaneous Blockade of Histamine H3 Receptors and Inhibition of Acetylcholine Esterase Alleviate Autistic-Like Behaviors in BTBR T+ tf/J Mouse Model of Autism
    Nermin Eissa, Petrilla Jayaprakash, Holger Stark, Dorota Łażewska, Katarzyna Kieć‐Kononowicz, Bassem Shaban Sadek · 2020 · Biomolecules
  47. Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures
    Fredrik Ekström, Andrea Gottinger, Nina Forsgren, Marco Catto, Luca Giacinto Iacovino, Leonardo Pisani, Claudia Binda · 2022 · ACS Medicinal Chemistry Letters
  48. Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy
    Marialuigia Fantacuzzi, Rosa Amoroso, Simone Carradori, Barbara De Filippis · 2022 · European Journal of Medicinal Chemistry
  49. Discovery of New 1,3,4-Oxadiazoles with Dual Activity Targeting the Cholinergic Pathway as Effective Anti-Alzheimer Agents
    Nehal H. Elghazawy, Dalia K. Zaafar, Reham R. Hassan, Mohamed Y. Mahmoud, Loay Bedda, Alaa F. Bakr, Reem K. Arafa · 2022 · ACS Chemical Neuroscience
  50. Parallel Synthesis and Cytotoxicity Evaluation of a Polyamine−Quinone Conjugates Library
    María Laura Bolognesi, Natalia Calonghi, Chiara Mangano, Lanfranco Masotti, Carlo Melchiorre · 2008 · Journal of Medicinal Chemistry
  51. 2-(2-indolyl-)-4(3 H )-quinazolines derivates as new inhibitors of AChE: design, synthesis, biological evaluation and molecular modelling
    Zeng Li, Bin Wang, Jinqiang Hou, Shi‐Liang Huang, Tian‐Miao Ou, Jia‐Heng Tan, Lin‐Kun An, Ding Li, Lian‐Quan Gu, Zhi‐Shu Huang · 2012 · Journal of Enzyme Inhibition and Medicinal Chemistry
  52. Hybrid benzothiazole derived fused triazole/thiazole derivatives as versatile anti-Alzheimer agents: synthesis, characterization, biological evaluation and molecular docking studies
    Shoaib Ahmed Khan, Rafaqat Hussain, Yousaf Khan, Tayyiaba Iqbal, Sampath Chinnam, Muhammad Akif, Ayed A. Dera · 2024 · Journal of Molecular Structure
  53. Cu(0)@Al 2 O 3 /SiO 2 NPs: an efficient reusable catalyst for the cross coupling reactions of aryl chlorides with amines and anilines
    P. Linga Reddy, Racha Arundhathi, Diwan Singh Rawat · 2015 · RSC Advances
  54. Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer’s disease
    Li Luo, Yan Li, Xiaoming Qiang, Zhongcheng Cao, Rui Xu, Yang Xia, Ganyuan Xiao, Qing Song, Zhenghuai Tan, Yong Deng · 2017 · Bioorganic & Medicinal Chemistry
  55. Design, Synthesis, and Pharmacological Characterization of Carbazole Based Dopamine Agonists as Potential Symptomatic and Neuroprotective Therapeutic Agents for Parkinson’s Disease
    Asma S.mohamed Elmabruk, Banibrata Das, Deepthi Yedlapudi, Liping Xu, Tamara Antonio, Maarten E. A. Reith, Aloke K. Dutta · 2018 · ACS Chemical Neuroscience
  56. Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer’s Disease
    Matheus de Freitas Silva, Ellen Tardelli Falleiros Lima, Letizia Pruccoli, Newton Gonçalves Castro, Marcos Jorge R. Guimarães, Fernanda da Silva, Nathália Fonseca Nadur, Luciana de Azevedo, Arthur Eugen Kümmerle, Isabella Alvim Guedes et al. · 2020 · Molecules
  57. Dual targeting of acetylcholinesterase and tau aggregation: Design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for Alzheimer’s disease
    Shoaib Manzoor, Moustafa Tarek Gabr, Bisma Rasool, Kavita Pal, Nasimul Hoda · 2021 · Bioorganic Chemistry
  58. Brominated Extracts As Source of Bioactive Compounds
    Luciana Méndez, Mario O. Salazar, Ivana Ayelen Ramallo, Ricardo L. E. Furlán · 2010 · ACS Combinatorial Science
  59. Human Disease and Drug Pharmacology, Complex as Real Life
    Elisabet Viayna, I. Sola, Ornella Di Pietro, Diego Muñoz‐Torrero · 2013 · Current Medicinal Chemistry
  60. Dual/Multitargeted Xanthone Derivatives for Alzheimer'S Disease: Where Do We Stand?
    Maria I Cruz, Honorina M. Cidade, Madalena M. M. Pinto · 2017 · Future Medicinal Chemistry
  61. A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease
    Bérénice Hatat, Samir Yahiaoui, Cédric Lecoutey, Audrey Davis, Thomas Fréret, Michel Boulouard, Sylvie Claeysen, Christophe Rochais, Patrick Dallemagne · 2019 · Frontiers in Aging Neuroscience
  62. Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments
    Óscar M. Bautista‐Aguilera, Lhassane Ismaïli, Isabel Iriepa, Daniel Diez‐Iriepa, Fakher Chabchoub, Jose Luis Marco, Marta Pérez · 2020 · The Chemical Record
  63. The Neuroprotective Activities of the Novel Multi-Target Iron-Chelators in Models of Alzheimer’s Disease, Amyotrophic Lateral Sclerosis and Aging
    Lana Kupershmidt, Moussa B. H. Youdim · 2023 · Cells
  64. Design, synthesis, and evaluation of novel benzofuran and pyrazole-based derivatives as dual AChE/BuChE inhibitors with antioxidant properties for Alzheimer's disease management
    Mahmoud S. Elkotamy, Mohamed K. Elgohary, Mahmoud Abdelrahman Alkabbani, Mohamed M Hefina, Haytham O. Tawfik, Mohamed Farès, Wagdy Mohamed Eldehna, Hatem A. Abdel‐Aziz · 2024 · European Journal of Medicinal Chemistry
  65. Dual Histamine H3R/Serotonin 5-HT4R Ligands with Antiamnesic Properties: Pharmacophore-Based Virtual Screening and Polypharmacology
    Alban Lepailleur, Thomas Fréret, Stéphane Lemaître, Michel Boulouard, François Dauphin, Antoine Hinschberger, Fabienne Dulin, Aurélien Lesnard, Ronan Bureau, Sylvain Rault · 2014 · Journal of Chemical Information and Modeling
  66. The Molecular Basis for Dual Fatty Acid Amide Hydrolase (FAAH)/Cyclooxygenase (COX) Inhibition
    Giulia Palermo, Angelo Danilo Favia, Marino Convertino, Marco De Vivo · 2015 · ChemMedChem
  67. Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids
    Slávka Hamuľaková, Ladislav Janovec, Ondřej Soukup, Daniel Jun, Kamil Kuča · 2017 · International Journal of Biological Macromolecules
  68. Protocol for fast screening of multi-target drug candidates: Application to Alzheimer’s disease
    Nguyen Quoc Thai, Hoang Linh Nguyen, Huynh Quang Linh, Mai Suan Li · 2017 · Journal of Molecular Graphics and Modelling
  69. Tacrine–deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug
    Karam Chand, Karam Rajeshwari, Emanuel Candeias, Sandra M. Cardoso, Sı́lvia Chaves, Maria Amélia Santos · 2018 · Metallomics
  70. Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors
    Jesús M. Roldán-Peña, Valle Romero-Real, Javier Hicke, Inés Maya, Antonio Franconetti, Irene Lagunes, José M. Padrón, Sabrina Petralla, Eleonora Poeta, Marina Naldi et al. · 2019 · European Journal of Medicinal Chemistry
  71. Multitarget Anticancer Agents Based on Histone Deacetylase and Protein Kinase CK2 Inhibitors
    Regina Martínez, Bruno Di Geronimo, Miryam Pastor, José María Zapico, Claire Coderch, Rostyslav R. Panchuk, Nadia R. Skorokhyd, Maciej Masłyk, Ana Ramos, Beatriz de Pascual‐Teresa · 2020 · Molecules
  72. Design, synthesis, and evaluation of chalcone-Vitamin E-donepezil hybrids as multi-target-directed ligands for the treatment of Alzheimer’s disease
    Zhipei Sang, Qing Song, Zhongcheng Cao, Yong Deng, Li Zhang · 2021 · Journal of Enzyme Inhibition and Medicinal Chemistry
  73. Recent advances in dopamine D 2 receptor ligands in the treatment of neuropsychiatric disorders
    Radomír Jůza, Kamil Musílek, Eva Mezeiová, Ondřej Soukup, Jan Korábečný · 2022 · Medicinal Research Reviews
  74. Structural Modifications of Neuroprotective Anti-Parkinsonian (−)- N 6-(2-(4-(Biphenyl-4-yl)piperazin-1-yl)-ethyl)- N 6-propyl-4,5,6,7-tetrahydrobenzo[ d ]thiazole-2,6-diamine (D-264): An Effort toward the Improvement of in Vivo Efficacy of the Parent Molecule
    Gyan Prakash Modi, Tamara Antonio, Maarten E. A. Reith, Aloke K. Dutta · 2014 · Journal of Medicinal Chemistry
  75. Docking Ligands on Protein Surfaces: The Case Study of Prion Protein
    Agata Kranjc, Salvatore Bongarzone, Giulia Rossetti, Xevi Biarnés, Andrea Cavalli, María Laura Bolognesi, Marinella Roberti, Giuseppe Legname, Paolo Carloni · 2009 · Journal of Chemical Theory and Computation
  76. Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update
    Vincenzo Tumiatti, María Laura Bolognesi, Anna Minarini, Michela Rosini, Andrea Milelli, Riccardo Matera, Carlo Melchiorre · 2008 · Expert Opinion on Therapeutic Patents
  77. Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease
    Zhipei Sang, Wanli Pan, Keren Wang, Qinge Ma, Lintao Yu, Wenmin Liu · 2017 · Bioorganic & Medicinal Chemistry
  78. The Histamine H3 Receptor Antagonist E159 Reverses Memory Deficits Induced by Dizocilpine in Passive Avoidance and Novel Object Recognition Paradigm in Rats
    Alaa Alachkar, Dorota Łażewska, Katarzyna Kieć‐Kononowicz, Bassem Shaban Sadek · 2017 · Frontiers in Pharmacology
  79. Pathogenic Feed-Forward Mechanisms in Alzheimer’s and Parkinson’s Disease Converge on GSK-3
    Abdalla M. Albeely, Scott D. Ryan, Melissa L. Perreault · 2018 · Brain Plasticity
  80. Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors
    Barbora Svobodová, Eva Mezeiová, Vendula Hepnarová, Martina Hrabinová, Ľubica Múčková, Tereza Kobrlová, Daniel Jun, Ondřej Soukup, M. Luísa Jimeno, Jose Luis Marco et al. · 2019 · Biomolecules
  81. Chromone–lipoic acid conjugate: Neuroprotective agent having acceptable butyrylcholinesterase inhibition, antioxidant and copper-chelation activities
    Leili Jalili‐Baleh, Hamid Nadri, Hamid Forootanfar, Tuba Tüylü Küçükkılınç, Beyza Ayazgök, Mohammad Sharif Sharifzadeh, Mahban Rahimifard, Maryam Baeeri, Mohammad Reza Abdollahi, Alireza Foroumadi et al. · 2021 · DARU Journal of Pharmaceutical Sciences
  82. SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer’s Disease
    Mercedes Unzeta, Mar Hernández‐Guillamón, Ping Sun, Montse Solé · 2021 · International Journal of Molecular Sciences
  83. Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer’s Disease
    Lukáš Górecki, Elisa Uliassi, Manuela Bartolini, Jana Janočková, Martina Hrabinová, Vendula Hepnarová, Lukáš Prchal, Ľubica Múčková, Jaroslav Pejchal, Jana Žďárová Karasová et al. · 2021 · ACS Chemical Neuroscience
  84. Design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and Nrf2 activating functions for Alzheimer's disease
    Yuanyuan Wang, Baichen Xiong, Hongzhi Lin, Qi Li, Hongyu Yang, Yuting Qiao, Qihang Li, Ziwei Xu, Weiping Lyu, Wei Qu et al. · 2022 · European Journal of Medicinal Chemistry
  85. Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents
    Begüm Nurpelin Sağlık, Serkan Levent, Derya Osmani̇ye, Asaf Evrim Evren, Abdullah Burak Karaduman, Yusuf Özkay, Zafer Asım Kaplancıklı · 2022 · ACS Omega
  86. Pathologically Activated Neuroprotection via Uncompetitive Blockade of N-Methyl-d-aspartate Receptors with Fast Off-rate by Novel Multifunctional Dimer Bis(propyl)-cognitin
    Jialie Luo, Wenming Li, Yuming Zhao, Hongjun Fu, Dik‐Lung Ma, Jing Tang, Zesong Li, Robert W. Peoples, Fushun Li, Qinwen Wang et al. · 2010 · Journal of Biological Chemistry
  87. Multiple Target-Centric Strategy to Tame Inflammation
    Gaganpreet Kaur, Om Silakari · 2017 · Future Medicinal Chemistry
  88. New classes of carbazoles as potential multi-functional anti-Alzheimer’s agents
    Niloufar Choubdar, Mostafa Golshani, Leili Jalili‐Baleh, Hamid Nadri, Tuba Tüylü Küçükkılınç, Beyza Ayazgök, Alireza Moradi, Farshad Homayouni Moghadam, Zahra Abdolahi, Alieh Ameri et al. · 2019 · Bioorganic Chemistry
  89. Ethyl Acetohydroxamate Incorporated Chalcones: Unveiling a Novel Class of Chalcones for Multitarget Monoamine Oxidase-B Inhibitors Against Alzheimer’s Disease
    Reeta Reeta, Seung Cheol Baek, Jae Pil Lee, T. M. Rangarajan, Ayushee, Rishi Pal Singh, Manjula Singh, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Hoon Kim et al. · 2019 · CNS & Neurological Disorders - Drug Targets
  90. Propargylamine: an Important Moiety in Drug Discovery
    Aitor Carneiro, Eugenio Uriarte, Fernanda Borges, María João Matos · 2023 · Future Medicinal Chemistry
  91. Synthesis and anti-Alzheimer potential of novel α-amino phosphonate derivatives and probing their molecular interaction mechanism with acetylcholinesterase
    Kandrakonda Yelamanda Rao, Shaik Jeelan Basha, Monika Kallubai, Mothukuru Sreelakshmi, Irla Sivakumar, Gunti Mallikarjuna, Ranay Mohan Yadav, Sandeep Kumar, Rajagopal Subramanyam, Amooru Gangaiah Damu · 2023 · European Journal of Medicinal Chemistry
  92. Perspectives on Inhibiting β‐Amyloid Aggregation through Structure‐Based Drug Design
    Pankaj Mishra, Senthil Raja Ayyannan, Gautam Panda · 2015 · ChemMedChem
  93. Synthesis, Pharmacological Study and Docking Calculations of New Benzo[ f ]coumarin Derivatives as Dual Inhibitors of Enzymatic Systems Involved in Neurodegenerative Diseases
    María João Matos, Patricia Janeiro, Rosa María González Franco, Santiago Vilar, Nicholas P. Tatonetti, Lourdes Santana, Eugenio Uriarte, Fernanda Borges, José Angel Fontenla, Dolores Viña · 2014 · Future Medicinal Chemistry
  94. The Bivalent Ligand Approach as a Tool for Improving the in vitro Anti‐Alzheimer Multitarget Profile of Dimebon
    Michela Rosini, Elena Simoni, Manuela Bartolini, Elena Soriano, Jose Luis Marco, Vincenza Andrisano, Barbara Monti, Manfred Windisch, Birgit Hutter‐Paier, David W. McClymont et al. · 2013 · ChemMedChem
  95. 1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders
    Ondřej Benek, Lukáš Hroch, Laura Aitken, Frank J. Gunn‐Moore, Lucie Vinklářová, Kamil Kuča, Daniel I. Pérez, Concepcion Perez, Ana Martı́nez, Zdeněk Fišar et al. · 2018 · Journal of Enzyme Inhibition and Medicinal Chemistry
  96. Experimental and Computational Evaluation of Piperonylic Acid Derived Hydrazones Bearing Isatin Moieties as Dual Inhibitors of Cholinesterases and Monoamine Oxidases
    Vishnu Mini Sasi, Pavankumar Vangavolu, Sandeep Kumar, A. S. Raja · 2019 · ChemMedChem
  97. Design, synthesis and biological evaluation of dual-function inhibitors targeting NMDAR and HDAC for Alzheimer’s disease
    Feng He, Yingying Ran, Xiaoyang Li, Defeng Wang, Qiuqiong Zhang, Jiahui Lv, Chenggong Yu, Ying Qu, Xiangna Zhang, Ana Xu et al. · 2020 · Bioorganic Chemistry
  98. Hyaluronan-carnosine conjugates inhibit Aβ aggregation and toxicity
    Valentina Greco, Налетова Ирина Николаевна, Ikhlas M. M. Ahmed, Susanna Vaccaro, Luciano Messina, Diego La Mendola, Francesco Bellia, Sebastiano Sciuto, Cristina Satriano, Enrico Rizzarelli · 2020 · Scientific Reports
  99. Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes
    Wolfgang Froestl, Andreas Muhs, Andrea Pfeifer · 2013 · Journal of Alzheimer s Disease
  100. Synthesis and structure–activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity
    Giovanni Morini, Mara Comini, Mirko Rivara, Silvia Rivara, Fabrizio Bordi, Pier Vincenzo Plazzi, Lisa Flammini, Francesca Saccani, Simona Bertoni, Vigilio Ballabeni et al. · 2008 · Bioorganic & Medicinal Chemistry