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Cited by 340

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Detection of Intensity Change Points in Time-Resolved Single-Molecule Measurements

Watkins, Lucas P., Yang, Haw·2005·The Journal of Physical Chemistry B

Abstract

We present a method for the analysis of optical single molecule emission data that exhibit discrete intensity jumps. This new method uses a generalized likelihood ratio test that determines the location of an intensity change point based on individual photon arrival times. This test is applied recursively to an entire single molecule intensity trajectory, thus finding each change points. Expectation-maximization clustering and the Bayesian information criterion is then used for accurate determination of the true number of states accessible to the system. This procedure allows rigorous and quantitative determination of intensity change points without the artificial time resolution limitations that arise from binning and thresholding.

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Crossref · 10.1021/jp0467548

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Metadata

Authors
Watkins, L. P., & Yang, H.
Venue
The Journal of Physical Chemistry B
Published
2004-12-14
Volume
109
Issue
1
Pages
617-628
ISSN
  • 1520-5207 (ISSN-L)
  • 1520-6106
OpenAlex
W2043736118
Cited by
340
References
28
FWCI
3.83
Type
journal article
Language
en
Open access
closed

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