The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Myosin V Walks Hand-Over-Hand: Single Fluorophore Imaging with 1.5-nm Localization
Abstract
Myosin V is a dimeric molecular motor that moves processively on actin, with the center of mass moving ∼37 nanometers for each adenosine triphosphate hydrolyzed. We have labeled myosin V with a single fluorophore at different positions in the light-chain domain and measured the step size with a standard deviation of <1.5 nanometers, with 0.5-second temporal resolution, and observation times of minutes. The step size alternates between 37 + 2x nm and 37 – 2x, where x is the distance along the direction of motion between the dye and the midpoint between the two heads. These results strongly support a hand-over-hand model of motility, not an inchworm model.
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Cites
Precise Nanometer Localization Analysis for Individual Fluorescent Probes
Thompson, R. E., Larson, D. R., & Webb, W. W. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)75618-x · Cited by 2,320
Distinguishing Inchworm and Hand-Over-Hand Processive Kinesin Movement by Neck Rotation Measurements
Hua, W., Chung, J., & Gelles, J. (2002) · Science · doi:10.1126/science.1063089 · Cited by 194
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Yildiz, A., Tomishige, M., Vale, R. D., & Selvin, P. R. (2004) · Science · doi:10.1126/science.1093753 · Cited by 965
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Metadata
- Authors
- Yildiz, A., Forkey, J. N., McKinney, S. A., Ha, T., Goldman, Y. E., & Selvin, P. R.
- Venue
- Science
- Published
- 2003-06-27
- Volume
- 300
- Issue
- 5628
- Pages
- 2061-2065
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2015404233
- Cited by
- 1,837
- References
- 2
- FWCI
- 46.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yildiz, A., Forkey, J. N., McKinney, S. A., Ha, T., Goldman, Y. E., & Selvin, P. R. (2003). Myosin V Walks Hand-Over-Hand: Single Fluorophore Imaging with 1.5-nm Localization. Science. https://doi.org/10.1126/science.1084398
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