The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Influence of PEG Architecture on Protein Adsorption and Conformation
Open accessAbstract
Poly(L-lysine)-g-poly(ethylene glycol) (PLL-g-PEG) copolymers with various grafting ratios were adsorbed to niobium pentoxide-coated silicon wafers and characterized before and after protein adsorption using X-ray photoelectron spectroscopy (XPS) and time-of-flight secondary ion mass spectrometry (ToF-SIMS). Three proteins of different sizes, myoglobin (16 kD), albumin (67 kD), and fibrinogen (340 kD), were studied. XPS was used to quantify the amount of protein adsorbed to the bare and PEGylated surfaces. ToF-SIMS and principal component analysis (PCA) were used to study protein conformational changes on these surfaces. The smallest protein, myoglobin, generally adsorbed in higher numbers than the much larger fibrinogen. Protein adsorption was lowest on the surfaces with the highest PEG chain surface density and increased as the PEG layer density decreased. The highest adsorption was found on lysine-coated and bare niobium surfaces. ToF-SIMS and PCA data evaluation provided further information on the degree of protein denaturation, which, for a particular protein, were found to decrease with increasing PEG surface density and increase with decreasing protein size.
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Cites
A User's Guide to Principal Components
Leigh, S., & Jackson, J. E. (1993) · Technometrics · doi:10.2307/1269292 · Cited by 3,332
A Use's Guide to Principal Components
Jackson, J. E. (1991) · Wiley Series in Probability and Statistics · doi:10.1002/0471725331 · Cited by 2,516
Prime, K. L., & Whitesides, G. M. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00076a032 · Cited by 1,620
Poly(ethylene glycol) chemistry : biotechnical and biomedical applications
Harris, J. M. (1992) · Plenum Press eBooks · Cited by 1,426
Poly(Ethylene Glycol) Chemistry: Biotechnical and Biomedical Applications
(1992) · Springer eBooks · doi:10.1007/978-1-4899-0703-5 · Cited by 1,420
Keselowsky, B. G., Collard, D. M., & García, A. J. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10537 · Cited by 949
Zwitterionic SAMs that Resist Nonspecific Adsorption of Protein from Aqueous Buffer
Holmlin, R. E., Chen, X., Chapman, R. G., Takayama, S., & Whitesides, G. M. (2001) · Langmuir · doi:10.1021/la0015258 · Cited by 891
Kenausis, G. L., Vörös, J., Elbert, D. L., Huang, N., Hofer, R., Ruiz-Taylor, L., Textor, M., Hubbell, J. A., & Spencer, N. D. (2000) · The Journal of Physical Chemistry B · doi:10.1021/jp993359m · Cited by 675
Self-citationPasche, S., De Paul, S. M., Vörös, J., Spencer, N. D., & Textor, M. (2003) · Langmuir · doi:10.1021/la034111y · Cited by 411
Self-citationBiomaterial biocompatibility and the macrophage
Anderson, J. M., & Miller, K. M. (1984) · Biomaterials · doi:10.1016/0142-9612(84)90060-7 · Cited by 403
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Metadata
- Authors
- Michel, R., Pasche, S., Textor, M., & Castner, D. G.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-11-24
- Volume
- 21
- Issue
- 26
- Pages
- 12327-12332
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W2012368513
- Cited by
- 340
- References
- 28
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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