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Core−Shell Magnetite Nanoparticles Surface Encapsulated with Smart Stimuli-Responsive Polymer: Synthesis, Characterization, and LCST of Viable Drug-Targeting Delivery System
Abstract
We describe here the synthesis of a novel magnetic drug-targeting carrier characterized by a core-shell structure. The core-shell carrier combines the advantages of a magnetic core and the stimuli-responsive property of the thermosensitive biodegradable polymer shell (e.g., an on-off mechanism responsive to external temperature change). The composite nanoparticles are approximately 8 nm in diameter with approximately 3 nm shell. The lower critical solution temperature (LCST) is approximately 38 degrees C as determined by UV-vis absorption spectroscopy. The carrier is composed of cross-linked dextran grafted with a poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) [dextran-g-poly(NIPAAm-co-DMAAm)] shell and superparamagnetic Fe3O4 core. Fourier transform infrared spectroscopy (FTIR) confirmed the composition of the carrier. The synthesized magnetic carrier system has potential applications in magnetic drug-targeting delivery and magnetic resonance imaging.
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Metadata
- Authors
- Zhang, J. L., Srivastava, R. S., & Misra, R. D. K.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-04-27
- Volume
- 23
- Issue
- 11
- Pages
- 6342-6351
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W1968573340
- Cited by
- 433
- References
- 0
- FWCI
- 13.98
- Type
- journal article
- Language
- en
- Open access
- closed
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