Biomimetic Anchors for Antifouling and Antibacterial Polymer Brushes on Stainless Steel
Abstract
Barnacle cement (BC) was beneficially applied on stainless steel (SS) to serve as the initiator anchor for surface-initiated polymerization. The amine and hydroxyl moieties of barnacle cement reacted with 2-bromoisobutyryl bromide to provide the alkyl halide initiator for the surface-initiated atom transfer radical polymerization (ATRP) of 2-hydroxyethyl methacrylate (HEMA). The hydroxyl groups of HEMA polymer (PHEMA) were then converted to carboxyl groups for coupling of chitosan (CS) to impart the SS surface with both antifouling and antibacterial properties. The surface-functionalized SS reduced bovine serum albumin adsorption, bacterial adhesion, and exhibited antibacterial efficacy against Escherichia coli (E. coli). The effectiveness of barnacle cement as an initiator anchor was compared to that of dopamine, a marine mussel inspired biomimetic anchor previously used in surface-initiated polymerization. The results indicate that the barnacle cement is a stable and effective anchor for functional surface coatings and polymer brushes.
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Handbook of X-Ray Photoelectron Spectroscopy
Moulder, J. F. (1995) · Medical Entomology and Zoology · Cited by 23,662 · see citing works
Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167 · see citing works
Mussel-inspired surface chemistry for multifunctional coatings
Lee, H., Dellatore, S. M., Miller, W. M., & Messersmith, P. B. (2007) · Science · doi:10.1126/science.1147241 · Cited by 10,965 · see citing works
Chitosan as antimicrobial agent: applications and mode of action.
Rabea, E. I., Badawy, M. E.-T., Stevens, C. V., Smagghe, G., & Steurbaut, W. (2003) · Biomacromolecules · doi:10.1021/bm034130m · Cited by 3,123 · see citing works
Biomaterial-Centered Infection: Microbial Adhesion Versus Tissue Integration
Gristina, A. G. (1987) · Science · doi:10.1126/science.3629258 · Cited by 2,161 · see citing works
Polymer brushes: surface-immobilized macromolecules
Zhao, B., & Brittain, W. J. (2000) · Progress in Polymer Science · doi:10.1016/s0079-6700(00)00012-5 · Cited by 1,628 · see citing works
Polymer brushes via surface-initiated polymerizations
Edmondson, S., Osborne, V. L., & Huck, W. T. S. (2003) · Chemical Society Reviews · doi:10.1039/b210143m · Cited by 1,347 · see citing works
Biomedical surface science: Foundations to frontiers
Castner, D. G., & Ratner, B. D. (2002) · Surface Science · doi:10.1016/s0039-6028(01)01587-4 · Cited by 1,329 · see citing works
Dopamine-Induced Reduction and Functionalization of Graphene Oxide Nanosheets
Xu, L., Yang, W. J., Neoh, K. G., Kang, E. T., & Fu, G. (2010) · Macromolecules · doi:10.1021/ma101526k · Cited by 781 · see citing works
Self-citationZhang, Z., Chen, S., Chang, Y., & Jiang, S. (2006) · The Journal of Physical Chemistry B · doi:10.1021/jp057266i · Cited by 541 · see citing works
Chua, P.-H., Neoh, K. G., Kang, E. T., & Wang, W. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2007.12.019 · Cited by 484 · see citing works
Self-citationZhang, Z., Chen, S., & Jiang, S. (2006) · Biomacromolecules · doi:10.1021/bm060750m · Cited by 473 · see citing works
Fu, J., Ji, J., Yuan, W., & Shen, J. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.04.034 · Cited by 457 · see citing works
Biomimetic Anchor for Surface-Initiated Polymerization from Metal Substrates
Fan, X., Lin, L., Dalsin, J. L., & Messersmith, P. B. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0532638 · Cited by 448 · see citing works
Bioactive surfaces and biomaterials via atom transfer radical polymerization
Xu, F., Neoh, K. G., & Kang, E. T. (2009) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2009.04.005 · Cited by 367 · see citing works
Self-citationFeng, W., Brash, J. L., & Zhu, S. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.07.006 · Cited by 349 · see citing works
Surface modification of plasma-pretreated poly(tetrafluoroethylene) films by graft copolymerization
Tan, K. L., Woon, L. L., Wong, H. K., et al. (1993) · Macromolecules · doi:10.1021/ma00063a030 · Cited by 283 · see citing works
Ku, S. H., Lee, J. S., & Park, C. B. (2010) · Langmuir · doi:10.1021/la102825p · Cited by 247 · see citing works
Simplified Polymer Mimics of Cross-Linking Adhesive Proteins
Westwood, G., Horton, T. N., & Wilker, J. J. (2007) · Macromolecules · doi:10.1021/ma0703002 · Cited by 232 · see citing works
Ma, H., Wells, M., Beebe, T. P., et al. (2006) · Advanced Functional Materials · doi:10.1002/adfm.200500426 · Cited by 232 · see citing works
Yoshikawa, C., Goto, A., Tsujii, Y., et al. (2006) · Macromolecules · doi:10.1021/ma0520242 · Cited by 216 · see citing works
Kamino, K. (2008) · Marine Biotechnology · doi:10.1007/s10126-007-9076-3 · Cited by 209 · see citing works
Zhang, F., Kang, E. T., Neoh, K. G., et al. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00310-0 · Cited by 206 · see citing works
Self-citationFunctionalizable and ultra-low fouling zwitterionic surfaces via adhesive mussel mimetic linkages
Gao, C., Li, G., Xue, H., Yang, W. M., Zhang, F., & Jiang, S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.11.025 · Cited by 185 · see citing works
Self-citationShi, Z., Neoh, K. G., Kang, E. T., Poh, C., & Wang, W. (2007) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31648 · Cited by 156 · see citing works
Self-citationApproaches in designing non-toxic polymer surfaces to deter marine biofouling
Grozea, C. M., & Walker, G. C. (2009) · Soft Matter · doi:10.1039/b910899h · Cited by 155 · see citing works
Adhesion of coagulase‐negative staphylococci to methacrylate polymers and copolymers
Hogt, A. H., Dankert, J., & Feijen, J. (1986) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820200409 · Cited by 155 · see citing works
Barnacle cement: a polymerization model based on evolutionary concepts
Dickinson, G. H., Vega, I. E., Wahl, K. J., et al. (2009) · Journal of Experimental Biology · doi:10.1242/jeb.029884 · Cited by 144 · see citing works
Self-citationTuning Cell Adhesion on Gradient Poly(2-hydroxyethyl methacrylate)-Grafted Surfaces
Mei, Y., Wu, T., Xu, C., et al. (2005) · Langmuir · doi:10.1021/la050668x · Cited by 142 · see citing works
Fast Disinfecting Antimicrobial Surfaces
Madkour, A. E., Dabkowski, J. M., Nüsslein, K. R., & Tew, G. N. (2008) · Langmuir · doi:10.1021/la802953v · Cited by 141 · see citing works
Smith, A. M., & Callow, J. A. (2006) · Springer eBooks · doi:10.1007/978-3-540-31049-5 · Cited by 137 · see citing works
Wiegemann, M. (2005) · Aquatic Sciences · doi:10.1007/s00027-005-0758-5 · Cited by 134 · see citing works
Superhydrophobic and Self-Cleaning Bio-Fiber Surfaces via ATRP and Subsequent Postfunctionalization
Nyström, D., Lindqvist, J., Östmark, E., Antoni, P., Carlmark, A., Hult, A., & Malmström, E. (2009) · ACS Applied Materials & Interfaces · doi:10.1021/am800235e · Cited by 130 · see citing works
Phylogenetic analysis of the Balanidae (Cirripedia, Balanomorpha)
Pitombo, F. B. (2004) · Zoologica Scripta · doi:10.1111/j.0300-3256.2004.00145.x · Cited by 125 · see citing works
The Biochemical Composition of the Cement of two Barnacle Species,Balanus HameriandBalanus Crenatus
Walker, G. C. (1972) · Journal of the Marine Biological Association of the United Kingdom · doi:10.1017/s0025315400018786 · Cited by 117 · see citing works
Surface elastic modulus of barnacle adhesive and release characteristics from silicone surfaces
Sun, Y., Guo, S., Walker, G. C., Kavanagh, C. J., & Swain, G. W. (2004) · Biofouling · doi:10.1080/08927010400026383 · Cited by 116 · see citing works
Marini, M., Bondi, M., Iseppi, R., et al. (2007) · European Polymer Journal · doi:10.1016/j.eurpolymj.2007.06.002 · Cited by 107 · see citing works
Identification and functional characterization of a novel barnacle cement protein
Urushida, Y., Nakano, M., Matsuda, S., et al. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05965.x · Cited by 106 · see citing works
Shi, Z., Neoh, K. G., Kang, E. T., Shuter, B., Wang, S., Poh, C., & Wang, W. (2008) · ACS Applied Materials & Interfaces · doi:10.1021/am8000538 · Cited by 106 · see citing works
Self-citationKavanagh, C. J., Swain, G. W., Kovach, B., et al. (2003) · Biofouling · doi:10.1080/08927010310001623296 · Cited by 96 · see citing works
Peculiarities of barnacle adhesive cured on non-stick surfaces
Wiegemann, M., & Watermann, B. T. (2003) · Journal of Adhesion Science and Technology · doi:10.1163/156856103770572070 · Cited by 94 · see citing works
Nanoscale structures and mechanics of barnacle cement
Sullan, R. M. A., Gunari, N., Tanur, A. E., Chan, Y., Dickinson, G. H., Orihuela, B., Rittschof, D., & Walker, G. C. (2009) · Biofouling · doi:10.1080/08927010802688095 · Cited by 92 · see citing works
Self-citationBerglin, M., & Gatenholm, P. (2003) · Colloids and Surfaces B Biointerfaces · doi:10.1016/s0927-7765(02)00149-2 · Cited by 91 · see citing works
Molecular Design of Barnacle Cement in Comparison with Those of Mussel and Tubeworm
Kamino, K. (2010) · The Journal of Adhesion · doi:10.1080/00218460903418139 · Cited by 89 · see citing works
Yuan, S., Pehkonen, S. O., Ting, Y., Neoh, K. G., & Kang, E. T. (2009) · ACS Applied Materials & Interfaces · doi:10.1021/am800182d · Cited by 81 · see citing works
Self-citationProtein adsorption resistance of anti-biofouling block copolymers containing amphiphilic side chains
Weinman, C. J., Gunari, N., Krishnan, S., Dong, R., Paik, M. Y., Sohn, K. E., Walker, G. C., Krämer, E. J., Fischer, D. A., & Ober, C. K. (2010) · Soft Matter · doi:10.1039/b925114f · Cited by 78 · see citing works
Gaharwar, A. K., Schexnailder, P. J., Jin, Q., Wu, C., & Schmidt, G. (2010) · ACS Applied Materials & Interfaces · doi:10.1021/am100609t · Cited by 75 · see citing works
Bozukova, D., Pagnoulle, C., Pauw‐Gillet, M. D., et al. (2008) · Langmuir · doi:10.1021/la7033774 · Cited by 67 · see citing works
Zhang, F., Shi, Z., Chua, P. H., et al. (2007) · Industrial & Engineering Chemistry Research · doi:10.1021/ie070795j · Cited by 66 · see citing works
Thermoresponsive Polymer Brush Surfaces with Hydrophobic Groups for All-Aqueous Chromatography
Nagase, K., Kumazaki, M., Kanazawa, H., et al. (2010) · ACS Applied Materials & Interfaces · doi:10.1021/am100122h · Cited by 66 · see citing works
Performance and effectiveness of non‐stick coatings in seawater
Watermann, B. T., Berger, H., Sönnichsen, H., et al. (1997) · Biofouling · doi:10.1080/08927019709378323 · Cited by 63 · see citing works
Ma, H., He, J., Liu, X., et al. (2010) · ACS Applied Materials & Interfaces · doi:10.1021/am1006832 · Cited by 58 · see citing works
Gao, X. Y., Feng, W., Zhu, S., et al. (2008) · Langmuir · doi:10.1021/la800729c · Cited by 55 · see citing works
Park, D., Finlay, J. A., Ward, R. J., Weinman, C. J., Krishnan, S., Paik, M. Y., Sohn, K. E., Callow, M. E., Callow, J. A., Handlin, D. L., et al. (2010) · ACS Applied Materials & Interfaces · doi:10.1021/am900748v · Cited by 54 · see citing works
Berglin, M., Larsson, A. I., Jonsson, P. R., et al. (2001) · Journal of Adhesion Science and Technology · doi:10.1163/156856101753213321 · Cited by 52 · see citing works
Diamanti, S. J., Arifuzzaman, S., Genzer, J., et al. (2009) · ACS Nano · doi:10.1021/nn800822c · Cited by 51 · see citing works
Surface initiated ATRP of acrylic acid on dopamine‐functionalized AAO membranes
Wang, W., Wang, J., Liao, Y., et al. (2010) · Journal of Applied Polymer Science · doi:10.1002/app.30939 · Cited by 48 · see citing works
Xu, F., Liu, L. Y., Yang, W., et al. (2009) · Biomacromolecules · doi:10.1021/bm900307c · Cited by 44 · see citing works
Self-citationLiu, X., Song, L. Y., Li, L., et al. (2006) · Journal of Applied Polymer Science · doi:10.1002/app.25421 · Cited by 43 · see citing works
Collagen-Coupled Poly(2-hydroxyethyl methacrylate)–Si(111) Hybrid Surfaces for Cell Immobilization
Xu, F., Zhong, S. P., Yung, L. Y. L., et al. (2005) · Tissue Engineering · doi:10.1089/ten.2005.11.1736 · Cited by 43 · see citing works
Grafted Glycopolymer-Based Receptor Mimics on Polymer Support for Selective Adhesion of Bacteria
Yang, Q., Strathmann, M., Rumpf, A., Schaule, G., & Ulbricht, M. (2010) · ACS Applied Materials & Interfaces · doi:10.1021/am1007276 · Cited by 38 · see citing works
Polymer Brush Guided Formation of Thin Gold and Palladium/Gold Bimetallic Films
Paripovic, D., & Klok, H. (2011) · ACS Applied Materials & Interfaces · doi:10.1021/am101270f · Cited by 30 · see citing works
Arifuzzaman, S., Özçam, A. E., Efimenko, K., et al. (2009) · Biointerphases · doi:10.1116/1.3114502 · Cited by 30 · see citing works
Cristescu, R., Mihailescu, I. N., Stamatin, I., et al. (2008) · Applied Surface Science · doi:10.1016/j.apsusc.2008.11.012 · Cited by 22 · see citing works
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Yu, Q., Wu, Z., & Chen, H. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.01.018 · Cited by 411 · see citing works
Wo, Y., Brisbois, E. J., Bartlett, R. H., & Meyerhoff, M. E. (2016) · Biomaterials Science · doi:10.1039/c6bm00271d · Cited by 251 · see citing works
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- Authors
- Yang, W. J., Cai, T., Neoh, K.-G., Kang, E.-T., Dickinson, G. H., Teo, S. L.-M., & Rittschof, D.
- Affiliations
- National University of Singapore (SG)
- Duke University (US)
- Corresponding author
- Kang, En-Tang
- Teo, Serena Lay-Ming
- Rittschof, Daniel
- ORCID
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-05-13
- Volume
- 27
- Issue
- 11
- Pages
- 7065-7076
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W2084275504
- Cited by
- 202
- References
- 64
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 8 · 2021: 13 · 2020: 10 · 2019: 19 · 2018: 14 · 2017: 18 · 2016: 25 · 2015: 24 · 2014: 18 · 2013: 18 · 2012: 14
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Langmuir (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Engineering › Ocean Engineering › Marine Biology and Environmental Chemistry
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Keywords
- barnacle cement, stainless steel, antifouling surfaces, antibacterial surfaces, polymer brushes, surface-initiated ATRP, 2-hydroxyethyl methacrylate, chitosan, bovine serum albumin adsorption, bacterial adhesion, Escherichia coli, dopamine, surface functionalization
- MeSH terms
- Adsorption, Animals, Anti-Bacterial Agents, Bacterial Adhesion, Thoracica, Cattle, Dopamine, Escherichia coli, Polyhydroxyethyl Methacrylate, Serum Albumin, Bovine, Stainless Steel, Surface Properties, Biomimetic Materials, Chitosan, Biofouling, Polymerization
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