The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Composite Block Copolymer Stabilized Nanoparticles: Simultaneous Encapsulation of Organic Actives and Inorganic Nanostructures
Abstract
We describe the preparation and characterization of hybrid block copolymer nanoparticles (NPs) for use as multimodal carriers for drugs and imaging agents. Stable, water-soluble, biocompatible poly(ethylene glycol)-block-poly(epsilon-caprolactone) NPs simultaneously co-encapsulating hydrophobic organic actives (beta-carotene) and inorganic imaging nanostructures (Au) are prepared using the flash nanoprecipitation process in a multi-inlet vortex mixer. These composite nanoparticles (CNPs) are produced with tunable sizes between 75 nm and 275 nm, narrow particle size distributions, high encapsulation efficiencies, specified component compositions, and long-term stability. The process is tunable and flexible because it relies on the control of mixing and aggregation timescales. It is anticipated that the technique can be applied to a variety of hydrophobic active compounds, fluorescent dyes, and inorganic nanostructures, yielding CNPs for combined therapy and multimodal imaging applications.
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Cites
Biodegradable polymeric nanoparticles as drug delivery devices
Soppimath, K. S., Aminabhavi, T. M., Kulkarni, A. R., & Rudzinski, W. E. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00339-4 · Cited by 3,549
Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems
Nasongkla, N., Bey, E., Ren, J., Ai, H., Khemtong, C., Guthi, J. S., Chin, S.-F., Sherry, A. D., Boothman, D. A., & Gao, J. (2006) · Nano Letters · doi:10.1021/nl061412u · Cited by 1,238
Amphiphilic block copolymers for drug delivery
Adams, M. L., Lavasanifar, A., & Kwon, G. S. (2003) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10397 · Cited by 1,078
Cited by
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
Kamaly, N., Xiao, Z., Valencia, P. M., Radovic-Moreno, A. F., & Farokhzad, O. C. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15344k · Cited by 1,730
Pansare, V. J., Hejazi, S., Faenza, W. J., & Prud’homme, R. K. (2012) · Chemistry of Materials · doi:10.1021/cm2028367 · Cited by 706
Self-citationTyrrell, Z. L., Shen, Y., & Radosz, M. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.06.003 · Cited by 481
Production methods for nanodrug particles using the bottom-up approach
Chan, H.-K., & Kwok, P. C. L. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.03.011 · Cited by 451
Thorat, A. A., & Dalvi, S. V. (2012) · Chemical Engineering Journal · doi:10.1016/j.cej.2011.12.044 · Cited by 438
Metadata
- Authors
- Gindy, M. E., Panagiotopoulos, A. Z., & Prud'homme, R. K.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-11-29
- Volume
- 24
- Issue
- 1
- Pages
- 83-90
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W2033820053
- Cited by
- 178
- References
- 3
- FWCI
- 5.62
- Type
- journal article
- Language
- en
- Open access
- closed
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