The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Redox-Sensitive Disassembly of Amphiphilic Copolymer Based Micelles
Open accessAbstract
Amphiphilic polymers of different hydrophilic-lipophilic ratios were prepared by free radical polymerization using two monomers consisting of triethylene glycol as the hydrophilic part and an alkyl chain connected by disulfide bond as the hydrophobic part. These polymers form micelle-like nanoassemblies in aqueous media and can encapsulate hydrophobic drug molecules up to 14% of their mass. In a reducing environment, these polymeric micelles disassemble and dissolve in water, since the amphiphilic polymers are converted into hydrophilic polymers upon cleavage of the disulfide bond. This disassembly event results in the release of hydrophobic molecules that had been encapsulated inside the micelle, the rate of which was found to be dependent on the concentration of the reducing agent, glutathione (GSH). In vitro experiments also show that the GSH-dependent release of the doxorubicin can be used to effect cytotoxicity in MCF-7 cells.
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Cites
Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233
Block copolymer micelles: preparation, characterization and application in drug delivery
Gaucher, G., Dufresne, M.-H., Sant, V. P., Kang, N., Maysinger, D., & Leroux, J.-C. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.09.034 · Cited by 1,498
Pluronic® block copolymers as novel polymer therapeutics for drug and gene delivery
Kabanov, A. V., Batrakova, E. V., & Alakhov, V. Y. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00009-3 · Cited by 1,474
Micelles based on AB block copolymers of poly (ethylene oxide) and poly (beta.-benzyl L-aspartate)
Kwon, G., Naito, M., Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K. (1993) · Langmuir · doi:10.1021/la00028a012 · Cited by 399
Cited by
Cheng, R., Feng, F., Meng, F., Deng, C., Feijen, J., & Zhong, Z. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.01.030 · Cited by 1,360
Fleige, E., Quadir, M. A., & Haag, R. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.01.020 · Cited by 1,111
CO2‐Responsive Polymeric Vesicles that Breathe
Yan, Q., Zhou, R., Fu, C., Zhang, H., Yin, Y., & Yuan, J. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201100708 · Cited by 310
Noncovalent Encapsulation Stabilities in Supramolecular Nanoassemblies
Jiwpanich, S., Ryu, J.-H., Bickerton, S., & Thayumanavan, S. (2010) · Journal of the American Chemical Society · doi:10.1021/ja105059g · Cited by 183
Self-citationMaiti, C., Parida, S., Kayal, S., Maiti, S., Mandal, M., & Dhara, D. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b18245 · Cited by 75
Metadata
- Authors
- Ryu, J.-H., Roy, R., Ventura, J., & Thayumanavan, S.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-01-14
- Volume
- 26
- Issue
- 10
- Pages
- 7086-7092
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W2013784950
- Cited by
- 186
- References
- 4
- FWCI
- 8.06
- Type
- journal article
- Language
- en
- Open access
- green
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