Noncovalent Encapsulation Stabilities in Supramolecular Nanoassemblies
Open accessAbstract
Exchange dynamics of lipophilic guest molecules, encapsulated in supramolecular nanoassemblies in aqueous solutions, have implications in evaluating the stability of drug delivery vehicles. This is because exchange dynamics is related to the propensity of a nanocarrier to be leaky. We describe a fluorescence resonance energy transfer (FRET) based method to evaluate guest exchange dynamics in the aqueous phase. We have utilized this method to analyze the stability of encapsulation in polymeric nanogels and other related amphiphilic nanoassemblies.
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FRET measurements are affected by low signal-to-noise ratio (SNR), resulting in difficulties to distinguish small differences in FRET efficiencies.
“FRET measurements are affected by low signal-to-noise ratio (SNR) resulting in difficulties to distinguish small differences in FRET efficiencies [231].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [231]
The passages describing the FRET method and measured FRET ratios (section labeled Abstract; page unavailable) do not discuss signal-to-noise ratio or difficulty distinguishing small differences in FRET efficiency. Searches for those terms and measurement limitations found no passage addressing the claim. (LLM, conf=0.72)
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Self-citation
- Authors
- Jiwpanich, S., Ryu, J.-H., Bickerton, S., & Thayumanavan, S.
- Affiliations
- University of Massachusetts Amherst (US)
- Corresponding author
- Thayumanavan, S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-07-20
- Volume
- 132
- Issue
- 31
- Pages
- 10683-10685
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- PMC
- PMC2923926
- OpenAlex
- W2061936146
- Cited by
- 183
- References
- 15
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 8 · 2023: 4 · 2022: 13 · 2021: 12 · 2020: 11 · 2019: 11 · 2018: 15 · 2017: 11 · 2016: 14 · 2015: 20 · 2014: 15 · 2013: 14 · 2012: 17
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Chemical Society (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM065255)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Supramolecular Chemistry and Complexes
- Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Keywords
- supramolecular nanoassemblies, encapsulation stability, drug carriers, fluorescence resonance energy transfer, polymer nanogels, aqueous solutions
- MeSH terms
- Drug Carriers, Gels, Solubility, Thermodynamics, Drug Delivery Systems, Fluorescence Resonance Energy Transfer, Macromolecular Substances, Nanostructures
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