Redox-Responsive Core-Cross-Linked Block Copolymer Micelles for Overcoming Multidrug Resistance in Cancer Cells
Abstract
Success of chemotherapy as a treatment for cancer has been often inhibited by multidrug resistance (MDR) of the cancer cells. There is a clear need to generate strategies to overcome this resistance. In this work, we have developed redox-responsive and core-cross-linked micellar nanocarriers using poly(ethylene glycol)- block -poly(2-(methacryloyloxy)ethyl 5-(1,2-dithiolan-3-yl)pentanoate) diblock copolymers (PEG- b -PLAHEMA) with tunable swelling properties for the delivery of drugs toward drug-sensitive MDA-MB-231 and drug-resistant MDA-MB-231 (231R) cancer cells. PEG- b -PLAHEMA containing varying number of 2-(methacryloyloxy)ethyl 5-(1,2-dithiolan-3-yl)pentanoate (LAHEMA) units were synthesized by employing the reversible addition-fragmentation chain transfer polymerization technique. The block copolymer self-assembly, cross-linking induced by reduction, and de-cross-linking triggered time-dependent controlled swelling of micelles were studied using dynamic light scattering, fluorescence spectroscopy, and transmission electron microscopy. In vitro cytotoxicity, cellular uptake efficiency, and glutathione-responsive anticancer activity of doxorubicin (DOX) encapsulated in core-cross-linked block copolymer micelles (CCMs) toward both drug-sensitive and drug-resistant cancer cell lines were evaluated. Significant reduction in IC 50 was observed by DOX-loaded CCMs toward drug-resistant 231R cancer cell lines, which was further improved by coencapsulating DOX and verapamil (a P-glycoprotein inhibitor) in CCMs. Thus, these reduction-sensitive biocompatible CCMs with tunable swelling property are very promising in overcoming MDR in cancer cells.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Non-coding microRNAs post-transcriptionally regulate mRNA expression by targeting the 3ʹ-UTR region and play a significant role in cellular functions such as differentiation, proliferation and apoptosis.
“Non-coding microRNAs (miRNAs) can post-transcriptionally regulate the mRNA expression by targeting the 3ʹ-UTR region, and thus play a significant role in various cellular functions such as differentiation, proliferation and apoptosis.15,16”
Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710 · see citing works
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565 · see citing works
Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233 · see citing works
Strategies in the design of nanoparticles for therapeutic applications
Petros, R. A., & DeSimone, J. M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd2591 · Cited by 3,651 · see citing works
Polymersomes: Tough Vesicles Made from Diblock Copolymers
Discher, B. M., Won, Y., Ege, D. S., Lee, J. C., Bates, F. S., Discher, D. E., & Hammer, D. A. (1999) · Science · doi:10.1126/science.284.5417.1143 · Cited by 2,513 · see citing works
Functional Polymers from Novel Carboxyl-Terminated Trithiocarbonates as Highly Efficient RAFT Agents
Lai, J. T., Filla, D., & Shea, R. (2002) · Macromolecules · doi:10.1021/ma020362m · Cited by 1,487 · see citing works
Saito, G., Swanson, J. A., & Lee, K.-D. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00179-5 · Cited by 1,407 · see citing works
Cheng, R., Feng, F., Meng, F., Deng, C., Feijén, J., & Zhong, Z. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.01.030 · Cited by 1,367 · see citing works
Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery
Cheng, R., Meng, F., Deng, C., Klok, H., & Zhong, Z. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.084 · Cited by 1,356 · see citing works
Microtubules and resistance to tubulin-binding agents
Kavallaris, M. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2803 · Cited by 1,134 · see citing works
Reduction-sensitive polymers and bioconjugates for biomedical applications
Meng, F., Hennink, W. E., & Zhong, Z. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.026 · Cited by 1,132 · see citing works
Stimuli-Responsive Polymersomes for Programmed Drug Delivery
Meng, F., Zhong, Z., & Feijén, J. (2009) · Biomacromolecules · doi:10.1021/bm801127d · Cited by 1,122 · see citing works
ABC transporters in cancer: more than just drug efflux pumps
Fletcher, J. I., Haber, M., Henderson, M. J., & Norris, M. D. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2789 · Cited by 1,022 · see citing works
Cross-linked block copolymer micelles: functional nanostructures of great potential and versatility
O’Reilly, R. K., Hawker, C. J., & Wooley, K. L. (2006) · Chemical Society Reviews · doi:10.1039/b514858h · Cited by 939 · see citing works
Enzyme-responsive polymeric assemblies, nanoparticles and hydrogels
Hu, J., Zhang, G., & Liu, S. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35103j · Cited by 725 · see citing works
Long circulating microparticulate drug carriers
Stolnik, S., Illum, L., & Davis, S. S. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00025-3 · Cited by 702 · see citing works
pH-Sensitive Vesicles Based on a Biocompatible Zwitterionic Diblock Copolymer
Du, J., Tang, Y., Lewis, A. L., & Armes, S. P. (2005) · Journal of the American Chemical Society · doi:10.1021/ja056514l · Cited by 603 · see citing works
Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice.
Nishiyama, N., Okazaki, S., Cabral, H., Miyamoto, M., Kato, Y., Sugiyama, Y., Nishio, K., Matsumura, Y., & Kataoka, K. (2003) · PubMed · Cited by 602 · see citing works
ABC Efflux Pump-Based Resistance to Chemotherapy Drugs
Eckford, P. D. W., & Sharom, F. J. (2009) · Chemical Reviews · doi:10.1021/cr9000226 · Cited by 602 · see citing works
Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds
Palmeira, A., Sousa, E., Vasconcelos, M. H., & Pinto, M. M. M. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712800167392 · Cited by 492 · see citing works
Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery
Li, Y., Maciel, D., Rodrigues, J., Shi, X., & Tomás, H. (2015) · Chemical Reviews · doi:10.1021/cr500131f · Cited by 480 · see citing works
Design and development of polymeric micelles with cleavable links for intracellular drug delivery
Wei, H., Zhuo, R., & Zhang, X. (2012) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2012.07.002 · Cited by 475 · see citing works
Li, Y., Zhu, L., Liu, Z., Cheng, R., Meng, F., Cui, J., Ji, S., & Zhong, Z. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200904260 · Cited by 451 · see citing works
New Generation of Multifunctional Nanoparticles for Cancer Imaging and Therapy
Park, K., Lee, S., Kang, E., Kim, K., Choi, K., & Kwon, I. C. (2009) · Advanced Functional Materials · doi:10.1002/adfm.200801655 · Cited by 430 · see citing works
Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients.
Ozols, R. F., Cunnion, R. E., Klecker, R. W., Hamilton, T. C., Ostchega, Y., Parrillo, J. E., & Young, R. C. (1987) · Journal of Clinical Oncology · doi:10.1200/jco.1987.5.4.641 · Cited by 426 · see citing works
van Dongen, S. F. M., de Hoog, H. M., Peters, R. J. R. W., Nallani, M., Nolte, R. J. M., & van Hest, J. C. M. (2009) · Chemical Reviews · doi:10.1021/cr900072y · Cited by 385 · see citing works
Russo, A., DeGraff, W., Friedman, N., & Mitchell, J. B. (1986) · PubMed · Cited by 384 · see citing works
Wong, H. L., Bendayan, R., Rauth, A. M., Xue, H. Y., Babakhanian, K., & Wu, X. Y. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.101154 · Cited by 344 · see citing works
Polyester-based micelles and nanoparticles for the parenteral delivery of taxanes
Gaucher, G., MARCHESSAULT, R. H., & Leroux, J. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.11.012 · Cited by 315 · see citing works
Bao, L., Hazari, S., Mehra, S., Kaushal, D., Moroz, K., & Dash, S. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.02.024 · Cited by 275 · see citing works
MAKING AND BREAKING DISULFIDE BONDS
Raina, S., & Missiakas, D. M. (1997) · Annual Review of Microbiology · doi:10.1146/annurev.micro.51.1.179 · Cited by 263 · see citing works
Wei, R., Cheng, L., Zheng, M., Cheng, R., Meng, F., Deng, C., & Zhong, Z. (2012) · Biomacromolecules · doi:10.1021/bm3006819 · Cited by 189 · see citing works
Redox-Sensitive Disassembly of Amphiphilic Copolymer Based Micelles
Ryu, J., Roy, R., Ventura, J., & Thayumanavan, S. (2010) · Langmuir · doi:10.1021/la904437u · Cited by 186 · see citing works
Thermally induced micelle to vesicle morphology transition for a charged chain end diblock copolymer
Moughton, A. O., & O’Reilly, R. K. (2009) · Chemical Communications · doi:10.1039/b922289h · Cited by 169 · see citing works
Zhan, Y., Gonçalves, M., Yi, P., Capelo, D., Zhang, Y., Rodrigues, J., Liu, C., Tomás, H., Li, Y., & He, P. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb00468c · Cited by 140 · see citing works
Chen, C., Liu, G., Liu, X., Pang, S., Zhu, C., Lv, L., & Ji, J. (2011) · Polymer Chemistry · doi:10.1039/c1py00094b · Cited by 118 · see citing works
Polymeric Nanofibers as Novel Carriers for the Delivery of Therapeutic Molecules
Kumbar, S. G., Nair, L. S., Bhattacharyya, S., & Laurencin, C. T. (2006) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2006.462 · Cited by 111 · see citing works
Wang, T., Chai, F., Fu, Q., Zhang, L., Liu, H., Li, L., Liao, Y., Su, Z., Wang, C., Duan, B., et al. (2011) · Journal of Materials Chemistry · doi:10.1039/c0jm04115g · Cited by 107 · see citing works
Biocompatible and biodegradable polymersomes as delivery vehicles in biomedical applications
Liu, G., Chen, C., & Ji, J. (2012) · Soft Matter · doi:10.1039/c2sm25721a · Cited by 106 · see citing works
Xu, Y., Meng, F., Cheng, R., & Zhong, Z. (2009) · Macromolecular Bioscience · doi:10.1002/mabi.200900233 · Cited by 102 · see citing works
Biocompatible CdSe−ZnS Core−Shell Quantum Dots Coated with Hydrophilic Polythiols
Yıldız, İ., McCaughan, B., Cruickshank, S. F., Callan, J. F., & Raymo, F. M. (2009) · Langmuir · doi:10.1021/la900148m · Cited by 101 · see citing works
Lipoic acid-derived amphiphiles for redox-controlled DNA delivery
Balakirev, M. Y., Schoehn, G., & Chroboczek, J. (2000) · Chemistry & Biology · doi:10.1016/s1074-5521(00)00030-2 · Cited by 91 · see citing works
Guo, Y., He, W., Yang, S., Zhao, D., Li, Z., & Luan, Y. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.12.012 · Cited by 87 · see citing works
Lee, Y., Koo, H., Jin, G., Mo, H., Cho, M. Y., Park, J.-Y., Choi, J. S., & Park, J. S. (2004) · Biomacromolecules · doi:10.1021/bm049658l · Cited by 85 · see citing works
Sun, J., Chen, X., Lu, T., Liu, S., Tian, H., Guo, Z., & Jing, X. (2008) · Langmuir · doi:10.1021/la8013877 · Cited by 82 · see citing works
Disulfide Cross-Linked Phosphorylcholine Micelles for Triggered Release of Camptothecin
McRae, S., Martorella, M., Parelkar, S. S., Kosif, I., & Emrick, T. S. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400114n · Cited by 77 · see citing works
Cao, X., Luo, J.-W., Gong, T., Zhang, Z.-R., Sun, X., & Fu, Y. (2015) · Molecular Pharmaceutics · doi:10.1021/mp500637b · Cited by 72 · see citing works
Luo, Z., Li, Y., Wang, B., & Jiang, J. (2016) · Macromolecules · doi:10.1021/acs.macromol.6b01211 · Cited by 68 · see citing works
Stefely, J., Markowitz, M. A., & Regen, S. L. (1988) · Journal of the American Chemical Society · doi:10.1021/ja00230a030 · Cited by 62 · see citing works
Controlled Delivery Systems: From Pharmaceuticals to Cells and Genes
Balmayor, E. R., Azevedo, H. S., & Reis, R. L. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0392-y · Cited by 60 · see citing works
Younes, M. N., Yigitbasi, O. G., Park, Y. W., Kim, S.-J., Jasser, S. A., Hawthorne, V. S., Yazici, Y. D., Mandal, M., Bekele, B. N., Bucana, C. D., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4196 · Cited by 55 · see citing works
Self-citationMaiti, C., Banerjee, R., Maiti, S., & Dhara, D. (2014) · Langmuir · doi:10.1021/la504165e · Cited by 49 · see citing works
Self-citationFolic Acid-Targeted Mesoporous Silica Nanoparticles for Two-Photon Fluorescence
Lebret, V., Raehm, L., Durand, J., Smaïhi, M., Werts, M. H. V., Blanchard-Desce, M. H., Methy‐Gonnot, D., & Dubernet, C. (2010) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2010.1112 · Cited by 47 · see citing works
“Bitter-Sweet” Polymeric Micelles Formed by Block Copolymers from Glucosamine and Cholic Acid
Zhang, K., Jia, Y., Tsai, I.-H., Strandman, S., Ren, L., Hong, L., Zhang, G., Guan, Y., Zhang, Y., & Zhu, X. X. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.6b01640 · Cited by 44 · see citing works
Li, N., Zhang, P., Huang, C., Song, Y., Garg, S., & Luan, Y. (2015) · RSC Advances · doi:10.1039/c5ra15313a · Cited by 41 · see citing works
Laskar, P., Saha, B., Ghosh, S. K., & Dey, J. (2015) · RSC Advances · doi:10.1039/c4ra11479e · Cited by 39 · see citing works
Zhao, X., Qi, M.-Z., Shuo, L., Tian, K., Zhou, T., Jia, X., Li, J., & Liu, P. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b08935 · Cited by 39 · see citing works
Functional Group-Dependent Self-Assembled Nanostructures from Thermo-Responsive Triblock Copolymers
Banerjee, R., & Dhara, D. (2014) · Langmuir · doi:10.1021/la500213h · Cited by 26 · see citing works
Self-citationBanerjee, R., Parida, S., Maiti, C., Mandal, M., & Dhara, D. (2015) · RSC Advances · doi:10.1039/c5ra17158j · Cited by 21 · see citing works
Self-citationSelf-Assembled PAEEP–PLLA Micelles with Varied Hydrophilic Block Lengths for Tumor Cell Targeting
Liu, X., Tan, X., Rao, R., Ren, Y., Li, Y., Yang, X., & Liu, W. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b06346 · Cited by 20 · see citing works
Maiti, C., Dey, D., Mandal, S., & Dhara, D. (2014) · The Journal of Physical Chemistry B · doi:10.1021/jp412273h · Cited by 19 · see citing works
Self-citationChan, D. C., Yu, A. C., & Appel, E. A. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b00249 · Cited by 18 · see citing works
Polymeric nanostructures with pH-labile core for controlled drug release
Banerjee, R., Maiti, S., Dey, D., & Dhara, D. (2015) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2015.09.068 · Cited by 14 · see citing works
Self-citationWater-soluble polymeric chemosensor for detection of Cu2+ions with high selectivity and sensitivity
Maiti, C., Banerjee, R., Maiti, S., & Dhara, D. (2016) · Designed Monomers & Polymers · doi:10.1080/15685551.2016.1199111 · Cited by 14 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis
Das, S. S., Bharadwaj, P., Bilal, M., Barani, M., Rahdar, A., Taboada, P., BUNGAU, S. G., & Kyzas, G. Z. (2020) · Polymers · doi:10.3390/polym12061397 · Cited by 607 · see citing works
Cancer multidrug-resistance reversal by ABCB1 inhibition: A recent update
Engle, K., & Kumar, G. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114542 · Cited by 209 · see citing works
Smart materials for drug delivery and cancer therapy
Yang, Y., Zeng, W., Huang, P., Zeng, X., & Mei, L. (2020) · Open Research (University of Surrey) · doi:10.1002/viw.20200042 · Cited by 194 · see citing works
Redox-responsive nano-carriers as tumor-targeted drug delivery systems
Raza, A., Hayat, U., Rasheed, T., Bilal, M., & Iqbal, H. M. N. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.08.034 · Cited by 187 · see citing works
Alsehli, M. (2020) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2020.01.004 · Cited by 171 · see citing works
Xiao, W., Song, M., Li, W., Huang, J., Yang, G. Y., & Wang, Y. (2021) · Theranostics · doi:10.7150/thno.59342 · Cited by 108 · see citing works
Intelligent polymeric micelles for multidrug co-delivery and cancer therapy
Yu, G., Ning, Q., Mo, Z., & Tang, S. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1601104 · Cited by 86 · see citing works
Onafuye, H., Pieper, S., Mulac, D., Cinatl, J. J., Wass, M. N., Langer, K., & Michaelis, M. (2019) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.10.166 · Cited by 78 · see citing works
Polymeric micelles: A novel drug delivery system for the treatment of breast cancer
Chaudhuri, A., Ramesh, K., Kumar, D. N., Dehari, D., Singh, S. K., Kumar, D. K., & Agrawal, A. K. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103886 · Cited by 76 · see citing works
Li, Z., Wang, F., Li, Y., Wang, X., Qiao, L., Wang, D., Qi, C., Li, C., Li, Z., Lian, B., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121003 · Cited by 64 · see citing works
Strategies To Design and Synthesize Polymer‐Based Stimuli‐Responsive Drug‐Delivery Nanosystems
Qin, X., & Li, Y. (2019) · ChemBioChem · doi:10.1002/cbic.201900550 · Cited by 63 · see citing works
Li, Y., Chen, M., Yao, B., Lu, X., Zhang, X., He, P., Vasilatos, S. N., Ren, X., Bian, W., & Yao, C. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb00651f · Cited by 61 · see citing works
Multifunctional Polymeric Nanogels for Biomedical Applications
Kaewruethai, T., Laomeephol, C., Pan, Y., & Luckanagul, J. A. (2021) · Gels · doi:10.3390/gels7040228 · Cited by 59 · see citing works
Fabrication of redox-responsive Bi(mPEG-PLGA)-Se2 micelles for doxorubicin delivery
Birhan, Y. S., Hailemeskel, B. Z., Mekonnen, T. W., Hanurry, E. Y., Darge, H. F., Andrgie, A. T., Chou, H., Lai, J., Hsiue, G., & Tsai, H. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118486 · Cited by 49 · see citing works
Li, Y., & Xu, X. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.05.007 · Cited by 48 · see citing works
Nanomedicines for combating multidrug resistance of cancer
Zhu, Y., Jia, H., Duan, Q., & Wu, F. (2021) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1715 · Cited by 46 · see citing works
He, X., Cai, K., Zhang, Y. X., Lü, Y., Guo, Q., Zhang, Y., Liu, L., Ruan, C., Chen, Q., Chen, X., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b09730 · Cited by 45 · see citing works
Zheng, T., Wang, W., Ashley, J. A., Zhang, M., Feng, X., Shen, J., & Sun, Y. (2020) · Nano-Micro Letters · doi:10.1007/s40820-020-00490-6 · Cited by 45 · see citing works
Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity
Pieper, S., Onafuye, H., Mulac, D., Cinatl, J. J., Wass, M. N., Michaelis, M., & Langer, K. (2019) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.10.201 · Cited by 44 · see citing works
Zou, T., Lü, W., Mezhuev, Y. O., Lan, M., Li, L., Liu, F., Cai, T., Wu, X. Y., & Cai, Y. (2021) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2021.05.029 · Cited by 43 · see citing works
Liang, X., Wang, Y., Shi, H., Dong, M., Han, H., & Li, Q. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s304526 · Cited by 41 · see citing works
Fraix, A., Conte, C., Gazzano, E., Riganti, C., Quaglia, F., & Sortino, S. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00290 · Cited by 40 · see citing works
Sniping Cancer Stem Cells with Nanomaterials
Wang, W.-D., Guo, Y., Yang, Z., Su, G.-L., & Sun, Z. (2023) · ACS Nano · doi:10.1021/acsnano.3c07828 · Cited by 38 · see citing works
Sui, J., He, M., Yang, Y., Ma, M., Guo, Z., Zhao, M., Liang, J., Sun, Y., Fan, Y., & Zhang, X. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c13986 · Cited by 39 · see citing works
Zhang, Y., Chang, J., Huang, F., Yang, L., Ren, C., Ma, L., Zhang, W., Dong, H. F., Liu, J., & Liu, J. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b01623 · Cited by 37 · see citing works
Two-photon AIE luminogen labeled multifunctional polymeric micelles for theranostics
Zhuang, W., Ma, B., Hu, J. X., Jiang, J., Li, G., Li, Y., & Wang, Y. (2019) · Theranostics · doi:10.7150/thno.33901 · Cited by 35 · see citing works
Samanta, P., Kapat, K., Maiti, S., Biswas, G., Dhara, S., & Dhara, D. (2019) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2019.07.069 · Cited by 34 · see citing works
Self-citationWang, F., Yuan, Z., McMullen, P., Li, R., Zheng, J., Xu, Y., Xu, M., He, Q., Li, B., & Chen, H. (2019) · Chemistry of Materials · doi:10.1021/acs.chemmater.9b00150 · Cited by 31 · see citing works
Micelle-engineered nanoplatforms for precision oncology
Gao, W., Bigham, A., Ghomi, M., Zarrabi, A., Rabiee, N., Saeb, M. R., Ertaş, Y. N., Goel, A., Sharifi, E., Ashrafizadeh, M., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.153438 · Cited by 30 · see citing works
Huang, Y., Yan, J., Peng, S., Tang, Z., Tan, C., Ling, J., Lin, W., Lin, X., Zu, X., & Yi, G. (2020) · Polymers · doi:10.3390/polym12010082 · Cited by 30 · see citing works
Birhan, Y. S., Darge, H. F., Hanurry, E. Y., Andrgie, A. T., Mekonnen, T. W., Chou, H., Lai, J., & Tsai, H. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12060580 · Cited by 30 · see citing works
Lin, W., Xue, Z., Wen, L., Li, Y., Liang, Z., Xu, J., Yang, C., Gu, Y., Zhang, J., Zu, X., et al. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.06.043 · Cited by 26 · see citing works
Tumor Microenvironment Stimuli-Responsive Polymeric Prodrug Micelles for Improved Cancer Therapy
Zhang, Z., Yu, M., An, T., Yang, J., Zou, M., Zhai, Y., Sun, W., & Cheng, G. (2019) · Pharmaceutical Research · doi:10.1007/s11095-019-2709-1 · Cited by 26 · see citing works
Stimuli-Responsive Polymeric Systems for Smart Drug Delivery
Bedoya, D. A., Figueroa, F. N., Macchione, M. A., & Strumia, M. C. (2020) · Advances in material research and technology · doi:10.1007/978-3-030-46923-8_5 · Cited by 24 · see citing works
Polysaccharide-based nanogels for drug and gene delivery
Kumari, L., & Badwaik, H. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102553-6.00018-0 · Cited by 23 · see citing works
Recent Progress of Novel Nanotechnology Challenging the Multidrug Resistance of Cancer
Zhang, C., Zhou, X., Zhang, H., Han, X., Li, B., Yang, R., & Zhou, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.776895 · Cited by 23 · see citing works
Influence of Polymer Structure and Architecture on Drug Loading and Redox-Triggered Release
Wu, P., Gao, J., Prasad, P., Dutta, K., Kanjilal, P., & Thayumanavan, S. (2021) · Biomacromolecules · doi:10.1021/acs.biomac.1c01295 · Cited by 22 · see citing works
Wang, X., Ren, J., Haiqing, H., Liang, L., Xie, X., Li, Z.-X., Zhao, J., & Yu, J. (2019) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2019.1599914 · Cited by 22 · see citing works
Gebrie, H. T., Addisu, K. D., Darge, H. F., Birhan, Y. S., Thankachan, D., Tsai, H., & Wu, S. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213015 · Cited by 21 · see citing works
Liu, Y., Wen, N., Li, K., Li, M., Qian, S., Li, S., Jiang, T., Wang, T., Wu, Y., & Liu, Z. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.1c00720 · Cited by 20 · see citing works
Jimaja, S., Varlas, S., Foster, J. C., Taton, D., Dove, A. P., & O’Reilly, R. K. (2022) · Polymer Chemistry · doi:10.1039/d2py00397j · Cited by 20 · see citing works
Polymer based Gels: Recent and Future Applications in Drug Delivery Field
Siafaka, P. I., Gündoğdu, E., Çağlar, E. Ş., Özgenç, E., González‐Álvarez, M., González‐Álvarez, I., & Okur, N. Ü. (2022) · Current Drug Delivery · doi:10.2174/1567201819666220907124040 · Cited by 20 · see citing works
Pal, J., Kola, P., Samanta, P., Mandal, M., & Dhara, D. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.4c00572 · Cited by 20 · see citing works
Self-citationKayal, S., Kola, P., Pal, J., Mandal, M., & Dhara, D. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c00878 · Cited by 20 · see citing works
Self-citationPoddar, P., Maity, P. P., Maiti, S., Sahoo, S., Dhara, S., & Dhara, D. (2020) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2020.104679 · Cited by 19 · see citing works
Self-citationRedox-Responsive Nanogels for Precision Protein Delivery
Dabas, R., & Kamaly, N. (2024) · European Polymer Journal · doi:10.1016/j.eurpolymj.2024.113183 · Cited by 19 · see citing works
Li, Q., Hou, W., Li, M., Ye, H., Li, H., & Wang, Z. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s251277 · Cited by 18 · see citing works
Ma, Y., Zhou, H.-Y., Hu, F., Pei, Z., Xu, Y., & Shuai, Q. (2018) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2018.1518910 · Cited by 17 · see citing works
Dual-responsive TPGS crosslinked nanocarriers to overcome multidrug resistance
Li, L., Liu, T., Liao, J.-X., Zhang, Z.-Y., Song, D., & Wang, G.-H. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01140a · Cited by 17 · see citing works
Smart polymeric nanostructures for targeted delivery of therapeutics
Dhara, M. (2020) · Journal of Macromolecular Science Part A · doi:10.1080/10601325.2020.1842766 · Cited by 16 · see citing works
Biswas, G., Jena, B. C., Sahoo, S., Samanta, P., Mandal, M., & Dhara, D. (2019) · Green Chemistry · doi:10.1039/c9gc01863h · Cited by 15 · see citing works
Self-citationHe, Y., Li, H., Zheng, X., Yuan, M., Yang, R., Yuan, M., & Yang, C. (2019) · Molecules · doi:10.3390/molecules24102024 · Cited by 14 · see citing works
Rezaei, S., Kashanian, S., Bahrami, Y., Zhaleh, H., & Cruz, L. J. (2020) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201021999200727153513 · Cited by 14 · see citing works
Biswas, G., Jena, B. C., Samanta, P., Mandal, M., & Dhara, D. (2021) · Journal of Macromolecular Science Part A · doi:10.1080/10601325.2021.1947748 · Cited by 14 · see citing works
Self-citationAptamer-functionalized nanomaterials (AFNs) for therapeutic management of hepatocellular carcinoma
Yin, X., Rong, J., Shao, M., Zhang, S., Yin, L., He, Z., & Wang, X. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02486-5 · Cited by 13 · see citing works
l -Histidine Crystals as Efficient Vehicles to Deliver Hydrophobic Molecules
Ravanfar, R., & Abbaspourrad, A. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b14239 · Cited by 12 · see citing works
Kumar, A., Saha, M., Vishwakarma, R., Behera, K., & Trivedi, S. (2024) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2024.125642 · Cited by 13 · see citing works
Dhara, M. (2023) · Journal of Macromolecular Science Part A · doi:10.1080/10601325.2023.2271040 · Cited by 11 · see citing works
Tanaka, R., Arai, K., Matsuno, J., Soejima, M., Lee, J. H., Takahashi, R., Sakurai, K., & Fujii, S. (2020) · Polymer Chemistry · doi:10.1039/d0py00610f · Cited by 10 · see citing works
Patra, D., Kumar, S., Kumar, P., Chakraborty, I., Basheer, B., & Shunmugam, R. (2022) · Biomacromolecules · doi:10.1021/acs.biomac.2c00302 · Cited by 10 · see citing works
Sarkar, P., Ghosh, S., Saha, R., & Sarkar, K. (2021) · RSC Advances · doi:10.1039/d1ra01660a · Cited by 9 · see citing works
Gebrie, H. T., Addisu, K. D., Darge, H. F., Mekonnen, T. W., kottackal, D. T., & Tsai, H. (2021) · Journal of Polymer Research · doi:10.1007/s10965-021-02776-8 · Cited by 9 · see citing works
Efficacy tumor therapeutic applications of stimuli-responsive block copolymer-based nano-assemblies
Zhou, J., Yang, R., Chen, Y., & Chen, D. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28166 · Cited by 7 · see citing works
Construction of pH ‐responsive core crosslinked micelles via thiol‐yne click reaction
Niu, Y., & Lu, Y. (2022) · Journal of Applied Polymer Science · doi:10.1002/app.52753 · Cited by 7 · see citing works
Zhang, S., Yu, J., Jiang, S., Wang, L., Chen, J., Long, J., Gu, S., & Li, H. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114327 · Cited by 8 · see citing works
Nanomedicine-based multidrug resistance reversal strategies in cancer therapy
Paliwal, R., Paliwal, S. R., & Kenwat, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819793-6.00013-8 · Cited by 6 · see citing works
Micellar self-assembly from pH-responsive polymer prodrug for targeted antitumor drug transportation
Kayal, S., Kola, P., Pal, J., Mandal, M., & Dhara, D. (2025) · Journal of Macromolecular Science Part A · doi:10.1080/10601325.2025.2487833 · Cited by 5 · see citing works
Self-citationBlock copolymer micelles as long-circulating drug delivery vehicles
Abuwatfa, W. H., AlSawaftah, N., & Husseini, G. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89868-3.00023-9 · Cited by 5 · see citing works
Wu, J., Qi, C., Xu, T., Zhang, Q., Liu, F., Zhao, H., Dong, J., & Liu, X. (2023) · ACS Applied Nano Materials · doi:10.1021/acsanm.2c04753 · Cited by 5 · see citing works
Polymeric micelles for drug codelivery
Amjad, M. W. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89868-3.00005-7 · Cited by 1 · see citing works
Research Progress of Stimuli-Sensitive Polymer Carriers for Anti-Tumor Drug Delivery
李, 景. (2019) · Journal of Advances in Physical Chemistry · doi:10.12677/japc.2019.84008
Role of Block Co-Polymers in Drug Delivery
Panda, P. K., Raikwar, S., Bidla, P. D., Rathee, S., & Jain, S. (2023) · Springer eBooks · doi:10.1007/978-981-99-6917-3_2
Redox‐Responsive Core Cross‐Linked Micelle as Anticancer Drug Delivery Vehicle
Biswas, G., Pal, J., Jena, B. C., Mandal, M., & Dhara, D. (2025) · Journal of Applied Polymer Science · doi:10.1002/app.58120
Self-citationBindingDB Entry 50019798: Cancer multidrug-resistance reversal by ABCB1 inhibition: A recent update.
BindingDB (2024) · UC San Diego · doi:10.7270/q2zp4bj1
- Authors
- Maiti, C., Parida, S., Kayal, S., Maiti, S., Mandal, M., & Dhara, D.
- Affiliations
- Indian Institute of Technology Kharagpur (IN)
- Corresponding author
- Dhara, Dibakar
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-02-05
- Volume
- 10
- Issue
- 6
- Pages
- 5318-5330
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2785262730
- Cited by
- 75
- References
- 64
- Citations by year
- 2025: 2 · 2024: 9 · 2023: 4 · 2022: 11 · 2021: 10 · 2020: 18 · 2019: 18 · 2018: 3
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ACS Applied Materials & Interfaces (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University Grants Commission
- Department of Science and Technology, Ministry of Science and Technology (EMR/2016/007040)
- Indian Institute of Technology Kharagpur
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Keywords
- multidrug resistance, redox-responsive nanocarriers, glutathione-responsive drug delivery, doxorubicin, verapamil, P-glycoprotein inhibition, MDA-MB-231 cells, chemoresistance, RAFT polymerization
- MeSH terms
- Doxorubicin, Drug Carriers, Humans, Micelles, Oxidation-Reduction, Polyethylene Glycols, Polymers, Drug Resistance, Multiple, Drug Resistance, Neoplasm, Cell Line, Tumor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review