The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Injectable Block Copolymer Hydrogels: Achievements and Future Challenges for Biomedical Applications
Abstract
In the past two decades, physical polymeric hydrogels have been extensively explored for biomedical applications, such as drug delivery and tissue engineering. These hydrogels exhibit a sol–gel phase transition in response to external stimuli, such as pH, temperature, glucose, electric field, magnetic field, ionic strength, or their combination. Hydrogel precursors can be mixed with bioactive molecules or cells and then simply injected into the body at specific sites. Substantial progress has been made in the development of novel hydrogels and applications. In this Perspective, we report recent progress in physically cross-linked hydrogels responding to pH and/or temperature and their pharmaceutical and tissue engineering applications. The outlook for the future, including remaining challenges of injectable hydrogels, is also discussed.
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Cites
Hydrogels for biomedical applications
Hoffman, A. S. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00239-3 · Cited by 4,864
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Supramolecular polymeric hydrogels
Appel, E. A., del Barrio, J., Loh, X. J., & Scherman, O. A. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35264h · Cited by 1,159
Multicomponent peptide assemblies
Raymond, D. M., & Nilsson, B. L. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00115d · Cited by 346
Recent advances in PLGA-based biomaterials for bone tissue regeneration
Jin, S., Xia, X., Huang, J., Yuan, C., Zuo, Y., Li, Y., & Li, J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.067 · Cited by 295
Biocatalytic Feedback‐Driven Temporal Programming of Self‐Regulating Peptide Hydrogels
Heuser, T., Weyandt, E., & Walther, A. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201505013 · Cited by 266
Engineered in-situ depot-forming hydrogels for intratumoral drug delivery
Fakhari, A., & Anand Subramony, J. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.11.014 · Cited by 164
Mussel-inspired hydrogel tissue adhesives for wound closure
Rahimnejad, M., & Zhong, W. (2017) · RSC Adv. · doi:10.1039/c7ra06743g · Cited by 135
Mussel-inspired epoxy bioadhesive with enhanced interfacial interactions for wound repair
Du, D., Chen, X., Shi, C., Zhang, Z., Shi, D., Kaneko, D., Kaneko, T., & Hua, Z. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.09.054 · Cited by 38
Sato, T., Aoyagi, T., Ebara, M., & Auzély-Velty, R. (2017) · Polymer Bulletin · doi:10.1007/s00289-017-1937-y · Cited by 30
Metadata
- Authors
- Huynh, C. T., Nguyen, M. K., & Lee, D. S.
- Venue
- Macromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-08-04
- Volume
- 44
- Issue
- 17
- Pages
- 6629-6636
- ISSN
- 0024-9297 (ISSN-L)
- 1520-5835
- OpenAlex
- W2083276839
- Cited by
- 240
- References
- 1
- FWCI
- 9.73
- Type
- journal article
- Language
- en
- Open access
- closed
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