The DOI matches its Crossref record.
Synthesis and Characterization of Enzymatically-Cross-Linked Poly(ethylene glycol) Hydrogels
Abstract
We demonstrate formation of a hydrogel network by cross-linking functionalized poly(ethylene glycol) (PEG) and a lysine-containing polypeptide through the action of a natural tissue enzyme, transglutaminase. The enzyme reaction rate using a PEG-modified peptide substrate is the same as the reaction rate for free substrate. Both the ratio and total concentration of the two macromers determine whether gelation will occur and the nature of the gel which forms. Under suitable conditions, clear gels form and swell to give a final composition which is 90% water. Diffusion coefficients of small proteins and albumin in the gel are comparable to those in free solution. Gelation proceeds under mild conditions and thus these gels hold potential for forming highly hydrated networks around living cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Lutolf, M. P., & Hubbell, J. A. (2003) · Biomacromolecules · doi:10.1021/bm025744e · Cited by 679
A mini review on hydrogels classification and recent developments in miscellaneous applications
Varaprasad, K., Raghavendra, G. M., Jayaramudu, T., Yallapu, M. M., & Sadiku, R. (2017) · Materials Science and Engineering: C · doi:10.1016/j.msec.2017.05.096 · Cited by 534
In situ cell manipulation through enzymatic hydrogel photopatterning
Mosiewicz, K. A., Kolb, L., van der Vlies, A. J., Martino, M. M., Lienemann, P. S., Hubbell, J. A., Ehrbar, M., & Lutolf, M. P. (2013) · Nature Materials · doi:10.1038/nmat3766 · Cited by 308
Lee, F., Chung, J. E., & Kurisawa, M. (2008) · Soft Matter · doi:10.1039/b719557e · Cited by 300
Hydrogels for Musculoskeletal Tissue Engineering
Varghese, S., & Elisseeff, J. H. (2006) · Advances in Polymer Science · doi:10.1007/12_072 · Cited by 173
Metadata
- Authors
- Sperinde, J. J., & Griffith, L. G.
- Venue
- Macromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 1997-09-01
- Volume
- 30
- Issue
- 18
- Pages
- 5255-5264
- ISSN
- 0024-9297 (ISSN-L)
- 1520-5835
- OpenAlex
- W2040011847
- Cited by
- 212
- References
- 0
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Synthesis and Characterization of Enzymatically-Cross-Linked Poly(ethylene glycol) Hydrogels. https://app.cochat.ai/papers/10.1021/ma970345a
- The paper
- Sperinde, J. J., & Griffith, L. G. (1997). Synthesis and Characterization of Enzymatically-Cross-Linked Poly(ethylene glycol) Hydrogels. Macromolecules. https://doi.org/10.1021/ma970345a
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
