The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
pH and Redox Dual Responsive Nanoparticle for Nuclear Targeted Drug Delivery
Abstract
To mimic the clinic dosing pattern, initially administering high loading dose and then low maintenance dose, we designed a novel poly(2-(pyridin-2-yldisulfanyl)ethyl acrylate) (PDS) based nanoparticle delivery system. Side chain functional PDS was synthesized by free radical polymerization. Polyethylene glycol and cyclo(Arg-Gly-Asp-d-Phe-Cys) (cRGD) peptide was conjugated to PDS through thiol-disulfide exchange reaction to achieve RPDSG polymer. RPDSG/DOX, RPDSG nanoparticle loaded with doxorubicin, was fabricated by cosolvent dialysis method. The size of the nanoparticles was 50.13 ± 0.5 nm in PBS. The RPDSG/DOX nanoparticle is stable in physiological condition while quickly releasing doxorubicin with the trigger of acidic pH and redox potential. Furthermore, it shows a two-phase release kinetics, providing both loading dose and maintenance dose for cancer therapy. The conjugation of RGD peptide enhanced the cellular uptake and nuclear localization of the RPDSG/DOX nanoparticles. RPDSG/DOX exhibits IC(50) close to that of free doxorubicin for HCT-116 colon cancer cells. Due to the synergetic effect of RGD targeting effect and its two-phase release kinetics, RPDSG/DOX nanoparticles display significantly higher anticancer efficacy than that of free DOX at concentrations higher than 5 μM. These results suggest that RPDSG/DOX could be a promising nanotherapeutic for tumor-targeted chemotherapy.
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Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
Polymeric worm micelles as nano-carriers for drug delivery
Kim, Y., Dalhaimer, P., Christian, D. A., & Discher, D. E. (2005) · Nanotechnology · doi:10.1088/0957-4484/16/7/024 · Cited by 207
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Barua, S., & Mitragotri, S. (2014) · Nano Today · doi:10.1016/j.nantod.2014.04.008 · Cited by 1,257
Xia, Q., Zhang, Y., Li, Z., Hou, X., & Feng, N. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.01.011 · Cited by 665
El-Sawy, H. S., Al-Abd, A. M., Ahmed, T. A., El-Say, K. M., & Torchilin, V. P. (2018) · ACS Nano · doi:10.1021/acsnano.8b06104 · Cited by 431
Recent advances in stimuli-responsive polymer systems for remotely controlled drug release
Zhang, A., Jung, K., Li, A., Liu, J., & Boyer, C. (2019) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2019.101164 · Cited by 268
Metadata
- Authors
- K. C., R. B., Thapa, B., & Xu, P.
- Venue
- Molecular Pharmaceutics
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-08-22
- Volume
- 9
- Issue
- 9
- Pages
- 2719-2729
- ISSN
- 1543-8384 (ISSN-L)
- 1543-8392
- OpenAlex
- W2320830565
- Cited by
- 162
- References
- 2
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- closed
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