Cited by 207Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsSurfactants and Colloidal Systems

Polymeric worm micelles as nano-carriers for drug delivery

Kim, Younghoon, Dalhaimer, Paul, Christian, David A, Discher, Dennis E·2005·Nanotechnology

Abstract

Nanoscale carriers of active compounds, especially drugs, need not be spherical in shape. Worm micelles as blends of degradable polylactic acid (PLA) and inert block copolymer amphiphiles were prepared for controlled release and initial study of carrier transport through nano-porous media. The loading capacity of a typical hydrophobic drug, Triamterene, and the release of hydrophobic dyes were evaluated together with morphological changes of the micelles. Degradation of PLA by hydrolysis led to the self-shortening of worms and a clear transition towards spherical micelles, correlating with the release of hydrophobic dyes. Perhaps equally important for application is the flexibility of worm micelles, which we show allows them to penetrate nanoporous gels where 100 nm sized vesicles cannot enter. Such gels have served as tissue models, and so the results here collectively suggest a new class of hydrophobic drug nano-carriers that are capable of tissue permeation as well as controlled release.

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Registry

Crossref · 10.1088/0957-4484/16/7/024

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24 of 24 references verified0 citation errors · 0 not checkable

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  • PLA has good biocompatibility and degradability, which has led to its being widely used in the medical field.

    “Polylactic acid has good biocompatibility and degradability, which has led to its being widely used in the medical field [40,70,71,72].”

    From Synthesis and Biological Application of Polylactic Acid (2020) · cites this paper as [70]

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Authors
Kim, Y., Dalhaimer, P., Christian, D. A., & Discher, D. E.
Affiliations
University of Pennsylvania (US)
Corresponding author
Dalhaimer, Paul
Venue
Nanotechnology
Published
2005-05-18
Volume
16
Issue
7
Pages
S484-S491
ISSN
  • 0957-4484 (ISSN-L)
  • 1361-6528
OpenAlex
W2127597183
Cited by
207
References
24
Citations by year
2026: 1 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 9 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 15 · 2013: 14 · 2012: 12
FWCI
6.97
Type
journal article
Language
en
Open access
closed
Locations
  • Nanotechnology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Biomedical Imaging and Bioengineering
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
Keywords
wormlike micelles, polymeric micelles, drug delivery, polylactic acid, amphiphilic block copolymers, controlled release, triamterene, hydrophobic drug loading, hydrolytic degradation, micelle morphology

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