Rewritable Memory by Controllable Nanopatterning of DNA
Abstract
Fabricating a nanostructure capable of reversibly patterning molecules is a fundamental goal within nanotechnology, underlying diverse processes such as information storage, scaffold-assisted assembly, and molecular transport. Here, we describe a DNA scaffold supporting a one-dimensional array of independently and reversibly addressable sites at 7 nm spacing. As a proof-of-concept, we demonstrate robust functioning of the device as rewritable memory. The bit state of each address is controlled by specific DNA strands with external readout provided by fluorescence measurements.
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In an alternative approach, five single-stranded nucleotides were annealed together to form an assembly with three addressable overhangs; when complementary strands to each of these overhangs were introduced, the site changed from a "0" (single-stranded) to a "1" (double-stranded) state, which could then be reversed using strand displacement.
“In an alternative approach, five single-stranded nucleotides were annealed together to form an assembly with three addressable overhangs; when complementary strands to each of these overhangs were introduced, the site changed from a “0” (single-stranded) to a “1” (double-stranded) state, which could then be reversed using strand displacement.115”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [115]
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- Authors
- Shin, J.-S., & Pierce, N. A.
- Affiliations
- California Institute of Technology (US)
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-04-13
- Volume
- 4
- Issue
- 5
- Pages
- 905-909
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2129953908
- Semantic Scholar
- b117bc60957ff66a0176b798cdab7bfdd1fd0f0a
- Cited by
- 59
- References
- 31
- Citations by year
- 2026: 5 · 2025: 3 · 2023: 3 · 2022: 2 · 2021: 3 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 4 · 2012: 5
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nano Letters (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Biological Computing
- Physical Sciences › Engineering › Biomedical Engineering › Nanopore and Nanochannel Transport Studies
- Keywords
- DNA nanotechnology, DNA scaffolds, nanopatterning, rewritable memory, DNA origami, fluorescence readout, information storage, molecular transport
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