Hairpin‐DNA memory Using Molecular Addressing
Abstract
A memorable loopy address: A simple molecular memory, named the “hairpin-DNA memory”, has been developed (see schematic). The memory employs the temperature-controlled conformational transition of hairpin-DNA strands in memory writing and erasing and allows parallel addressing of a very large memory space without physical wiring. Experiments on repetitive memory writing and erasing demonstrated that the molecular addressing was highly selective and parallel.
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DNA strands were used as molecular memory by thermally transitioning between a hairpin structure (unwritten state) and a duplex structure (written state).
“In an early example, DNA strands were used as “molecular memory” by transitioning thermally between a hairpin structure (unwritten state) and a duplex structure (written state).118”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [118]
In that molecular memory system, fluorophore/quencher pairs cause the fluorescence output to reversibly switch between two defined states, producing a binary signal.
“The oligonucleotides were appended with fluorophore/quencher pairs; as the thermal cycling occurs, the fluorescence output reversibly switches between two defined states to produce a binary signal.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [118]
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- Authors
- Takinoue, M., & Suyama, A.
- Affiliations
- The University of Tokyo (JP)
- ORCID
- Takinoue, Masahiro
- Venue
- Small
- Publisher
- Wiley
- Published
- 2006-10-02
- Volume
- 2
- Issue
- 11
- Pages
- 1244-1247
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W1969448879
- Cited by
- 37
- References
- 26
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2013: 2 · 2012: 6
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Small (publishedVersion)
- PubMed (publishedVersion)
- Tokyo Tech Research Repository (Tokyo Institute of Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Biological Computing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Advanced Memory and Neural Computing
- Keywords
- DNA hairpins, molecular memory, DNA conformational change, DNA nanotechnology
- MeSH terms
- Base Sequence, DNA, Molecular Sequence Data, Nucleic Acid Conformation, Nucleic Acid Denaturation, Nucleic Acid Hybridization, Temperature, Time Factors, Base Pairing, Nanotechnology, Nanocomposites
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