The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Nanoparticle-Mediated Local and Remote Manipulation of Protein Aggregation
Open accessAbstract
The local heat delivered by metallic nanoparticles selectively attached to their target can be used as a molecular surgery to safely remove toxic and clogging aggregates. We apply this principle to protein aggregates, in particular to the amyloid beta protein (Abeta) involved in Alzheimer's disease (AD), a neurodegenerative disease where unnaturally folded Abeta proteins self-assemble and deposit forming amyloid fibrils and plaques. We show the possibility to remotely redissolve these deposits and to interfere with their growth, using the local heat dissipated by gold nanoparticles (AuNP) selectively attached to the aggregates and irradiated with low gigahertz electromagnetic fields. Simultaneous tagging and manipulation by AuNP of Abeta at different stages of aggregation allow both, noninvasive exploration and dissolution of molecular aggregates.
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Citations
Cites
Ciliary photoreceptors with a vertebrate-type opsin in an invertebrate brain
Arendt, D., Tessmar-Raible, K., Snyman, H., Dorresteijn, A. W., & Wittbrodt, J. (2004) · Science · doi:10.1126/science.1099955 · Cited by 458
Cited by
Aggarwal, P., Hall, J. B., McLeland, C. B., Dobrovolskaia, M. A., & McNeil, S. E. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.009 · Cited by 1,791
Extinction coefficient of gold nanoparticles with different sizes and different capping ligands
Liu, X., Atwater, M., Wang, J., & Huo, Q. (2007) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2006.08.005 · Cited by 1,379
Time Evolution of the Nanoparticle Protein Corona
Casals, E., Pfaller, T., Duschl, A., Oostingh, G. J., & Puntes, V. (2010) · ACS Nano · doi:10.1021/nn901372t · Cited by 1,211
Self-citationBioaccumulation and toxicity of gold nanoparticles after repeated administration in mice
Lasagna-Reeves, C., Gonzalez-Romero, D., Barria, M. A., Olmedo, I., Clos, A., Sadagopa Ramanujam, V. M., Urayama, A., Vergara, L., Kogan, M. J., & Soto, C. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.046 · Cited by 584
Self-citationPiella, J., Bastús, N. G., & Puntes, V. (2016) · Chemistry of Materials · doi:10.1021/acs.chemmater.5b04406 · Cited by 572
Self-citation
Metadata
- Authors
- Kogan, M. J., Bastus, N. G., Amigo, R., Grillo-Bosch, D., Araya, E., Turiel, A., Labarta, A., Giralt, E., & Puntes, V. F.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-12-17
- Volume
- 6
- Issue
- 1
- Pages
- 110-115
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2001386023
- Cited by
- 322
- References
- 1
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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