Electronic Cortisol Detection Using an Antibody-Embedded Polymer Coupled to a Field-Effect Transistor
Open accessAbstract
A field-effect transistor-based cortisol sensor was demonstrated in physiological conditions. An antibody-embedded polymer on the remote gate was proposed to overcome the Debye length issue (λ D ). The sensing membrane was made by linking poly(styrene- co -methacrylic acid) (PSMA) with anticortisol before coating the modified polymer on the remote gate. The embedded receptor in the polymer showed sensitivity from 10 fg/mL to 10 ng/mL for cortisol and a limit of detection (LOD) of 1 pg/mL in 1× PBS where λ D is 0.2 nm. A LOD of 1 ng/mL was shown in lightly buffered artificial sweat. Finally, a sandwich ELISA confirmed the antibody binding activity of antibody-embedded PSMA.
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Cites
Rozanski, A., Blumenthal, J. A., & Kaplan, J. (1999) · Circulation · doi:10.1161/01.cir.99.16.2192 · Cited by 2,846 · see citing works
Importance of the Debye Screening Length on Nanowire Field Effect Transistor Sensors
Stern, E., Wagner, R., Sigworth, F. J., Breaker, R., Fahmy, T. M., & Reed, M. A. (2007) · Nano Letters · doi:10.1021/nl071792z · Cited by 806 · see citing works
Label-free biomarker detection from whole blood
STERN, E. W., Vacic, A., Rajan, N. K., Criscione, J. M., Park, J. Y., Ilic, B. R., Mooney, D. J., Reed, M. A., & Fahmy, T. M. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.353 · Cited by 548 · see citing works
Recent advances in cortisol sensing technologies for point-of-care application
Kaushik, A., Vasudev, A., Arya, S. K., Pasha, S. K., & Bhansali, S. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.09.060 · Cited by 316 · see citing works
Formulation and stability of a novel artificial human sweat under conditions of storage and use
Harvey, C. J., LeBouf, R. F., & Stefaniak, A. B. (2010) · Toxicology in Vitro · doi:10.1016/j.tiv.2010.06.016 · Cited by 275 · see citing works
Portable biosensor for monitoring cortisol in low-volume perspired human sweat
Kinnamon, D., Ghanta, R., Lin, K.-C., Muthukumar, S., & Prasad, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-13684-7 · Cited by 231 · see citing works
The Detection of Cortisol in Human Sweat
Russell, E., Koren, G., Rieder, M. J., & Uum, S. H. M. V. (2013) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0b013e31829daa0a · Cited by 195 · see citing works
Magliulo, M., Mallardi, A., Mulla, M. Y., et al. (2013) · Advanced Materials · doi:10.1002/adma.201203587 · Cited by 188 · see citing works
Stevens, R. C., Soelberg, S. D., Near, S., & Furlong, C. E. (2008) · Analytical Chemistry · doi:10.1021/ac800892h · Cited by 179 · see citing works
Zhang, L., Wang, G., Wu, D., et al. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2017.09.006 · Cited by 149 · see citing works
Flexible nanoporous tunable electrical double layer biosensors for sweat diagnostics
Munje, R. D., Muthukumar, S., Panneer Selvam, A., & Prasad, S. (2015) · Scientific Reports · doi:10.1038/srep14586 · Cited by 138 · see citing works
Ultralow Voltage, OTFT‐Based Sensor for Label‐Free DNA Detection
Lai, S., Demelas, M., Casula, G., et al. (2012) · Advanced Materials · doi:10.1002/adma.201202996 · Cited by 128 · see citing works
Hammock, M. L., Knopfmacher, O., Naab, B. D., Tok, J. B. ‐., & Bao, Z. (2013) · ACS Nano · doi:10.1021/nn305903q · Cited by 128 · see citing works
Molecular Analysis of Blood with Micro‐/Nanoscale Field‐Effect‐Transistor Biosensors
Makowski, M. S., & Ivanisevic, A. (2011) · Small · doi:10.1002/smll.201100211 · Cited by 118 · see citing works
Song, J. J., Dailey, J., Li, H., Jang, H., Zhang, P., Wang, J. T.-H., Everett, A. D., & Katz, H. E. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201606506 · Cited by 100 · see citing works
Self-citationKhan, H. U., Jang, J., Kim, J., & Knoll, W. (2011) · Journal of the American Chemical Society · doi:10.1021/ja107088m · Cited by 90 · see citing works
Minami, T., Sasaki, Y., Minamiki, T., Wakida, S., Kurita, R., Niwa, O., & Tokito, S. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.02.036 · Cited by 90 · see citing works
Huang, W., Besar, K., LeCover, R., Dulloor, P., Sinha, J., Martínez Hardigree, J. F., Pick, C., Swavola, J., Everett, A. D., Frechette, J., et al. (2014) · Chem. Sci. · doi:10.1039/c3sc52638k · Cited by 83 · see citing works
Self-citationElectrochemical Sensing of Cortisol: A Recent Update
Singh, A., Kaushik, A. K., Kumar, R., Nair, M. G., & Bhansali, S. (2014) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-014-0894-2 · Cited by 80 · see citing works
Guan, W., Duan, X., & Reed, M. A. (2013) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.07.061 · Cited by 80 · see citing works
Jang, H.-J., Gu, J.-G., & Cho, W.-J. (2013) · Sensors and Actuators B: Chemical · doi:10.1016/j.snb.2013.02.056 · Cited by 76 · see citing works
Self-citationKumar, A., Aravamudhan, S., Gordic, M., Bhansali, S., & Mohapatra, S. S. (2006) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2006.09.035 · Cited by 75 · see citing works
Minami, T., Minamiki, T., Hashima, Y., et al. (2014) · Chemical Communications · doi:10.1039/c4cc07498j · Cited by 70 · see citing works
Zang, Y., Zhang, F., Huang, D., Di, C., & Zhu, D. (2015) · Advanced Materials · doi:10.1002/adma.201503542 · Cited by 65 · see citing works
17-Hydroxyprogesterone in children, adolescents and adults
Honour, J. W. (2014) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563214529748 · Cited by 62 · see citing works
Jang, H., Ahn, J., Kim, M., Shin, Y., Jeun, M., Cho, W.-J., & Lee, K. H. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.09.020 · Cited by 59 · see citing works
Self-citationLee, I.-K., Jeun, M., Jang, H., et al. (2015) · Nanoscale · doi:10.1039/c5nr03146j · Cited by 57 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Parlak, O., Keene, S. T., Marais, A., Curto, V. F., & Salleo, A. (2018) · Science Advances · doi:10.1126/sciadv.aar2904 · Cited by 603 · see citing works
Extended gate field-effect-transistor for sensing cortisol stress hormone
Sheibani, S., Capua, L., Kamaei, S., Akbari, S. S. A., Zhang, J., Guerin, H., & Ionescu, A. M. (2021) · Communications Materials · doi:10.1038/s43246-020-00114-x · Cited by 158 · see citing works
Lee, H.-B., Meeseepong, M., Trung, T. Q., Kim, B.-Y., & Lee, N.-E. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112133 · Cited by 153 · see citing works
Klinghammer, S., Voitsekhivska, T., Licciardello, N., Kim, K., Baek, C.-K., Cho, H., Wolter, K.-J., Kirschbaum, C., Baraban, L., & Cuniberti, G. (2020) · ACS Sensors · doi:10.1021/acssensors.0c02267 · Cited by 62 · see citing works
Shajari, S., Salahandish, R., Zare, A., Hassani, M., Moossavi, S., Munro, E., Rashid, R., Rosenegger, D., Bains, J. S., & Sanati Nezhad, A. (2023) · Advanced Science · doi:10.1002/advs.202204171 · Cited by 55 · see citing works
Kim, K. H., Lee, S. H., Seo, S. E., Bae, J., Park, S. J., & Kwon, O. S. (2020) · Micromachines · doi:10.3390/mi11040439 · Cited by 26 · see citing works
- Authors
- Jang, H.-J., Lee, T., Song, J., Russell, L., Li, H., Dailey, J., Searson, P. C., & Katz, H. E.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Katz, Howard E.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-04-27
- Volume
- 10
- Issue
- 19
- Pages
- 16233-16237
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- PMC
- PMC6026499
- OpenAlex
- W2799650283
- Cited by
- 80
- References
- 27
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 9 · 2023: 11 · 2022: 14 · 2021: 19 · 2020: 11 · 2019: 4 · 2018: 1
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- ACS Applied Materials & Interfaces (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Air Force Research Laboratory
- National Institute of Biomedical Imaging and Bioengineering (R21EB018426)
- Topics
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
- Keywords
- cortisol detection, field-effect transistor biosensors, poly(styrene-co-methacrylic acid), Debye length, artificial sweat, electrochemical biosensor, sandwich ELISA
- MeSH terms
- Equipment Design, Hydrocortisone, Polymers, Transistors, Electronic, Biosensing Techniques
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