The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Method for Analysis of Nanoparticle Hemolytic Properties in Vitro
Open accessAbstract
Hemolysis (destruction of red blood cells) in vivo can lead to anemia, jaundice, and other pathological conditions; therefore the hemolytic potential of all intravenously administered pharmaceuticals must be evaluated. Nanotechnology-derived devices and drug carriers are emerging as alternatives to conventional small-molecule drugs, and in vitro evaluation of their biocompatibility with blood components is a necessary part of early preclinical development. The small size and unique physicochemical properties of nanoparticles may cause their interactions with erythrocytes to differ from those observed for conventional pharmaceuticals and may also cause interference with standardized in vitro tests. Separating true hemolytic responses from the false-positive or false-negative results caused by particle interference is important for correct interpretation of these tests. Here we describe validation of an in vitro assay for the analysis of nanoparticle hemolytic properties and discuss observed nanointerferences with the assay. We propose alternative methods to avoid misleading results from nanoparticles and discuss the potential relevance of nanoparticle in vitro hemolytic properties to in vivo systems.
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Citations
Cites
Immunological properties of engineered nanomaterials
Dobrovolskaia, M. A., & McNeil, S. E. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.223 · Cited by 1,823
Self-citation
Cited by
Sharifi, S., Behzadi, S., Laurent, S., Laird Forrest, M., Stroeve, P., & Mahmoudi, M. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15188f · Cited by 1,460
Cytotoxicity of Graphene Oxide and Graphene in Human Erythrocytes and Skin Fibroblasts
Liao, K.-H., Lin, Y.-S., Macosko, C. W., & Haynes, C. L. (2011) · ACS Applied Materials & Interfaces · doi:10.1021/am200428v · Cited by 1,370
Mesoporous Silica Nanoparticles for Reducing Hemolytic Activity Towards Mammalian Red Blood Cells
Slowing, I. I., Wu, C., Vivero‐Escoto, J. L., & Lin, V. S. ‐. (2009) · Small · doi:10.1002/smll.200800926 · Cited by 527
Lin, Y.-S., & Haynes, C. L. (2009) · Chemistry of Materials · doi:10.1021/cm901259n · Cited by 364
Synthesis of ZnO nanoparticles and evaluation of antioxidant and cytotoxic activity
Das, D., Nath, B. C., Phukon, P., kalita, A., & Dolui, S. K. (2013) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2013.06.041 · Cited by 349
Metadata
- Authors
- Dobrovolskaia, M. A., Clogston, J. D., Neun, B. W., Hall, J. B., Patri, A. K., & McNeil, S. E.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-07-08
- Volume
- 8
- Issue
- 8
- Pages
- 2180-2187
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2409459743
- Cited by
- 716
- References
- 1
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- green
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