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Copper Selenide Nanocrystals for Photothermal Therapy
Open accessAbstract
Ligand-stabilized copper selenide (Cu(2-x)Se) nanocrystals, approximately 16 nm in diameter, were synthesized by a colloidal hot injection method and coated with amphiphilic polymer. The nanocrystals readily disperse in water and exhibit strong near-infrared (NIR) optical absorption with a high molar extinction coefficient of 7.7 × 10(7) cm(-1) M(-1) at 980 nm. When excited with 800 nm light, the Cu(2-x)Se nanocrystals produce significant photothermal heating with a photothermal transduction efficiency of 22%, comparable to nanorods and nanoshells of gold (Au). In vitro photothermal heating of Cu(2-x)Se nanocrystals in the presence of human colorectal cancer cell (HCT-116) led to cell destruction after 5 min of laser irradiation at 33 W/cm(2), demonstrating the viabilitiy of Cu(2-x)Se nanocrystals for photothermal therapy applications.
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Metadata
- Authors
- Hessel, C. M., Pattani, V. P., Rasch, M., Panthani, M. G., Koo, B., Tunnell, J. W., & Korgel, B. A.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-05-10
- Volume
- 11
- Issue
- 6
- Pages
- 2560-2566
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W1988783116
- Cited by
- 1,451
- References
- 45
- FWCI
- 29.17
- Type
- journal article
- Language
- en
- Open access
- green
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