The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mesoporous Multifunctional Upconversion Luminescent and Magnetic “Nanorattle” Materials for Targeted Chemotherapy
Abstract
Nanorattles consisting of hydrophilic, rare-earth-doped NaYF(4) shells each containing a loose magnetic nanoparticle were fabricated through an ion-exchange process. The inner magnetic Fe(3)O(4) nanoparticles are coated with a SiO(2) layer to avoid iron leaching in acidic biological environments. This multifunctional mesoporous nanostructure with both upconversion luminescent and magnetic properties has excellent water dispersibility and a high drug-loading capacity. The material emits visible luminescence upon NIR excitation and can be directed by an external magnetic field to a specific target, making it an attractive system for a variety of biological applications. Measurements on cells incubated with the nanorattles show them to have low cytotoxicity and excellent cell imaging properties. In vivo experiments yield highly encouraging tumor shrinkage with the antitumor drug doxorubicin (DOX) and significantly enhanced tumor targeting in the presence of an applied magnetic field.
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Drug Delivery Systems: Entering the Mainstream
Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552
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Mura, S., Nicolas, J., & Couvreur, P. (2013) · Nature Materials · doi:10.1038/nmat3776 · Cited by 6,289
Mesoporous silica nanoparticles in drug delivery and biomedical applications
Wang, Y., Zhao, Q., Han, N., Bai, L., Li, J., Liu, J., Che, E., Hu, L., Zhang, Q., Jiang, T., et al. (2015) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2014.09.014 · Cited by 1,192
Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications
Li, C., Chen, G., Zhang, Y., Wu, F., & Wang, Q. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07022 · Cited by 1,037
Self-citationZhong, Y., Tian, G., Gu, Z., Yang, Y., Gu, L., Zhao, Y., Ma, Y., & Yao, J. (2014) · Advanced Materials · doi:10.1002/adma.201304903 · Cited by 448
Nexus between in silico and in vivo models to enhance clinical translation of nanomedicine
Moradi Kashkooli, F., Soltani, M., Souri, M., Meaney, C., & Kohandel, M. (2021) · Nano Today · doi:10.1016/j.nantod.2020.101057 · Cited by 120
Metadata
- Authors
- Zhang, F., Braun, G. B., Pallaoro, A., Zhang, Y., Shi, Y., Cui, D., Moskovits, M., Zhao, D., & Stucky, G. D.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-12-01
- Volume
- 12
- Issue
- 1
- Pages
- 61-67
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2066182057
- Cited by
- 377
- References
- 1
- FWCI
- 25.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, F., Braun, G. B., Pallaoro, A., Zhang, Y., Shi, Y., Cui, D., Moskovits, M., Zhao, D., & Stucky, G. D. (2012). Mesoporous Multifunctional Upconversion Luminescent and Magnetic “Nanorattle” Materials for Targeted Chemotherapy. Nano Letters. https://doi.org/10.1021/nl202949y
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