The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Slowing down DNA Translocation through a Nanopore in Lithium Chloride
Open accessAbstract
The charge of a DNA molecule is a crucial parameter in many DNA detection and manipulation schemes such as gel electrophoresis and lab-on-a-chip applications. Here, we study the partial reduction of the DNA charge due to counterion binding by means of nanopore translocation experiments and all-atom molecular dynamics (MD) simulations. Surprisingly, we find that the translocation time of a DNA molecule through a solid-state nanopore strongly increases as the counterions decrease in size from K(+) to Na(+) to Li(+), both for double-stranded DNA (dsDNA) and single-stranded DNA (ssDNA). MD simulations elucidate the microscopic origin of this effect: Li(+) and Na(+) bind DNA stronger than K(+). These fundamental insights into the counterion binding to DNA also provide a practical method for achieving at least 10-fold enhanced resolution in nanopore applications.
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Self-citation
Metadata
- Authors
- Kowalczyk, S. W., Wells, D. B., Aksimentiev, A., & Dekker, C.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-01-27
- Volume
- 12
- Issue
- 2
- Pages
- 1038-1044
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2015359849
- Cited by
- 440
- References
- 29
- FWCI
- 17.61
- Type
- journal article
- Language
- en
- Open access
- green
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