The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Synthetic Ligand-Coated Magnetic Nanoparticles for Microfluidic Bacterial Separation from Blood
Abstract
Bacterial sepsis is a serious clinical condition that can lead to multiple organ dysfunction and death despite timely treatment with antibiotics and fluid resuscitation. We have developed an approach to clearing bacteria and endotoxin from the bloodstream, using magnetic nanoparticles (MNPs) modified with bis-Zn-DPA, a synthetic ligand that binds to both Gram-positive and Gram-negative bacteria. Magnetic microfluidic devices were used to remove MNPs bound to Escherichia coli , a Gram-negative bacterium commonly implicated in bacterial sepsis, from bovine whole blood at flows as high as 60 mL/h, resulting in almost 100% clearance. Such devices could be adapted to clear bacteria from septicemic patients.
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Cites
The crisis in antibiotic resistance
Neu, H. C. (1992) · Science · doi:10.1126/science.257.5073.1064 · Cited by 2,834
The immunopathogenesis of sepsis
Cohen, J. (2002) · Nature · doi:10.1038/nature01326 · Cited by 2,742
Endotoxemia: Methods of detection and clinical correlates
Hurley, J. C. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.2.268 · Cited by 318
Cited by
Lab on a chip for continuous-flow magnetic cell separation
Hejazian, M., Li, W., & Nguyen, N.-T. (2015) · Lab on a Chip · doi:10.1039/c4lc01422g · Cited by 347
Nanotools for Sepsis Diagnosis and Treatment
Papafilippou, L., Claxton, A., Dark, P., Kostarelos, K., & Hadjidemetriou, M. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202001378 · Cited by 118
The revolution of PDMS microfluidics in cellular biology
Banik, S., Uchil, A., Kalsang, T., Chakrabarty, S., Ali, M. A., Srisungsitthisunti, P., Mahato, K. K., Surdo, S., & Mazumder, N. (2023) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2022.2034733 · Cited by 84
Metadata
- Authors
- Lee, J.-J., Jeong, K. J., Hashimoto, M., Kwon, A. H., Rwei, A., Shankarappa, S. A., Tsui, J. H., & Kohane, D. S.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-01-31
- Volume
- 14
- Issue
- 1
- Pages
- 1-5
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2036395248
- Cited by
- 258
- References
- 3
- FWCI
- 12.22
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.