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Cited by 258

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Synthetic Ligand-Coated Magnetic Nanoparticles for Microfluidic Bacterial Separation from Blood

Lee, Jung-Jae, Jeong, Kyung Jae, Hashimoto, Michinao, Kwon, Albert H., Rwei, Alina, Shankarappa, Sahadev A., Tsui, Jonathan H., Kohane, Daniel S.·2014·Nano Letters

Abstract

Bacterial sepsis is a serious clinical condition that can lead to multiple organ dysfunction and death despite timely treatment with antibiotics and fluid resuscitation. We have developed an approach to clearing bacteria and endotoxin from the bloodstream, using magnetic nanoparticles (MNPs) modified with bis-Zn-DPA, a synthetic ligand that binds to both Gram-positive and Gram-negative bacteria. Magnetic microfluidic devices were used to remove MNPs bound to Escherichia coli , a Gram-negative bacterium commonly implicated in bacterial sepsis, from bovine whole blood at flows as high as 60 mL/h, resulting in almost 100% clearance. Such devices could be adapted to clear bacteria from septicemic patients.

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Crossref · 10.1021/nl3047305

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Metadata

Authors
Lee, J.-J., Jeong, K. J., Hashimoto, M., Kwon, A. H., Rwei, A., Shankarappa, S. A., Tsui, J. H., & Kohane, D. S.
Venue
Nano Letters
Published
2013-01-31
Volume
14
Issue
1
Pages
1-5
ISSN
  • 1530-6984 (ISSN-L)
  • 1530-6992
OpenAlex
W2036395248
Cited by
258
References
3
FWCI
12.22
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.