Endosomal escape pathways for delivery of biologicals

Varkouhi, Amir K.; Scholte, Marije; Storm, Gert; Haisma, Hidde J.

doi:10.1016/j.jconrel.2010.11.004

Cited by 1,561RNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryCellular transport and secretion

Endosomal escape pathways for delivery of biologicals

Open access

Varkouhi, Amir K., Scholte, Marije, Storm, Gert, Haisma, Hidde J.·2011·Journal of Controlled Release

DOI 10.1016/j.jconrel.2010.11.004

Open this paper in CoChat — free account

Abstract

Despite continuous improvements in delivery systems, the development of methods for efficient and specific delivery of targeted therapeutic agents still remains an issue in biological treatments such as protein and gene therapy. The endocytic pathway is the major uptake mechanism of cells and any biological agents, such as DNA, siRNA and proteins. These agents become entrapped in endosomes and are degraded by specific enzymes in the lysosome. Thus, a limiting step in achieving an effective biological based therapy is to facilitate the endosomal escape and ensure cytosolic delivery of the therapeutics. Bacteria and viruses are pathogens which use different mechanisms to penetrate the membranes of their target cells and escape the endosomal pathway. Different mechanisms such as pore formation in the endosomal membrane, pH-buffering effect of protonable groups and fusion into the lipid bilayer of endosomes have been proposed to facilitate the endosomal escape. Several viral and bacterial proteins have been identified that are involved in this process. In addition, chemical agents and photochemical methods to rupture the endosomal membrane have been described. New synthetic biomimetic peptides and polymers with high efficacy in facilitating the endosomal escape, low pathogenicity and toxicity have been developed. Each strategy has different characteristics and challenges for designing the best agents and techniques to facilitate the endosomal escape are ongoing. In this review, several mechanisms and agents which are involved in endosomal escape are introduced.

Integrity signals

Registry

Crossref · 10.1016/j.jconrel.2010.11.004

Cites

148 of 148 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.
Boussif, O., Lezoualc’h, F., Zanta, M. A., Djavaheri‐Mergny, M., Scherman, D., DEMENEIX, B. A., & Behr, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7297 · Cited by 6,256 · see citing works
Peptide Antimicrobial Agents
Jenssen, H., Hamill, P., & Hancock, R. E. W. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00056-05 · Cited by 2,531 · see citing works
ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS
Mellman, I., Fuchs, R., & Helenius, A. (1986) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.55.070186.003311 · Cited by 2,010 · see citing works
Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells
Lewin, M., Carlesso, N., Tung, C., Tang, X. S., Cory, D. G., Scadden, D. T., & Weissleder, R. (2000) · Nature Biotechnology · doi:10.1038/74464 · Cited by 1,716 · see citing works
Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics
Kay, M., Glorioso, J., & Naldini, L. (2001) · Nature Medicine · doi:10.1038/83324 · Cited by 1,444 · see citing works
THE STRUCTURE AND FUNCTION OF THE HEMAGGLUTININ MEMBRANE GLYCOPROTEIN OF INFLUENZA VIRUS
Wiley, D. C., & Skehel, J. J. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.002053 · Cited by 1,413 · see citing works
Cell Internalization of the Third Helix of the Antennapedia Homeodomain Is Receptor-independent
Derossi, D., Calvet, S., Trembleau, A., Brunissen, A., Chassaing, G., & Prochiantz, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.18188 · Cited by 1,073 · see citing works
The actions of melittin on membranes
Dempsey, C. E. (1990) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(90)90006-x · Cited by 852 · see citing works
Stepwise dismantling of adenovirus 2 during entry into cells
Greber, U. F., Willetts, M., Webster, P. C., & Helenius, A. (1993) · Cell · doi:10.1016/0092-8674(93)90382-z · Cited by 811 · see citing works
Nonviral Gene Delivery: Principle, Limitations, and Recent Progress
Al-Dosari, M. S., & Gao, X. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9143-y · Cited by 706 · see citing works
The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems.
Plank, C., Oberhauser, B., Mechtler, K., Koch, C., & Wagner, E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99963-1 · Cited by 666 · see citing works
Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle.
Wagner, E., Plank, C., Zatloukal, K., Cotten, M. L., & Birnstiel, M. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.17.7934 · Cited by 657 · see citing works
A triploblast origin for Myxozoa?
Anderson, C. L., Canning, E. U., & Okamura, B. (1998) · Nature · doi:10.1038/32801 · Cited by 654 · see citing works
MHC class I-cestricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses
Yang, Y., Ertl, H. C. J., & Wilson, J. M. (1994) · Immunity · doi:10.1016/1074-7613(94)90074-4 · Cited by 612 · see citing works
Virus Entry into Animal Cells
Marsh, M., & Helenius, A. (1989) · Advances in virus research · doi:10.1016/s0065-3527(08)60583-7 · Cited by 602 · see citing works
Nonviral Vectors in the New Millennium: Delivery Barriers in Gene Transfer
Nishikawa, M., & Huang, L. (2001) · Human Gene Therapy · doi:10.1089/104303401750195836 · Cited by 573 · see citing works
Efficient Gene Transfer by Histidylated Polylysine/pDNA Complexes
Midoux, P., & Monsigny, M. L. P. (1999) · Bioconjugate Chemistry · doi:10.1021/bc9801070 · Cited by 503 · see citing works
Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells
Simeoni, F. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg385 · Cited by 481 · see citing works
Cholesterol-Dependent Cytolysins, a Family of Versatile Pore-Forming Toxins
Tweten, R. K. (2005) · Infection and Immunity · doi:10.1128/iai.73.10.6199-6209.2005 · Cited by 464 · see citing works
Design, Synthesis, and Characterization of a Cationic Peptide That Binds to Nucleic Acids and Permeabilizes Bilayers
Wyman, T. B., Nicol, F., Zelphati, O., Scaria, P. V., Plank, C., & Szoka, F. C. (1997) · Biochemistry · doi:10.1021/bi9618474 · Cited by 454 · see citing works
Photochemical internalization: a novel technology for delivery of macromolecules into cytosol.
Berg, K., Selbo, P. K., Prasmickaite, L., Tjelle, T. E., Sandvig, K., Moan, J. E., Gaudernack, G., Fodstad, Ø., Kjølsrud, S., Anholt, H., et al. (1999) · PubMed · Cited by 423 · see citing works
Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome–DNA complexes
Torchilin, V. P., Levchenko, T. S., Rammohan, R., Volodina, N., Papahadjopoulos‐Sternberg, B., & D’Souza, G. G. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0435906100 · Cited by 419 · see citing works
Adenovirus endocytosis
Meier, O. C., & Greber, U. F. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.553 · Cited by 415 · see citing works
Ribosome-inactivating proteins
Stirpe, F. (2004) · Toxicon · doi:10.1016/j.toxicon.2004.05.004 · Cited by 389 · see citing works
Mechanisms of pathogen entry through the endosomal compartments
Gruenberg, J., & van der Goot, F. G. (2006) · Nature reviews. Molecular cell biology · doi:10.1038/nrm1959 · Cited by 360 · see citing works
Poliovirus Cell Entry: Common Structural Themes in Viral Cell Entry Pathways
Hogle, J. M. (2002) · Annual Review of Microbiology · doi:10.1146/annurev.micro.56.012302.160757 · Cited by 352 · see citing works
Gene Therapy: Promises and Problems
Pfeifer, A., & Verma, I. M. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.177 · Cited by 344 · see citing works
Molecular Mechanism of Peptide-Induced Pores in Membranes
Huang, H. W., Chen, F.-Y., & Lee, M.-T. (2004) · Physical Review Letters · doi:10.1103/physrevlett.92.198304 · Cited by 335 · see citing works
Delivery of short interfering RNA using endosomolytic cell‐penetrating peptides
Lundberg, P., Andaloussi, S. E., Sütlü, T., Johansson, H. J., & Langel, Ü. (2007) · The FASEB Journal · doi:10.1096/fj.06-6502com · Cited by 322 · see citing works
Novel Bioreducible Poly(amido amine)s for Highly Efficient Gene Delivery
Lin, C., Zhong, Z., Lok, M. C., Jiang, X., Hennink, W. E., Feijén, J., & Engbersen, J. F. J. (2006) · Bioconjugate Chemistry · doi:10.1021/bc060200l · Cited by 308 · see citing works
Biomembrane fusion: a new concept derived from model studies using two interacting planar lipid bilayers
Chernomordik, L., Melikyan, G. B., & Chizmadzhev, Y. A. (1987) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(87)90016-5 · Cited by 304 · see citing works
Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA
Parente, R. A., Nir, S., & Szoka, F. C. (1990) · Biochemistry · doi:10.1021/bi00489a031 · Cited by 301 · see citing works
An endosomolytic Tat peptide produced by incorporation of histidine and cysteine residues as a nonviral vector for DNA transfection
Lo, S. L., & Wang, S. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.01.031 · Cited by 290 · see citing works
Protein Transduction Domain of HIV-1 Tat Protein Promotes Efficient Delivery of DNA into Mammalian Cells
Eguchi, A., Akuta, T., Okuyama, H., Senda, T., Yokoi, H., Inokuchi, H., Fujita, S., Hayakawa, T., Takeda, K., Hasegawa, M., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010625200 · Cited by 289 · see citing works
Intracellular trafficking of adeno-associated virus vectors: routing to the late endosomal compartment and proteasome degradation
Douar, A.-M., Poulard, K., Stockholm, D., & Danos, O. (2001) · Journal of Virology · doi:10.1128/jvi.75.4.1824-1833.2001 · Cited by 282 · see citing works
The Listeria monocytogenes hemolysin has an acidic pH optimum to compartmentalize activity and prevent damage to infected host cells
Glomski, I. J., Gedde, M. M., Tsang, A. W., Swanson, J. A., & Portnoy, D. A. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201081 · Cited by 281 · see citing works
Oligomers of the Arginine-rich Motif of the HIV-1 TAT Protein Are Capable of Transferring Plasmid DNA into Cells
Rudolph, C., Plank, C., Lausier, J., Schillinger, U., Müller, R. H., & Rosenecker, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211891200 · Cited by 275 · see citing works
Endosomal Escape of Polymeric Gene Delivery Complexes Is Not Always Enhanced by Polymers Buffering at Low pH
Funhoff, A. M., van Nostrum, C. F., Koning, G. A., Schuurmans-Nieuwenbroek, N. M. E., Crommelin, D. J. A., & Hennink, W. E. (2003) · Biomacromolecules · doi:10.1021/bm034041+ · Cited by 272 · see citing works
Transferrin-Modified Liposomes Equipped with a pH-Sensitive Fusogenic Peptide: An Artificial Viral-like Delivery System
Kakudo, T., Chaki, S., Futaki, S., Nakase, I., Akaji, K., Kawakami, T., Maruyama, K., Kamiya, H., & Harashima, H. (2004) · Biochemistry · doi:10.1021/bi035802w · Cited by 269 · see citing works
Breathing Life into Polycations: Functionalization with pH-Responsive Endosomolytic Peptides and Polyethylene Glycol Enables siRNA Delivery
Meyer, M., Philipp, A. B., Oskuee, R. K., Schmidt, C., & Wagner, E. (2008) · Journal of the American Chemical Society · doi:10.1021/ja710344v · Cited by 263 · see citing works
Membrane binding and conformational properties of peptides representing the NH2 terminus of influenza HA-2.
Lear, J. D., & DeGrado, W. F. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48270-1 · Cited by 257 · see citing works
A novel DNA-peptide complex for efficient gene transfer and expression in mammalian cells.
Gottschalk, S. M., Sparrow, J. T., Hauer, J., Mims, M. P., Leland, F. E., Woo, S. L. C., & Smith, L. C. (1996) · PubMed · Cited by 252 · see citing works
A PEST-Like Sequence in Listeriolysin O Essential for Listeria monocytogenes Pathogenicity
Decatur, A. L., & Portnoy, D. A. (2000) · Science · doi:10.1126/science.290.5493.992 · Cited by 239 · see citing works
Targeting adenovirus
Wickham, T. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301115 · Cited by 236 · see citing works
Fluorescent Virions: Dynamic Tracking of the Pathway of Adenoviral Gene Transfer Vectors in Living Cells
Leopold, P. L., Ferris, B., Grinberg, I., Worgall, S., Hackett, N. R., & Crystal, R. G. (1998) · Human Gene Therapy · doi:10.1089/hum.1998.9.3-367 · Cited by 231 · see citing works
Histidine-rich amphipathic peptide antibiotics promote efficient delivery of DNA into mammalian cells
Kichler, A., Leborgne, C., März, J., Danos, O., & Bechinger, B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337677100 · Cited by 229 · see citing works
Melittin Enables Efficient Vesicular Escape and Enhanced Nuclear Access of Nonviral Gene Delivery Vectors
Ogris, M., Carlisle, R. C., Bettinger, T., & Seymour, L. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108331200 · Cited by 225 · see citing works
Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells
Bettinger, T. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.18.3882 · Cited by 224 · see citing works
Adenoviral Gene Therapy
Vorburger, S. A., & Hunt, K. K. (2002) · The Oncologist · doi:10.1634/theoncologist.7-1-46 · Cited by 220 · see citing works
Cytosolic Delivery of Granzyme B by Bacterial Toxins: Evidence that Endosomal Disruption, in Addition to Transmembrane Pore Formation, Is an Important Function of Perforin
Browne, K. A., Blink, E. J., Sutton, V. R., Froelich, C. J., Jans, D. A., & Trapani, J. A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8604 · Cited by 208 · see citing works
A Membrane-Destabilizing Peptide in Capsid Protein L2 Is Required for Egress of Papillomavirus Genomes from Endosomes
Kämper, N., Day, P. M., Nowak, T., Selinka, H., Florin, L., Bolscher, J. G. M., Hilbig, L., Schiller, J. T., & Sapp, M. J. (2005) · Journal of Virology · doi:10.1128/jvi.80.2.759-768.2006 · Cited by 194 · see citing works
Degradable-Brushed pHEMA–pDMAEMA Synthesized via ATRP and Click Chemistry for Gene Delivery
Jiang, X., Lok, M. C., & Hennink, W. E. (2007) · Bioconjugate Chemistry · doi:10.1021/bc0701186 · Cited by 190 · see citing works
A novel potent strategy for gene delivery using a single peptide vector as a carrier
Morris, M. C., Chaloin, L., Méry, J., Heitz, F., & Divita, G. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.17.3510 · Cited by 182 · see citing works
pH-dependent fusion of phosphatidylcholine small vesicles. Induction by a synthetic amphipathic peptide.
Parente, R. A., Nir, S., & Szoka, F. C. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68843-x · Cited by 175 · see citing works
Cell penetrating peptide conjugates of steric block oligonucleotides
Lebleu, B., Moulton, H. M., Abes, R., Ivanova, G. D., Abes, S., Stein, D. A., Iversen, P. L., Arzumanov, A. A., & Gait, M. J. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.09.002 · Cited by 175 · see citing works
Cell killing by lysosomotropic detergents.
Miller, D. K., Griffiths, E., Lenard, J., & Firestone, R. A. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.6.1841 · Cited by 174 · see citing works
Cytotoxic ribosome-inactivating lectins from plants
Hartley, M. R., & Lord, J. M. (2004) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2004.06.004 · Cited by 173 · see citing works
Functional Characterization of an Endosome-disruptive Peptide and Its Application in Cytosolic Delivery of Immunoliposome-entrapped Proteins
Mastrobattista, E., Koning, G. A., van Bloois, L., Filipe, A. C. S., Jiskoot, W., & Storm, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200429200 · Cited by 173 · see citing works
Self-citation
Single cell optical transfection
Stevenson, D. J., Gunn‐Moore, F. J., Campbell, P. A., & Dholakia, K. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2009.0463 · Cited by 171 · see citing works
Potential Peptide Carriers: Amphipathic Proline‐Rich Peptides Derived from the N‐Terminal Domain of γ‐Zein
Fernández‐Carneado, J., Kogan, M. J., Castel, S., & Giralt, E. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200352540 · Cited by 170 · see citing works
A pH-Sensitive Polymer That Enhances Cationic Lipid-Mediated Gene Transfer
Cheung, C., Murthy, N., Stayton, P. S., & Hoffman, A. S. (2001) · Bioconjugate Chemistry · doi:10.1021/bc0100408 · Cited by 164 · see citing works
Mechanisms of gene transfer mediated by lipoplexes associated with targeting ligands or pH-sensitive peptides
Simões, S., Slepushkin, V., Pires, P., Gaspar, R. S., de Lima, M. C. P., & Düzgüneş, N. (1999) · Gene Therapy · doi:10.1038/sj.gt.3301015 · Cited by 161 · see citing works
Improving chitosan-mediated gene transfer by the introduction of intracellular buffering moieties into the chitosan backbone
Moreira, C., Oliveira, H., Pires, L. R., Simões, S., Barbosa, M. A., & Pêgo, A. P. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.04.021 · Cited by 160 · see citing works
Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes
Oliveira, S., VANROOY, I., Kranenburg, O., Storm, G., & Schiffelers, R. M. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.11.050 · Cited by 155 · see citing works
Self-citation
Arginine-rich cell penetrating peptides: from endosomal uptake to nuclear delivery
Melikov, K., & Chernomordik, L. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5293-y · Cited by 155 · see citing works
Adenovirus endocytosis
Meier, O. C., & Greber, U. F. (2003) · The Journal of Gene Medicine · doi:10.1002/jgm.409 · Cited by 154 · see citing works
Efficient splicing correction by PNA conjugation to an R6-Penetratin delivery peptide
Abes, S., Turner, J. J., Ivanova, G. D., Owen, D., Williams, D., Arzumanov, A. A., Clair, P., Gait, M. J., & Lebleu, B. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm418 · Cited by 149 · see citing works
Transfer of monoclonal antibodies into mammalian cells by electroporation
Chakrabarti, R., Wylie, D. E., & Schuster, S. M. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84857-3 · Cited by 148 · see citing works
Impaired Intracellular Trafficking of Adeno-Associated Virus Type 2 Vectors Limits Efficient Transduction of Murine Fibroblasts
Hansen, J. J., Qing, K., Kwon, H., Mah, C. S., & Srivastava, A. (2000) · Journal of Virology · doi:10.1128/jvi.74.2.992-996.2000 · Cited by 147 · see citing works
Virus-mediated release of endosomal content in vitro: different behavior of adenovirus and rhinovirus serotype 2.
Prchla, E., Plank, C., Wagner, E., Blaas, D., & Fuchs, R. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.1.111 · Cited by 140 · see citing works
siRNA applications in nanomedicine
Tokatlian, T., & Segura, T. (2010) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.81 · Cited by 138 · see citing works
Induction of splice correction by cell‐penetrating peptide nucleic acids
Andaloussi, S. E., Johansson, H. J., Lundberg, P., & Langel, Ü. (2006) · The Journal of Gene Medicine · doi:10.1002/jgm.950 · Cited by 137 · see citing works
Decoding the Entry of Two Novel Cell-Penetrating Peptides in HeLa Cells: Lipid Raft-Mediated Endocytosis and Endosomal Escape
Foerg, C., Ziegler, U., Fernández‐Carneado, J., Giralt, E., Rennert, R. C., Beck‐Sickinger, A. G., & Merkle, H. P. (2004) · Biochemistry · doi:10.1021/bi048330+ · Cited by 133 · see citing works
Melittin analogs with high lytic activity at endosomal pH enhance transfection with purified targeted PEI polyplexes
Boeckle, S., Fahrmeir, J., Röedl, W., Ogris, M., & Wagner, E. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.02.002 · Cited by 132 · see citing works
Effect of chemical functionalities in poly(amido amine)s for non-viral gene transfection
Lin, C., & Engbersen, J. F. J. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.06.022 · Cited by 132 · see citing works
Oral tolerization to adenoviral antigens permits long-term gene expression using recombinant adenoviral vectors.
Ilan, Y., Prakash, R., Davidson, A., Jona, Droguett, G., Horwitz, M. S., Chowdhury, N. R., & Chowdhury, J. R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119238 · Cited by 132 · see citing works
Pathways followed by protein toxins into cells
Sandvig, K., Spilsberg, B., Lauvrak, S. U., Torgersen, M. L., Iversen, T., & van Deurs, B. O. (2004) · International Journal of Medical Microbiology · doi:10.1078/1438-4221-00294 · Cited by 130 · see citing works
Sugar‐based tertiary amino gemini surfactants with a vesicle‐to‐micelle transition in the endosomal pH range mediate efficient transfection in vitro
Fielden, M. L., Perrin, C., Kremer, A., Bergsma, M., Stuart, M. C. A., Camilleri, P., & Engberts, J. B. F. N. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.01995.x · Cited by 128 · see citing works
Target Cell-specific DNA Transfer Mediated by a Chimeric Multidomain Protein
Fominaya, J. M., & Wels, W. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10560 · Cited by 126 · see citing works
A new gene delivery formulation of polyethylenimine/DNA complexes coated with PEG conjugated fusogenic peptide
Lee, H., Jeong, J. H., & Park, T. G. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00426-6 · Cited by 126 · see citing works
Theoretical and functional analysis of the SIV fusion peptide.
Horth, M., Lambrecht, B., Khim, M. C. L., Bex, F., Thiriart, C., Ruysschaert, J., Burny, A., & Brasseur, R. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07823.x · Cited by 125 · see citing works
Poly(3-guanidinopropyl methacrylate): A Novel Cationic Polymer for Gene Delivery
Funhoff, A. M., van Nostrum, C. F., Lok, M. C., Fretz, M. M., Crommelin, D. J. A., & Hennink, W. E. (2004) · Bioconjugate Chemistry · doi:10.1021/bc049864q · Cited by 118 · see citing works
An artificial virus-like nano carrier system: enhanced endosomal escape of nanoparticles via synergistic action of pH-sensitive fusogenic peptide derivatives
Sasaki, K., Kogure, K., Chaki, S., Nakamura, Y., Moriguchi, R., Hamada, H., Danev, R., Nagayama, K., Futaki, S., & Harashima, H. (2008) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-008-2012-1 · Cited by 115 · see citing works
Novel Polymerizable Surfactants with pH-Sensitive Amphiphilicity and Cell Membrane Disruption for Efficient siRNA Delivery
Wang, X.-L., Ramusovic, S., Nguyen, T. D., & Lu, Z. (2007) · Bioconjugate Chemistry · doi:10.1021/bc700285q · Cited by 115 · see citing works
Delivery systems intended for in vivo gene therapy of cancer: targeting and replication competent viral vectors
Galanis, E., Vile, R. G., & Russell, S. J. (2001) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00103-2 · Cited by 111 · see citing works
Modeling the Endosomal Escape of Cell-Penetrating Peptides: Transmembrane pH Gradient Driven Translocation across Phospholipid Bilayers
Magzoub, M. M., Pramanik, A., & Gräslund, A. (2005) · Biochemistry · doi:10.1021/bi051356w · Cited by 110 · see citing works
Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia
Cho, J. Y., Guo, C., Torello, M., Lunstrum, G. P., Iwata, T., Deng, C., & Horton, W. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2237184100 · Cited by 110 · see citing works
A proline-rich peptide improves cell transfection of solid lipid nanoparticle-based non-viral vectors
del Pozo‐Rodríguez, A., Pujals, S., Delgado, D., Solinís, M. Á., Rodríguez‐Gascón, A., Giralt, E., & Pedraz, J. L. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.09.004 · Cited by 106 · see citing works
N-terminal peptides from unprocessed prion proteins enter cells by macropinocytosis
Magzoub, M. M., Sandgren, S., Lundberg, P., Oglęcka, K., Lilja, J., Wittrup, A., Eriksson, L. E. G., Langel, Ü., Belting, M., & Gräslund, A. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.07.065 · Cited by 105 · see citing works
Photochemical internalization enhances silencing of epidermal growth factor receptor through improved endosomal escape of siRNA
Oliveira, S., Fretz, M. M., Høgset, A., Storm, G., & Schiffelers, R. M. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.01.013 · Cited by 104 · see citing works
Self-citation
Application of an HIV gp41-Derived Peptide for Enhanced Intracellular Trafficking of Synthetic Gene and siRNA Delivery Vehicles
Kwon, E. J., Bergen, J. M., & Pun, S. H. (2008) · Bioconjugate Chemistry · doi:10.1021/bc700448h · Cited by 101 · see citing works
Reversal of doxorubicin resistance in breast cancer cells by photochemical internalization
Lou, P., Lai, P., Shieh, M., MacRobert, A. J., Berg, K., & Bown, S. G. (2006) · International Journal of Cancer · doi:10.1002/ijc.22098 · Cited by 100 · see citing works
Cyclic amphipathic peptide-DNA complexes mediate high-efficiency transfection of adherent mammalian cells.
Legendre, J., & Szoka, F. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.3.893 · Cited by 98 · see citing works
Cell membrane translocation of the N-terminal (1-28) part of the prion protein.
Lundberg, P., Magzoub, M., Lindberg, M., Hällbrink, M., Jarvet, J., Eriksson, L., Langel, Ü., & Gräslund, A. (2002) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/s0006-291x(02)02595-0 · Cited by 94 · see citing works
A molecular code dictates sequence‐specific DNA recognition by homeodomains.
Damante, G., Pellizzari, L., Esposito, G., Fogolari, F., Viglino, P., Fabbro, D., Tell, G., Formisano, S., & Lauro, R. D. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00879.x · Cited by 93 · see citing works
Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells
Vago, R., Marsden, C. J., Lord, J. M., Ippoliti, R., Flavell, D. J., Flavell, S. U., Ceriotti, A., & Fabbrini, M. S. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.04908.x · Cited by 91 · see citing works
Antiviral state against influenza virus neutralized by microinjection of antibodies to interferon‐induced Mx proteins.
Arnheiter, H., & Haller, O. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02946.x · Cited by 91 · see citing works
Evaluation of Different Photosensitizers for Use in Photochemical Gene Transfection¶
Prasmickaite, L., Høgset, A., & Berg, K. (2001) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2001)0730388eodpfu2.0.co2 · Cited by 87 · see citing works
Polymer Side-Chain Degradation as a Tool to Control the Destabilization of Polyplexes
Funhoff, A. M., van Nostrum, C. F., Janssen, A. P. C. A., Fens, M. H. A. M., Crommelin, D. J. A., & Hennink, W. E. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000012165.68765.e6 · Cited by 86 · see citing works
Listeriolysin O-liposome-mediated cytosolic delivery of macromolecule antigen in vivo: enhancement of antigen-specific cytotoxic T lymphocyte frequency, activity, and tumor protection
Mandal, M., & Lee, K. (2002) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(02)00368-1 · Cited by 82 · see citing works
Inhibition of Endoplasmic Reticulum-Associated Degradation in CHO Cells Resistant to Cholera Toxin, Pseudomonas aeruginosa Exotoxin A, and Ricin
Teter, K., & Holmes, R. K. (2002) · Infection and Immunity · doi:10.1128/iai.70.11.6172-6179.2002 · Cited by 82 · see citing works
Cellular siRNA Delivery Mediated by a Cell-Permeant RNA-Binding Protein and Photoinduced RNA Interference
Endoh, T., Sisido, M., & Ohtsuki, T. (2008) · Bioconjugate Chemistry · doi:10.1021/bc800020n · Cited by 80 · see citing works
Design of “Smart” polymers that can direct intracellular drug delivery
Hoffman, A. S., Stayton, P. S., Press, O. W., Murthy, N., Lackey, C. A., Cheung, C., Black, F. E., Campbell, J. S., Fausto, N., Kyriakides, T. R., et al. (2002) · Polymers for Advanced Technologies · doi:10.1002/pat.232 · Cited by 80 · see citing works
A Photo-Activated Targeting Chemotherapy Using Glutathione Sensitive Camptothecin-Loaded Polymeric Micelles
Cabral, H., Nakanishi, M., Kumagai, M., Jang, W., Nishiyama, N., & Kataoka, K. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9712-2 · Cited by 79 · see citing works
Enhanced cytosolic delivery of plasmid DNA by a sulfhydryl-activatable listeriolysin O/protamine conjugate utilizing cellular reducing potential
Saito, G., Amidon, G. L., & Lee, K.-D. (2003) · Gene Therapy · doi:10.1038/sj.gt.3301859 · Cited by 77 · see citing works
Conditional gene targeting for cancer gene therapy
Haviv, Y. S., & Curiel, D. T. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00225-3 · Cited by 76 · see citing works
Binding of Ricin A-Chain to Negatively Charged Phospholipid Vesicles Leads to Protein Structural Changes and Destabilizes the Lipid Bilayer
Day, P. J., Pinheiro, T. J. T., Roberts, L. M., & Lord, J. M. (2002) · Biochemistry · doi:10.1021/bi012012i · Cited by 76 · see citing works
On the Gene Delivery Efficacies of pH-Sensitive Cationic Lipids via Endosomal Protonation
Singh, R. S., Gonçalves, C., Sandrin, P., Pichon, C., Midoux, P., & Chaudhuri, A. (2004) · Chemistry & Biology · doi:10.1016/j.chembiol.2004.03.026 · Cited by 74 · see citing works
Unique features of a pH-sensitive fusogenic peptide that improves the transfection efficiency of cationic liposomes
Futaki, S., Masui, Y., Nakase, I., Sugiura, Y., Nakamura, T., Kogure, K., & Harashima, H. (2005) · The Journal of Gene Medicine · doi:10.1002/jgm.796 · Cited by 72 · see citing works
Specific tumoricidal activity of a secreted proapoptotic protein consisting of HER2 antibody and constitutively active caspase-3.
Jia, L., Zhang, L.-H., Yu, C.-J., Zhao, J., Xu, Y., Gui, J.-H., Jin, M., Ji, Z., Wen, W.-H., Wang, C.-J., et al. (2003) · PubMed · Cited by 69 · see citing works
Specific Redistribution of Cell-Penetrating Peptides from Endosomes to the Cytoplasm and Nucleus upon Laser Illumination
Maiolo, J. R., Ottinger, E. A., & Ferrer, M. (2004) · Journal of the American Chemical Society · doi:10.1021/ja044867z · Cited by 67 · see citing works
A composite gene delivery system consisting of polyethylenimine and an amphipathic peptide KALA
Min, S., Lee, D. C., Lim, M. J., Park, H. S., Kim, D., Cho, C., Yoon, D. Y., & Yeom, Y. I. (2006) · The Journal of Gene Medicine · doi:10.1002/jgm.973 · Cited by 63 · see citing works
Association between the pH-dependent Conformational Change of West Nile Flavivirus E Protein and Virus-mediated Membrane Fusion
Kimura, T., & Ohyama, A. (1988) · Journal of General Virology · doi:10.1099/0022-1317-69-6-1247 · Cited by 62 · see citing works
Characterization of the gene transfer process mediated by histidine-rich peptides
Kichler, A., Leborgne, C., Danos, O., & Bechinger, B. (2006) · Journal of Molecular Medicine · doi:10.1007/s00109-006-0119-4 · Cited by 62 · see citing works
The conjugation of diphtheria toxin T domain to poly(ethylenimine) based vectors for enhanced endosomal escape during gene transfection
Kakimoto, S., Hamada, T., Komatsu, Y., Takagi, M., Tanabe, T., Azuma, H., Shinkai, S., & Nagasaki, T. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.09.042 · Cited by 60 · see citing works
Poly(amidoamine)-mediated intracytoplasmic delivery of ricin A-chain and gelonin
Pattrick, N. G., Richardson, S. C. W., Casolaro, M., Ferruti, P., & Duncan, R. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00476-x · Cited by 58 · see citing works
Arginine‐rich cell penetrating peptides: Design, structure–activity, and applications to alter pre‐mRNA splicing by steric‐block oligonucleotides
Abes, R., Arzumanov, A. A., Moulton, H. M., Abes, S., Ivanova, G. D., Gait, M. J., Iversen, P. L., & Lebleu, B. (2008) · Journal of Peptide Science · doi:10.1002/psc.979 · Cited by 58 · see citing works
Enhancing Polysaccharide-Mediated Delivery of Nucleic Acids Through Functionalization with Secondary and Tertiary Amines
Roy, K., Ghosn, B., & Kasturi, S. P. (2008) · Current Topics in Medicinal Chemistry · doi:10.2174/156802608783790947 · Cited by 58 · see citing works
Protein Transduction Domains and their Utility in Gene Therapy
Beerens, A.-S., Hadithy, A. A., Rots, M. G., & Haisma, H. J. (2003) · Current Gene Therapy · doi:10.2174/1566523034578258 · Cited by 57 · see citing works
Self-citation
How bacterial protein toxins enter cells: the role of partial unfolding in membrane translocation
London, E. (1992) · Molecular Microbiology · doi:10.1111/j.1365-2958.1992.tb02195.x · Cited by 56 · see citing works
Differentiation Restricted Endocytosis of Cell Penetrating Peptides in MDCK Cells Corresponds with Activities of Rho-GTPases
Foerg, C., Ziegler, U., Fernández‐Carneado, J., Giralt, E., & Merkle, H. P. (2007) · Pharmaceutical Research · doi:10.1007/s11095-006-9212-1 · Cited by 55 · see citing works
The recombinant anti-EGF receptor immunotoxin 425(scFv)-ETA' suppresses growth of a highly metastatic pancreatic carcinoma cell line
Bruell, D., Stöcker, M., Hühn, M., Redding, N., Kupper, M. B., Schumacher, P., Paetz, A., Bruns, C. J., Haisma, H. J., Fischer, R., et al. (2003) · International Journal of Oncology · doi:10.3892/ijo.23.4.1179 · Cited by 53 · see citing works
Self-citation
Recombinant polymer‐protein fusion: a promising approach towards efficient and targeted gene delivery
Hatefi, A., Megeed, Z., & Ghandehari, H. (2006) · The Journal of Gene Medicine · doi:10.1002/jgm.872 · Cited by 52 · see citing works
A fusogenic segment of glycoprotein H from herpes simplex virus enhances transfection efficiency of cationic liposomes
Tu, Y., & Kim, J. (2008) · The Journal of Gene Medicine · doi:10.1002/jgm.1184 · Cited by 52 · see citing works
Nonviral gene delivery to human breast cancer cells by targeted Ad5 penton proteins
Medina‐Kauwe, L. K., Maguire, M., Kasahara, N., & Kedes, L. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301583 · Cited by 52 · see citing works
Translocation mediated by domain II of Pseudomonas exotoxin A: transport of barnase into the cytosol
Prior, T. I., FitzGerald, D. J., & Pastan, I. H. (1992) · Biochemistry · doi:10.1021/bi00129a001 · Cited by 47 · see citing works
Photochemical enhancement of transgene expression by polymeric micelles incorporating plasmid DNA and dendrimer-based photosensitizer
Nishiyama, N., Arnida, Jang, W., Date, K., Miyata, K., & Kataoka, K. (2006) · Journal of drug targeting · doi:10.1080/10611860600834508 · Cited by 46 · see citing works
Heparin-Induced Cancer Cell Death
Linhardt, R. J. (2004) · Chemistry & Biology · doi:10.1016/j.chembiol.2004.04.001 · Cited by 43 · see citing works
Cytosolic Delivery of Liposomally Targeted Proteins Induced by Photochemical Internalization
Fretz, M. M., Høgset, A., Koning, G. A., Jiskoot, W., & Storm, G. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9338-9 · Cited by 43 · see citing works
Self-citation
In vitro gene delivery by a novel human calcitonin (hCT)-derived carrier peptide
Krauss, U., Müller, M. J., Stahl, M., & Beck‐Sickinger, A. G. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2003.10.014 · Cited by 40 · see citing works
Specific gene transfer mediated by galactosylated poly-l-lysine into hepatoma cells
Han, J., & Yeom, Y. I. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00441-5 · Cited by 40 · see citing works
Poly(amido amine)s as Gene Delivery Vectors: Effects of Quaternary Nicotinamide Moieties in the Side Chains
Mateos‐Timoneda, M. A., Lok, M. C., Hennink, W. E., Feijén, J., & Engbersen, J. F. J. (2007) · ChemMedChem · doi:10.1002/cmdc.200700279 · Cited by 39 · see citing works
Listeriolysin O enhances cytoplasmic delivery by Her-2 targeting liposomes
Kullberg, M., Owens, J. L., & Mann, K. (2010) · Journal of drug targeting · doi:10.3109/10611861003663549 · Cited by 37 · see citing works
Time-dependent effects of chloroquine on pH of hepatocyte lysosomes
Tietz, P. S., Yamazaki, K., & LaRusso, N. F. (1990) · Biochemical Pharmacology · doi:10.1016/0006-2952(90)90414-g · Cited by 36 · see citing works
Calcitonin-derived peptide carriers: Mechanisms and application
Rennert, R. C., Neundorf, I., & Beck‐Sickinger, A. G. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.09.008 · Cited by 34 · see citing works
Membrane translocation of diphtheria toxin A-fragment: role of carboxy-terminal region
Ariansen, S. L., Afanasiev, B. N., Moskaug, J. Ø., Stenmark, H., Madshus, I. H., & Olsnes, S. (1993) · Biochemistry · doi:10.1021/bi00052a012 · Cited by 33 · see citing works
Lipoplex and peptide-based strategies for the delivery of steric-block oligonucleotides
Resina, S., Abes, S., Turner, J. J., Prévôt, P., Travo, A., Clair, P., Gait, M. J., Thierry, A. R., & Lebleu, B. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.04.039 · Cited by 32 · see citing works
Adenovirus or HA‐2 fusogenic peptide‐assisted lipofection increases cytoplasmic levels of plasmid in nondividing endothelium with little enhancement of transgene expression
Subramanian, A., Ma, H., Dahl, K. N., Zhu, J., & Diamond, S. L. (2001) · The Journal of Gene Medicine · doi:10.1002/jgm.235 · Cited by 31 · see citing works
Development of an on-line monitoring system of human keratinocyte growth by image analysis and its application to bioreactor culture
Kino‐oka, M., & Přenosil, J. E. (2000) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(20000120)67:2 · Cited by 31 · see citing works
Enhanced plasmid DNA delivery using anionic LPDII by listeriolysin O incorporation
Lorenzi, G. L., & Lee, K. (2005) · The Journal of Gene Medicine · doi:10.1002/jgm.750 · Cited by 29 · see citing works
Hybrid Tetanus Toxin C Fragment-Diphtheria Toxin Translocation Domain Allows Specific Gene Transfer into PC12 Cells
Barati, S., Chegini, F., Hurtado, P. R., & Rush, R. A. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7999 · Cited by 24 · see citing works
Membrane destabilization by ricin
Sun, J., Pohl, E. E., Krylova, O. O., Krause, E., Agapov, I. I., Tonevitsky, A., & Pohl, P. (2004) · European Biophysics Journal · doi:10.1007/s00249-004-0400-9 · Cited by 19 · see citing works
Photochemical Enhancement of DNA Delivery by EGF Receptor Targeted Polyplexes
Bonsted, A., Wagner, E., Prasmickaite, L., Høgset, A., & Berg, K. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-248-3_11 · Cited by 19 · see citing works
A DNA delivery system containing listeriolysin O results in enhanced hepatocyte-directed gene expression
Walton, C. M. (1999) · World Journal of Gastroenterology · doi:10.3748/wjg.v5.i6.465 · Cited by 18 · see citing works
Evidence for the modulation of Pseudomonas aeruginosa Exotoxin A-Induced Pore Formation by Membrane Surface Charge Density
Rasper, D., & Merrill, A. R. (1994) · Biochemistry · doi:10.1021/bi00248a006 · Cited by 17 · see citing works
Aminated poly(L-histidine) as new pH-sensitive DNA carrier
Asayama, S. (2004) · Nucleic Acids Symposium Series · doi:10.1093/nass/48.1.229 · Cited by 13 · see citing works
Efficient splicing correction by PNA conjugation to an R6-Penetratin delivery peptide
Abes, S., Turner, J. J., Ivanova, G. D., Owen, D., Williams, D. K., Arzumanov, A. A., Clair, P., Gait, M. J., & Lebleu, B. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm1115 · Cited by 8 · see citing works
On the Gene Delivery Efficacies of pH-Sensitive Cationic Lipids via Endosomal Protonation
Singh, R. S., Gonçalves, C., Sandrin, P., Pichon, C., Midoux, P., & Chaudhuri, A. (2004) · Chemistry & Biology · doi:10.1016/j.chembiol.2004.05.006 · Cited by 1 · see citing works

Flagged first, then by citations

3 of the 151 references couldn’t be matched to a known paper.

Sorted by citations

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
Kamaly, N., Xiao, Z., Valencia, P. M., Radovic‐Moreno, A. F., & Farokhzad, O. C. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15344k · Cited by 1,734 · see citing works
Noncoding RNA therapeutics—Challenges and potential solutions
Winkle, M., El-Daly, S. M., Fabbri, M., & Calin, G. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00219-z · Cited by 1,551 · see citing works
Cell-Penetrating Peptides: From Basic Research to Clinics
Guidotti, G., Brambilla, L., & Rossi, D. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.01.003 · Cited by 1,158 · see citing works
DNA Nanotechnology-Enabled Drug Delivery Systems
Hu, Q., Li, H., Wang, L., Gu, H., & Fan, C. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00663 · Cited by 1,125 · see citing works
Multifunctional Mesoporous Silica Nanoparticles as a Universal Platform for Drug Delivery
Argyo, C., Weiß, V., Bräuchle, C., & Bein, T. (2013) · Chemistry of Materials · doi:10.1021/cm402592t · Cited by 903 · see citing works
The delivery of therapeutic oligonucleotides
Juliano, R. L. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw236 · Cited by 863 · see citing works
Cell‐penetrating peptides: 20 years later, where do we stand?
Bechara, C., & Sagan, S. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.04.031 · Cited by 859 · see citing works
Chemistry, structure and function of approved oligonucleotide therapeutics
Egli, M., & Manoharan, M. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad067 · Cited by 864 · see citing works
Antisense oligonucleotides: the next frontier for treatment of neurological disorders
Rinaldi, C., & Wood, M. J. A. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.148 · Cited by 788 · see citing works
Basics and Recent Advances in Peptide and Protein Drug Delivery
Bruno, B. J., Miller, G. D., & Lim, C. S. (2013) · Therapeutic Delivery · doi:10.4155/tde.13.104 · Cited by 760 · see citing works
Energy Transfer with Semiconductor Quantum Dot Bioconjugates: A Versatile Platform for Biosensing, Energy Harvesting, and Other Developing Applications
Hildebrandt, N., Spillmann, C. M., Algar, W. R., Pons, T., Stewart, M. H., Oh, E., Susumu, K., Dı́az, S. A., Delehanty, J. B., & Medintz, I. L. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00030 · Cited by 732 · see citing works
Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency
Li, Z., Lai, X., Fu, S., Ren, L. F., Cai, H., Zhang, H., Gu, Z., Ma, X., & Luo, K. (2022) · Advanced Science · doi:10.1002/advs.202201734 · Cited by 688 · see citing works
Self‐assembled DNA nanoclews for the efficient delivery of CRISPR–Cas9 for genome editing
Sun, W., Ji, W., Hall, J. M., Hu, Q., Wang, C., Beisel, C. L., & Gu, Z. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201506030 · Cited by 629 · see citing works
Lipids and Lipid Derivatives for RNA Delivery
Zhang, Y., Sun, C., Wang, C., Jankovic, K. E., & Dong, Y. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00244 · Cited by 638 · see citing works
Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering
Billingsley, M. M., Singh, N., Ravikumar, P., Zhang, R., June, C. H., & Mitchell, M. J. (2020) · Nano Letters · doi:10.1021/acs.nanolett.9b04246 · Cited by 636 · see citing works
Advances in COVID-19 mRNA vaccine development
Fang, E., Liu, X., Li, M., Zhang, Z., Song, L., Zhu, B., Wu, X., Liu, J., Zhao, D., & Li, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00950-y · Cited by 601 · see citing works
Therapeutic in vivo delivery of gene editing agents
Raguram, A., Banskota, S., & Liu, D. R. (2022) · Cell · doi:10.1016/j.cell.2022.03.045 · Cited by 532 · see citing works
RNAi Efficiency, Systemic Properties, and Novel Delivery Methods for Pest Insect Control: What We Know So Far
Joga, M. R., Zotti, M. J., Smagghe, G. J., & Christiaens, O. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00553 · Cited by 522 · see citing works
A vector-free microfluidic platform for intracellular delivery
Sharei, A., Zoldan, J., Adamo, A., Sim, W. Y., Cho, N., Jackson, E., Mao, S., Schneider, S., Han, M.-J., Lytton‐Jean, A. K. R., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218705110 · Cited by 497 · see citing works
Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression
Pi, F., Binzel, D. W., Lee, T. J., Li, Z., Sun, M., Rychahou, P. G., Li, H., Haque, F., Wang, S., Croce, C. M., et al. (2017) · Nature Nanotechnology · doi:10.1038/s41565-017-0012-z · Cited by 495 · see citing works
Endocytosis: The Nanoparticle and Submicron Nanocompounds Gateway into the Cell
Manzanares, D., & Ceña, V. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12040371 · Cited by 490 · see citing works
Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine
Zhang, X., Xu, X., Bertrand, N., Pridgen, E. M., Swami, A., & Farokhzad, O. C. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.005 · Cited by 494 · see citing works
MicroRNA delivery through nanoparticles
Lee, S. W. L., Paoletti, C., Campisi, M., Osaki, T., Adriani, G., Kamm, R. D., Mattu, C., & Chiono, V. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.10.007 · Cited by 443 · see citing works
Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing
Zhang, S., Shen, J., Li, D., & Cheng, Y. (2021) · Theranostics · doi:10.7150/thno.47007 · Cited by 430 · see citing works
Drug delivery to the central nervous system
Nance, E. A., Pun, S. H., Saigal, R., & Sellers, D. L. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00394-w · Cited by 423 · see citing works
Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities
Li, L., Hu, S., & Chen, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.04.031 · Cited by 415 · see citing works
The great escape: how cationic polyplexes overcome the endosomal barrier
Buś, T., Traeger, A., & Schubert, U. S. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb00967h · Cited by 411 · see citing works
Overcoming Endosomal Entrapment in Drug Delivery
Pei, D., & Buyanova, M. Y. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.8b00778 · Cited by 405 · see citing works
Biomaterials and emerging anticancer therapeutics: engineering the microenvironment
Gu, L., & Mooney, D. J. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2015.3 · Cited by 407 · see citing works
Three Valuable Peptides from Bee and Wasp Venoms for Therapeutic and Biotechnological Use: Melittin, Apamin and Mastoparan
Moreno, M. R., & Giralt, E. (2015) · Toxins · doi:10.3390/toxins7041126 · Cited by 377 · see citing works
Self-assembly of extracellular vesicle-like metal–organic framework nanoparticles for protection and intracellular delivery of biofunctional proteins
Cheng, G., Li, W., Ha, L., Han, X., Hao, S., Wan, Y., Wang, Z., Dong, F., Zou, X., Mao, Y., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b03584 · Cited by 371 · see citing works
Targeted gene silencing in vivo by platelet membrane–coated metal-organic framework nanoparticles
Zhuang, J., Gong, H., Zhou, J., Zhang, Q., Gao, W., Fang, R. H., & Zhang, L. (2020) · Science Advances · doi:10.1126/sciadv.aaz6108 · Cited by 365 · see citing works
Ex Vivo Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of Biomacromolecular Drugs
Evans, B. C., Nelson, C. E., Yu, S. S., Beavers, K. R., Kim, A. J., Li, H., Nelson, H. M., Giorgio, T. D., & Duvall, C. L. (2013) · Journal of Visualized Experiments · doi:10.3791/50166 · Cited by 356 · see citing works
Polyethylenimine (PEI) in gene therapy: Current status and clinical applications
Casper, J., Schenk, S., Parhizkar, E., Detampel, P., Dehshahri, A., & Huwyler, J. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.09.001 · Cited by 351 · see citing works
The proton sponge hypothesis: Fable or fact?
Vermeulen, L. M. P., Smedt, S. C. D., Remaut, K., & Braeckmans, K. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.05.034 · Cited by 345 · see citing works
Revisiting structure-property relationship of pH-responsive polymers for drug delivery applications
Bazban‐Shotorbani, S., Hasani‐Sadrabadi, M. M., Karkhaneh, A., Serpooshan, V., Jacob, K. I., Moshaverinia, A., & Mahmoudi, M. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.02.021 · Cited by 346 · see citing works
Intracellular delivery of nanomaterials: How to catch endosomal escape in the act
Martens, T., Remaut, K., Demeester, J., Smedt, S. C. D., & Braeckmans, K. (2014) · Nano Today · doi:10.1016/j.nantod.2014.04.011 · Cited by 341 · see citing works
<scp>pH</scp> ‐Sensitive stimulus‐responsive nanocarriers for targeted delivery of therapeutic agents
Karimi, M., Eslami, M., Sahandi‐Zangabad, P., Mirab, F., Farajisafiloo, N., Shafaei, Z., Ghosh, D., Bozorgomid, M., Dashkhaneh, F., & Hamblin, M. R. (2016) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1389 · Cited by 327 · see citing works
Acoustically Propelled Nanomotors for Intracellular siRNA Delivery
de Ávila, B. E., Angell, C., Soto, F., Lopez‐Ramirez, M. A., Báez, D. F., Xie, S., Wang, J., & Chen, Y. (2016) · ACS Nano · doi:10.1021/acsnano.6b01415 · Cited by 309 · see citing works
Challenges in design and characterization of ligand-targeted drug delivery systems
Muro, S. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.05.052 · Cited by 308 · see citing works
Nanoparticle‐mediated double‐stranded RNA delivery system: A promising approach for sustainable pest management
Yan, S., Ren, B., & Shen, J. (2020) · Insect Science · doi:10.1111/1744-7917.12822 · Cited by 307 · see citing works
Mechanisms of secretion and spreading of pathological tau protein
Brunello, C. A., Merezhko, M., Uronen, R.-L., & Huttunen, H. J. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03349-1 · Cited by 304 · see citing works
Cell-Penetrating Peptides: Design Strategies beyond Primary Structure and Amphipathicity
Kalafatović, D., & Giralt, E. (2017) · Molecules · doi:10.3390/molecules22111929 · Cited by 303 · see citing works
Biophysical insight into mechanisms of sonoporation
Helfield, B. L., Chen, X., Watkins, S. C., & Villanueva, F. S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606915113 · Cited by 301 · see citing works
Rekindling RNAi Therapy: Materials Design Requirements for In Vivo siRNA Delivery
Kim, B., Park, J., & Sailor, M. J. (2019) · Advanced Materials · doi:10.1002/adma.201903637 · Cited by 301 · see citing works
Discovery and Mechanism of Highly Efficient Cyclic Cell-Penetrating Peptides
Qian, Z., Martyna, A., Hard, R. L., Wang, J., Appiah‐Kubi, G., Coss, C. C., Phelps, M. A., Rossman, J. S., & Pei, D. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00226 · Cited by 298 · see citing works
Cell Penetrating Peptides as Molecular Carriers for Anti-Cancer Agents
Borrelli, A., Tornesello, A. L., Tornesello, M. L., & Buonaguro, F. M. (2018) · Molecules · doi:10.3390/molecules23020295 · Cited by 296 · see citing works
Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics
Huang, Y. (2016) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2016.12.003 · Cited by 295 · see citing works
RNAi therapeutic and its innovative biotechnological evolution
Weng, Y., Xiao, H., Zhang, J., Liang, X., & Huang, Y. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.04.012 · Cited by 288 · see citing works
Going beyond the liver: progress and challenges of targeted delivery of siRNA therapeutics
Lorenzer, C., Dirin, M., Winkler, A.-M., Baumann, V., & Winkler, J. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.02.003 · Cited by 284 · see citing works
“The endocytic vessels fuse with endosomes, and for successfully attaining the siRNA machinery, the oligonucleotides still have to pass through this last barrier [72,73].”
Background
Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates
Brown, C. R., Gupta, S., Qin, J., Racie, T., He, G., Lentini, S., Malone, R., Yu, M., Matsuda, S., Shulga-Morskaya, S., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa670 · Cited by 285 · see citing works
Nanoescapology: progress toward understanding the endosomal escape of polymeric nanoparticles
FitzGerald, L. I., Cortez‐Jugo, C., Such, G. K., & Johnston, A. P. R. (2017) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1452 · Cited by 285 · see citing works
Magnetic Nanoparticles in Targeted Drug Delivery: a Review
Kianfar, E. (2021) · Journal of Superconductivity and Novel Magnetism · doi:10.1007/s10948-021-05932-9 · Cited by 286 · see citing works
Influencing factors and strategies of enhancing nanoparticles into tumors in vivo
Zhang, M., Gao, S., Yang, D., Fang, Y., Lin, X., Jin, X., Liu, Y., Liu, X., Su, K., & Shi, K. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.033 · Cited by 277 · see citing works
Organelle targeting: third level of drug targeting
Padh, H., & Sakhrani, N. (2013) · Drug Design Development and Therapy · doi:10.2147/dddt.s45614 · Cited by 271 · see citing works
Multifunctional Efficiency: Extending the Concept of Atom Economy to Functional Nanomaterials
Freund, R., Lächelt, U., Gruber, T., Rühle, B., & Wuttke, S. (2018) · ACS Nano · doi:10.1021/acsnano.8b00932 · Cited by 263 · see citing works
Exocytosis of nanoparticles from cells: Role in cellular retention and toxicity
Sakhtianchi, R., Minchin, R. F., Lee, K., Alkilany, A. M., Serpooshan, V., & Mahmoudi, M. (2013) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2013.10.013 · Cited by 262 · see citing works
Challenges in design of translational nanocarriers
Sun, Q., Radosz, M., & Shen, Y. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.05.042 · Cited by 260 · see citing works
Theoretical and Computational Investigations of Nanoparticle–Biomembrane Interactions in Cellular Delivery
Ding, H., & Ma, Y. (2014) · Small · doi:10.1002/smll.201401943 · Cited by 259 · see citing works
Non-viral Delivery of Nucleic Acids: Insight Into Mechanisms of Overcoming Intracellular Barriers
Durymanov, M. O., & Reineke, J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00971 · Cited by 258 · see citing works
Overcoming Barriers for siRNA Therapeutics: From Bench to Bedside
Sajid, M. I., Moazzam, M., Kato, S., Cho, K. Y., & Tiwari, R. K. (2020) · Pharmaceuticals · doi:10.3390/ph13100294 · Cited by 259 · see citing works
Multifunctional carbon dots with high quantum yield for imaging and gene delivery
Hu, L., Sun, Y., Li, S., Wang, X., Hu, K., Wang, L., Liang, X., & Wu, Y. F. (2013) · Carbon · doi:10.1016/j.carbon.2013.10.023 · Cited by 253 · see citing works
Boosting intracellular delivery of lipid nanoparticle-encapsulated mRNA
Patel, S., Ashwanikumar, N., Robinson, E., DuRoss, A., Sun, C., Murphy-Benenato, K. E., Mihai, C., Almarsson, Ö., & Sahay, G. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b02664 · Cited by 251 · see citing works
Different strategies to overcome multidrug resistance in cancer
Manju, S., & Gong, S. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.06.004 · Cited by 250 · see citing works
Orchestrating immune responses: How size, shape and rigidity affect the immunogenicity of particulate vaccines
Benne, N., van Duijn, J., Kuiper, J., Jiskoot, W., & Slütter, B. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.033 · Cited by 247 · see citing works
Engineering siRNA therapeutics: challenges and strategies
Zaidi, S. S. A., Fatima, F., Zaidi, S. A. A., Zhou, D., Deng, W., & Liu, S. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02147-z · Cited by 266 · see citing works
Recent advances on thermosensitive and pH-sensitive liposomes employed in controlled release
Aghdam, M. A., Bagheri, R., Mosafer, J., Baradaran, B., Hashemzaei, M., Baghbanzadeh, A., de la Guárdia, M., & Mokhtarzadeh, A. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.09.018 · Cited by 242 · see citing works
A mesoporous silica nanoparticle – PEI – Fusogenic peptide system for siRNA delivery in cancer therapy
Xu, L., Chen, Y., Wang, M., Ma, Y., Xia, W., & Gu, H. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.10.072 · Cited by 237 · see citing works
Enhanced Endosomal Escape by Light-Fueled Liquid-Metal Transformer
Lü, Y., Lin, Y., Chen, Z., Hu, Q., Liu, Y., Yu, S., Gao, W., Dickey, M. D., & Gu, Z. (2017) · Nano Letters · doi:10.1021/acs.nanolett.6b04346 · Cited by 239 · see citing works
Overcoming Endosomal Barrier by Amphotericin B-Loaded Dual pH-Responsive PDMA-b-PDPA Micelleplexes for siRNA Delivery
Yu, H., Zou, Y., Wang, Y., Huang, X., Huang, G., Sumer, B. D., Boothman, D. A., & Gao, J. (2011) · ACS Nano · doi:10.1021/nn203503h · Cited by 237 · see citing works
Mesoporous silica nanoparticles: Synthesis, pharmaceutical applications, biodistribution, and biosafety assessment
Farjadian, F., Roointan, A., Mohammadi‐Samani, S., & Hosseini, M. H. (2018) · Chemical Engineering Journal · doi:10.1016/j.cej.2018.11.156 · Cited by 240 · see citing works
Cancer-Cell-Membrane-Coated Nanoparticles with a Yolk–Shell Structure Augment Cancer Chemotherapy
Nie, D., Dai, Z., Li, J., Yang, Y., Xi, Z., Wang, J., Zhang, W., Qian, K., Guo, S., Zhu, C., et al. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b03817 · Cited by 231 · see citing works
Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting
Perche, F., & Torchilin, V. P. (2013) · Journal of Drug Delivery · doi:10.1155/2013/705265 · Cited by 232 · see citing works
Lipid and Polymer-Based Nanoparticle siRNA Delivery Systems for Cancer Therapy
Mainini, F., & Eccles, M. R. (2020) · Molecules · doi:10.3390/molecules25112692 · Cited by 225 · see citing works
pH-sensitive polymeric micelles triggered drug release for extracellular and intracellular drug targeting delivery
Liu, Y., Wang, W., Yang, J., Zhou, C., & Sun, J. (2013) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2013.07.021 · Cited by 224 · see citing works
Current Development of siRNA Bioconjugates: From Research to the Clinic
Chernikov, I. V., Vlassov, V. V., & Chernolovskaya, E. L. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00444 · Cited by 216 · see citing works
Nanoparticles Modified with Cell-Penetrating Peptides: Conjugation Mechanisms, Physicochemical Properties, and Application in Cancer Diagnosis and Therapy
Gessner, I., & Neundorf, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072536 · Cited by 212 · see citing works
Endosomal Size and Membrane Leakiness Influence Proton Sponge-Based Rupture of Endosomal Vesicles
Vermeulen, L. M. P., Brans, T., Samal, S. K., Dubruel, P., Demeester, J., Smedt, S. C. D., Remaut, K., & Braeckmans, K. (2018) · ACS Nano · doi:10.1021/acsnano.7b07583 · Cited by 216 · see citing works
Delivery of CRISPR/Cas systems for cancer gene therapy and immunotherapy
Song, X., Liu, C., Wang, N., Huang, H., He, S., Gong, C., & Wei, Y. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.04.010 · Cited by 214 · see citing works
A review of the current status of siRNA nanomedicines in the treatment of cancer
Resnier, P., Montier, T., Mathieu, V., Benoît, J., & Passirani, C. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.04.060 · Cited by 210 · see citing works
Polymeric delivery systems for nucleic acid therapeutics: Approaching the clinic
van den Berg, A. I. S., Yun, C., Schiffelers, R. M., & Hennink, W. E. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.01.014 · Cited by 209 · see citing works
Reversal of multidrug resistance by co-delivery of paclitaxel and lonidamine using a TPGS and hyaluronic acid dual-functionalized liposome for cancer treatment
ASSANHOU, A. G., Li, W., Zhang, L., Xue, L., Kong, L., Sun, H., Mo, R., & Zhang, C. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.09.022 · Cited by 208 · see citing works
Targeted therapy for cancer using pH-responsive nanocarrier systems
Manchun, S., Dass, C. R., & Sriamornsak, P. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.01.008 · Cited by 208 · see citing works
Multi-functionalized carbon dots as theranostic nanoagent for gene delivery in lung cancer therapy
Wu, Y., Wu, H., Kuan, C., Lin, C.-J., Wang, L.-W., Chang, C., & Wang, T. (2016) · Scientific Reports · doi:10.1038/srep21170 · Cited by 208 · see citing works
Targeting the hard to reach: challenges and novel strategies in the treatment of intracellular bacterial infections
Kamaruzzaman, N. F., Kendall, S. L., & Good, L. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13664 · Cited by 202 · see citing works
Protein delivery into cells using inorganic nanoparticle–protein supramolecular assemblies
Scaletti, F., Hardie, J., Lee, Y.-W., Luther, D. C., Ray, M., & Rotello, V. M. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00008e · Cited by 208 · see citing works
Recent Advances in Nanostrategies Capable of Overcoming Biological Barriers for Tumor Management
Huo, D., Jiang, X., & Hu, Y. (2019) · Advanced Materials · doi:10.1002/adma.201904337 · Cited by 206 · see citing works
Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and Challenges
Zhou, J., Shum, K., Burnett, J., & Rossi, J. J. (2013) · Pharmaceuticals · doi:10.3390/ph6010085 · Cited by 206 · see citing works
Theoretical and computational studies of dendrimers as delivery vectors
Tian, W., & Ma, Y. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35306g · Cited by 204 · see citing works
Challenges in DNA Delivery and Recent Advances in Multifunctional Polymeric DNA Delivery Systems
Shi, B., Zheng, M., Tao, W., Chung, R. S., Jin, D., Ghaffari, D., & Farokhzad, O. C. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b00803 · Cited by 202 · see citing works
The new era of nanotechnology, an alternative to change cancer treatment
Jurj, A. M., Braicu, C., Pop, L., Tomuleasa, C., Gherman, C. D., & Berindan‐Neagoe, I. (2017) · Drug Design Development and Therapy · doi:10.2147/dddt.s142337 · Cited by 201 · see citing works
(Macro)molecular self-assembly for hydrogel drug delivery
Webber, M. J., & Pashuck, E. T. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.01.006 · Cited by 202 · see citing works
Comparison of Gold Nanoparticle Mediated Photoporation: Vapor Nanobubbles Outperform Direct Heating for Delivering Macromolecules in Live Cells
Xiong, R., Raemdonck, K., Peynshaert, K., Lentacker, I., Cock, I. D., Demeester, J., Smedt, S. C. D., Skirtach, A. G., & Braeckmans, K. (2014) · ACS Nano · doi:10.1021/nn5017742 · Cited by 195 · see citing works
Cyclic Peptides as Drugs for Intracellular Targets: The Next Frontier in Peptide Therapeutic Development
Buckton, L. K., Rahimi, M. N., & McAlpine, S. R. (2020) · Chemistry - A European Journal · doi:10.1002/chem.201905385 · Cited by 194 · see citing works
Single‐Layered MoS2–PEI–PEG Nanocomposite‐Mediated Gene Delivery Controlled by Photo and Redox Stimuli
Kim, J., Kim, H., & Kim, W. J. (2015) · Small · doi:10.1002/smll.201501655 · Cited by 194 · see citing works
Merging the best of both worlds: hybrid lipid-enveloped matrix nanocomposites in drug delivery
Raemdonck, K., Braeckmans, K., Demeester, J., & Smedt, S. C. D. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60299k · Cited by 190 · see citing works
Peptide-based strategies for enhanced cell uptake, transcellular transport, and circulation: Mechanisms and challenges
Komin, A., Russell, L. M., Hristova, K. A., & Searson, P. C. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.06.002 · Cited by 189 · see citing works
Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery
Alabi, C. A., Love, K. T., Sahay, G., Yin, H., Luly, K. M., Langer, R., & Anderson, D. G. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306529110 · Cited by 188 · see citing works
Nanoparticles: Cellular Uptake and Cytotoxicity
Adjei, I. M., Sharma, B., & Labhasetwar, V. D. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-94-017-8739-0_5 · Cited by 186 · see citing works
Applications and challenges of ultra-small particle size nanoparticles in tumor therapy
Xu, J., Song, M., Zhou, F., Zheng, L., Huang, X., & Liu, K. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.12.028 · Cited by 186 · see citing works

Endosomal Escape: A Bottleneck in Intracellular Delivery
Shete, H. K., Prabhu, R. H., & Patravale, V. B. (2014) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2014.9082 · Cited by 193 · see citing works
Overcoming Endosomal Entrapment in Drug Delivery
Pei, D., & Buyanova, M. Y. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.8b00778 · Cited by 405 · see citing works
The Biology of Endosomal Escape: Strategies for Enhanced Delivery of Therapeutics
Chahal, G., Helbig, K. J., Parton, R. G., & Monson, E. A. (2026) · ACS Nano · doi:10.1021/acsnano.5c18112 · Cited by 76 · see citing works
Strategies in the design of endosomolytic agents for facilitating endosomal escape in nanoparticles
Ahmad, A., Khan, J. M., & Haque, S. (2019) · Biochimie · doi:10.1016/j.biochi.2019.02.012 · Cited by 153 · see citing works
Enhancing Targeted Drug Delivery through Cell‐Specific Endosomal Escape
Chen, P., & Cabral, H. (2024) · ChemMedChem · doi:10.1002/cmdc.202400274 · Cited by 21 · see citing works

Authors: Varkouhi, A. K., Scholte, M., Storm, G., & Haisma, H. J.
Affiliations: Utrecht University (NL)
University of Groningen (NL)
Corresponding author: Haisma, Hidde J.
ORCID: Varkouhi, Amir K.
Storm, Gert
Haisma, Hidde J.
Venue: Journal of Controlled Release
Publisher: Elsevier BV
Published: 2011-05
Volume: 151
Issue: 3
Pages: 220-228
ISSN: 0168-3659 (ISSN-L)
DOI: 10.1016/j.jconrel.2010.11.004
OpenAlex: W2008028087
Cited by: 1,561
References: 151
Citations by year: 2026: 82 · 2025: 82 · 2024: 90 · 2023: 94 · 2022: 122 · 2021: 100 · 2020: 123 · 2019: 120 · 2018: 137 · 2017: 111 · 2016: 127 · 2015: 116 · 2014: 98 · 2013: 90 · 2012: 51
FWCI: 4.32
Type: journal article
Language: en
Open access: green
research.wur.nl
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Controlled Release (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: European Commission
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: endosomal escape, endocytosis, lysosomal degradation, protein delivery, gene delivery, siRNA delivery, viral fusion, pH buffering, biomimetic peptides, polymers, biologic therapy
MeSH terms: Animals, Cytosol, DNA, Drug Carriers, Endocytosis, Humans, Intracellular Membranes, Membrane Fusion, Models, Biological, Proteins, Endosomes, RNA, Small Interfering

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Endosomal escape pathways for delivery of biologicals

Abstract

Integrity signals

Claims the paper makes

Self-check

Cites

Cited by

Related

Record

About these checks