The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
High Contrast in Vitro and in Vivo Photoluminescence Bioimaging Using Near Infrared to Near Infrared Up-Conversion in Tm3+ and Yb3+ Doped Fluoride Nanophosphors
Open accessAbstract
A new approach for photoluminescence imaging in vitro and in vivo has been shown utilizing near infrared to near infrared (NIR-to-NIR) up-conversion in nanophosphors. This NIR-to-NIR up-conversion process provides deeper light penetration into biological specimen and results in high contrast optical imaging due to absence of an autofluorescence background and decreased light scattering. Aqueous dispersible fluoride (NaYF4) nanocrystals (20-30 nm size) co-doped with the rare earth ions, Tm(3+) and Yb(3+), were synthesized and characterized by TEM, XRD, and photoluminescence (PL) spectroscopy. In vitro cellular uptake was shown by the PL microscopy visualizing the characteristic emission of Tm(3+) at approximately 800 nm excited with 975 nm. No apparent cytotoxicity was observed. Subsequent animal imaging studies were performed using Balb-c mice injected intravenously with up-converting nanophosphors, demonstrating the high contrast PL imaging in vivo.
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A clearer vision for in vivo imaging
Weissleder, R. (2001) · Nature Biotechnology · doi:10.1038/86684 · Cited by 3,839
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Chen, G., Ohulchanskyy, T. Y., Kumar, R., Ågren, H., & Prasad, P. N. (2010) · ACS Nano · doi:10.1021/nn100457j · Cited by 632
Self-citationCheng, L., Yang, K., Li, Y., Zeng, X., Shao, M., Lee, S.-T., & Liu, Z. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.11.069 · Cited by 386
Liu, K., Liu, X., Zeng, Q., Zhang, Y., Tu, L., Liu, T., Kong, X., Wang, Y., Cao, F., Lambrechts, S. A. G., et al. (2012) · ACS Nano · doi:10.1021/nn300436b · Cited by 382
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Rocha, U., Jacinto da Silva, C., Ferreira Silva, W., Guedes, I., Benayas, A., Martínez Maestro, L., Acosta Elias, M., Bovero, E., van Veggel, F. C. J. M., García Solé, J. A., et al. (2013) · ACS Nano · doi:10.1021/nn304373q · Cited by 382
Metadata
- Authors
- Nyk, M., Kumar, R., Ohulchanskyy, T. Y., Bergey, E. J., & Prasad, P. N.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-10-18
- Volume
- 8
- Issue
- 11
- Pages
- 3834-3838
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W1994460217
- Cited by
- 905
- References
- 1
- FWCI
- 28.80
- Type
- journal article
- Language
- en
- Open access
- green
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