The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Graphene-Based Single-Bacterium Resolution Biodevice and DNA Transistor: Interfacing Graphene Derivatives with Nanoscale and Microscale Biocomponents
Abstract
Establishing "large-contact-area" interfaces of sensitive nanostructures with microbes and mammalian cells will lead to the development of valuable tools and devices for biodiagnostics and biomedicine. Chemically modified graphene (CMG) nanostructures with their microscale area, sensitive electrical properties, and modifiable chemical functionality are excellent candidates for such biodevices at both biocellular and biomolecular scale. Here, we report on the fabrication and functioning of a novel CMG-based (i) single-bacterium biodevice, (ii) label-free DNA sensor, and (iii) bacterial DNA/protein and polyelectrolyte chemical transistor. The bacteria biodevice was highly sensitive with a single-bacterium attachment generating approximately 1400 charge carriers in a p-type CMG. Similarly, single-stranded DNA tethered on graphene hybridizes with its complementary DNA strand to reversibly increase the hole density by 5.61 x 1012 cm(-2). We further demonstrate (a) a control on the device sensitivity by manipulating surface groups, (b) switching of polarity specificity by changing surface polarity, and (c) a preferential attachment of DNA on thicker CMG surfaces and sharp CMG wrinkles.
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Cites
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Cited by
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Metadata
- Authors
- Mohanty, N., & Berry, V.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-11-05
- Volume
- 8
- Issue
- 12
- Pages
- 4469-4476
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2147290521
- Cited by
- 1,208
- References
- 38
- FWCI
- 41.09
- Type
- journal article
- Language
- en
- Open access
- closed
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