Fluorescent, Superparamagnetic Nanospheres for Drug Storage, Targeting, and Imaging: A Multifunctional Nanocarrier System for Cancer Diagnosis and Treatment
Abstract
For early cancer diagnosis and treatment, a nanocarrier system is designed and developed with key components uniquely structured at nanoscale according to medical requirements. For imaging, quantum dots with emissions in the near-infrared range (∼800 nm) are conjugated onto the surface of a nanocomposite consisting of a spherical polystyrene matrix (∼150 nm) and the internally embedded, high fraction of superparamagnetic Fe(3)O(4) nanoparticles (∼10 nm). For drug storage, the chemotherapeutic agent paclitaxel (PTX) is loaded onto the surfaces of these composite multifunctional nanocarriers by using a layer of biodegradable poly(lactic-co-glycolic acid) (PLGA). A cell-based cytotoxicity assay is employed to verify successful loading of pharmacologically active drug. Cell viability of human, metastatic PC3mm2 prostate cancer cells is assessed in the presence and absence of various multifunctional nanocarrier populations using the MTT assay. PTX-loaded composite nanocarriers are synthesized by conjugating anti-prostate specific membrane antigen (anti-PSMA) for targeting. Specific detection studies of anti-PSMA-conjugated nanocarrier binding activity in LNCaP prostate cancer cells are carried out. LNCaP cells are targeted successfully in vitro by the conjugation of anti-PSMA on the nanocarrier surfaces. To further explore targeting, the nanocarriers conjugated with anti-PSMA are intravenously injected into tumor-bearing nude mice. Substantial differences in fluorescent signals are observed ex vivo between tumor regions treated with the targeted nanocarrier system and the nontargeted nanocarrier system, indicating considerable targeting effects due to anti-PSMA functionalization of the nanocarriers.
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The composite nanoparticles were successfully targeted to the LNCaP cells with the targeted receptor PSMA and the tumor area in vivo and in vitro.
“The composite nanoparticles were successfully targeted to the LNCaP cells with the targeted receptor PSMA and the tumor area in vivo and in vitro.208”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [208]
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- Authors
- Cho, H.-S., Dong, Z., Pauletti, G. M., Zhang, J., Xu, H., Gu, H., Wang, L., Ewing, R. C., Huth, C., Wang, F., & Shi, D.
- Affiliations
- School of Energy, Environmental, Biological and Medical Engineering, University of Cincinnati, Cincinnati, Ohio 45221
- University of Cincinnati (US)
- University of Michigan (US)
- Shanghai Jiao Tong University (CN)
- Tongji University (CN)
- Corresponding author
- Shi, Donglu
- ORCID
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-08-13
- Volume
- 4
- Issue
- 9
- Pages
- 5398-5404
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2049288031
- Cited by
- 265
- References
- 30
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 5 · 2021: 10 · 2020: 13 · 2019: 11 · 2018: 11 · 2017: 21 · 2016: 20 · 2015: 19 · 2014: 23 · 2013: 43 · 2012: 32
- FWCI
- 13.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- multifunctional nanocarriers, superparamagnetic iron oxide nanoparticles, quantum dots, near-infrared fluorescence imaging, PLGA coating, prostate-specific membrane antigen, targeted cancer therapy, prostate cancer, tumor targeting, polystyrene nanospheres, cancer diagnosis
- MeSH terms
- Polylactic Acid-Polyglycolic Acid Copolymer, Animals, Cell Transformation, Neoplastic, Drug Carriers, Fluorescent Dyes, Humans, Male, Polyglycolic Acid, Prostatic Neoplasms, Paclitaxel, Lactic Acid, Quantum Dots, Cell Line, Tumor, Nanomedicine, Mice, Molecular Imaging, Magnetite Nanoparticles
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