The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Gold Nanoparticles Promote Osteogenic Differentiation of Mesenchymal Stem Cells through p38 MAPK Pathway
Abstract
Understanding the interaction mechanisms between nanomaterials and biological cells is important for the control and manipulation of these interactions for biomedical applications. In this study, we investigated the cellular effects of gold nanoparticles (AuNPs) on the differentiation of mesenchymal stem cells (MSCs) and the associated molecular mechanisms. The results showed that AuNPs promoted the differentiation of MSCs toward osteoblast cells over adipocyte cells by inducing an enhanced osteogenic transcriptional profile and an attenuated adipogenic transcriptional profile. AuNPs exerted the effects by interacting with the cell membrane and binding with proteins in the cytoplasm, causing mechanical stress on the MSCs to activate p38 mitogen-activated protein kinase pathway (MAPK) signaling pathway, which regulates the expression of relevant genes to induce osteogenic differentiation and inhibit adipogenic differentiation.
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1 retracted
RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow
Jiang, Y., Jahagirdar, B. N., Reinhardt, R. L., Schwartz, R. E., Keene, C. D., Ortiz-Gonzalez, X. R., Reyes, M., Lenvik, T., Lund, T., Blackstad, M., et al. (2002) · Nature · doi:10.1038/nature00870 · Cited by 5,518
RetractedMultilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Mammalian MAP kinase signalling cascades
Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,111
How Matrix Metalloproteinases Regulate Cell Behavior
Sternlicht, M. D., & Werb, Z. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.463 · Cited by 3,959
Carmichael, J., DeGraff, W., Gazdar, A. F., Minna, J. D., & Mitchell, J. B. (1987) · PubMed · Cited by 3,813
Growth Factors, Matrices, and Forces Combine and Control Stem Cells
Discher, D. E., Mooney, D. J., & Zandstra, P. W. (2009) · Science · doi:10.1126/science.1171643 · Cited by 2,667
The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder
Dalby, M. J., Gadegaard, N., Tare, R., Andar, A., Riehle, M. O., Herzyk, P., Wilkinson, C. D. W., & Oreffo, R. O. C. (2007) · Nature Materials · doi:10.1038/nmat2013 · Cited by 2,416
STEIN, G. S., & LIAN, J. B. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-4-424 · Cited by 1,078
Stem cells in tissue engineering
Bianco, P., & Robey, P. G. (2001) · Nature · doi:10.1038/35102181 · Cited by 965
Sekiya, I., Larson, B. L., Smith, J. R., Pochampally, R., Cui, J., & Prockop, D. J. (2002) · STEM CELLS · doi:10.1634/stemcells.20-6-530 · Cited by 943
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Origin of Enhanced Stem Cell Growth and Differentiation on Graphene and Graphene Oxide
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Current Advances in Immunomodulatory Biomaterials for Bone Regeneration
Lee, J., Byun, H., Madhurakkat Perikamana, S. K., Lee, S., & Shin, H. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801106 · Cited by 452
Lin, H., Sohn, J., Shen, H., Langhans, M. T., & Tuan, R. S. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.06.026 · Cited by 445
When stem cells meet graphene: Opportunities and challenges in regenerative medicine
Kenry, Lee, W. C., Loh, K. P., & Lim, C. T. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2017.10.004 · Cited by 293
Gelatin methacryloyl hydrogel, from standardization, performance, to biomedical application
He, J., Sun, Y., Gao, Q., He, C., Yao, K., Wang, T., Xie, M., Yu, K., Nie, J., Chen, Y., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300395 · Cited by 275
Metadata
- Authors
- Yi, C., Liu, D., Fong, C.-C., Zhang, J., & Yang, M.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-10-28
- Volume
- 4
- Issue
- 11
- Pages
- 6439-6448
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2024936019
- Cited by
- 440
- References
- 59
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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