The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Dual-Surface Modified Virus Capsids for Targeted Delivery of Photodynamic Agents to Cancer Cells
Abstract
Bacteriophage MS2 was used to construct a targeted, multivalent photodynamic therapy vehicle for the treatment of Jurkat leukemia T cells. The self-assembling spherical virus capsid was modified on the interior surface with up to 180 porphyrins capable of generating cytotoxic singlet oxygen upon illumination. The exterior of the capsid was modified with ∼20 copies of a Jurkat-specific aptamer using an oxidative coupling reaction targeting an unnatural amino acid. The capsids were able to target and selectively kill more than 76% of the Jurkat cells after only 20 min of illumination. Capsids modified with a control DNA strand did not target Jurkat cells, and capsids modified with the aptamer were found to be specific for Jurkat cells over U266 cells (a control B cell line). The doubly modified capsids were also able to kill Jurkat cells selectively even when mixed with erythrocytes, suggesting the possibility of using our system to target blood-borne cancers or other pathogens in the blood supply.
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Cites
In vivo imaging of siRNA delivery and silencing in tumors
Medarova, Z., Pham, W., Farrar, C., Petkova, V., & Moore, A. (2007) · Nature Medicine · doi:10.1038/nm1486 · Cited by 697
Polyester Dendritic Systems for Drug Delivery Applications: In Vitro and In Vivo Evaluation
Padilla De Jesús, O. L., Ihre, H. R., Gagne, L., Fréchet, J. M. J., & Szoka, F. C. (2002) · Bioconjugate Chemistry · doi:10.1021/bc010103m · Cited by 507
The three-dimensional structure of the bacterial virus MS2
Valegård, K., Liljas, L., Fridborg, K., & Unge, T. (1990) · Nature · doi:10.1038/345036a0 · Cited by 411
A chemical toolkit for proteins — an expanded genetic code
Xie, J., & Schultz, P. G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2005 · Cited by 408
Cited by
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy
Zhou, Z., Song, J., Nie, L., & Chen, X. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00271d · Cited by 2,098
Aptamer-based targeted therapy
Zhu, G., & Chen, X. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.08.005 · Cited by 522
One-step site-specific modification of native proteins with 2-pyridinecarboxyaldehydes
MacDonald, J. I., Munch, H. K., Moore, T., & Francis, M. B. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1792 · Cited by 317
Self-citationAptamer-guided nanomedicines for anticancer drug delivery
Alshaer, W., Hillaireau, H., & Fattal, E. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.09.011 · Cited by 187
Bacteriophages as Solid Tumor Theragnostic Agents
Veeranarayanan, S., Azam, A. H., Kiga, K., Watanabe, S., & Cui, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010402 · Cited by 39
Metadata
- Authors
- Stephanopoulos, N., Tong, G. J., Hsiao, S. C., & Francis, M. B.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-09-23
- Volume
- 4
- Issue
- 10
- Pages
- 6014-6020
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2332714309
- Cited by
- 211
- References
- 4
- FWCI
- 12.05
- Type
- journal article
- Language
- en
- Open access
- closed
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