Cited by 187Nanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniques

Aptamer-guided nanomedicines for anticancer drug delivery

Alshaer, Walhan, Hillaireau, Hervé, Fattal, Elias·2018·Advanced Drug Delivery Reviews

Abstract

Aptamers are versatile nucleic acid-based macromolecules characterized by their high affinity and specificity to a specific target. Taking advantage of such binding properties, several aptamers have been selected to bind tumor biomarkers and have been used as targeting ligands for the functionalization of nanomedicines. Different functionalization methods have been used to link aptamers to the surface drug nanocarriers. The pre-clinical data of such nanomedicines overall show an enhanced and selective delivery of therapeutic payloads to cancer cells, thereby accelerating steps towards more effective therapeutic systems. This review describes the current advances in the use of aptamers as targeting moieties for the delivery of therapeutic and imaging agents to tumors by conjugation to organic and inorganic nanocarriers.

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Crossref · 10.1016/j.addr.2018.09.011

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171 of 171 references verified0 citation errors · 0 not checkable

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Authors
Alshaer, W., Hillaireau, H., & Fattal, E.
Affiliations
  • University of Jordan (JO)
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
Hillaireau, Hervé
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2018-09
Volume
134
Pages
122-137
ISSN
0169-409X (ISSN-L)
OpenAlex
W2892586379
Cited by
187
References
171
Citations by year
2026: 7 · 2025: 21 · 2024: 24 · 2023: 23 · 2022: 35 · 2021: 29 · 2020: 29 · 2019: 14 · 2018: 4
FWCI
1.27
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
Keywords
aptamers, nanomedicine, anticancer drug delivery, tumor targeting, tumor markers, aptamer conjugation, nanocarriers, targeted drug delivery, imaging agents, nucleic acid therapeutics
MeSH terms
Antineoplastic Agents, Drug Carriers, Humans, Ligands, Neoplasms, Drug Delivery Systems, Nanomedicine, Aptamers, Nucleotide, Nanoparticles

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