Aptamer-guided nanomedicines for anticancer drug delivery
Abstract
Aptamers are versatile nucleic acid-based macromolecules characterized by their high affinity and specificity to a specific target. Taking advantage of such binding properties, several aptamers have been selected to bind tumor biomarkers and have been used as targeting ligands for the functionalization of nanomedicines. Different functionalization methods have been used to link aptamers to the surface drug nanocarriers. The pre-clinical data of such nanomedicines overall show an enhanced and selective delivery of therapeutic payloads to cancer cells, thereby accelerating steps towards more effective therapeutic systems. This review describes the current advances in the use of aptamers as targeting moieties for the delivery of therapeutic and imaging agents to tumors by conjugation to organic and inorganic nanocarriers.
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Aptamers can specifically recognize various targets.
“Aptamers, also called “chemical antibodies”, are short DNA/RNA oligonucleotides and selected by SELEX technology based on nucleic acid libraries, which can specifically recognize various targets.45,46”
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Liposomes: Structure, composition, types, and clinical applications
Nsairat, H., Khater, D., Sayed, U., Odeh, F., Al Bawab, A., & Alshaer, W. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09394 · Cited by 1,561 · see citing works
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Biotin-decorated all-HPMA polymeric micelles for paclitaxel delivery
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Samani, R. K., Tavakoli, M. B., Maghsoudinia, F., Motaghi, H., Hejazi, S. H., & Mehrgardi, M. A. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105487 · Cited by 40 · see citing works
- Authors
- Alshaer, W., Hillaireau, H., & Fattal, E.
- Affiliations
- University of Jordan (JO)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Hillaireau, Hervé
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 134
- Pages
- 122-137
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2892586379
- Cited by
- 187
- References
- 171
- Citations by year
- 2026: 7 · 2025: 21 · 2024: 24 · 2023: 23 · 2022: 35 · 2021: 29 · 2020: 29 · 2019: 14 · 2018: 4
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Keywords
- aptamers, nanomedicine, anticancer drug delivery, tumor targeting, tumor markers, aptamer conjugation, nanocarriers, targeted drug delivery, imaging agents, nucleic acid therapeutics
- MeSH terms
- Antineoplastic Agents, Drug Carriers, Humans, Ligands, Neoplasms, Drug Delivery Systems, Nanomedicine, Aptamers, Nucleotide, Nanoparticles
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