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Impact of Silica Nanoparticle Design on Cellular Toxicity and Hemolytic Activity
Open accessAbstract
Understanding the toxicity of silica nanoparticles (SiO(2)) on the cellular level is crucial for rational design of these nanomaterials for biomedical applications. Herein, we explore the impacts of geometry, porosity, and surface charge of SiO(2) on cellular toxicity and hemolytic activity. Nonporous Stöber silica nanospheres (115 nm diameter), mesoporous silica nanospheres (120 nm diameter, aspect ratio 1), mesoporous silica nanorods with aspect ratio of 2, 4, and 8 (width by length 80 × 200 nm, 150 × 600 nm, 130 × 1000 nm), and their cationic counterparts were evaluated on macrophages, lung carcinoma cells, and human erythrocytes. It was shown that the toxicity of SiO(2) is cell-type dependent and that surface charge and pore size govern cellular toxicity. Using inductively coupled plasma mass spectrometry, the cellular association of SiO(2) was quantitated with the association amount increasing in the following order: mesoporous SiO(2) (aspect ratio 1, 2, 4, 8) < amine-modified mesoporous SiO(2) (aspect ratio 1, 2, 4, 8) < amine-modified nonporous Stöber SiO(2) < nonporous Stöber SiO(2). Geometry did not seem to influence the extent of SiO(2) association at early or extended time points. The level of cellular association of the nanoparticles was directly linked to the extent of plasma membrane damage, suggesting a biological cause-and-effect relationship. Hemolysis assay showed that the hemolytic activity was porosity- and geometry-dependent for bare SiO(2) and surface-charge-dependent for amine-modified SiO(2). A good correlation between hemolytic activity and cellular association was found on a similar dosage basis. These results can provide useful guidelines for the rational design of SiO(2) in nanomedicine.
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Cites
The effect of particle design on cellular internalization pathways
Gratton, S. E. A., Ropp, P. A., Pohlhaus, P. D., Luft, J. C., Madden, V. J., Napier, M. E., & DeSimone, J. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801763105 · Cited by 2,918
Cao, S.-W., & Zhu, Y.-J. (2010) · Nanoscale Research Letters · doi:10.1007/s11671-010-9742-7 · Cited by 2,357
Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery
Liong, M., Lu, J., Kovochich, M., Xia, T., Ruehm, S. G., Nel, A. E., Tamanoi, F., & Zink, J. I. (2008) · ACS Nano · doi:10.1021/nn800072t · Cited by 1,929
Analysis of apoptosis by propidium iodide staining and flow cytometry
Riccardi, C., & Nicoletti, I. (2006) · Nature Protocols · doi:10.1038/nprot.2006.238 · Cited by 1,685
Lu, J., Liong, M., Li, Z., Zink, J. I., & Tamanoi, F. (2010) · Small · doi:10.1002/smll.201000538 · Cited by 1,074
Size Effect on Cell Uptake in Well‐Suspended, Uniform Mesoporous Silica Nanoparticles
Lu, F., Wu, S., Hung, Y., & Mou, C. (2009) · Small · doi:10.1002/smll.200900005 · Cited by 1,041
Dobrovolskaia, M. A., Aggarwal, P., Hall, J. B., & McNeil, S. E. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800032f · Cited by 1,022
Mesoporous Silica Nanoparticles for Intracellular Controlled Drug Delivery
Vivero‐Escoto, J. L., Slowing, I. I., Trewyn, B. G., & Lin, V. S. ‐. (2010) · Small · doi:10.1002/smll.200901789 · Cited by 998
Giri, S., Trewyn, B. G., Stellmaker, M. P., & Lin, V. S. ‐. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200501819 · Cited by 997
Silica Particles: A Novel Drug‐Delivery System
Barbé, C., Bartlett, J., Kong, L., Finnie, K., Lin, H. Q., Larkin, M., Calleja, S., Bush, A., & Calleja, G. (2004) · Advanced Materials · doi:10.1002/adma.200400771 · Cited by 859
Slowing, I., Trewyn, B. G., & Lin, V. S.-Y. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0645943 · Cited by 846
Lin, Y.-S., & Haynes, C. L. (2010) · Journal of the American Chemical Society · doi:10.1021/ja910846q · Cited by 837
Huh, S., Wiench, J. W., Yoo, J.-C., Pruski, M., & Lin, V. S.-Y. (2003) · Chemistry of Materials · doi:10.1021/cm0210041 · Cited by 787
Chung, T.-H., Wu, S.-H., Yao, M., Lu, C.-W., Lin, Y.-S., Hung, Y., Mou, C.-Y., Chen, Y.-C., & Huang, D.-M. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.03.006 · Cited by 617
Zhao, Y., Sun, X., Zhang, G., Trewyn, B. G., Slowing, I. I., & Lin, V. S.-Y. (2011) · ACS Nano · doi:10.1021/nn103077k · Cited by 572
Muro, S., Garnacho, C., Champion, J. A., Leferovich, J., Gajewski, C., Schuchman, E. H., Mitragotri, S., & Muzykantov, V. R. (2008) · Molecular Therapy · doi:10.1038/mt.2008.127 · Cited by 564
In vitro assessments of nanomaterial toxicity
Jones, C. F., & Grainger, D. W. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.005 · Cited by 554
Arnida, Janát-Amsbury, M. M., Ray, A., Peterson, C. M., & Ghandehari, H. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.11.010 · Cited by 547
Self-citationThe biocompatibility of mesoporous silicates
Hudson, S. P., Padera, R. F., Langer, R., & Kohane, D. S. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.07.007 · Cited by 538
Mesoporous Silica Nanoparticles for Reducing Hemolytic Activity Towards Mammalian Red Blood Cells
Slowing, I. I., Wu, C., Vivero‐Escoto, J. L., & Lin, V. S. ‐. (2009) · Small · doi:10.1002/smll.200800926 · Cited by 527
Li, L., Tang, F., Liu, H., Liu, T., Hao, N., Chen, D., Teng, X., & He, J. (2010) · ACS Nano · doi:10.1021/nn100918a · Cited by 332
Intracellular Localization and Cytotoxicity of Spherical Mesoporous Silica Nano‐ and Microparticles
He, Q., Zhang, Z., Gao, Y., Shi, J., & Li, Y. (2009) · Small · doi:10.1002/smll.200900923 · Cited by 303
Colloidal Suspensions of Functionalized Mesoporous Silica Nanoparticles
Kobler, J., Möller, K., & Bein, T. (2008) · ACS Nano · doi:10.1021/nn700008s · Cited by 271
Tsai, C.-P., Chen, C.-Y., Hung, Y., Chang, F.-H., & Mou, C.-Y. (2009) · Journal of Materials Chemistry · doi:10.1039/b905158a · Cited by 252
Role of Surface Electric Charge in Red Blood Cell Interactions
Jan, K.-M., & Chien, S. (1973) · The Journal of General Physiology · doi:10.1085/jgp.61.5.638 · Cited by 240
Cheng, S.-H., Lee, C.-H., Chen, M.-C., Souris, J. S., Tseng, F.-G., Yang, C.-S., Mou, C.-Y., Chen, C.-T., & Lo, L.-W. (2010) · Journal of Materials Chemistry · doi:10.1039/c0jm00645a · Cited by 222
Cellular Uptake and Cytotoxicity of Silica Nanotubes
Nan, A., Bai, X., Son, S. J., Lee, S. B., & Ghandehari, H. (2008) · Nano Letters · doi:10.1021/nl0802741 · Cited by 212
Self-citationTsai, C., Hung, Y., Chou, Y., Huang, D., Hsiao, J., Chang, C., Chen, Y., & Mou, C. (2008) · Small · doi:10.1002/smll.200700457 · Cited by 206
On the Origin of Helical Mesostructures
Yang, S., Zhao, L., Yu, C., Zhou, X., Tang, J., Yuan, P., Chen, D., & Zhao, D. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0619049 · Cited by 205
Synthesis of functionalized SBA-15 with ordered large pore size and its adsorption properties of BSA
Nguyen, T. P. B., Lee, J.-W., Shim, W. G., & Moon, H. (2008) · Microporous and Mesoporous Materials · doi:10.1016/j.micromeso.2007.06.054 · Cited by 196
Preparation of Fluorescent Silica Nanotubes and Their Application in Gene Delivery
Chen, C. ‐., Liu, Y. ‐., Wu, C. ‐., Yeh, C. ‐., Su, M. ‐., & Wu, Y. ‐. (2005) · Advanced Materials · doi:10.1002/adma.200400966 · Cited by 172
Functional Assessment of Metal Oxide Nanoparticle Toxicity in Immune Cells
Maurer-Jones, M. A., Lin, Y.-S., & Haynes, C. L. (2010) · ACS Nano · doi:10.1021/nn9018834 · Cited by 171
Control of Morphology and Helicity of Chiral Mesoporous Silica
Jin, H., Liu, Z., Ohsuna, T., Terasaki, O., Inoue, Y., Sakamoto, K., Nakanishi, T., Ariga, K., & Che, S. (2006) · Advanced Materials · doi:10.1002/adma.200502038 · Cited by 157
Mesoporosity and Functional Group Dependent Endocytosis and Cytotoxicity of Silica Nanomaterials
Tao, Z., Toms, B. B., Goodisman, J., & Asefa, T. (2009) · Chemical Research in Toxicology · doi:10.1021/tx900276u · Cited by 142
Uptake of Silica-Coated Nanoparticles by HeLa Cells
Xing, X., He, X., Peng, J., Wang, K., & Tan, W. (2005) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2005.199 · Cited by 128
Template synthesis of multifunctional nanotubes for controlled release
Son, S. J., Bai, X., Nan, A., Ghandehari, H., & Lee, S. B. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.06.004 · Cited by 116
Self-citationPetushkov, A., Intra, J., Graham, J. B., Larsen, S. C., & Salem, A. K. (2009) · Chemical Research in Toxicology · doi:10.1021/tx900153k · Cited by 88
Nabeshi, H., Yoshikawa, T., Arimori, A., Yoshida, T., Tochigi, S., Hirai, T., Akase, T., Nagano, K., Abe, Y., Kamada, H., et al. (2011) · Nanoscale Research Letters · doi:10.1186/1556-276x-6-93 · Cited by 83
Effect of Surfactant Concentration on the Morphology and Texture of MCM-41 Materials
Lelong, G., Bhattacharyya, S., Kline, S. R., Cacciaguerra, T., Gonzalez, M. A., & Saboungi, M. (2008) · The Journal of Physical Chemistry C · doi:10.1021/jp800898n · Cited by 81
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Mesoporous silica nanoparticles in target drug delivery system: A review
Bharti, C., Gulati, N., Nagaich, U., & Pal, A. (2015) · International Journal of Pharmaceutical Investigation · doi:10.4103/2230-973x.160844 · Cited by 817
Abbasi, R., Shineh, G., Mobaraki, M., Doughty, S., & Tayebi, L. (2023) · Journal of Nanoparticle Research · doi:10.1007/s11051-023-05690-w · Cited by 623
Croissant, J. G., Fatieiev, Y., Almalik, A., & Khashab, N. M. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201700831 · Cited by 594
Nanotoxicology and in vitro studies: The need of the hour
Arora, S., Rajwade, J. M., & Paknikar, K. M. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.11.010 · Cited by 537
Toxicology of silica nanoparticles: an update
Murugadoss, S., Lison, D., Godderis, L., Van Den Brule, S., Mast, J., Brassinne, F., Sebaihi, N., & Hoet, P. H. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-1993-y · Cited by 518
Metadata
- Authors
- Yu, T., Malugin, A., & Ghandehari, H.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-06-08
- Volume
- 5
- Issue
- 7
- Pages
- 5717-5728
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2055182511
- Cited by
- 666
- References
- 39
- FWCI
- 23.39
- Type
- journal article
- Language
- en
- Open access
- green
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