Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution

Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles

OWENSIII, D., & PEPPAS, N. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.10.010 · Cited by 3,637 · see citing works

Immunological properties of engineered nanomaterials

Dobrovolskaia, M. A., & McNeil, S. E. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.223 · Cited by 1,823 · see citing works

Exploiting lymphatic transport and complement activation in nanoparticle vaccines

Reddy, S. T., van der Vlies, A. J., Simeoni, E., Angeli, V., Randolph, G. J., O’Neil, C. P., Lee, L. K., Swartz, M. A., & Hubbell, J. A. (2007) · Nature Biotechnology · doi:10.1038/nbt1332 · Cited by 1,355 · see citing works

Dendrimers:

Malik, N., Wiwattanapatapee, R., Klopsch, R., Lorenz, K., Frey, H., Weener, J.-W., Meijer, E. W., Paulus, W., & Duncan, R. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00246-1 · Cited by 1,228 · see citing works

PEG-modified gold nanorods with a stealth character for in vivo applications

Niidome, T., Yamagata, M., Okamoto, Y., Akiyama, Y., Takahashi, H., Kawano, T., Katayama, Y., & Niidome, Y. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.06.017 · Cited by 1,201 · see citing works

Colloidal Gold: A Novel Nanoparticle Vector for Tumor Directed Drug Delivery

Paciotti, G. F., Myer, L. D., Weinreich, D. M., Goia, D. V., Pavel, N., McLaughlin, R. E., & Tamarkin, L. (2004) · Drug Delivery · doi:10.1080/10717540490433895 · Cited by 1,184 · see citing works

The nanoparticle–protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century

Lynch, I., Cedervall, T., Lundqvist, M., Cabaleiro-Lago, C., Linse, S. S., & Dawson, K. A. (2007) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2007.04.021 · Cited by 712 · see citing works

Nanoparticle‐induced platelet aggregation and vascular thrombosis

Radomski, A. S., Jurasz, P., Alonso‐Escolano, D., Drews, M., Morandi, M. T., Maliñski, T., & Radomski, M. W. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706386 · Cited by 636 · see citing works

The role of complement in inflammation and phagocytosis

Frank, M. M., & Fries, L. F. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90009-i · Cited by 504 · see citing works

Complement activation following first exposure to pegylated liposomal doxorubicin (Doxil®): possible role in hypersensitivity reactions

Chanan-Khan, A., Szebeni, J., Savay, S., Liebes, L., Rafique, N. M., Alving, C. R., & Muggia, F. M. (2003) · Annals of Oncology · doi:10.1093/annonc/mdg374 · Cited by 479 · see citing works

In vivo tumor targeting of tumor necrosis factor-α-loaded stealth nanoparticles: Effect of MePEG molecular weight and particle size

Fang, C., Shi, B., Pei, Y., Hong, M., Wu, J., & Chen, H. (2005) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2005.08.002 · Cited by 424 · see citing works

Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation

Redhead, H. M., Davis, S. S., & Illum, L. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00367-9 · Cited by 420 · see citing works

Characterization of Nanoparticles for Therapeutics

Hall, J. B., Dobrovolskaia, M. A., Patri, A. K., & McNeil, S. E. (2007) · Nanomedicine · doi:10.2217/17435889.2.6.789 · Cited by 413 · see citing works

In vivo recognition and clearance of red blood cells containing phosphatidylserine in their plasma membranes.

Schroit, A. J., Madsen, J. W., & Tanaka, Y. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89189-x · Cited by 349 · see citing works

Macrophage Uptake of Core−Shell Nanoparticles Surface Modified with Poly(ethylene glycol)

Zahr, A. S., Davis, C. A., & Pishko, M. V. (2006) · Langmuir · doi:10.1021/la060951b · Cited by 324 · see citing works

Physicochemical and Biological Characterization of Targeted, Nucleic Acid-Containing Nanoparticles

Bartlett, D. W., & Davis, M. E. (2007) · Bioconjugate Chemistry · doi:10.1021/bc0603539 · Cited by 283 · see citing works

Time-dependent changes in opsonin amount associated on nanoparticles alter their hepatic uptake characteristics

Nagayama, S., Ogawara, K., Fukuoka, Y., Higaki, K., & Kimura, T. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.04.036 · Cited by 225 · see citing works

Phagocytic Uptake and Cytotoxicity of Solid Lipid Nanoparticles (SLN) Sterically Stabilized with Poloxamine 908 and Poloxamer 407

Müller, R., Maaben, S., Weyhers, H., & Mehnert, W. (1996) · Journal of drug targeting · doi:10.3109/10611869609015973 · Cited by 222 · see citing works

Evaluation of pegylated lipid nanocapsules versus complement system activation and macrophage uptake

Vonarbourg, A., Passirani, C., Saulnier, P., Simard, P., Leroux, J., & Benoît, J. (2006) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30711 · Cited by 216 · see citing works

Investigations on the toxicological profile of functionalized fifth-generation poly(propylene imine) dendrimer

Agashe, H. B., Dutta, T., Garg, M., & Jain, N. K. (2006) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.58.11.0010 · Cited by 185 · see citing works

Complement Activation by Core–Shell Poly(isobutylcyanoacrylate)–Polysaccharide Nanoparticles: Influences of Surface Morphology, Length, and Type of Polysaccharide

Bertholon, I., Vauthier, C., & Labarre, D. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-0069-0 · Cited by 169 · see citing works

Poly (propyleneimine) dendrimer based nanocontainers for targeting of efavirenz to human monocytes/macrophagesin vitro

Dutta, T., Agashe, H. B., Garg, M., Balasubramanium, P., Kabra, M., & Jain, N. K. (2007) · Journal of drug targeting · doi:10.1080/10611860600965914 · Cited by 157 · see citing works

PLATELET PHAGOCYTOSIS AND AGGREGATION

Movat, H. Z., Weiser, W. J., Glynn, M. F. X., & Mustard, J. F. (1965) · The Journal of Cell Biology · doi:10.1083/jcb.27.3.531 · Cited by 157 · see citing works

Influence of PAMAM dendrimers on human red blood cells

Domański, D. M., Klajnert‐Maculewicz, B., & Bryszewska, M. J. (2004) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2003.09.023 · Cited by 150 · see citing works

DNA transfection and transfected cell viability using amphipathic asymmetric dendrimers

Shah, D. S., Sakthivel, T., Tóth, I., et al. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00534-2 · Cited by 150 · see citing works

Water-soluble carbosilane dendrimers: synthesis biocompatibility and complexation with oligonucleotides; evaluation for medical applications.

Bermejo, J. F., Ortega, P., Chonco, L., Eritja, R., Samaniego, R., Müllner, M., de Jesús, E., de la Mata, F. J., Flores, J. C., Gómez, R., et al. (2007) · Chemistry · doi:10.1002/chem.200600594 · Cited by 148 · see citing works

Interaction of PLGA nanoparticles with human blood constituents

Kim, D., El‐Shall, H., Dennis, D. M., & Morey, T. E. (2004) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2004.05.007 · Cited by 146 · see citing works

Protein adsorption patterns on poloxamer- and poloxamine-stabilized solid lipid nanoparticles (SLN)

Göppert, T. M., & Müller, R. (2005) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2005.02.006 · Cited by 141 · see citing works

Blood Compatibility of Cetyl Alcohol/Polysorbate-Based Nanoparticles

Koziara, J. M., Oh, J. J., Akers, W. S., Ferraris, S. P., & Mumper, R. J. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-7547-7 · Cited by 123 · see citing works

PLGA: Poloxamer and PLGA: Poloxamine blend nanostructures as carriers for nasal gene delivery

Csaba, N., Sánchez, A., & Alonso, M. J. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.03.017 · Cited by 118 · see citing works

Hemolytic Effects of Water-Soluble Fullerene Derivatives

Bosi, S., Feruglio, L., Ros, T. D., et al. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm0497489 · Cited by 117 · see citing works

Receptor-Mediated Gene Delivery into Antigen Presenting Cells Using Mannosylated Chitosan/DNA Nanoparticles

Kim, T. H., Nah, J. W., Cho, M., et al. (2006) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2006.434 · Cited by 117 · see citing works

Nanoconjugate based on polymalic acid for tumor targeting

Ljubimova, J. Y., Fujita, M., Khazenzon, N. M., et al. (2007) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2007.01.015 · Cited by 97 · see citing works

Gating the Radical Hemoglobin to Macrophages: The Anti-Inflammatory Role of CD163, a Scavenger Receptor

Schaer, D. J., Alayash, A. I., & Buehler, P. W. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1576 · Cited by 88 · see citing works

Metalloproteinase and cytokine production by THP-1 macrophages following exposure to chitosan-DNA nanoparticles

Chellat, F., Grandjean-Laquerriere, A., Naour, R. L., Fernandes, J., Yahia, L., Guenounou, M., & Laurent‐Maquin, D. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.04.006 · Cited by 88 · see citing works

Concentration Dependent Structural Ordering of Poloxamine 908 on Polystyrene Nanoparticles and Their Modulatory Role on Complement Consumption

Al-Hanbali, O. A., Rutt, K. J., Sarker, D. K., et al. (2006) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2006.406 · Cited by 67 · see citing works

Development of Phosphorylated Glucomannan-Coated Chitosan Nanoparticles as Nanocarriers for Protein Delivery

Cuña, M., Alonso-Sande, M., Remuñán‐López, C., et al. (2006) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2006.435 · Cited by 66 · see citing works

Apoptosis: The Physiologic Pathway of Cell Death

Cohen, J. (1993) · Hospital Practice · doi:10.1080/21548331.1993.11442887 · Cited by 64 · see citing works

Coating of cationized protein on engineered nanoparticles results in enhanced immune responses

Cui, Z., & Mumper, R. J. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00079-0 · Cited by 60 · see citing works

Novel function of complement C3d as an autologous helper T‐cell target

Knopf, P. M., Rivera, D. S., Hai, S., et al. (2008) · Immunology and Cell Biology · doi:10.1038/sj.icb.7100147 · Cited by 24 · see citing works

Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy

Aggarwal, P., Hall, J. B., McLeland, C. B., Dobrovolskaia, M. A., & McNeil, S. E. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.009 · Cited by 1,791 · see citing works

Nanoparticles in the clinic

Anselmo, A. C., & Mitragotri, S. (2016) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10003 · Cited by 1,321 · see citing works

Challenges in Development of Nanoparticle-Based Therapeutics

Desai, N. (2012) · The AAPS Journal · doi:10.1208/s12248-012-9339-4 · Cited by 1,173 · see citing works

Nanoparticles for Cancer Therapy: Current Progress and Challenges

Gavas, S., Quazi, S., & Karpiński, T. M. (2021) · Nanoscale Research Letters · doi:10.1186/s11671-021-03628-6 · Cited by 1,069 · see citing works

The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles

Xiao, K., Li, Y., Luo, J., Lee, J. S., Xiao, W., Gonik, A. M., Agarwal, R. G., & Lam, K. S. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.01.021 · Cited by 1,039 · see citing works

Minireview: Nanoparticles and the Immune System

Zolnik, B. S., González-Fernández, A., Sadrieh, N., & Dobrovolskaia, M. A. (2010) · Endocrinology · doi:10.1210/en.2009-1082 · Cited by 914 · see citing works

Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities

Li, L., Hu, S., & Chen, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.04.031 · Cited by 415 · see citing works

Lipid nanoparticle technology for therapeutic gene regulation in the liver

Witzigmann, D., Kulkarni, J. A., Leung, J., Chen, S., Cullis, P. R., & van der Meel, R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.026 · Cited by 376 · see citing works

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

Mizrak, A., Bolukbasi, M. F., Ozdener, G. B., Brenner, G. J., Madlener, S., Erkan, E. P., Ströbel, T., Breakefield, X. O., & Saydam, O. (2013) · Molecular Therapy · doi:10.1038/mt.2012.161 · Cited by 337 · see citing works

Improved implant osseointegration of a nanostructured titanium surface via mediation of macrophage polarization

Ma, Q.-L., Zhao, L.-Z., Liu, R.-R., Jin, B.-Q., Song, W., Wang, Y., Zhang, Y.-S., Chen, L.-H., & Zhang, Y.-M. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.08.025 · Cited by 319 · see citing works

Nanoformulations for combination or cascade anticancer therapy

Miao, L., Guo, S., Lin, C. M., Liu, Q., & Huang, L. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.06.003 · Cited by 178 · see citing works

Particle-mediated intravenous delivery of antigen mRNA results in strong antigen-specific T-cell responses despite the induction of type I interferon

Broos, K., Van der Jeught, K., Puttemans, J., Goyvaerts, C., Heirman, C., Dewitte, H., Verbeke, R., Lentacker, I., Thielemans, K., & Breckpot, K. (2016) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2016.38 · Cited by 121 · see citing works

PEG-Graft Density Controls Polymeric Nanoparticle Micelle Stability

Logie, J., Owen, S. C., McLaughlin, C. K., & Shoichet, M. S. (2014) · Chemistry of Materials · doi:10.1021/cm500448x · Cited by 110 · see citing works

Analysis on migration and activation of live macrophages on transparent flat and nanostructured titanium

Lee, S., Choi, J., Shin, S., Im, Y.-M., Song, J., Kang, S. S., Nam, T.-H., Webster, T. J., Kim, S.-H., & Khang, D. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.01.006 · Cited by 108 · see citing works

Nanoparticle technology for treatment of Parkinson’s disease: The role of surface phenomena in reaching the brain

Leyva-Gómez, G., Cortés, H., Magaña, J. J., Leyva-García, N., Quintanar-Guerrero, D., & Florán, B. (2015) · Drug Discovery Today · doi:10.1016/j.drudis.2015.02.009 · Cited by 102 · see citing works

Biomedical nanoparticles modulate specific CD4⁺T cell stimulation by inhibition of antigen processing in dendritic cells

Blank, F., Gerber, P., Rothen-Rutishauser, B., Sakulkhu, U., Salaklang, J., De Peyer, K., Gehr, P., Nicod, L. P., Hofmann, H., Geiser, T., et al. (2011) · Nanotoxicology · doi:10.3109/17435390.2010.541293 · Cited by 97 · see citing works

Spatial heterogeneity of nanomedicine investigated by multiscale imaging of the drug, the nanoparticle and the tumour environment

de Maar, J. S., Sofias, A. M., Porta Siegel, T., Vreeken, R. J., Moonen, C., Bos, C., & Deckers, R. (2020) · Theranostics · doi:10.7150/thno.38625 · Cited by 71 · see citing works

Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip

Han, B., Qu, C., Park, K., Konieczny, S. F., & Korc, M. (2016) · Cancer Letters · doi:10.1016/j.canlet.2015.12.003 · Cited by 53 · see citing works

Negative Surface Shielded Polymeric Micelles with Colloidal Stability for Intracellular Endosomal/Lysosomal Escape

Zhu, Y., Meng, T., Tan, Y., Yang, X., Liu, Y., Liu, X., Yu, F., Wen, L., Dai, S., Yuan, H., et al. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00842 · Cited by 42 · see citing works

Standardization of Models and Methods Used to Assess Nanoparticles in Cardiovascular Applications

Fitzgerald, K. T., Holladay, C. A., McCarthy, C., Power, K. A., Pandit, A., & Gallagher, W. M. (2011) · Small · doi:10.1002/smll.201001347 · Cited by 26 · see citing works

Surface-functionalized nanoparticles for targeted drug delivery across the blood-brain barrier: advances and challenges in neurodegenerative disease therapy

Pramoda, G., Verma, R. K., Kesharwani, P., & Shukla, R. (2025) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2025.127938 · Cited by 15 · see citing works

The biodistribution of NC100668 and the effect of excess NC100668 on the biodistribution and kidney retention of 99mTc-NC100668 in the rat

Edwards, D. S., Lewis, J., Battle, M. R., et al. (2007) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2007.01.008 · Cited by 4 · see citing works

Synthesis, hypoxic radiosensitization and biodistribution of N- (5-nitroindazole-3-formyl) tyrosine sodium

Wang, H., & Zhou, Z. (2015) · Int J Radiat Med Nucl Med · doi:10.3760/cma.j.issn.1673-4114.2015.03.010

An in vivo study of the biodistribution of gold nanoparticles after intervaginal space injection in the tarsal tunnel

Xiaoli, Shi, J.-R., Yuting, et al. (2016) · 纳米研究：英文版

Synthesis and biodistribution studies of [~(99)Tc~m(CO)_3-EC] complexes

Zhang, H. (2004) · Nuclear Techniques

Preparation and Biodistribution of ~(99)Tc~m-HEDTMP

Shu, J. (2002) · Tongweisu