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Chitosan Oligosaccharide-Stabilized Ferrimagnetic Iron Oxide Nanocubes for Magnetically Modulated Cancer Hyperthermia
Abstract
Magnetic nanoparticles have gained significant attention as a therapeutic agent for cancer treatment. Herein, we developed chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes (Chito-FIONs) as an effective heat nanomediator for cancer hyperthermia. Dynamic light scattering and transmission electron microscopic analyses revealed that Chito-FIONs were composed of multiple 30-nm-sized FIONs encapsulated by a chitosan polymer shell. Multiple FIONs in an interior increased the total magnetic moments, which leads to localized accumulation under an applied magnetic field. Chito-FIONs also exhibited superior magnetic heating ability with a high specific loss power value (2614 W/g) compared with commercial superparamagnetic Feridex nanoparticles (83 W/g). The magnetically guided Chito-FIONs successfully eradicated target cancer cells through caspase-mediated apoptosis. Furthermore, Chito-FIONs showed excellent antitumor efficacy on an animal tumor model without any severe toxicity.
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Cites
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Lee, H., Dellatore, S. M., Miller, W. M., & Messersmith, P. B. (2007) · Science · doi:10.1126/science.1147241 · Cited by 10,965
Ultra-large-scale syntheses of monodisperse nanocrystals
Park, J., An, K., Hwang, Y., Park, J.-G., Noh, H.-J., Kim, J.-Y., Park, J.-H., Hwang, N.-M., & Hyeon, T. (2004) · Nature Materials · doi:10.1038/nmat1251 · Cited by 4,076
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Cited by
Surface modification of magnetic iron oxide nanoparticles
Zhu, N., Ji, H., Yu, P., Niu, J., Farooq, M. U., Akram, M. W., Udego, I. O., Li, H., & Niu, X. (2018) · Nanomaterials · doi:10.3390/nano8100810 · Cited by 569
Chemical Synthesis and Assembly of Uniformly Sized Iron Oxide Nanoparticles for Medical Applications
Ling, D., Lee, N., & Hyeon, T. (2015) · Accounts of Chemical Research · doi:10.1021/acs.accounts.5b00038 · Cited by 513
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Self-citationDissecting the Molecular Mechanism of Apoptosis during Photothermal Therapy Using Gold Nanoprisms
Pérez-Hernández, M., del Pino, P., Mitchell, S. G., Moros, M., Stepien, G., Pelaz, B., Parak, W. J., Gálvez, E. M., Pardo, J., & de la Fuente, J. M. (2015) · ACS Nano · doi:10.1021/nn505468v · Cited by 398
Biodegradation of Iron Oxide Nanocubes: High-Resolution In Situ Monitoring
Lartigue, L., Alloyeau, D., Kolosnjaj-Tabi, J., Javed, Y., Guardia, P., Riedinger, A., Péchoux, C., Pellegrino, T., Wilhelm, C., & Gazeau, F. (2013) · ACS Nano · doi:10.1021/nn305719y · Cited by 274
Metadata
- Authors
- Bae, K. H., Park, M., Do, M. J., Lee, N., Ryu, J. H., Kim, G. W., Kim, C., Park, T. G., & Hyeon, T.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-05-22
- Volume
- 6
- Issue
- 6
- Pages
- 5266-5273
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2321959337
- Cited by
- 313
- References
- 2
- FWCI
- 18.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bae, K. H., Park, M., Do, M. J., Lee, N., Ryu, J. H., Kim, G. W., Kim, C., Park, T. G., & Hyeon, T. (2012). Chitosan Oligosaccharide-Stabilized Ferrimagnetic Iron Oxide Nanocubes for Magnetically Modulated Cancer Hyperthermia. ACS Nano. https://doi.org/10.1021/nn301046w
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