The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Chitosan Oligosaccharide-Stabilized Ferrimagnetic Iron Oxide Nanocubes for Magnetically Modulated Cancer Hyperthermia
Abstract
Magnetic nanoparticles have gained significant attention as a therapeutic agent for cancer treatment. Herein, we developed chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes (Chito-FIONs) as an effective heat nanomediator for cancer hyperthermia. Dynamic light scattering and transmission electron microscopic analyses revealed that Chito-FIONs were composed of multiple 30-nm-sized FIONs encapsulated by a chitosan polymer shell. Multiple FIONs in an interior increased the total magnetic moments, which leads to localized accumulation under an applied magnetic field. Chito-FIONs also exhibited superior magnetic heating ability with a high specific loss power value (2614 W/g) compared with commercial superparamagnetic Feridex nanoparticles (83 W/g). The magnetically guided Chito-FIONs successfully eradicated target cancer cells through caspase-mediated apoptosis. Furthermore, Chito-FIONs showed excellent antitumor efficacy on an animal tumor model without any severe toxicity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mussel-inspired surface chemistry for multifunctional coatings
Lee, H., Dellatore, S. M., Miller, W. M., & Messersmith, P. B. (2007) · Science · doi:10.1126/science.1147241 · Cited by 10,965
Applications of magnetic nanoparticles in biomedicine
Pankhurst, Q. A., Connolly, J., Jones, S. K., & Dobson, J. (2003) · Journal of Physics D: Applied Physics · doi:10.1088/0022-3727/36/13/201 · Cited by 5,881
Ultra-large-scale syntheses of monodisperse nanocrystals
Park, J., An, K., Hwang, Y., Park, J.-G., Noh, H.-J., Kim, J.-Y., Park, J.-H., Hwang, N.-M., & Hyeon, T. (2004) · Nature Materials · doi:10.1038/nmat1251 · Cited by 4,076
Self-citationNanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
Hirsch, L. R., Stafford, R. J., Bankson, J. A., Sershen, S. R., Rivera, B., Price, R. E., Hazle, J. D., Halas, N. J., & West, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232479100 · Cited by 3,955
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
Earnshaw, W. C., Martins, L. M., & Kaufmann, S. H. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.383 · Cited by 2,760
Applications of Magnetic Nanoparticles in Biomedicine
Bárcena, C., Sra, A. K., & Gao, J. (2009) · Nanoscale Magnetic Materials and Applications · doi:10.1007/978-0-387-85600-1_20 · Cited by 2,565
Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery
Kumar, C. S. S. R., & Mohammad, F. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.03.008 · Cited by 1,666
Functionalisation of magnetic nanoparticles for applications in biomedicine
Berry, C. C., & Curtis, A. S. G. (2003) · Journal of Physics D: Applied Physics · doi:10.1088/0022-3727/36/13/203 · Cited by 1,588
Synthesis, Functionalization, and Biomedical Applications of Multifunctional Magnetic Nanoparticles
Hao, R., Xing, R., Xu, Z., Hou, Y., Gao, S., & Sun, S. (2010) · Advanced Materials · doi:10.1002/adma.201000260 · Cited by 1,372
Exchange-coupled magnetic nanoparticles for efficient heat induction
Lee, J.-H., Jang, J.-T., Choi, J.-S., Moon, S. H., Noh, S.-H., Kim, J.-W., Kim, J.-G., Kim, I.-S., Park, K. I., & Cheon, J. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.95 · Cited by 1,364
Frey, N. A., Peng, S., Cheng, K., & Sun, S. (2009) · Chemical Society Reviews · doi:10.1039/b815548h · Cited by 1,200
Size-Sorted Anionic Iron Oxide Nanomagnets as Colloidal Mediators for Magnetic Hyperthermia
Fortin, J.-P., Wilhelm, C., Servais, J., Ménager, C., Bacri, J.-C., & Gazeau, F. (2007) · Journal of the American Chemical Society · doi:10.1021/ja067457e · Cited by 1,038
Magnetic particle hyperthermia: nanoparticle magnetism and materials development for cancer therapy
Hergt, R., Dutz, S., Müller, R., & Zeisberger, M. (2006) · Journal of Physics: Condensed Matter · doi:10.1088/0953-8984/18/38/s26 · Cited by 977
Cell-specific targeting of nanoparticles by multivalent attachment of small molecules
Weissleder, R., Kelly, K., Sun, E. Y., Shtatland, T., & Josephson, L. (2005) · Nature Biotechnology · doi:10.1038/nbt1159 · Cited by 904
Xu, C., Xu, K., Gu, H., Zheng, R., Liu, H., Zhang, X., Guo, Z., & Xu, B. (2004) · Journal of the American Chemical Society · doi:10.1021/ja0464802 · Cited by 887
Xie, J., Xu, C., Kohler, N., Hou, Y., & Sun, S. (2007) · Advanced Materials · doi:10.1002/adma.200701975 · Cited by 686
Synergistically Integrated Nanoparticles as Multimodal Probes for Nanobiotechnology
Cheon, J., & Lee, J.-H. (2008) · Accounts of Chemical Research · doi:10.1021/ar800045c · Cited by 683
Jang, J., Nah, H., Lee, J., Moon, S. H., Kim, M. G., & Cheon, J. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200805149 · Cited by 625
Chitosan-based delivery systems for protein therapeutics and antigens
Amidi, M., Mastrobattista, E., Jiskoot, W., & Hennink, W. E. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.009 · Cited by 620
Targeted hyperthermia using metal nanoparticles
Cherukuri, P., Glazer, E. S., & Curley, S. A. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.006 · Cited by 569
Magnetically mediated hyperthermia: current status and future directions
Moroz, P., Jones, S. K., & Gray, B. N. (2002) · International Journal of Hyperthermia · doi:10.1080/02656730110108785 · Cited by 538
Monodisperse Magnetic Nanoparticles for Theranostic Applications
Ho, D., Sun, X., & Sun, S. (2011) · Accounts of Chemical Research · doi:10.1021/ar200090c · Cited by 504
Sanson, C., Diou, O., Thévenot, J., Ibarboure, E., Soum, A., Brûlet, A., Miraux, S., Thiaudière, E., Tan, S., Brisson, A., et al. (2011) · ACS Nano · doi:10.1021/nn102762f · Cited by 489
Synthesis of Uniform Ferrimagnetic Magnetite Nanocubes
Kim, D., Lee, N., Park, M., Kim, B. H., An, K., & Hyeon, T. (2009) · Journal of the American Chemical Society · doi:10.1021/ja8086906 · Cited by 485
Self-citationPiao, Y., Kim, J., Na, H. B., Kim, D., Baek, J. S., Ko, M. K., Lee, J. H., Shokouhimehr, M., & Hyeon, T. (2008) · Nature Materials · doi:10.1038/nmat2118 · Cited by 415
Self-citationMultifunctional Yolk−Shell Nanoparticles: A Potential MRI Contrast and Anticancer Agent
Gao, J., Liang, G., Cheung, J. S., Pan, Y., Kuang, Y., Zhao, F., Zhang, B., Zhang, X., Wu, E. X., & Xu, B. (2008) · Journal of the American Chemical Society · doi:10.1021/ja803920b · Cited by 366
EGFR-Targeted Magnetic Nanoparticle Heaters Kill Cancer Cells without a Perceptible Temperature Rise
Creixell, M., Bohórquez, A. C., Torres-Lugo, M., & Rinaldi, C. (2011) · ACS Nano · doi:10.1021/nn201822b · Cited by 325
Alphandéry, E., Faure, S., Seksek, O., Guyot, F., & Chebbi, I. (2011) · ACS Nano · doi:10.1021/nn201290k · Cited by 307
Remotely Triggered Release from Magnetic Nanoparticles
Derfus, A. M., von Maltzahn, G., Harris, T. J., Duza, T., Vecchio, K. S., Ruoslahti, E., & Bhatia, S. N. (2007) · Advanced Materials · doi:10.1002/adma.200700091 · Cited by 282
Lartigue, L., Innocenti, C., Kalaivani, T., Awwad, A., Sanchez Duque, M. D. M., Guari, Y., Larionova, J., Guérin, C., Montero, J.-L. G., Barragan-Montero, V., et al. (2011) · Journal of the American Chemical Society · doi:10.1021/ja111448t · Cited by 262
Optimizing Magnetic Nanoparticle Design for Nanothermotherapy
Gazeau, F., Lévy, M., & Wilhelm, C. (2008) · Nanomedicine · doi:10.2217/17435889.3.6.831 · Cited by 258
Interactions of Phospholipid Bilayer with Chitosan: Effect of Molecular Weight and pH
Fang, N., Chan, V., Mao, H.-Q., & Leong, K. W. (2001) · Biomacromolecules · doi:10.1021/bm015548s · Cited by 229
Controlled Release from Bilayer-Decorated Magnetoliposomes via Electromagnetic Heating
Chen, Y., Bose, A., & Bothun, G. D. (2010) · ACS Nano · doi:10.1021/nn100274v · Cited by 223
Lee, N., Kim, H., Choi, S. H., Park, M., Kim, D., Kim, H.-C., Choi, Y., Lin, S., Kim, B. H., Jung, H. S., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016409108 · Cited by 200
Self-citationRole of dipole-dipole interactions for hyperthermia heating of magnetic nanoparticle ensembles
Haase, C., & Nowak, U. (2012) · Physical Review B · doi:10.1103/physrevb.85.045435 · Cited by 193
Enhanced electrostatic interaction between chitosan-modified PLGA nanoparticle and tumor
Yang, R., Shim, W., Cui, F., Cheng, G., Han, X., Jin, Q., Kim, D., Chung, S., & Shim, C. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.12.007 · Cited by 148
Ling, D., Park, W., Park, Y. I., Lee, N., Li, F., Song, C., Yang, S., Choi, S. H., Na, K., & Hyeon, T. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201101521 · Cited by 134
Self-citationMulticore Assemblies Potentiate Magnetic Properties of Biomagnetic Nanoparticles
Yoon, T., Lee, H., Shao, H., Hilderbrand, S. A., & Weissleder, R. (2011) · Advanced Materials · doi:10.1002/adma.201102948 · Cited by 98
Yuk, S. H., Oh, K. S., Cho, S. H., Lee, B. S., Kim, S. Y., Kwak, B.-K., Kim, K., & Kwon, I. C. (2011) · Biomacromolecules · doi:10.1021/bm200413a · Cited by 89
Cited by
Nanotechnology in hyperthermia cancer therapy: From fundamental principles to advanced applications
Beik, J., Abed, Z., Ghoreishi, F. S., Hosseini-Nami, S., Mehrzadi, S., Shakeri-Zadeh, A., & Kamrava, S. K. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.062 · Cited by 579
Surface modification of magnetic iron oxide nanoparticles
Zhu, N., Ji, H., Yu, P., Niu, J., Farooq, M. U., Akram, M. W., Udego, I. O., Li, H., & Niu, X. (2018) · Nanomaterials · doi:10.3390/nano8100810 · Cited by 569
Chemical Synthesis and Assembly of Uniformly Sized Iron Oxide Nanoparticles for Medical Applications
Ling, D., Lee, N., & Hyeon, T. (2015) · Accounts of Chemical Research · doi:10.1021/acs.accounts.5b00038 · Cited by 513
Self-citationBio-inspired adhesive catechol-conjugated chitosan for biomedical applications: A mini review
Ryu, J. H., Hong, S., & Lee, H. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.08.043 · Cited by 428
Self-citationDissecting the Molecular Mechanism of Apoptosis during Photothermal Therapy Using Gold Nanoprisms
Pérez-Hernández, M., del Pino, P., Mitchell, S. G., Moros, M., Stepien, G., Pelaz, B., Parak, W. J., Gálvez, E. M., Pardo, J., & de la Fuente, J. M. (2015) · ACS Nano · doi:10.1021/nn505468v · Cited by 398
Metadata
- Authors
- Bae, K. H., Park, M., Do, M. J., Lee, N., Ryu, J. H., Kim, G. W., Kim, C., Park, T. G., & Hyeon, T.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-05-22
- Volume
- 6
- Issue
- 6
- Pages
- 5266-5273
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2321959337
- Cited by
- 313
- References
- 39
- FWCI
- 18.83
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
