The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Photoacoustic Imaging of Mesenchymal Stem Cells in Living Mice via Silica-Coated Gold Nanorods
Open accessAbstract
Improved imaging modalities are critically needed for optimizing stem cell therapy. Techniques with real-time content to guide and quantitate cell implantation are especially important in applications such as musculoskeletal regenerative medicine. Here, we report the use of silica-coated gold nanorods as a contrast agent for photoacoustic imaging and quantitation of mesenchymal stem cells in rodent muscle tissue. The silica coating increased the uptake of gold into the cell more than 5-fold, yet no toxicity or proliferation changes were observed in cells loaded with this contrast agent. Pluripotency of the cells was retained, and secretome analysis indicated that only IL-6 was disregulated more than 2-fold from a pool of 26 cytokines. The low background of the technique allowed imaging of down to 100,000 cells in vivo. The spatial resolution is 340 μm, and the temporal resolution is 0.2 s, which is at least an order of magnitude below existing cell imaging approaches. This approach has significant advantages over traditional cell imaging techniques like positron emission tomography and magnetic resonance imaging including real time monitoring of stem cell therapy.
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1 retracted
RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow
Jiang, Y., Jahagirdar, B. N., Reinhardt, R. L., Schwartz, R. E., Keene, C. D., Ortiz-Gonzalez, X. R., Reyes, M., Lenvik, T., Lund, T., Blackstad, M., et al. (2002) · Nature · doi:10.1038/nature00870 · Cited by 5,518
RetractedPreparation and Growth Mechanism of Gold Nanorods (NRs) Using Seed-Mediated Growth Method
Nikoobakht, B., & El-Sayed, M. A. (2003) · Chemistry of Materials · doi:10.1021/cm020732l · Cited by 5,069
Human mesenchymal stem cells modulate allogeneic immune cell responses
Aggarwal, S., & Pittenger, M. F. (2005) · Blood · doi:10.1182/blood-2004-04-1559 · Cited by 4,511
Growth Factors, Matrices, and Forces Combine and Control Stem Cells
Discher, D. E., Mooney, D. J., & Zandstra, P. W. (2009) · Science · doi:10.1126/science.1171643 · Cited by 2,667
種結晶を媒介とした成長法を用いた金ナノロッド(NR)の調製と成長メカニズム
Nikoobakht, B., & El-Sayed, M. A. (2003) · Chemistry of Materials · Cited by 1,419
Carbon nanotubes as photoacoustic molecular imaging agents in living mice
De La Zerda, A., Zavaleta, C., Keren, S., Vaithilingam, S., Bodapati, S., Liu, Z., Levi, J., Smith, B. R., Ma, T.-J., Oralkan, O., et al. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.231 · Cited by 1,271
Self-citationLiechty, K. W., MacKenzie, T. C., Shaaban, A. F., Radu, A., Moseley, A. B., Deans, R., Marshak, D. R., & Flake, A. W. (2000) · Nature Medicine · doi:10.1038/81395 · Cited by 1,215
Stem-cell therapy for cardiac disease
Segers, V. F. M., & Lee, R. T. (2008) · Nature · doi:10.1038/nature06800 · Cited by 1,179
Direct Isolation of Satellite Cells for Skeletal Muscle Regeneration
Montarras, D., Morgan, J., Collins, C., Relaix, F., Zaffran, S., Cumano, A., Partridge, T., & Buckingham, M. (2005) · Science · doi:10.1126/science.1114758 · Cited by 1,100
Alkilany, A. M., Nagaria, P. K., Hexel, C. R., Shaw, T. J., Murphy, C. J., & Wyatt, M. D. (2009) · Small · doi:10.1002/smll.200801546 · Cited by 1,029
Metadata
- Authors
- Jokerst, J. V., Thangaraj, M., Kempen, P. J., Sinclair, R., & Gambhir, S. S.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-06-20
- Volume
- 6
- Issue
- 7
- Pages
- 5920-5930
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2074245293
- Cited by
- 317
- References
- 56
- FWCI
- 15.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Jokerst, J. V., Thangaraj, M., Kempen, P. J., Sinclair, R., & Gambhir, S. S. (2012). Photoacoustic Imaging of Mesenchymal Stem Cells in Living Mice via Silica-Coated Gold Nanorods. ACS Nano. https://doi.org/10.1021/nn302042y
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
