The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
(α-NaYbF4:Tm3+)/CaF2 Core/Shell Nanoparticles with Efficient Near-Infrared to Near-Infrared Upconversion for High-Contrast Deep Tissue Bioimaging
Open accessAbstract
We describe the development of novel and biocompatible core/shell (α-NaYbF(4):Tm(3+))/CaF(2) nanoparticles that exhibit highly efficient NIR(in)-NIR(out) upconversion (UC) for high contrast and deep bioimaging. When excited at ~980 nm, these nanoparticles emit photoluminescence (PL) peaked at ~800 nm. The quantum yield of this UC PL under low power density excitation (~0.3 W/cm(2)) is 0.6 ± 0.1%. This high UC PL efficiency is realized by suppressing surface quenching effects via heteroepitaxial growth of a biocompatible CaF(2) shell, which results in a 35-fold increase in the intensity of UC PL from the core. Small-animal whole-body UC PL imaging with exceptional contrast (signal-to-background ratio of 310) is shown using BALB/c mice intravenously injected with aqueously dispersed nanoparticles (700 pmol/kg). High-contrast UC PL imaging of deep tissues is also demonstrated, using a nanoparticle-loaded synthetic fibrous mesh wrapped around rat femoral bone and a cuvette with nanoparticle aqueous dispersion covered with a 3.2 cm thick animal tissue (pork).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The use of nanocrystals in biological detection
Alivisatos, P. (2004) · Nature Biotechnology · doi:10.1038/nbt927 · Cited by 3,008
Second window for in vivo imaging
Smith, A. M., Mancini, M. C., & Nie, S. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.326 · Cited by 2,848
Haase, M., & Schäfer, H. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201005159 · Cited by 2,503
Tuning upconversion through energy migration in core–shell nanoparticles
Wang, F., Deng, R., Wang, J., Wang, Q., Han, Y., Zhu, H., Chen, X., & Liu, X. (2011) · Nature Materials · doi:10.1038/nmat3149 · Cited by 1,795
Upconversion nanophosphors for small-animal imaging
Zhou, J., Liu, Z., & Li, F. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15187h · Cited by 1,581
Upconversion nanoparticles in biological labeling, imaging, and therapy
Wang, F., Banerjee, D., Liu, Y., Chen, X., & Liu, X. (2010) · The Analyst · doi:10.1039/c0an00144a · Cited by 1,409
A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice
Welsher, K., Liu, Z., Sherlock, S. P., Robinson, J. T., Chen, Z., Daranciang, D., & Dai, H. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.294 · Cited by 1,287
Hexagonal Sodium Yttrium Fluoride Based Green and Blue Emitting Upconversion Phosphors
Krämer, K. W., Biner, D., Frei, G., Güdel, H. U., Hehlen, M. P., & Lüthi, S. R. (2004) · Chemistry of Materials · doi:10.1021/cm031124o · Cited by 1,172
Near-infrared fluorescence: application to in vivo molecular imaging
Hilderbrand, S. A., & Weissleder, R. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.09.029 · Cited by 1,023
Upconversion fluorescence imaging of cells and small animals using lanthanide doped nanocrystals
Chatterjee, D. K., Rufaihah, A. J., & Zhang, Y. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2007.10.051 · Cited by 988
In vitro and in vivo two-photon luminescence imaging of single gold nanorods
Wang, H., Huff, T. B., Zweifel, D. A., He, W., Low, P. S., Wei, A., & Cheng, J.-X. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504892102 · Cited by 950
Nyk, M., Kumar, R., Ohulchanskyy, T. Y., Bergey, E. J., & Prasad, P. N. (2008) · Nano Letters · doi:10.1021/nl802223f · Cited by 905
Self-citationAbsolute quantum yield measurements of colloidal NaYF4: Er3+, Yb3+ upconverting nanoparticles
Boyer, J.-C., & van Veggel, F. C. J. M. (2010) · Nanoscale · doi:10.1039/c0nr00253d · Cited by 876
Bogdan, N., Vetrone, F., Ozin, G. A., & Capobianco, J. A. (2011) · Nano Letters · doi:10.1021/nl1041929 · Cited by 806
Liu, Q., Sun, Y., Yang, T., Feng, W., Li, C., & Li, F. (2011) · Journal of the American Chemical Society · doi:10.1021/ja207078s · Cited by 798
Sharma, P., Brown, S., Walter, G., Santra, S., & Moudgil, B. (2006) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2006.05.026 · Cited by 755
Non-blinking and photostable upconverted luminescence from single lanthanide-doped nanocrystals
Wu, S., Han, G., Milliron, D. J., Aloni, S., Altoe, V., Talapin, D. V., Cohen, B. E., & Schuck, P. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904792106 · Cited by 710
Self-citationPrasad, P. N. (2003) · Wiley eBooks · doi:10.1002/0471465380 · Cited by 653
Self-citationChen, G., Ohulchanskyy, T. Y., Kumar, R., Ågren, H., & Prasad, P. N. (2010) · ACS Nano · doi:10.1021/nn100457j · Cited by 632
Self-citationSmall Upconverting Fluorescent Nanoparticles for Biomedical Applications
Chatterjee, D. K., Gnanasammandhan, M. K., & Zhang, Y. (2010) · Small · doi:10.1002/smll.201000418 · Cited by 539
Zhang, F., Braun, G. B., Shi, Y., Zhang, Y., Sun, X., Reich, N. O., Zhao, D., & Stucky, G. (2010) · Journal of the American Chemical Society · doi:10.1021/ja909108x · Cited by 475
Chen, G., Ohulchanskyy, T. Y., Liu, S., Law, W.-C., Wu, F., Swihart, M. T., Ågren, H., & Prasad, P. N. (2012) · ACS Nano · doi:10.1021/nn2042362 · Cited by 449
Self-citationUpconverting luminescent nanoparticles for use in bioconjugation and bioimaging
Mader, H. S., Kele, P., Saleh, S. M., & Wolfbeis, O. S. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2010.08.014 · Cited by 446
Dong, N.-N., Pedroni, M., Piccinelli, F., Conti, G., Sbarbati, A., Ramírez-Hernández, J. E., Maestro, L. M., Iglesias-de la Cruz, M. C., Sanz-Rodriguez, F., Juarranz, A., et al. (2011) · ACS Nano · doi:10.1021/nn202490m · Cited by 427
Zhang, H., Li, Y., Ivanov, I. A., Qu, Y., Huang, Y., & Duan, X. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200905805 · Cited by 383
Chen, G., Ohulchanskyy, T. Y., Kachynski, A., Ågren, H., & Prasad, P. N. (2011) · ACS Nano · doi:10.1021/nn201083j · Cited by 374
Self-citationA General Approach for Transferring Hydrophobic Nanocrystals into Water
Zhang, T., Ge, J., Hu, Y., & Yin, Y. (2007) · Nano Letters · doi:10.1021/nl071928t · Cited by 362
Shen, J., Zhao, L., & Han, G. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.05.007 · Cited by 309
Self-citationLong‐Term Real‐Time Tracking of Lanthanide Ion Doped Upconverting Nanoparticles in Living Cells
Nam, S. H., Bae, Y. M., Park, Y. I., Kim, J. H., Kim, H. M., Choi, J. S., Lee, K. T., Hyeon, T., & Suh, Y. D. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201007979 · Cited by 273
Schneider, G. F., & Decher, G. (2008) · Langmuir · doi:10.1021/la7021837 · Cited by 212
Yong, K.-T., Qian, J., Roy, I., Lee, H. H., Bergey, E. J., Tramposch, K. M., He, S., Swihart, M. T., Maitra, A., & Prasad, P. N. (2007) · Nano Letters · doi:10.1021/nl063031m · Cited by 196
Self-citationUltrasmall Near‐Infrared Non‐cadmium Quantum Dots for in vivo Tumor Imaging
Gao, J., Chen, K., Xie, R., Xie, J., Lee, S., Cheng, Z., Peng, X., & Chen, X. (2010) · Small · doi:10.1002/smll.200901672 · Cited by 194
Chen, G., Ohulchanskyy, T. Y., Law, W. C., Ågren, H., & Prasad, P. N. (2011) · Nanoscale · doi:10.1039/c0nr01018a · Cited by 181
Self-citationXu, C. T., Svenmarker, P., Liu, H., Wu, X. J., Messing, M. E., Wallenberg, R., & Andersson‐Engels, S. (2012) · ACS Nano · doi:10.1021/nn3015807 · Cited by 134
Non-invasive image acquisition and advanced processing in optical bioimaging
Farkas, D. L., Du, C., Fisher, G. W., et al. (1998) · Computerized Medical Imaging and Graphics · doi:10.1016/s0895-6111(98)00011-1 · Cited by 107
High‐resolution light microscopy using luminescent nanoparticles
Ohulchanskyy, T. Y., Roy, I., Yong, K., Pudavar, H. E., & Prasad, P. N. (2010) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.67 · Cited by 41
Self-citation
Cited by
Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics
Chen, G., Qiu, H., Prasad, P. N., & Chen, X. (2014) · Chemical Reviews · doi:10.1021/cr400425h · Cited by 2,699
Self-citationZheng, W., Huang, P., Tu, D., Ma, E., Zhu, H., & Chen, X. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00178h · Cited by 894
Li, X., Zhang, F., & Zhao, D. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00163j · Cited by 615
Xiao, Q., Zheng, X., Bu, W., Ge, W., Zhang, S., Chen, F., Xing, H., Ren, Q., Fan, W., Zhao, K., et al. (2013) · Journal of the American Chemical Society · doi:10.1021/ja404985w · Cited by 554
Phototherapy in cancer treatment: strategies and challenges
Cai, Y., Chai, T., Nguyen, W., Liu, J., Xiao, E., Ran, X., Ran, Y., Du, D., Chen, W., & Chen, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02140-y · Cited by 453
Metadata
- Authors
- Chen, G., Shen, J., Ohulchanskyy, T. Y., Patel, N. J., Kutikov, A., Li, Z., Song, J., Pandey, R. K., Ågren, H., Prasad, P. N., & Han, G.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-09-04
- Volume
- 6
- Issue
- 9
- Pages
- 8280-8287
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W1990135886
- Cited by
- 720
- References
- 36
- FWCI
- 30.55
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
