The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Polyethylene Glycol Conjugated Polymeric Nanocapsules for Targeted Delivery of Quercetin to Folate-Expressing Cancer Cells in Vitro and in Vivo
Open accessAbstract
In this work we describe the formulation and characterization of chemically modified polymeric nanocapsules incorporating the anticancer drug, quercetin, for the passive and active targeting to tumors. Folic acid was conjugated to poly(lactide-co-glycolide) (PLGA) polymer to facilitate active targeting to cancer cells. Two different methods for the conjugation of PLGA to folic acid were employed utilizing polyethylene glycol (PEG) as a spacer. Characterization of the conjugates was performed using FTIR and (1)H NMR studies. The PEG and folic acid content was independent of the conjugation methodology employed. PEGylation has shown to reduce the size of the nanocapsule; moreover, zeta-potential was shown to be polymer-type dependent. Comparative studies on the cytotoxicity and cellular uptake of the different formulations by HeLa cells, in the presence and absence of excess folic acid, were carried out using MTT assay and Confocal Laser Scanning Microscopy, respectively. Both results confirmed the selective uptake and cytotoxicity of the folic acid targeted nanocapsules to the folate enriched cancer cells in a folate-dependent manner. Finally, the passive tumor accumulation and the active targeting of the nanocapsules to folate-expressing cells were confirmed upon intravenous administration in HeLa or IGROV-1 tumor-bearing mice. The developed nanocapsules provide a system for targeted delivery of a range of hydrophobic anticancer drugs in vivo.
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Cites
PEGylated PLGA nanoparticles as protein carriers: Synthesis, preparation and biodistribution in rats
Li, Y.-P., Pei, Y.-Y., Zhang, X.-Y., Gu, Z.-H., Zhou, Z.-H., Yuan, W.-F., Zhou, J.-J., Zhu, J.-H., & Gao, X.-J. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00218-8 · Cited by 540
Development of Biodegradable Nanoparticles for Delivery of Quercetin
Kumari, A., Yadav, S. K., Pakade, Y. B., Singh, B., & Yadav, S. C. (2010) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2010.06.002 · Cited by 460
Kuntsche, J., Horst, J. C., & Bunjes, H. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.02.001 · Cited by 363
Cited by
Hu, K., Miao, L., Goodwin, T. J., Li, J., Liu, Q., & Huang, L. (2017) · ACS Nano · doi:10.1021/acsnano.7b01522 · Cited by 292
Al-Jamal, K. T., Bai, J., Wang, J. T.-W., Protti, A., Southern, P., Bogart, L., Heidari, H., Li, X., Cakebread, A., Asker, D., et al. (2016) · Nano Letters · doi:10.1021/acs.nanolett.6b02261 · Cited by 179
Self-citationHe, Z., Huang, J., Xu, Y., Zhang, X., Teng, Y., Huang, C., Wu, Y., Zhang, X., Zhang, H., & Sun, W. (2015) · Oncotarget · doi:10.18632/oncotarget.6243 · Cited by 112
Gaspar, V. M., Gonçalves, C., de Melo-Diogo, D., Costa, E. C., Queiroz, J. A., Pichon, C., Sousa, F., & Correia, I. J. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.040 · Cited by 91
Tawfik, S. M., Sharipov, M., Huy, B. T., Gerelkhuu, Z., Biechele-Speziale, D., & Lee, Y.-I. (2018) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2017.08.051 · Cited by 56
Metadata
- Authors
- El-Gogary, R. I., Rubio, N., Wang, J. T.-W., Al-Jamal, W. T., Bourgognon, M., Kafa, H., Naeem, M., Klippstein, R., Abbate, V., Leroux, F., Bals, S., Van Tendeloo, G., Kamel, A. O., Awad, G. A. S., Mortada, N. D., & Al-Jamal, K. T.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-01-23
- Volume
- 8
- Issue
- 2
- Pages
- 1384-1401
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2138539254
- Cited by
- 180
- References
- 3
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- green
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