Mapping of Molecular Structure of the Nanoscale Surface in Bionanoparticles
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Abstract Characterizing the orientation of covalently conjugated proteins on nanoparticles, produced for in vitro and in vivo targeting, though an important feature of such a system, has proved challenging. Although extensive physicochemical characterization of targeting nanoparticles can be addressed in detail, relevant biological characterization of the nanointerface is crucial in order to select suitable nanomaterials for further in vitro or in vivo experiments. In this work, we adopt a methodology using antibody fragments (Fab) conjugated to gold nanoparticles (immunogold) to map the available epitopes on a transferrin grafted silica particle (SiO2–PEG8–Tf) as a proxy methodology to predict nanoparticle biological function, and therefore cellular receptor engagement. Data from the adopted method suggest that, on average, only ∼3.5% of proteins grafted on the SiO2–PEG8–Tf nanoparticle surface have a favorable orientation for recognition by the cellular receptor.
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Covalent attachment of counterparts on particles significantly changes their conformations and particle surface properties, inducing potential detrimental interactions with external biomolecules rather than stabilizing them.
“covalent attachment of their counterparts on particles significantly changes their conformations and particle surface properties (e.g., hydrophobicity and charge density), inducing potential detrimental interactions with external biomolecules, rather than stabilizing them13,19,37.”
From Cloaking nanoparticles with protein corona shield for targeted drug delivery. (2018) · cites this paper as [37]
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- Authors
- Herda, L. M., Hristov, D. R., Lo Giudice, M. C., Polo, E., & Dawson, K. A.
- Affiliations
- University College Dublin (IE)
- University College Dublin , , Belfield, ,
- Corresponding author
- Polo, Ester
- Dawson, Kenneth A.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-12-22
- Volume
- 139
- Issue
- 1
- Pages
- 111-114
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2566100154
- Cited by
- 100
- References
- 26
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 13 · 2021: 8 · 2020: 16 · 2019: 13 · 2018: 17 · 2017: 17
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of the American Chemical Society (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Research Repository UCD (University College Dublin) (submittedVersion, cc-by-nc-nd)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- Science Foundation Ireland (12/IA/1422)
- Seventh Framework Programme (604602)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- bionanoparticles, antibody fragments, epitope mapping, transferrin, silica nanoparticles, PEGylation, targeted drug delivery
- MeSH terms
- Antibodies, Gold, Particle Size, Silicon Dioxide, Surface Properties, Molecular Structure, Metal Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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