The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Core–Shell Supramolecular Gelatin Nanoparticles for Adaptive and “On-Demand” Antibiotic Delivery
Abstract
The treatment of bacterial infection is one of the most challenging tasks in the biomedical field. Antibiotics were developed over 70 years and are regarded as the most efficient type of drug to treat bacterial infection. However, there is a concern that the overuse of antibiotics can lead to a growing number of multidrug-resistant bacteria. The development of antibiotic delivery systems to improve the biodistribution and bioavailability of antibiotics is a practical strategy for reducing the generation of antibiotic resistance and increasing the lifespan of newly developed antibiotics. Here we present an antibiotic delivery system (Van⊂SGNPs@RBC) based on core-shell supramolecular gelatin nanoparticles (SGNPs) for adaptive and "on-demand" antibiotic delivery. The core composed of cross-linked SGNPs allows for bacterial infection-microenvironment responsive release of antibiotics. The shell coated with uniform red blood cell membranes executes the function of disguise for reducing the clearance by the immune system during the antibiotic delivery, as well as absorbs the bacterial exotoxin to relieve symptoms caused by bacterial infection. This approach demonstrates an innovative and biomimetic antibiotic delivery system for the treatment of bacterial infection with a minimum dose of antibiotics.
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Cites
Campoccia, D., Montanaro, L., Speziale, P., & Arciola, C. R. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.005 · Cited by 392
Bacteria‐Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery
Xiong, M., Li, Y., Bao, Y., Yang, X., Hu, B., & Wang, J. (2012) · Advanced Materials · doi:10.1002/adma.201202847 · Cited by 299
Sémiramoth, N., Meo, C. D., Zouhiri, F., Saïd-Hassane, F., Valetti, S., Gorges, R., Nicolas, V., Poupaert, J. H., Chollet-Martin, S., Desmaële, D., et al. (2012) · ACS Nano · doi:10.1021/nn204928v · Cited by 133
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Fang, R. H., Kroll, A. V., Gao, W., & Zhang, L. (2018) · Advanced Materials · doi:10.1002/adma.201706759 · Cited by 1,885
Combatting antibiotic-resistant bacteria using nanomaterials
Gupta, A., Mumtaz, S., Li, C.-H., Hussain, I., & Rotello, V. M. (2019) · Chemical Society Reviews · doi:10.1039/c7cs00748e · Cited by 1,115
Cell or Cell Membrane-Based Drug Delivery Systems
Tan, S., Wu, T., Zhang, D., & Zhang, Z. (2015) · Theranostics · doi:10.7150/thno.11852 · Cited by 466
Carbon Dot-Based Platform for Simultaneous Bacterial Distinguishment and Antibacterial Applications
Yang, J., Zhang, X., Ma, Y.-H., Gao, G., Chen, X., Jia, H.-R., Li, Y.-H., Chen, Z., & Wu, F.-G. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b10398 · Cited by 409
Nanoparticle-based local antimicrobial drug delivery
Gao, W., Chen, Y., Zhang, Y., Zhang, Q., & Zhang, L. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.09.015 · Cited by 396
Metadata
- Authors
- Li, L.-L., Xu, J.-H., Qi, G.-B., Zhao, X., Yu, F., & Wang, H.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-04-14
- Volume
- 8
- Issue
- 5
- Pages
- 4975-4983
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2330461172
- Cited by
- 291
- References
- 3
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- closed
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