The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Nanoparticle-based local antimicrobial drug delivery
Open accessAbstract
Despite the wide success of antibiotics in modern medicine, the treatment of bacterial infections still faces critical challenges, especially due to the rapid emergence of antibiotic resistance. As a result, local antimicrobial treatment aimed at enhancing drug concentration at the site of infection while avoiding systemic exposure is becoming increasingly attractive, as it may alleviate resistance development. Meanwhile, therapeutic nanoparticles, especially liposomes, polymeric nanoparticles, dendrimers, and inorganic nanoparticles, are gaining traction to improve the therapeutic efficacy with many applications specifically focused on local antimicrobial treatment. This review highlights topics where nanoparticle-based strategies hold significant potential to advance treatment against local bacterial infections, including (1) promoting antibiotic localization to the pathogen, (2) modulating drug-pathogen interaction against antibiotic resistance, and (3) enabling novel anti-virulence approaches for ‘drug-free’ antimicrobial activity. In each area, we highlight the innovative antimicrobial strategies tailored for local applications and review the progress made for the treatment of bacterial infections.
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Cites
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Self-citationNew antifungal strategies: Drug combination and co-delivery
Zhu, P., Li, Y., Guo, T., Liu, S., Tancer, R. J., Hu, C., Zhao, C., Xue, C., & Liao, G. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114874 · Cited by 63
The role of HPV gene expression and selected cellular MiRNAs in lung cancer development
Hussen, B. M., Ahmadi, G., Marzban, H., Fard Azar, M. E., Sorayyayi, S., Karampour, R., Nahand, J. S., Hidayat, H. J., & Moghoofei, M. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104692 · Cited by 62
Metadata
- Authors
- Gao, W., Chen, Y., Zhang, Y., Zhang, Q., & Zhang, L.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 127
- Pages
- 46-57
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2759096297
- Cited by
- 396
- References
- 135
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
