Cited by 299Nanoparticle-Based Drug DeliveryHydrogels: synthesis, properties, applicationsAdvanced Drug Delivery Systems

Bacteria‐Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery

Xiong, Meng‐Hua, Li, Ya‐Juan, Bao, Yan, Yang, Xian‐Zhu, Hu, Bing, Wang, Jun·2012·Advanced Materials

Abstract

Bacteria-Responsive Multifunctional Nanogel: We developed a bacteria-responsive multifunctional nanogel for targeted antibiotic delivery, in which bacterial enzymes are utilized to trigger antibiotic release by degrading the polyphosphoester core. The mannosylated nanogel preferentially delivers drugs to macrophages and leads to drug accumulation at bacterial infection sites through macrophage transport. This nanogel provides macrophage targeting and lesion site-activatable drug release properties, which enhances bacterial growth inhibition.

Integrity signals

Registry

Crossref · 10.1002/adma.201202847

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In a zebrafish model of MRSA infection, phosphatase-sensitive nanoparticles enhanced survival by 20 percentage points over free-drug controls.

    “In a zebrafish model of methicillin-resistant S. aureus infection, the phosphatase-sensitive nanoparticles enhanced survival by 20 percentage points over free-drug controls.”

    From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [60]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Xiong, M., Li, Y., Bao, Y., Yang, X., Hu, B., & Wang, J.
Affiliations
University of Science and Technology of China (CN)
Corresponding author
  • Hu, Bing
  • Wang, Jun
Venue
Advanced Materials
Publisher
Wiley
Published
2012-09-10
Volume
24
Issue
46
Pages
6175-6180
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
OpenAlex
W2135595096
Cited by
299
References
49
Citations by year
2026: 6 · 2025: 15 · 2024: 20 · 2023: 22 · 2022: 38 · 2021: 41 · 2020: 31 · 2019: 25 · 2018: 23 · 2017: 25 · 2016: 17 · 2015: 11 · 2014: 14 · 2013: 10
FWCI
4.54
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Materials (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
targeted antibiotic delivery, enzyme-responsive drug release, polyphosphoesters, macrophage targeting, bacterial infection, bacterial growth inhibition
MeSH terms
Nanogels, Animals, Anti-Bacterial Agents, Bacteria, Cell Line, Drug Carriers, Embryo, Nonmammalian, Macrophages, Phagocytosis, Phospholipases, Polyethylene Glycols, Polyethyleneimine, Vancomycin, Zebrafish, Microscopy, Confocal, Mice, Methicillin-Resistant Staphylococcus aureus

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review