Bacteria‐Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery
Abstract
Bacteria-Responsive Multifunctional Nanogel: We developed a bacteria-responsive multifunctional nanogel for targeted antibiotic delivery, in which bacterial enzymes are utilized to trigger antibiotic release by degrading the polyphosphoester core. The mannosylated nanogel preferentially delivers drugs to macrophages and leads to drug accumulation at bacterial infection sites through macrophage transport. This nanogel provides macrophage targeting and lesion site-activatable drug release properties, which enhances bacterial growth inhibition.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a zebrafish model of MRSA infection, phosphatase-sensitive nanoparticles enhanced survival by 20 percentage points over free-drug controls.
“In a zebrafish model of methicillin-resistant S. aureus infection, the phosphatase-sensitive nanoparticles enhanced survival by 20 percentage points over free-drug controls.”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [60]
Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710 · see citing works
Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558 · see citing works
Animal models of human disease: zebrafish swim into view
Lieschke, G. J., & Currie, P. D. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2091 · Cited by 2,162 · see citing works
Molecular Mechanisms of Antibacterial Multidrug Resistance
Alekshun, M. N., & Levy, S. B. (2007) · Cell · doi:10.1016/j.cell.2007.03.004 · Cited by 1,648 · see citing works
Immune evasion by staphylococci
Foster, T. J. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1289 · Cited by 1,214 · see citing works
Du, J., Du, X., Mao, C., & Wang, J. (2011) · Journal of the American Chemical Society · doi:10.1021/ja207150n · Cited by 1,176 · see citing works
Self-citationProctor, R. A., von Eiff, C., Kahl, B. C., Becker, K., McNamara, P., Herrmann, M., & Peters, G. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1384 · Cited by 1,175 · see citing works
Reduction-sensitive polymers and bioconjugates for biomedical applications
Meng, F., Hennink, W. E., & Zhong, Z. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.026 · Cited by 1,132 · see citing works
Multistage nanoparticle delivery system for deep penetration into tumor tissue
Wong, C., Stylianopoulos, T., Cui, J., Martin, J. D., Chauhan, V. P., Jiang, W., Popović, Z., Jain, R. K., Bawendi, M. G., & Fukumura, D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018382108 · Cited by 1,067 · see citing works
Tumor imaging by means of proteolytic activation of cell-penetrating peptides
Jiang, T., Olson, E. S., Nguyen, Q. T., Roy, M., Jennings, P. A., & Tsien, R. Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408191101 · Cited by 823 · see citing works
Glutathione-Mediated Delivery and Release Using Monolayer Protected Nanoparticle Carriers
Hong, R., Han, G., Fernández, J. M., Kim, B., Forbes, N. S., & Rotello, V. M. (2006) · Journal of the American Chemical Society · doi:10.1021/ja056726i · Cited by 817 · see citing works
Zhao, Y., Trewyn, B. G., Slowing, I. I., & Lin, V. S. ‐. (2009) · Journal of the American Chemical Society · doi:10.1021/ja901831u · Cited by 771 · see citing works
Super pH-Sensitive Multifunctional Polymeric Micelle
Lee, E. S., Na, K., & Bae, Y. H. (2005) · Nano Letters · doi:10.1021/nl0479987 · Cited by 611 · see citing works
Multi-Stimuli Sensitive Amphiphilic Block Copolymer Assemblies
Klaikherd, A., Nagamani, C., & Thayumanavan, S. (2009) · Journal of the American Chemical Society · doi:10.1021/ja809475a · Cited by 594 · see citing works
Radovic‐Moreno, A. F., Lu, T. K., Puscasu, V. A., Yoon, S.-S., Langer, R., & Farokhzad, O. C. (2012) · ACS Nano · doi:10.1021/nn3008383 · Cited by 542 · see citing works
Extracellularly Activated Nanocarriers: A New Paradigm of Tumor Targeted Drug Delivery
Gullotti, E., & Yeo, Y. (2009) · Molecular Pharmaceutics · doi:10.1021/mp900090z · Cited by 471 · see citing works
Staphylococcus aureus: new evidence for intracellular persistence
Garzoni, C., & Kelley, W. L. (2009) · Trends in Microbiology · doi:10.1016/j.tim.2008.11.005 · Cited by 471 · see citing works
Oh, J. K., Siegwart, D. J., Lee, H., Sherwood, G. A., Peteanu, L. A., Hollinger, J. O., Kataoka, K., & Matyjaszewski, K. A. (2007) · Journal of the American Chemical Society · doi:10.1021/ja069150l · Cited by 467 · see citing works
Targeted delivery of antibiotics using liposomes and nanoparticles: research and applications
Pinto‐Alphandary, H., Andremont, A., & Couvreur, P. (2000) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(99)00121-1 · Cited by 428 · see citing works
A Protein Nanocarrier from Charge-Conversion Polymer in Response to Endosomal pH
Lee, Y., Fukushima, S., Bae, Y., Hiki, S., Ishii, T., & Kataoka, K. (2007) · Journal of the American Chemical Society · doi:10.1021/ja071090b · Cited by 405 · see citing works
Antimicrobial-resistant bacteria in the community setting
Furuya, E. Y., & Lowy, F. D. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1325 · Cited by 386 · see citing works
Lipase-Sensitive Polymeric Triple-Layered Nanogel for “On-Demand” Drug Delivery
Xiong, M., Bao, Y., Yang, X., Wang, Y., Sun, B., & Wang, J. (2012) · Journal of the American Chemical Society · doi:10.1021/ja211279u · Cited by 362 · see citing works
Self-citationLayer-by-Layer Nanoparticles with a pH-Sheddable Layer for<i>in Vivo</i>Targeting of Tumor Hypoxia
Poon, Z., Chang, D., Zhao, X., & Hammond, P. T. (2011) · ACS Nano · doi:10.1021/nn200876f · Cited by 343 · see citing works
Mannose-targeted systems for the delivery of therapeutics
Irache, J. M., Salman, H. H., Gamazo, C., & Espuelas, S. (2008) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.6.703 · Cited by 295 · see citing works
Pornpattananangkul, D., Zhang, L., Olson, S., Aryal, S., Obonyo, M., Vecchio, K. S., Huang, C.-M., & Zhang, L. (2011) · Journal of the American Chemical Society · doi:10.1021/ja111110e · Cited by 294 · see citing works
Penetration of vancomycin into human lung tissue
Cruciani, M., Gatti, G., Lazzarini, L., Furlan, G., Broccali, G., Malena, M., Franchini, C., & Concia, E. (1996) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/38.5.865 · Cited by 264 · see citing works
Zebrafish as a correlative and predictive model for assessing biomaterial nanotoxicity
Fako, V. E., & Furgeson, D. Y. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.008 · Cited by 261 · see citing works
Multistage pH‐Responsive Liposomes for Mitochondrial‐Targeted Anticancer Drug Delivery
Mo, R., Sun, Q., Xue, J., Li, N., Li, W., Zhang, C., & Ping, Q.-N. (2012) · Advances in Materials · doi:10.1002/adma.201201498 · Cited by 232 · see citing works
Delivery systems to increase the selectivity of antibiotics in phagocytic cells
Briones, E., Colino, C. I., & Lanao, J. M. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.10.027 · Cited by 226 · see citing works
Rational Molecular Design of Stimulus‐Responsive Supramolecular Hydrogels Based on Dipeptides
Ikeda, M., Tanida, T., Yoshii, T., & Hamachi, I. (2011) · Advanced Materials · doi:10.1002/adma.201004658 · Cited by 202 · see citing works
Bacterial phospholipases and pathogenesis
Schmiel, D. H., & Miller, V. L. (1999) · Microbes and Infection · doi:10.1016/s1286-4579(99)00205-1 · Cited by 193 · see citing works
Jiang, H., Kang, M. L., Quan, J., Kang, S., Akaike, T., Yoo, H. S., & Cho, C. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2007.12.025 · Cited by 162 · see citing works
Targeted delivery of antibiotics to intracellular chlamydial infections using PLGA nanoparticles
Toti, U. S., Guru, B. R., Hali, M., McPharlin, C. M., Wykes, S. M., Panyam, J., & Whittum-Hudson, J. A. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.05.038 · Cited by 143 · see citing works
Gordijo, C. R., Koulajian, K., Shuhendler, A. J., Bonifácio, L. D. S., Huang, H. Y., Chiang, S., Ozin, G. A., Giacca, A., & Wu, X. Y. (2010) · Advanced Functional Materials · doi:10.1002/adfm.201001762 · Cited by 124 · see citing works
Glucose‐Responsive Bioinorganic Nanohybrid Membrane for Self‐Regulated Insulin Release
Gordijo, C. R., Shuhendler, A. J., & Wu, X. Y. (2010) · Advanced Functional Materials · doi:10.1002/adfm.200901581 · Cited by 118 · see citing works
Wachiralarpphaithoon, C., Iwasaki, Y., & Akiyoshi, K. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.10.024 · Cited by 111 · see citing works
Phosphatases and kinases delivered to the host cell by bacterial pathogens
DeVinney, R., Steele‐Mortimer, O., & Finlay, B. B. (2000) · Trends in Microbiology · doi:10.1016/s0966-842x(99)01657-1 · Cited by 110 · see citing works
Räisänen, S. R., Alatalo, S. L., Ylipahkala, H., Halleen, J. M., Cassady, A. I., Hume, D. A., & Väänänen, H. K. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.133 · Cited by 79 · see citing works
Lu, Z., Wu, J., Sun, T., Ji, J., Yan, L., & Wang, J. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.10.033 · Cited by 69 · see citing works
Self-citationXiong, M., Wu, J., Wang, Y., Li, L., Liu, X., Zhang, G., Yan, L., & Wang, J. (2009) · Macromolecules · doi:10.1021/ma802688y · Cited by 65 · see citing works
Self-citationTitball, R. W. (1997) · Trends in Microbiology · doi:10.1016/s0966-842x(97)88834-8 · Cited by 63 · see citing works
Balland, O., Pinto‐Alphandary, H., Viron, A., Puvion, E., Andremont, A., & Couvreur, P. (1996) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/37.1.105 · Cited by 61 · see citing works
Wijagkanalan, W., Kawakami, S., Higuchi, Y., Yamashita, F., & Hashida, M. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.12.016 · Cited by 59 · see citing works
Yang, X., Sun, T., Dou, S., Wu, J., Wang, Y., & Wang, J. (2009) · Biomacromolecules · doi:10.1021/bm900390k · Cited by 57 · see citing works
Self-citationPinto-Alphandary, H., Balland, O., Laurent, M., Andremont, A., Puisieux, F., & Couvreur, P. (1994) · Pharmaceutical Research · doi:10.1023/a:1018985308984 · Cited by 53 · see citing works
Huang, C. F., & Cabot, M. C. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)38187-0 · Cited by 51 · see citing works
Delivery of antimicrobials to infected tissue macrophages
Bakker‐Woudenberg, I. A. J. M. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00037-8 · Cited by 51 · see citing works
Phagocyte Transport as Mechanism for Enhanced Therapeutic Activity of Liposomal Amphotericin B
Mehta, R. T., McQueen, T. J., Keyhani, A., & Lopez‐Berestein, G. (2009) · Chemotherapy · doi:10.1159/000239202 · Cited by 34 · see citing works
Macrophage functions in antimicrobial defense
Schaffner, T. J., Keller, H. U., Hess, M. W., & Cottier, H. (1982) · Journal of Molecular Medicine · doi:10.1007/bf01716563 · Cited by 28 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The antimicrobial activity of nanoparticles: present situation and prospects for the future
Wang, L., Hu, C., & Shao, L. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s121956 · Cited by 4,062 · see citing works
Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery
Torchilin, V. P. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4333 · Cited by 1,674 · see citing works
Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems
Karimi, M., Ghasemi, A., Zangabad, P. S., Rahighi, R., Basri, S. M. M., Mirshekari, H., Amiri, M., Shafaei, Z., Aslani, A., Bozorgomid, M., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00798d · Cited by 1,526 · see citing works
Lü, Y., Aimetti, A. A., Langer, R., & Gu, Z. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.75 · Cited by 1,432 · see citing works
Polymeric Nanoparticles for Drug Delivery
Beach, M. A., Nayanathara, U., Gao, Y., Zhang, C., Xiong, Y., Wang, Y., & Such, G. K. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00705 · Cited by 1,229 · see citing works
Nanotechnology approaches for global infectious diseases
Kirtane, A. R., Verma, M., Karandikar, P., Furin, J., Langer, R., & Traverso, G. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00866-8 · Cited by 520 · see citing works
Polymeric Nanostructures for Imaging and Therapy
Elsabahy, M., Heo, G. S., Lim, S., Sun, G., & Wooley, K. L. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00135 · Cited by 507 · see citing works
Wang, Z., Dong, K., Liu, Z., Zhang, Y., Chen, Z., Sun, H., Ren, J., & Qu, X. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.041 · Cited by 403 · see citing works
Nanoparticle-based local antimicrobial drug delivery
Gao, W., Chen, Y., Zhang, Y., Zhang, Q., & Zhang, L. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.09.015 · Cited by 404 · see citing works
Micro- and nanogels with labile crosslinks – from synthesis to biomedical applications
Zhang, X., Malhotra, S., Molina, M. A., & Haag, R. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00341a · Cited by 369 · see citing works
Polymeric nanostructured materials for biomedical applications
Tang, Z., He, C., Tian, H., Ding, J., Hsiao, B. S., Chu, B., & Chen, X. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2016.05.005 · Cited by 364 · see citing works
Nanomedicine in the management of microbial infection – Overview and perspectives
Zhu, X., Radovic‐Moreno, A. F., Wu, J., Langer, R., & Shi, J. (2014) · Nano Today · doi:10.1016/j.nantod.2014.06.003 · Cited by 364 · see citing works
Nanoparticle approaches against bacterial infections
Gao, W., Thamphiwatana, S., Angsantikul, P., & Zhang, L. (2014) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1282 · Cited by 351 · see citing works
The Role of Macrophages in Staphylococcus aureus Infection
Pidwill, G. R., Gibson, J. F., Cole, J., Renshaw, S. A., & Foster, S. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.620339 · Cited by 341 · see citing works
Delivery of antibiotics with polymeric particles
Xiong, M., Bao, Y., Yang, X., Zhu, Y., & Wang, J. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.02.002 · Cited by 304 · see citing works
Self-citationCore–Shell Supramolecular Gelatin Nanoparticles for Adaptive and “On-Demand” Antibiotic Delivery
Li, L., Xu, J., Qi, G., Zhao, X., Yu, F., & Wang, H. (2014) · ACS Nano · doi:10.1021/nn501040h · Cited by 291 · see citing works
Infection microenvironment-related antibacterial nanotherapeutic strategies
Wang, Z., Liu, X., Duan, Y., & Huang, Y. P. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121249 · Cited by 269 · see citing works
Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery of doxorubicin
Li, M., Tang, Z., Lv, S., Song, W., Hong, H., Jing, X., Zhang, Y., & Chen, X. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.01.018 · Cited by 262 · see citing works
Paper-based chemical and biological sensors: Engineering aspects
Ahmed, S., Bui, M.-P. N., & Abbas, A. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.09.038 · Cited by 249 · see citing works
Nanotechnology as a Novel Approach in Combating Microbes Providing an Alternative to Antibiotics
Mubeen, B., Ansar, A. N., Rasool, R., Ullah, I., Imam, S. S., Alshehri, S., Ghoneim, M. M., Alzarea, S. I., Nadeem, M. S., & Kazmi, I. A. (2021) · Antibiotics · doi:10.3390/antibiotics10121473 · Cited by 254 · see citing works
Wang, X. S., Shan, M., Zhang, S., Chen, X., Liu, W., Chen, J., & Liu, X. (2022) · Advanced Science · doi:10.1002/advs.202104843 · Cited by 244 · see citing works
Wang, Y., Jin, Y., Chen, W., Wang, J., Chen, H., Sun, L. N., Li, X., Ji, J., Yu, Q., Shen, L., et al. (2018) · Chemical Engineering Journal · doi:10.1016/j.cej.2018.10.002 · Cited by 245 · see citing works
Self-citationMultifunctional Coatings and Nanotopographies: Toward Cell Instructive and Antibacterial Implants
Mas‐Moruno, C., Su, B., & Dalby, M. J. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201801103 · Cited by 242 · see citing works
Ji, H., Dong, K., Yan, Z., Ding, C., Chen, Z., Ren, J., & Qu, X. (2016) · Small · doi:10.1002/smll.201601729 · Cited by 241 · see citing works
Li, X., Wu, B., Chen, H., Nan, K., Jin, Y., Sun, L. N., & Wang, B. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb01245h · Cited by 237 · see citing works
Wang, H., Di, J., Sun, Y., Fu, J., Wei, Z., Matsui, H., Alonso, A. D. C., & Zhou, S. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201501524 · Cited by 232 · see citing works
He, J., Wang, W., Sun, F., Shi, W., Qi, D., Wang, K., Shi, R., Cui, F., Wang, C., & Chen, X. (2015) · ACS Nano · doi:10.1021/acsnano.5b04236 · Cited by 226 · see citing works
Gram‐Positive Antimicrobial Activity of Amino Acid‐Based Hydrogels
Irwansyah, I., Li, Y., Shi, W., Qi, D., Leow, W. R., Tang, M. B. Y., Li, S., & Chen, X. (2014) · Advanced Materials · doi:10.1002/adma.201403339 · Cited by 224 · see citing works
Self-citationBioresponsive Nanoparticles Targeted to Infectious Microenvironments for Sepsis Management
Zhang, C. Y., Gao, J., & Wang, Z. (2018) · Advanced Materials · doi:10.1002/adma.201803618 · Cited by 222 · see citing works
Nano-therapeutics: A revolution in infection control in post antibiotic era
Zaidi, S., Misba, L., & Khan, A. U. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.06.015 · Cited by 194 · see citing works
Zhang, Y., Zhang, J., Chen, W., Angsantikul, P., Spiekermann, K., Fang, R. H., Gao, W., & Zhang, L. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.01.016 · Cited by 194 · see citing works
Ding, X., Wang, A., Tong, W., & Xu, F. (2019) · Small · doi:10.1002/smll.201900999 · Cited by 193 · see citing works
Multiple strategies to activate gold nanoparticles as antibiotics
Zhao, Y., & Jiang, X. (2013) · Nanoscale · doi:10.1039/c3nr01990j · Cited by 189 · see citing works
Bauer, K. N., Tee, H. T., Velencoso, M. M., & Wurm, F. R. (2017) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2017.05.004 · Cited by 189 · see citing works
Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies
Si, Z., Zheng, W., Pranantyo, D., Li, J., Koh, C. H., Kang, E. T., Pethe, K., & Chan‐Park, M. B. E. (2021) · Chemical Science · doi:10.1039/d1sc05835e · Cited by 181 · see citing works
Feng, W., Li, G., Kang, X., Wang, R., Liu, F., Zhao, D., Li, H., Bu, F., Yu, Y., Moriarty, T. F., et al. (2022) · Advanced Materials · doi:10.1002/adma.202109789 · Cited by 173 · see citing works
Liu, Z., Liu, X., & Ramakrishna, S. (2021) · Biotechnology Journal · doi:10.1002/biot.202000116 · Cited by 167 · see citing works
Antibacterial surface design of biomedical titanium materials for orthopedic applications
Zhang, Y., He, Y., Lin, C., Liu, P., & Cai, K. (2020) · Journal of Material Science and Technology · doi:10.1016/j.jmst.2020.10.066 · Cited by 166 · see citing works
Functional Microgels: Recent Advances in Their Biomedical Applications
Agrawal, G., & Agrawal, R. (2018) · Small · doi:10.1002/smll.201801724 · Cited by 164 · see citing works
Hu, Q., Sun, W., Lü, Y., Bomba, H. N., Ye, Y., Jiang, T., Isaacson, A., & Gu, Z. (2016) · Nano Letters · doi:10.1021/acs.nanolett.5b04343 · Cited by 162 · see citing works
Shreffler, J., Pullan, J. E., Dailey, K. M., Mallik, S., & Brooks, A. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236056 · Cited by 164 · see citing works
Bacteria‐Assisted Activation of Antimicrobial Polypeptides by a Random‐Coil to Helix Transition
Xiong, M., Han, Z., Song, Z., Yu, J. Z., Ying, H., Yin, L., & Cheng, J. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201706071 · Cited by 159 · see citing works
Self-citationNonleaching Bacteria-Responsive Antibacterial Surface Based on a Unique Hierarchical Architecture
Yan, S., Shi, H., Song, L., Wang, X., Liu, L., Luan, S., Yang, Y., & Yin, J. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b08436 · Cited by 157 · see citing works
Wu, Y., Song, Z., Wang, H., & Han, H. (2019) · Nature Communications · doi:10.1038/s41467-019-12233-2 · Cited by 148 · see citing works
Nanogels: A novel approach in antimicrobial delivery systems and antimicrobial coatings
Keskin, D., Zu, G., Forson, A. M., Tromp, L., Sjollema, J., & van Rijn, P. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.03.004 · Cited by 149 · see citing works
Synthetic macromolecules as therapeutics that overcome resistance in cancer and microbial infection
Tan, J., Tay, J., Hedrick, J. L., & Yang, Y. Y. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120078 · Cited by 143 · see citing works
Gao, F., Xu, L., Yang, B., Fan, F., & Yang, L. (2018) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.8b00212 · Cited by 141 · see citing works
Stimuli‐Responsive Hydrogels for Antibacterial Applications
Hao, Z., Li, X., Zhang, R., & Zhang, L. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400513 · Cited by 135 · see citing works
An AIEgen‐Peptide Conjugate as a Phototheranostic Agent for Phagosome‐Entrapped Bacteria
Qi, G., Hu, F., Kenry, K., Shi, L., Wu, M., & Liu, B. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201906099 · Cited by 135 · see citing works
Towards Robust Delivery of Antimicrobial Peptides to Combat Bacterial Resistance
Drayton, M., Kizhakkedathu, J. N., & Straus, S. K. (2020) · Molecules · doi:10.3390/molecules25133048 · Cited by 134 · see citing works
Nanoparticles for treatment of bovine Staphylococcus aureus mastitis
Algharib, S. A., Dawood, A. S., & Xie, S. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1724209 · Cited by 132 · see citing works
Wang, H., Yi, J., Mukherjee, S., Banerjee, P., & Zhou, S. (2014) · Nanoscale · doi:10.1039/c4nr03748k · Cited by 127 · see citing works
Zhu, K., Qian, S., Guo, H., Wang, Q., Chu, X., Wang, X., Lu, S. T., Peng, Y., Guo, Y., Zhu, Z., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c03971 · Cited by 127 · see citing works
Aflakian, F., Mirzavi, F., Aiyelabegan, H. T., Soleimani, A., Navashenaq, J. G., Karimi-Sani, I., Zomorodi, A. R., & Vakili‐Ghartavol, R. (2023) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2023.106515 · Cited by 127 · see citing works
In Situ Capture of Bacterial Toxins for Antivirulence Vaccination
Wei, X., Gao, J., Wang, F., Man, Y. M., Angsantikul, P., Kroll, A. V., Zhou, J., Gao, W., Lu, W., Fang, R. H., et al. (2017) · Advanced Materials · doi:10.1002/adma.201701644 · Cited by 118 · see citing works
Responsive crosslinked polymer nanogels for imaging and therapeutics delivery
Ekkelenkamp, A. E., Elzes, M. R., Engbersen, J. F. J., & Paulusse, J. M. J. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb02239e · Cited by 119 · see citing works
Design of smart targeted and responsive drug delivery systems with enhanced antibacterial properties
Chen, H., Jin, Y., Wang, J., Wang, Y., Jiang, W., Dai, H., Pang, S., Lei, L., Ji, J., & Wang, B. (2018) · Nanoscale · doi:10.1039/c8nr07146b · Cited by 118 · see citing works
Self-citationNanotools for Sepsis Diagnosis and Treatment
Papafilippou, L., Claxton, A., Dark, P., Kostarelos, K., & Hadjidemetriou, M. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202001378 · Cited by 118 · see citing works
Shah, S., Rangaraj, N., Laxmikeshav, K., & Sampathi, S. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119268 · Cited by 117 · see citing works
Photo, pH and redox multi-responsive nanogels for drug delivery and fluorescence cell imaging
Chen, S., Bian, Q., Wang, P., Zheng, X., Lv, L., Dang, Z., & Wang, G. (2017) · Polymer Chemistry · doi:10.1039/c7py01424d · Cited by 114 · see citing works
Wang, H., Ke, F., Mararenko, A., Wei, Z., Banerjee, P., & Zhou, S. (2014) · Nanoscale · doi:10.1039/c4nr01030b · Cited by 112 · see citing works
Yu, L., Li, K., Zhang, J., Jin, H., Saleem, A., Song, Q., Jia, Q., & Li, P. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c01132 · Cited by 111 · see citing works
Stimuli-Activable Metal-Bearing Nanomaterials and Precise On-Demand Antibacterial Strategies
Zhong, Y., Zheng, X. T., Zhao, S., Su, X., & Loh, X. J. (2022) · ACS Nano · doi:10.1021/acsnano.2c08262 · Cited by 109 · see citing works
Liu, Y., Ren, Y.-J., Li, Y.-F., Su, L., Zhang, Y.-M., Huang, F., Liu, J.-J., Liu, J.-F., van Kooten, T. V., An, Y.-L., et al. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.08.038 · Cited by 98 · see citing works
Self-citationEmerging antibacterial nanomedicine for enhanced antibiotic therapy
Wang, S., Gao, Y., Jin, Q., & Ji, J. (2020) · Biomaterials Science · doi:10.1039/d0bm00974a · Cited by 107 · see citing works
Devnarain, N., Osman, N., Fasiku, V. O., Makhathini, S. S., Salih, M., Ibrahim, U. H., & Govender, T. (2020) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1664 · Cited by 106 · see citing works
Enzyme-triggered smart antimicrobial drug release systems against bacterial infections
Zhou, Q., Si, Z., Wang, K., Li, K., Hong, W., Zhang, Y., & Li, P. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.10.038 · Cited by 104 · see citing works
Role and modulation of the secondary structure of antimicrobial peptides to improve selectivity
Liang, Y., Zhang, X., Yuan, Y., Bao, Y., & Xiong, M. (2020) · Biomaterials Science · doi:10.1039/d0bm00801j · Cited by 103 · see citing works
Self-citationMin, T., Zhou, L., Sun, X., Du, H., Bian, X., Zhu, Z., & Wen, Y. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111256 · Cited by 103 · see citing works
He, W., Zhang, Y., Li, J., Gao, Y., Luo, F., Tan, H. S., Wang, K., & Fu, Q. (2016) · Scientific Reports · doi:10.1038/srep32140 · Cited by 100 · see citing works
Subramaniam, S., Joyce, P., Thomas, N., & Prestidge, C. A. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113948 · Cited by 99 · see citing works
Current progress and prospects of organic nanoparticles against bacterial biofilm
Li, X., Chen, D., & Xie, S. (2021) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2021.102475 · Cited by 99 · see citing works
Biodegradable Polymers and Polymer Composites with Antibacterial Properties
Smola-Dmochowska, A., Lewicka, K., Macyk, A., Rychter, P., Pamuła, E., & Dobrzyński, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087473 · Cited by 99 · see citing works
Kalhapure, R. S., Sikwal, D. R., Rambharose, S., Mocktar, C., Singh, S. D., Bester, L. A., Oh, J. K., Renukuntla, J., & Govender, T. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.04.010 · Cited by 95 · see citing works
Uskoković, V. (2014) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.2014010920 · Cited by 95 · see citing works
Wang, B., Liu, H., Wang, Z., Shi, S., Nan, K., Xu, Q., Ye, Z., & Chen, H. (2017) · Journal of Materials Chemistry B · doi:10.1039/c6tb02614a · Cited by 94 · see citing works
RetractedA review on core–shell structured unimolecular nanoparticles for biomedical applications
Chen, G., Wang, Y., Xie, R., & Gong, S. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.07.008 · Cited by 95 · see citing works
Mosaiab, T., Farr, D. C., Kiefel, M. J., & Houston, T. A. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.09.002 · Cited by 92 · see citing works
Controlled drug delivery systems in eradicating bacterial biofilm-associated infections
Liu, Y., Li, Y., & Shi, L. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.10.038 · Cited by 91 · see citing works
Self-citationAdeniji, O. O., Nontongana, N., Okoh, J. C., & Okoh, A. I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315038 · Cited by 93 · see citing works
Liu, Z., Zhu, Y., Liu, X., Yeung, K., & Wu, S. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.12.016 · Cited by 87 · see citing works
Cai, Q., Fei, Y., Hu, L., Huang, Z., Li, L., & Wang, H. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b02286 · Cited by 87 · see citing works
Obuobi, S. A. O., Julin, K., Fredheim, E. G. A., Johannessen, M., & Škalko‐Basnet, N. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.06.002 · Cited by 90 · see citing works
Wang, T., Rong, F., Tang, Y., Li, M., Feng, T., Zhou, Q., Li, P., & Huang, W. (2021) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2021.101389 · Cited by 86 · see citing works
Cell Membrane-Cloaked Nanotherapeutics for Targeted Drug Delivery
Lee, N., You, S., Taghizadeh, A. A., Taghizadeh, M., & Kim, H. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042223 · Cited by 80 · see citing works
Wang, B., Liu, H., Sun, L. N., Jin, Y., Ding, X., Li, L., Ji, J., & Chen, H. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b01268 · Cited by 81 · see citing works
Deng, Y., Gao, X., Shi, X., Lu, S., Yang, W., Duan, C., & Chen, Z. (2020) · Chemistry of Materials · doi:10.1021/acs.chemmater.0c00290 · Cited by 80 · see citing works
Capeletti, L. B., de Oliveira, J. F. A., Loiola, L. M. D., Galdino, F. E., Santos, D. E. S., Soares, T. A., Freitas, R. O., & Cardoso, M. B. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201904216 · Cited by 78 · see citing works
Kalhapure, R. S., Jadhav, M., Rambharose, S., Mocktar, C., Singh, S. D., Renukuntla, J., & Govender, T. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.07.049 · Cited by 77 · see citing works
Nanomaterial-based strategies in antimicrobial applications: Progress and perspectives
Zhao, Y., Chen, L., Wang, Y., Song, X., Li, K., Yan, X., Yu, L., & He, Z. (2021) · Nano Research · doi:10.1007/s12274-021-3417-4 · Cited by 77 · see citing works
Chen, X., Wang, X., Fang, Y., Zhang, L., Zhao, M., & Liu, Y. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c00877 · Cited by 77 · see citing works
Zhang, Y., Huang, S., Lan, S., Xiong, H., Tao, B., Ding, Y., Liu, Y., Liu, P., & Cai, K. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb01918e · Cited by 75 · see citing works
Yu, M., Guo, X., Lü, H., Li, P., Huang, R., Xu, C., Gong, X., Xiao, Y., & Xing, X. (2022) · Carbon · doi:10.1016/j.carbon.2022.07.065 · Cited by 75 · see citing works
Elsabahy, M., Zhang, S., Zhang, F., Deng, Z. J., Lim, Y. H., Wang, H., Parsamian, P., Hammond, P. T., & Wooley, K. L. (2013) · Scientific Reports · doi:10.1038/srep03313 · Cited by 73 · see citing works
Macrophage-Instructed Intracellular Staphylococcus aureus Killing by Targeting Photodynamic Dimers
Cai, Q., Fei, Y., An, H., Zhao, X., Ma, Y., Cong, Y., Hu, L., Li, L., & Wang, H. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b19056 · Cited by 73 · see citing works
Xiong, M., Bao, Y., Du, X., Tan, Z., Jiang, Q., Wang, H., Zhu, Y., & Wang, J. (2013) · ACS Nano · doi:10.1021/nn403146t · Cited by 72 · see citing works
Self-citationPolyphosphoesters: New trends in synthesis and drug delivery applications
Yilmaz, Z. E., & Jérôme, C. (2016) · Macromolecular Bioscience · doi:10.1002/mabi.201600269 · Cited by 71 · see citing works
Menina, S., Eisenbeis, J., Kamal, M. A. M., Koch, M., Bischoff, M., Gordon, S., Loretz, B., & Lehr, C. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900564 · Cited by 71 · see citing works
Zhang, Y., Pi, Y., Hua, Y., Xie, J., Wang, C., Guo, K., Zhao, Z., & Yong, Y. (2020) · Theranostics · doi:10.7150/thno.49008 · Cited by 70 · see citing works
Nanoparticles: Antimicrobial Applications and Its Prospects
Varier, K. M., Gudeppu, M., Chinnasamy, A., Sumathi, T., Balasubramanian, J., Li, Y., & Gajendran, B. (2019) · Environmental chemistry for a sustainable world · doi:10.1007/978-3-030-04477-0_12 · Cited by 69 · see citing works
Self-citation
- Authors
- Xiong, M., Li, Y., Bao, Y., Yang, X., Hu, B., & Wang, J.
- Affiliations
- University of Science and Technology of China (CN)
- Corresponding author
- Hu, Bing
- Wang, Jun
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2012-09-10
- Volume
- 24
- Issue
- 46
- Pages
- 6175-6180
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2135595096
- Cited by
- 299
- References
- 49
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 20 · 2023: 22 · 2022: 38 · 2021: 41 · 2020: 31 · 2019: 25 · 2018: 23 · 2017: 25 · 2016: 17 · 2015: 11 · 2014: 14 · 2013: 10
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- targeted antibiotic delivery, enzyme-responsive drug release, polyphosphoesters, macrophage targeting, bacterial infection, bacterial growth inhibition
- MeSH terms
- Nanogels, Animals, Anti-Bacterial Agents, Bacteria, Cell Line, Drug Carriers, Embryo, Nonmammalian, Macrophages, Phagocytosis, Phospholipases, Polyethylene Glycols, Polyethyleneimine, Vancomycin, Zebrafish, Microscopy, Confocal, Mice, Methicillin-Resistant Staphylococcus aureus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review