The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Chelator-Free 64Cu-Integrated Gold Nanomaterials for Positron Emission Tomography Imaging Guided Photothermal Cancer Therapy
Open accessAbstract
Using positron emission tomography (PET) imaging to monitor and quantitatively analyze the delivery and localization of Au nanomaterials (NMs), a widely used photothermal agent, is essential to optimize therapeutic protocols to achieve individualized medicine and avoid side effects. Coupling radiometals to Au NMs via a chelator faces the challenges of possible detachment of the radiometals as well as surface property changes of the NMs. In this study, we reported a simple and general chelator-free (64)Cu radiolabeling method by chemically reducing (64)Cu on the surface of polyethylene glycol (PEG)-stabilized Au NMs regardless of their shape and size. Our (64)Cu-integrated NMs are proved to be radiochemically stable and can provide an accurate and sensitive localization of NMs through noninvasive PET imaging. We further integrated (64)Cu onto arginine-glycine-aspartic acid (RGD) peptide modified Au nanorods (NRs) for tumor theranostic application. These NRs showed high tumor targeting ability in a U87MG glioblastoma xenograft model and were successfully used for PET image-guided photothermal therapy.
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Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
Longmire, M., Choyke, P. L., & Kobayashi, H. (2008) · Nanomedicine · doi:10.2217/17435889.3.5.703 · Cited by 2,149
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Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
Recent Progress in Cancer Thermal Therapy Using Gold Nanoparticles
Abadeer, N. S., & Murphy, C. J. (2016) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.5b11232 · Cited by 919
Ha, M., Kim, J.-H., You, M., Li, Q., Fan, C., & Nam, J.-M. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00234 · Cited by 466
Song, J., Yang, X., Jacobson, O., Lin, L., Huang, P., Niu, G., Ma, Q., & Chen, X. (2015) · ACS Nano · doi:10.1021/acsnano.5b03804 · Cited by 319
Self-citationA Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy
Liu, Y., Ashton, J. R., Moding, E. J., Yuan, H., Register, J. K., Fales, A. M., Choi, J., Whitley, M. J., Zhao, X., Qi, Y., et al. (2015) · Theranostics · doi:10.7150/thno.11974 · Cited by 308
Metadata
- Authors
- Sun, X., Huang, X., Yan, X., Wang, Y., Guo, J., Jacobson, O., Liu, D., Szajek, L. P., Zhu, W., Niu, G., Kiesewetter, D. O., Sun, S., & Chen, X.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-07-24
- Volume
- 8
- Issue
- 8
- Pages
- 8438-8446
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W1143245980
- Cited by
- 187
- References
- 2
- FWCI
- 12.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sun, X., Huang, X., Yan, X., Wang, Y., Guo, J., Jacobson, O., Liu, D., Szajek, L. P., Zhu, W., Niu, G., Kiesewetter, D. O., Sun, S., & Chen, X. (2014). Chelator-Free 64Cu-Integrated Gold Nanomaterials for Positron Emission Tomography Imaging Guided Photothermal Cancer Therapy. ACS Nano. https://doi.org/10.1021/nn502950t
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