The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Supramolecular Chemistry on Water-Soluble Carbon Nanotubes for Drug Loading and Delivery
Abstract
We show that large surface areas exist for supramolecular chemistry on single-walled carbon nanotubes (SWNTs) prefunctionalized noncovalently or covalently by common surfactant or acid-oxidation routes. Water-soluble SWNTs with poly(ethylene glycol) (PEG) functionalization via these routes allow for surprisingly high degrees of pi-stacking of aromatic molecules, including a cancer drug (doxorubicin) with ultrahigh loading capacity, a widely used fluorescence molecule (fluorescein), and combinations of molecules. Binding of molecules to nanotubes and their release can be controlled by varying the pH. The strength of pi-stacking of aromatic molecules is dependent on nanotube diameter, leading to a method for controlling the release rate of molecules from SWNTs by using nanotube materials with suitable diameter. This work introduces the concept of "functionalization partitioning" of SWNTs, i.e., imparting multiple chemical species, such as PEG, drugs, and fluorescent tags, with different functionalities onto the surface of the same nanotube. Such chemical partitioning should open up new opportunities in chemical, biological, and medical applications of novel nanomaterials.
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A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice
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Self-citationPolyethylene glycol (PEG): A versatile polymer for pharmaceutical applications
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Carbon nanotubes: properties, synthesis, purification, and medical applications
Eatemadi, A., Daraee, H., Karimkhanloo, H., Kouhi, M., Zarghami, N., Akbarzadeh, A., Abasi, M., Hanifehpour, Y., & Joo, S. W. (2014) · Nanoscale Research Letters · doi:10.1186/1556-276x-9-393 · Cited by 1,239
Metadata
- Authors
- Liu, Z., Sun, X., Nakayama-Ratchford, N., & Dai, H.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-08-01
- Volume
- 1
- Issue
- 1
- Pages
- 50-56
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2161105252
- Cited by
- 1,368
- References
- 28
- FWCI
- 31.26
- Type
- journal article
- Language
- en
- Open access
- closed
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