The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Synthesis, Characterization, and in Vitro Testing of Superparamagnetic Iron Oxide Nanoparticles Targeted Using Folic Acid-Conjugated Dendrimers
Abstract
Organic-coated superparamagnetic iron oxide nanoparticles (OC-SPIONs) were synthesized and characterized by transmission electron microscopy and X-ray photoelectron spectroscopy. OC-SPIONs were transferred from organic media into water using poly(amidoamine) dendrimers modified with 6-TAMRA fluorescent dye and folic acid molecules. The saturation magnetization of the resulting dendrimer-coated SPIONs (DC-SPIONs) was determined, using a superconducting quantum interference device, to be 60 emu/g Fe versus 90 emu/g Fe for bulk magnetite. Selective targeting of the DC-SPIONs to KB cancer cells in vitro was demonstrated and quantified using two distinct and complementary imaging modalities: UV-visible and X-ray fluorescence; confocal microscopy confirmed internalization. The results were consistent between the uptake distribution quantified by flow cytometry using 6-TAMRA UV-visible fluorescence intensity and the cellular iron content determined using X-ray fluorescence microscopy.
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Block copolymer micelles: preparation, characterization and application in drug delivery
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Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems
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Cited by
Applications and potential toxicity of magnetic iron oxide nanoparticles
Liu, G., Gao, J., Ai, H., & Chen, X. (2013) · Small · doi:10.1002/smll.201201531 · Cited by 570
Palanisamy, S., & Wang, Y.-M. (2019) · Dalton Transactions · doi:10.1039/c9dt00459a · Cited by 230
Engineered nanoparticles for imaging and drug delivery in colorectal cancer
Pavitra, E., Dariya, B., Srivani, G., Kang, S.-M., Alam, A., Sudhir, P.-R., Kamal, M. A., Raju, G. S. R., Han, Y.-K., Lakkakula, B. V. K. S., et al. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.06.017 · Cited by 102
Blank, F., Gerber, P., Rothen-Rutishauser, B., Sakulkhu, U., Salaklang, J., De Peyer, K., Gehr, P., Nicod, L. P., Hofmann, H., Geiser, T., et al. (2011) · Nanotoxicology · doi:10.3109/17435390.2010.541293 · Cited by 97
Multiscale observation of biological interactions of nanocarriers: From nano to macro
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Metadata
- Authors
- Landmark, K. J., DiMaggio, S., Ward, J., Kelly, C., Vogt, S., Hong, S., Kotlyar, A., Myc, A., Thomas, T. P., Penner-Hahn, J. E., Baker, J. R., Holl, M. M. B., & Orr, B. G.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-04-01
- Volume
- 2
- Issue
- 4
- Pages
- 773-783
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2079529157
- Cited by
- 172
- References
- 3
- FWCI
- 12.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Landmark, K. J., DiMaggio, S., Ward, J., Kelly, C., Vogt, S., Hong, S., Kotlyar, A., Myc, A., Thomas, T. P., Penner-Hahn, J. E., Baker, J. R., Holl, M. M. B., & Orr, B. G. (2008). Synthesis, Characterization, and in Vitro Testing of Superparamagnetic Iron Oxide Nanoparticles Targeted Using Folic Acid-Conjugated Dendrimers. ACS Nano. https://doi.org/10.1021/nn800034w
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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