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Uptake and Intracellular Fate of Surface-Modified Gold Nanoparticles
Abstract
Understanding and controlling the interactions between nanoscale objects and living cells is of great importance for arising diagnostic and therapeutic applications of nanoparticles and for nanotoxicology studies. Here we report a detailed transmission electron microscopy (TEM) study of the uptake of ca. 16 nm surface-modified gold nanoparticles by human fibroblast cells (HeLa cells). It is demonstrated that the well-established endosomal route of cellular uptake can be bypassed to a significant extent by controlling the uptake mechanism either via the delivery of the nanoparticles by liposomes or by surface modification of the nanoparticles with so-called cell penetrating peptides (CPPs). Successful nuclear targeting is demonstrated using surface modification with a cocktail of CPPs and a peptide acting as a nuclear localization signal (NLS).
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Cited by
Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements
Her, S., Jaffray, D. A., & Allen, C. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.12.012 · Cited by 865
Cho, E. C., Xie, J., Wurm, P. A., & Xia, Y. (2009) · Nano Letters · doi:10.1021/nl803487r · Cited by 819
Gold nanoparticles: opportunities and challenges in nanomedicine
Arvizo, R., Bhattacharya, R., & Mukherjee, P. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425241003777010 · Cited by 538
Yang, C., Uertz, J., Yohan, D., & Chithrani, B. D. (2014) · Nanoscale · doi:10.1039/c4nr02535k · Cited by 156
Metadata
- Authors
- Nativo, P., Prior, I. A., & Brust, M.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-07-22
- Volume
- 2
- Issue
- 8
- Pages
- 1639-1644
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2051565538
- Cited by
- 659
- References
- 0
- FWCI
- 19.14
- Type
- journal article
- Language
- en
- Open access
- closed
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