The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Targeting of Porous Hybrid Silica Nanoparticles to Cancer Cells
Abstract
Mesoporous silica nanoparticles functionalized by surface hyperbranching polymerization of poly(ethylene imine), PEI, were further modified by introducing both fluorescent and targeting moieties, with the aim of specifically targeting cancer cells. Owing to the high abundance of folate receptors in many cancer cells as compared to normal cells, folic acid was used as the targeting ligand. The internalization of the particles in cell lines expressing different levels of folate receptors was studied. Flow cytometry was used to quantify the mean number of nanoparticles internalized per cell. Five times more particles were internalized by cancer cells expressing folate receptors as compared to the normal cells expressing low levels of the receptor. Not only the number of nanoparticles internalized per cell, but also the fraction of cells that had internalized nanoparticles was higher. The total number of particles internalized by the cancer cells was, therefore, about an order of magnitude higher than the total number of particles internalized by normal cells, a difference high enough to be of significant biological importance. In addition, the biospecifically tagged hybrid PEI-silica particles were shown to be noncytotoxic and able to specifically target folate receptor-expressing cancer cells also under coculture conditions.
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Cites
Mesoporous silica nanoparticles for drug delivery and biosensing applications
Slowing, I. I., Trewyn, B. G., Giri, S., & Lin, V. S. ‐. (2007) · Advanced Functional Materials · doi:10.1002/adfm.200601191 · Cited by 1,699
Lim, Y.-B., Kim, S.-M., Lee, Y., Lee, W.-K., Yang, T.-G., Lee, M.-J., Suh, H., & Park, J.-S. (2001) · Journal of the American Chemical Society · doi:10.1021/ja005715g · Cited by 138
Cited by
Mesoporous silica nanoparticles in biomedical applications
Li, Z., Barnes, J. C., Bosoy, A., Stoddart, J. F., & Zink, J. I. (2012) · Chemical Society Reviews · doi:10.1039/c1cs15246g · Cited by 1,907
Mesoporous silica nanoparticles in drug delivery and biomedical applications
Wang, Y., Zhao, Q., Han, N., Bai, L., Li, J., Liu, J., Che, E., Hu, L., Zhang, Q., Jiang, T., et al. (2015) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2014.09.014 · Cited by 1,192
Xia, T., Kovochich, M., Liong, M., Meng, H., Kabehie, S., George, S., Zink, J. I., & Nel, A. E. (2009) · ACS Nano · doi:10.1021/nn900918w · Cited by 933
Thomas, C. R., Ferris, D. P., Lee, J.-H., Choi, E., Cho, M. H., Kim, E. S., Stoddart, J. F., Shin, J.-S., Cheon, J., & Zink, J. I. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1022267 · Cited by 615
Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights
Vallet-Regí, M., Colilla, M., Izquierdo-Barba, I., & Manzano, M. (2017) · Molecules · doi:10.3390/molecules23010047 · Cited by 538
Metadata
- Authors
- Rosenholm, J. M., Meinander, A., Peuhu, E., Niemi, R., Eriksson, J. E., Sahlgren, C., & Lindén, M.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-12-23
- Volume
- 3
- Issue
- 1
- Pages
- 197-206
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2059898245
- Cited by
- 520
- References
- 2
- FWCI
- 12.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rosenholm, J. M., Meinander, A., Peuhu, E., Niemi, R., Eriksson, J. E., Sahlgren, C., & Lindén, M. (2009). Targeting of Porous Hybrid Silica Nanoparticles to Cancer Cells. ACS Nano. https://doi.org/10.1021/nn800781r
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